headline_finding: ctdnajam-20261010-protocol-ccga1-validation-sens-98spec
Headline finding of CCGA substudy 1 validation set: cancer signal sensitivity at 98% specificity
In a multivariate analysis of detection against log10(cTAF), cancer type and clinical stage, cTAF was the only significant predictor of classifier performance; without cTAF, stage became significant. cTAF accounted for 72% of the variance in WG methylation classifier scores.
Descriptive fact transcribed from the pinned source.
Evidence
Source checking verifies the cited claim or transcription. It does not establish independent reproduction.
Evidence table
Inspect claims, sources and review details
Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.
One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.
6 evidence rows matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|---|---|
| Claimed field headline_finding Context-only references | Evaluation of cell-free DNA approaches for multi-cancer early detection Results, cTAF; Table S1 and Figure S7 (supplement not extracted) Version: Cancer Cell 40(12):1537-1549.e12, published 2022-12-12; publisher PDF (1-s2.0-S153561082200513X-main.pdf) as deposited by the Francis Crick Institute on figshare, 10.25418/crick.21731870.v1 | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: pdftotext -layout text layer, parsed by extract/extract_ctdna_jamshidi.py |
| Source location Results, cTAF; Table S1 and Figure S7 (supplement not extracted) Context-only references | Evaluation of cell-free DNA approaches for multi-cancer early detection Results, cTAF; Table S1 and Figure S7 (supplement not extracted) Version: Cancer Cell 40(12):1537-1549.e12, published 2022-12-12; publisher PDF (1-s2.0-S153561082200513X-main.pdf) as deposited by the Francis Crick Institute on figshare, 10.25418/crick.21731870.v1 | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: pdftotext -layout text layer, parsed by extract/extract_ctdna_jamshidi.py |
| Claimed value In a multivariate analysis of detection against log10(cTAF), cancer type and clinical stage, cTAF was the only significant predictor of classifier performance; without cTAF, stage became significant. cTAF accounted for 72% of the variance in WG methylation classifier scores. Context-only references | Evaluation of cell-free DNA approaches for multi-cancer early detection Results, cTAF; Table S1 and Figure S7 (supplement not extracted) Version: Cancer Cell 40(12):1537-1549.e12, published 2022-12-12; publisher PDF (1-s2.0-S153561082200513X-main.pdf) as deposited by the Francis Crick Institute on figshare, 10.25418/crick.21731870.v1 | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: pdftotext -layout text layer, parsed by extract/extract_ctdna_jamshidi.py |
| Description Descriptive fact transcribed from the pinned source. Context-only references | Evaluation of cell-free DNA approaches for multi-cancer early detection Results, cTAF; Table S1 and Figure S7 (supplement not extracted) Version: Cancer Cell 40(12):1537-1549.e12, published 2022-12-12; publisher PDF (1-s2.0-S153561082200513X-main.pdf) as deposited by the Francis Crick Institute on figshare, 10.25418/crick.21731870.v1 | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: pdftotext -layout text layer, parsed by extract/extract_ctdna_jamshidi.py |
| Relationship: subject ctdnajam-20261010-protocol-ccga1-validation-sens-98spec Context-only references | Evaluation of cell-free DNA approaches for multi-cancer early detection Results, cTAF; Table S1 and Figure S7 (supplement not extracted) Version: Cancer Cell 40(12):1537-1549.e12, published 2022-12-12; publisher PDF (1-s2.0-S153561082200513X-main.pdf) as deposited by the Francis Crick Institute on figshare, 10.25418/crick.21731870.v1 | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: pdftotext -layout text layer, parsed by extract/extract_ctdna_jamshidi.py |
| Name headline_finding: ctdnajam-20261010-protocol-ccga1-validation-sens-98spec Context-only references | Evaluation of cell-free DNA approaches for multi-cancer early detection Results, cTAF; Table S1 and Figure S7 (supplement not extracted) Version: Cancer Cell 40(12):1537-1549.e12, published 2022-12-12; publisher PDF (1-s2.0-S153561082200513X-main.pdf) as deposited by the Francis Crick Institute on figshare, 10.25418/crick.21731870.v1 | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: pdftotext -layout text layer, parsed by extract/extract_ctdna_jamshidi.py |
Sources and history
Release 2026-10-10-457d7eaef7d6 · Record review: source checked
1 source record and release history
- Evaluation of cell-free DNA approaches for multi-cancer early detection · Original source · Cancer Cell 40(12):1537-1549.e12, published 2022-12-12; publisher PDF (1-s2.0-S153561082200513X-main.pdf) as deposited by the Francis Crick Institute on figshare, 10.25418/crick.21731870.v1
Technical metadata and extraction receipts
Stable ID: ctdnajam-20261010-claim-ctaf-predictor
- field
- headline_finding
- value
- In a multivariate analysis of detection against log10(cTAF), cancer type and clinical stage, cTAF was the only significant predictor of classifier performance; without cTAF, stage became significant. cTAF accounted for 72% of the variance in WG methylation classifier scores.
- source locator
- Results, cTAF; Table S1 and Figure S7 (supplement not extracted)
- review
- method: source-hash-verification; ai-assisted-source-review; method note: Compared the claim with the cited text of the re-downloaded PDF.; reviewer: claude; reviewer note: Separate Claude review agent, independent of the extractor; no human review claimed; date: 2026-10-10; artifact sha256: 5159294dd203d511dd437837a34555b276e14e0edf615bcb58bae5d9a1246d9a; retrieval url: https://ndownloader.figshare.com/files/38559380; note: Text matches the source. Descriptive claim; no value or execution.