Source

Evaluation of cell-free DNA approaches for multi-cancer early detection

Cancer Cell 40(12):1537-1549.e12, published 2022-12-12; publisher PDF (1-s2.0-S153561082200513X-main.pdf) as deposited by the Francis Crick Institute on figshare, 10.25418/crick.21731870.v1 · Peer-reviewed

DOI: 10.1016/j.ccell.2022.10.022

Developer study: most authors are GRAIL employees with equity in Illumina, and several are inventors on related GRAIL patent applications (Declaration of interests). All classifiers were built and run by GRAIL. Samples are from CCGA (NCT02889978) substudy 1.

Evidence

Source checking verifies the cited claim or transcription. It does not establish independent reproduction.

Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

23 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-10-10-cbb3da59bc08
Property and statement	Original source and location	Review and provenance
Access and reuse CC BY-NC-ND 4.0, printed on the first page of the article and on the figshare record. Source metadata	Evaluation of cell-free DNA approaches for multi-cancer early detection Original source ↗ No field-specific location recorded Version: Cancer Cell 40(12):1537-1549.e12, published 2022-12-12; publisher PDF (1-s2.0-S153561082200513X-main.pdf) as deposited by the Francis Crick Institute on figshare, 10.25418/crick.21731870.v1 Retrieved: 2026-10-10T06:05:17Z	catalogued No individual claim review recorded Audit details Field: `attributes.access_and_reuse` Source artifact SHA-256: `5159294dd203d511dd437837a34555b276e14e0edf615bcb58bae5d9a1246d9a` Hash scope: pdftotext -layout text layer, parsed by extract/extract_ctdna_jamshidi.py Inspected artifact
Archive note Not archived in the batch: the licence forbids commercial reuse and the PDF is 2,459,162 bytes. The artifact_sha256 pins the bytes that were read; figshare's computed MD5 for the file is 6f51c7dc523d231b6c0ce268257bd3b8. Source metadata	Evaluation of cell-free DNA approaches for multi-cancer early detection Original source ↗ No field-specific location recorded Version: Cancer Cell 40(12):1537-1549.e12, published 2022-12-12; publisher PDF (1-s2.0-S153561082200513X-main.pdf) as deposited by the Francis Crick Institute on figshare, 10.25418/crick.21731870.v1 Retrieved: 2026-10-10T06:05:17Z	catalogued No individual claim review recorded Audit details Field: `attributes.archive_note` Source artifact SHA-256: `5159294dd203d511dd437837a34555b276e14e0edf615bcb58bae5d9a1246d9a` Hash scope: pdftotext -layout text layer, parsed by extract/extract_ctdna_jamshidi.py Inspected artifact
attributes.artifact_sha256 5159294dd203d511dd437837a34555b276e14e0edf615bcb58bae5d9a1246d9a Source metadata	Evaluation of cell-free DNA approaches for multi-cancer early detection Original source ↗ No field-specific location recorded Version: Cancer Cell 40(12):1537-1549.e12, published 2022-12-12; publisher PDF (1-s2.0-S153561082200513X-main.pdf) as deposited by the Francis Crick Institute on figshare, 10.25418/crick.21731870.v1 Retrieved: 2026-10-10T06:05:17Z	catalogued No individual claim review recorded Audit details Field: `attributes.artifact_sha256` Source artifact SHA-256: `5159294dd203d511dd437837a34555b276e14e0edf615bcb58bae5d9a1246d9a` Hash scope: pdftotext -layout text layer, parsed by extract/extract_ctdna_jamshidi.py Inspected artifact
Artifact url https://ndownloader.figshare.com/files/38559380 Source metadata	Evaluation of cell-free DNA approaches for multi-cancer early detection Original source ↗ No field-specific location recorded Version: Cancer Cell 40(12):1537-1549.e12, published 2022-12-12; publisher PDF (1-s2.0-S153561082200513X-main.pdf) as deposited by the Francis Crick Institute on figshare, 10.25418/crick.21731870.v1 Retrieved: 2026-10-10T06:05:17Z	catalogued No individual claim review recorded Audit details Field: `attributes.artifact_url` Source artifact SHA-256: `5159294dd203d511dd437837a34555b276e14e0edf615bcb58bae5d9a1246d9a` Hash scope: pdftotext -layout text layer, parsed by extract/extract_ctdna_jamshidi.py Inspected artifact
Doi 10.1016/j.ccell.2022.10.022 Source metadata	Evaluation of cell-free DNA approaches for multi-cancer early detection Original source ↗ No field-specific location recorded Version: Cancer Cell 40(12):1537-1549.e12, published 2022-12-12; publisher PDF (1-s2.0-S153561082200513X-main.pdf) as deposited by the Francis Crick Institute on figshare, 10.25418/crick.21731870.v1 Retrieved: 2026-10-10T06:05:17Z	catalogued No individual claim review recorded Audit details Field: `attributes.doi` Source artifact SHA-256: `5159294dd203d511dd437837a34555b276e14e0edf615bcb58bae5d9a1246d9a` Hash scope: pdftotext -layout text layer, parsed by extract/extract_ctdna_jamshidi.py Inspected artifact
Extraction method pdftotext -layout text layer, parsed by extract/extract_ctdna_jamshidi.py Source metadata	Evaluation of cell-free DNA approaches for multi-cancer early detection Original source ↗ No field-specific location recorded Version: Cancer Cell 40(12):1537-1549.e12, published 2022-12-12; publisher PDF (1-s2.0-S153561082200513X-main.pdf) as deposited by the Francis Crick Institute on figshare, 10.25418/crick.21731870.v1 Retrieved: 2026-10-10T06:05:17Z	catalogued No individual claim review recorded Audit details Field: `attributes.extraction_method` Source artifact SHA-256: `5159294dd203d511dd437837a34555b276e14e0edf615bcb58bae5d9a1246d9a` Hash scope: pdftotext -layout text layer, parsed by extract/extract_ctdna_jamshidi.py Inspected artifact
Licence CC-BY-NC-ND-4.0 Source metadata	Evaluation of cell-free DNA approaches for multi-cancer early detection Original source ↗ No field-specific location recorded Version: Cancer Cell 40(12):1537-1549.e12, published 2022-12-12; publisher PDF (1-s2.0-S153561082200513X-main.pdf) as deposited by the Francis Crick Institute on figshare, 10.25418/crick.21731870.v1 Retrieved: 2026-10-10T06:05:17Z	catalogued No individual claim review recorded Audit details Field: `attributes.licence` Source artifact SHA-256: `5159294dd203d511dd437837a34555b276e14e0edf615bcb58bae5d9a1246d9a` Hash scope: pdftotext -layout text layer, parsed by extract/extract_ctdna_jamshidi.py Inspected artifact
Media type application/pdf Source metadata	Evaluation of cell-free DNA approaches for multi-cancer early detection Original source ↗ No field-specific location recorded Version: Cancer Cell 40(12):1537-1549.e12, published 2022-12-12; publisher PDF (1-s2.0-S153561082200513X-main.pdf) as deposited by the Francis Crick Institute on figshare, 10.25418/crick.21731870.v1 Retrieved: 2026-10-10T06:05:17Z	catalogued No individual claim review recorded Audit details Field: `attributes.media_type` Source artifact SHA-256: `5159294dd203d511dd437837a34555b276e14e0edf615bcb58bae5d9a1246d9a` Hash scope: pdftotext -layout text layer, parsed by extract/extract_ctdna_jamshidi.py Inspected artifact
Publication status peer_reviewed Source metadata	Evaluation of cell-free DNA approaches for multi-cancer early detection Original source ↗ No field-specific location recorded Version: Cancer Cell 40(12):1537-1549.e12, published 2022-12-12; publisher PDF (1-s2.0-S153561082200513X-main.pdf) as deposited by the Francis Crick Institute on figshare, 10.25418/crick.21731870.v1 Retrieved: 2026-10-10T06:05:17Z	catalogued No individual claim review recorded Audit details Field: `attributes.publication_status` Source artifact SHA-256: `5159294dd203d511dd437837a34555b276e14e0edf615bcb58bae5d9a1246d9a` Hash scope: pdftotext -layout text layer, parsed by extract/extract_ctdna_jamshidi.py Inspected artifact
Retrieval note Not in PMC; Europe PMC has no full text or supplementary files; cell.com and ScienceDirect returned 403 and the Elsevier API returned 429. The Crick figshare deposit holds the publisher PDF of the version of record. Source metadata	Evaluation of cell-free DNA approaches for multi-cancer early detection Original source ↗ No field-specific location recorded Version: Cancer Cell 40(12):1537-1549.e12, published 2022-12-12; publisher PDF (1-s2.0-S153561082200513X-main.pdf) as deposited by the Francis Crick Institute on figshare, 10.25418/crick.21731870.v1 Retrieved: 2026-10-10T06:05:17Z	catalogued No individual claim review recorded Audit details Field: `attributes.retrieval_note` Source artifact SHA-256: `5159294dd203d511dd437837a34555b276e14e0edf615bcb58bae5d9a1246d9a` Hash scope: pdftotext -layout text layer, parsed by extract/extract_ctdna_jamshidi.py Inspected artifact

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Sources and history

Release 2026-10-10-cbb3da59bc08 · Record review: source checked

Primary source retrieved and hashed for the CCGA substudy 1 follow-up pass.

Release history

No supporting source is linked yet.

Read original source

Download this release (gzip)

Technical metadata and extraction receipts

Stable ID: ctdnajam-20261010-source-jamshidi2022

areas: dna-genomes
contexts: clinical_research
url: https://doi.org/10.1016/j.ccell.2022.10.022
artifact url: https://ndownloader.figshare.com/files/38559380
version: Cancer Cell 40(12):1537-1549.e12, published 2022-12-12; publisher PDF (1-s2.0-S153561082200513X-main.pdf) as deposited by the Francis Crick Institute on figshare, 10.25418/crick.21731870.v1
retrieved at: 2026-10-10T06:05:17Z
artifact sha256: 5159294dd203d511dd437837a34555b276e14e0edf615bcb58bae5d9a1246d9a
publication status: peer_reviewed
licence: CC-BY-NC-ND-4.0
media type: application/pdf
doi: 10.1016/j.ccell.2022.10.022
source locator: Full artifact bytes; per-record locators on each record
access and reuse: CC BY-NC-ND 4.0, printed on the first page of the article and on the figshare record.
archive note: Not archived in the batch: the licence forbids commercial reuse and the PDF is 2,459,162 bytes. The artifact_sha256 pins the bytes that were read; figshare's computed MD5 for the file is 6f51c7dc523d231b6c0ce268257bd3b8.
retrieval note: Not in PMC; Europe PMC has no full text or supplementary files; cell.com and ScienceDirect returned 403 and the Elsevier API returned 429. The Crick figshare deposit holds the publisher PDF of the version of record.
extraction method: pdftotext -layout text layer, parsed by extract/extract_ctdna_jamshidi.py
scope note: Developer study: most authors are GRAIL employees with equity in Illumina, and several are inventors on related GRAIL patent applications (Declaration of interests). All classifiers were built and run by GRAIL. Samples are from CCGA (NCT02889978) substudy 1.

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