Whole-genome methylation classifier (GRAIL prototype)
Removes fragments with methylation states common in non-cancer samples, keeps mostly hyper- or hypo-methylated fragments with at least 5 CpGs, scores their cancer likelihood by genome location, and classifies the top-ranked fragment likelihoods with kernel logistic regression.
Results are recorded on linked configurations and versions of this method. Their settings and evaluations are kept separate below.
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- Whole-genome methylation classifier (GRAIL prototype), CCGA substudy 1 Configuration · configuration · 3 evaluations · 3 results
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Sources and history
Release 2026-10-10-cbb3da59bc08 · Record review: source checked
1 source record and release history
- Evaluation of cell-free DNA approaches for multi-cancer early detection · Original source · Cancer Cell 40(12):1537-1549.e12, published 2022-12-12; publisher PDF (1-s2.0-S153561082200513X-main.pdf) as deposited by the Francis Crick Institute on figshare, 10.25418/crick.21731870.v1
Technical metadata and extraction receipts
Stable ID: ctdnajam-20261010-method-wg-methylation
- areas
- dna-genomes
- contexts
- clinical_research
- method types
- supervised_machine_learning
- reported name
- WG methylation
- entity level
- method
- source locator
- STAR Methods, WGBS: WG methylation classifier
- missing metadata
- version: reason: inapplicable; note: Family record; settings are on configurations
Related records
- configuration of: Whole-genome methylation classifier (GRAIL prototype), CCGA substudy 1