Pan-feature classifier over all cfDNA classifier scores (GRAIL prototype), CCGA substudy 1

Overview

Pan-feature classifier over all cfDNA classifier scores (GRAIL prototype): Gradient-boosted decision trees (XGBoost) over the output scores of the nine cfDNA feature classifiers, excluding the clinical classifier.

Consult the linked sources for architecture or protocol details. Missing evidence is not evidence of a missing capability.

Evaluations and results

1 evaluation · 1 result. Different protocols are not a single leaderboard.

Filter evaluations

Tested model or methodProtocolDatasetEvaluation setupMetricEvidence origin

Applied filters: All linked evaluations

Exact evaluated configurations and original reported results
Tested configuration	Protocol and dataset	Finding	Evidence and details
Configuration: Pan-feature classifier over all cfDNA classifier scores (GRAIL prototype), CCGA substudy 1	Protocol: CCGA substudy 1 validation set: cancer signal sensitivity at 98% specificity Dataset: CCGA substudy 1 validation set (847 analysable participants)	36% (31%–40%) Sensitivity at 98% specificity (validation set, post hoc 98% specificity threshold) percent · higher Uncertainty: 95% CI 31 to 40. Clopper-Pearson exact binomial interval (STAR Methods, statistical analysis) Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source pan-feature on CCGA substudy 1 validation set: cancer signal sensitivity at 98% specificity ctdnajam-20261010-protocol-ccga1-validation-sens-98spec Aggregation: Not reported Evaluation of cell-free DNA approaches for multi-cancer early detection · Table 3, row 'pan-feature', validation set, sensitivity and TP/total cancer samples 165/464

Source checking is not independent reproduction. Release 2026-10-10-cbb3da59bc08.

Use this configuration

How it works, versions and access

Evidence

Source checking verifies the cited claim or transcription. It does not establish independent reproduction.

Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

0 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-10-10-cbb3da59bc08
Property and statement	Original source and location	Review and provenance

No evidence rows match these filters. Choose another scope or clear the search.

All evidence (JSONL) (gzip)How to read the evidence

Sources and history

Release 2026-10-10-cbb3da59bc08 · Record review: source checked

1 source record and release history

Evaluation of cell-free DNA approaches for multi-cancer early detection · Original source · Cancer Cell 40(12):1537-1549.e12, published 2022-12-12; publisher PDF (1-s2.0-S153561082200513X-main.pdf) as deposited by the Francis Crick Institute on figshare, 10.25418/crick.21731870.v1

Download this release (gzip)

Technical metadata and extraction receipts

Stable ID: ctdnajam-20261010-config-pan-feature

areas: dna-genomes
contexts: clinical_research
method types: supervised_machine_learning
reported name: pan-feature
foundation model eligible: false
source locator: Table 2; STAR Methods, Pan-feature classifier
parameters: Scores from the WGBS, targeted sequencing and WGS classifiers
missing metadata: version: reason: unreported; note: Prototype classifier; no release or commit is printed

Related records