Sensitivity at 98% specificity (validation set, post hoc 98% specificity threshold) of Pan-feature classifier over all cfDNA classifier scores (GRAIL prototype), CCGA substudy 1 on CCGA substudy 1 validation set (847 analysable participants)
36% (31%–40%) Sensitivity at 98% specificity (validation set, post hoc 98% specificity threshold)
Methods
- Tested configuration
- Pan-feature classifier over all cfDNA classifier scores (GRAIL prototype), CCGA substudy 1
- Protocol
- CCGA substudy 1 validation set: cancer signal sensitivity at 98% specificity
- Dataset
- CCGA substudy 1 validation set (847 analysable participants)
- Procedure
- CCGA substudy 1 validation set: cancer signal sensitivity at 98% specificity
- Evaluation
- pan-feature on CCGA substudy 1 validation set: cancer signal sensitivity at 98% specificity
- Coverage
- Not reported scored / Not reported eligible
- Uncertainty
- 95% CI 31 to 40. Clopper-Pearson exact binomial interval (STAR Methods, statistical analysis)
- Evidence
- Author-reported evaluation · source checkedEvaluation of cell-free DNA approaches for multi-cancer early detection · Table 3, row 'pan-feature', validation set, sensitivity and TP/total cancer samples 165/464
A source-checked result verifies the numerical transcription, not every model or protocol detail. Evaluation metadata: source checked. Source checked does not mean independently reproduced.
Reproduction
- Split
- Independent validation set, classifier locked on the training set
- Adaptation
- Trained on the CCGA substudy 1 training set
- Scoring implementation
- Sensitivity at a post hoc 98% specificity threshold; Clopper-Pearson 95% CI
No execution recipe has been verified for this exact configuration and evaluation. A benchmark's general instructions may use different inputs, splits or model settings.
Reproducing this published result requires matching its model configuration, data, split and scorer. Source checking or a successful smoke test does not establish score reproduction.
Evidence
Source checking verifies the cited claim or transcription. It does not establish independent reproduction.
Evidence table
Inspect claims, sources and review details
Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.
One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.
1 evidence row matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|---|---|
| Reported result 36% (31%–40%) Individual claims | Evaluation of cell-free DNA approaches for multi-cancer early detection Table 3, row 'pan-feature', validation set, sensitivity and TP/total cancer samples 165/464 Version: Cancer Cell 40(12):1537-1549.e12, published 2022-12-12; publisher PDF (1-s2.0-S153561082200513X-main.pdf) as deposited by the Francis Crick Institute on figshare, 10.25418/crick.21731870.v1 | source checked ["source-hash-verification","pdf-text-parse","independent-cell-check"] · 2026-10-10 author reported Audit detailsExtracted by deterministic parse of the PDF text layer (pdftotext -layout). Independent review 2026-10-10: value, interval and identity match the source. Field: Source artifact SHA-256: Hash scope: pdftotext -layout text layer, parsed by extract/extract_ctdna_jamshidi.py Extraction artifact SHA-256: |
Sources and history
Release 2026-10-10-cbb3da59bc08 · Record review: source checked
1 source record and release history
- Evaluation of cell-free DNA approaches for multi-cancer early detection · Original source · Cancer Cell 40(12):1537-1549.e12, published 2022-12-12; publisher PDF (1-s2.0-S153561082200513X-main.pdf) as deposited by the Francis Crick Institute on figshare, 10.25418/crick.21731870.v1
Technical metadata and extraction receipts
Stable ID: ctdnajam-20261010-result-validation-pan-feature-sensitivity
- metric
- sensitivity-at-98-percent-specificity
- metric qualifier
- validation set, post hoc 98% specificity threshold
- metric direction
- higher
- unit
- percent
- printed value
- 36% (31%–40%)
- numeric value
- 36
- source locator
- Table 3, row 'pan-feature', validation set, sensitivity and TP/total cancer samples 165/464
- review
- method: source-hash-verification; pdf-text-parse; independent-cell-check; method note: Re-downloaded the figshare file and matched its SHA-256 and the figshare MD5. Read the text layer with pdftotext and a separate parser. Checked the Table 3 cell, its footnote marks, the TP/total count, metric, qualifier and links, recomputed the percentage from TP/total and recomputed the 95% Clopper-Pearson interval with scipy; both match the printed values.; reviewer: claude; reviewer note: Separate Claude review agent, independent of the extractor; no human review claimed; date: 2026-10-10; artifact sha256: 5159294dd203d511dd437837a34555b276e14e0edf615bcb58bae5d9a1246d9a; retrieval url: https://ndownloader.figshare.com/files/38559380; note: Extracted by deterministic parse of the PDF text layer (pdftotext -layout). Independent review 2026-10-10: value, interval and identity match the source.
- uncertainty
- type: confidence_interval; printed: 31%–40%; lower: 31; upper: 40; level: 0.95; method: analytic; note: Clopper-Pearson exact binomial interval (STAR Methods, statistical analysis); n: 464
- numerator
- 165
- denominator
- 464
- reported p value
- not marked (not significant at p < 0.01), paired McNemar test against WG methylation (Table 3 footnotes b and c)