observed_specificity: ctdnajam-20261010-protocol-ccga1-validation-sens-98spec
Observed specificity of CCGA substudy 1 validation set: cancer signal sensitivity at 98% specificity
At the 98% target the observed specificity was 97.9% (548/560) in training and 97.8% (354/362) in validation for every cfDNA classifier; for the clinical data classifier it was 98.0% (540/551) and 97.8% (350/358), with fewer participants because of a missing clinical variable.
Descriptive fact transcribed from the pinned source.
Evidence
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Evidence table
Inspect claims, sources and review details
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6 evidence rows matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|---|---|
| Claimed field observed_specificity Context-only references | Evaluation of cell-free DNA approaches for multi-cancer early detection Table 3 footnotes a and e Version: Cancer Cell 40(12):1537-1549.e12, published 2022-12-12; publisher PDF (1-s2.0-S153561082200513X-main.pdf) as deposited by the Francis Crick Institute on figshare, 10.25418/crick.21731870.v1 | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: pdftotext -layout text layer, parsed by extract/extract_ctdna_jamshidi.py |
| Source location Table 3 footnotes a and e Context-only references | Evaluation of cell-free DNA approaches for multi-cancer early detection Table 3 footnotes a and e Version: Cancer Cell 40(12):1537-1549.e12, published 2022-12-12; publisher PDF (1-s2.0-S153561082200513X-main.pdf) as deposited by the Francis Crick Institute on figshare, 10.25418/crick.21731870.v1 | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: pdftotext -layout text layer, parsed by extract/extract_ctdna_jamshidi.py |
| Claimed value At the 98% target the observed specificity was 97.9% (548/560) in training and 97.8% (354/362) in validation for every cfDNA classifier; for the clinical data classifier it was 98.0% (540/551) and 97.8% (350/358), with fewer participants because of a missing clinical variable. Context-only references | Evaluation of cell-free DNA approaches for multi-cancer early detection Table 3 footnotes a and e Version: Cancer Cell 40(12):1537-1549.e12, published 2022-12-12; publisher PDF (1-s2.0-S153561082200513X-main.pdf) as deposited by the Francis Crick Institute on figshare, 10.25418/crick.21731870.v1 | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: pdftotext -layout text layer, parsed by extract/extract_ctdna_jamshidi.py |
| Description Descriptive fact transcribed from the pinned source. Context-only references | Evaluation of cell-free DNA approaches for multi-cancer early detection Table 3 footnotes a and e Version: Cancer Cell 40(12):1537-1549.e12, published 2022-12-12; publisher PDF (1-s2.0-S153561082200513X-main.pdf) as deposited by the Francis Crick Institute on figshare, 10.25418/crick.21731870.v1 | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: pdftotext -layout text layer, parsed by extract/extract_ctdna_jamshidi.py |
| Relationship: subject ctdnajam-20261010-protocol-ccga1-validation-sens-98spec Context-only references | Evaluation of cell-free DNA approaches for multi-cancer early detection Table 3 footnotes a and e Version: Cancer Cell 40(12):1537-1549.e12, published 2022-12-12; publisher PDF (1-s2.0-S153561082200513X-main.pdf) as deposited by the Francis Crick Institute on figshare, 10.25418/crick.21731870.v1 | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: pdftotext -layout text layer, parsed by extract/extract_ctdna_jamshidi.py |
| Name observed_specificity: ctdnajam-20261010-protocol-ccga1-validation-sens-98spec Context-only references | Evaluation of cell-free DNA approaches for multi-cancer early detection Table 3 footnotes a and e Version: Cancer Cell 40(12):1537-1549.e12, published 2022-12-12; publisher PDF (1-s2.0-S153561082200513X-main.pdf) as deposited by the Francis Crick Institute on figshare, 10.25418/crick.21731870.v1 | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: pdftotext -layout text layer, parsed by extract/extract_ctdna_jamshidi.py |
Sources and history
Release 2026-10-10-457d7eaef7d6 · Record review: source checked
1 source record and release history
- Evaluation of cell-free DNA approaches for multi-cancer early detection · Original source · Cancer Cell 40(12):1537-1549.e12, published 2022-12-12; publisher PDF (1-s2.0-S153561082200513X-main.pdf) as deposited by the Francis Crick Institute on figshare, 10.25418/crick.21731870.v1
Technical metadata and extraction receipts
Stable ID: ctdnajam-20261010-claim-observed-specificity
- field
- observed_specificity
- value
- At the 98% target the observed specificity was 97.9% (548/560) in training and 97.8% (354/362) in validation for every cfDNA classifier; for the clinical data classifier it was 98.0% (540/551) and 97.8% (350/358), with fewer participants because of a missing clinical variable.
- source locator
- Table 3 footnotes a and e
- review
- method: source-hash-verification; ai-assisted-source-review; method note: Compared the claim with the cited text of the re-downloaded PDF.; reviewer: claude; reviewer note: Separate Claude review agent, independent of the extractor; no human review claimed; date: 2026-10-10; artifact sha256: 5159294dd203d511dd437837a34555b276e14e0edf615bcb58bae5d9a1246d9a; retrieval url: https://ndownloader.figshare.com/files/38559380; note: Text matches the source. Descriptive claim; no value or execution.