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1 evaluation · 1 result. Different protocols are not a single leaderboard.
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| Tested configuration | Protocol and dataset | Finding | Evidence and details |
|---|---|---|---|
| Configuration: Fragment length classifier (GRAIL prototype), CCGA substudy 1 | Protocol: CCGA substudy 1 validation set: cancer signal sensitivity at 98% specificity Dataset: CCGA substudy 1 validation set (847 analysable participants) | 29% (25%–34%) Sensitivity at 98% specificity (validation set, post hoc 98% specificity threshold) percent · higher Uncertainty: 95% CI 25 to 34. Clopper-Pearson exact binomial interval (STAR Methods, statistical analysis) Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourcefragment lengths on CCGA substudy 1 validation set: cancer signal sensitivity at 98% specificity ctdnajam-20261010-protocol-ccga1-validation-sens-98spec Aggregation: Not reported Evaluation of cell-free DNA approaches for multi-cancer early detection · Table 3, row 'fragment lengths', validation set, sensitivity and TP/total cancer samples 136/464 |
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CCGA substudy 1 validation set: cancer signal sensitivity at 98% specificity
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19 evidence rows matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|---|---|
| Comparison: adaptation Trained on the CCGA substudy 1 training set Context-only references | Evaluation of cell-free DNA approaches for multi-cancer early detection Table 3, row 'fragment lengths', validation set columns Version: Cancer Cell 40(12):1537-1549.e12, published 2022-12-12; publisher PDF (1-s2.0-S153561082200513X-main.pdf) as deposited by the Francis Crick Institute on figshare, 10.25418/crick.21731870.v1 | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: pdftotext -layout text layer, parsed by extract/extract_ctdna_jamshidi.py |
| Comparison: aggregation Pooled over participants Context-only references | Evaluation of cell-free DNA approaches for multi-cancer early detection Table 3, row 'fragment lengths', validation set columns Version: Cancer Cell 40(12):1537-1549.e12, published 2022-12-12; publisher PDF (1-s2.0-S153561082200513X-main.pdf) as deposited by the Francis Crick Institute on figshare, 10.25418/crick.21731870.v1 | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: pdftotext -layout text layer, parsed by extract/extract_ctdna_jamshidi.py |
| Comparison: budget Not reported Context-only references | Evaluation of cell-free DNA approaches for multi-cancer early detection Table 3, row 'fragment lengths', validation set columns Version: Cancer Cell 40(12):1537-1549.e12, published 2022-12-12; publisher PDF (1-s2.0-S153561082200513X-main.pdf) as deposited by the Francis Crick Institute on figshare, 10.25418/crick.21731870.v1 | missing or unspecified No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: pdftotext -layout text layer, parsed by extract/extract_ctdna_jamshidi.py |
| Comparison: dataset version CCGA substudy 1 validation set Context-only references | Evaluation of cell-free DNA approaches for multi-cancer early detection Table 3, row 'fragment lengths', validation set columns Version: Cancer Cell 40(12):1537-1549.e12, published 2022-12-12; publisher PDF (1-s2.0-S153561082200513X-main.pdf) as deposited by the Francis Crick Institute on figshare, 10.25418/crick.21731870.v1 | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: pdftotext -layout text layer, parsed by extract/extract_ctdna_jamshidi.py |
| Comparison: inputs Whole-genome sequencing of cfDNA, about 30x Context-only references | Evaluation of cell-free DNA approaches for multi-cancer early detection Table 3, row 'fragment lengths', validation set columns Version: Cancer Cell 40(12):1537-1549.e12, published 2022-12-12; publisher PDF (1-s2.0-S153561082200513X-main.pdf) as deposited by the Francis Crick Institute on figshare, 10.25418/crick.21731870.v1 | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: pdftotext -layout text layer, parsed by extract/extract_ctdna_jamshidi.py |
| Comparison: metric implementation Sensitivity at a post hoc 98% specificity threshold; Clopper-Pearson 95% CI Context-only references | Evaluation of cell-free DNA approaches for multi-cancer early detection Table 3, row 'fragment lengths', validation set columns Version: Cancer Cell 40(12):1537-1549.e12, published 2022-12-12; publisher PDF (1-s2.0-S153561082200513X-main.pdf) as deposited by the Francis Crick Institute on figshare, 10.25418/crick.21731870.v1 | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: pdftotext -layout text layer, parsed by extract/extract_ctdna_jamshidi.py |
| Comparison: population 464 cancers and 362 non-cancers Context-only references | Evaluation of cell-free DNA approaches for multi-cancer early detection Table 3, row 'fragment lengths', validation set columns Version: Cancer Cell 40(12):1537-1549.e12, published 2022-12-12; publisher PDF (1-s2.0-S153561082200513X-main.pdf) as deposited by the Francis Crick Institute on figshare, 10.25418/crick.21731870.v1 | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: pdftotext -layout text layer, parsed by extract/extract_ctdna_jamshidi.py |
| Comparison: protocol id ctdnajam-20261010-protocol-ccga1-validation-sens-98spec Context-only references | Evaluation of cell-free DNA approaches for multi-cancer early detection Table 3, row 'fragment lengths', validation set columns Version: Cancer Cell 40(12):1537-1549.e12, published 2022-12-12; publisher PDF (1-s2.0-S153561082200513X-main.pdf) as deposited by the Francis Crick Institute on figshare, 10.25418/crick.21731870.v1 | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: pdftotext -layout text layer, parsed by extract/extract_ctdna_jamshidi.py |
| Comparison: split Independent validation set, classifier locked on the training set Context-only references | Evaluation of cell-free DNA approaches for multi-cancer early detection Table 3, row 'fragment lengths', validation set columns Version: Cancer Cell 40(12):1537-1549.e12, published 2022-12-12; publisher PDF (1-s2.0-S153561082200513X-main.pdf) as deposited by the Francis Crick Institute on figshare, 10.25418/crick.21731870.v1 | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: pdftotext -layout text layer, parsed by extract/extract_ctdna_jamshidi.py |
Limitations2 values
| Evaluation of cell-free DNA approaches for multi-cancer early detection Table 3, row 'fragment lengths', validation set columns Version: Cancer Cell 40(12):1537-1549.e12, published 2022-12-12; publisher PDF (1-s2.0-S153561082200513X-main.pdf) as deposited by the Francis Crick Institute on figshare, 10.25418/crick.21731870.v1 | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: pdftotext -layout text layer, parsed by extract/extract_ctdna_jamshidi.py |
Release 2026-10-10-cbb3da59bc08 · Record review: source checked
Stable ID: ctdnajam-20261010-eval-validation-fragment-lengths