Accuracy (cancer signal origin among 127 jointly detected validation cancers) of Whole-genome methylation classifier (GRAIL prototype), CCGA substudy 1 on CCGA substudy 1 validation cancers detected by all three representative classifiers (127)
75% Accuracy (cancer signal origin among 127 jointly detected validation cancers)
Methods
- Tested configuration
- Whole-genome methylation classifier (GRAIL prototype), CCGA substudy 1
- Protocol
- CCGA substudy 1 validation set: cancer signal origin accuracy among jointly detected cancers
- Dataset
- CCGA substudy 1 validation cancers detected by all three representative classifiers (127)
- Procedure
- CCGA substudy 1 validation set: cancer signal origin accuracy among jointly detected cancers
- Evaluation
- WG methylation on CCGA substudy 1 validation set: cancer signal origin accuracy among jointly detected cancers
- Coverage
- Not reported scored / Not reported eligible
- Uncertainty
- Not reported by the source
- Evidence
- Author-reported evaluation · source checkedEvaluation of cell-free DNA approaches for multi-cancer early detection · Results, cancer signal origin prediction: 75% (95/127)
A source-checked result verifies the numerical transcription, not every model or protocol detail. Evaluation metadata: source checked. Source checked does not mean independently reproduced.
Reproduction
- Split
- Independent validation set
- Adaptation
- Separate multinomial origin classifier trained on the training set, using the detection classifier's features
- Scoring implementation
- Share of correct origin labels; 'other' counted as correct for six cancer types
No execution recipe has been verified for this exact configuration and evaluation. A benchmark's general instructions may use different inputs, splits or model settings.
Reproducing this published result requires matching its model configuration, data, split and scorer. Source checking or a successful smoke test does not establish score reproduction.
Evidence
Source checking verifies the cited claim or transcription. It does not establish independent reproduction.
Evidence table
Inspect claims, sources and review details
Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.
One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.
1 evidence row matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|---|---|
| Reported result 75% Individual claims | Evaluation of cell-free DNA approaches for multi-cancer early detection Results, cancer signal origin prediction: 75% (95/127) Version: Cancer Cell 40(12):1537-1549.e12, published 2022-12-12; publisher PDF (1-s2.0-S153561082200513X-main.pdf) as deposited by the Francis Crick Institute on figshare, 10.25418/crick.21731870.v1 | source checked ["source-hash-verification","pdf-text-parse","independent-cell-check"] · 2026-10-10 author reported Audit detailsExtracted by deterministic parse of the PDF text layer (pdftotext -layout). Independent review 2026-10-10: value, interval and identity match the source. Field: Source artifact SHA-256: Hash scope: pdftotext -layout text layer, parsed by extract/extract_ctdna_jamshidi.py Extraction artifact SHA-256: |
Sources and history
Release 2026-10-10-457d7eaef7d6 · Record review: source checked
1 source record and release history
- Evaluation of cell-free DNA approaches for multi-cancer early detection · Original source · Cancer Cell 40(12):1537-1549.e12, published 2022-12-12; publisher PDF (1-s2.0-S153561082200513X-main.pdf) as deposited by the Francis Crick Institute on figshare, 10.25418/crick.21731870.v1
Technical metadata and extraction receipts
Stable ID: ctdnajam-20261010-result-cso-wg-methylation-accuracy
- metric
- accuracy
- metric qualifier
- cancer signal origin among 127 jointly detected validation cancers
- metric direction
- higher
- unit
- percent
- printed value
- 75%
- numeric value
- 75
- source locator
- Results, cancer signal origin prediction: 75% (95/127)
- review
- method: source-hash-verification; pdf-text-parse; independent-cell-check; method note: Re-downloaded the figshare file and matched its SHA-256 and the figshare MD5. Read the text layer with pdftotext and a separate parser. Checked the percentage and count in the Results sentence and recomputed the percentage from the count.; reviewer: claude; reviewer note: Separate Claude review agent, independent of the extractor; no human review claimed; date: 2026-10-10; artifact sha256: 5159294dd203d511dd437837a34555b276e14e0edf615bcb58bae5d9a1246d9a; retrieval url: https://ndownloader.figshare.com/files/38559380; note: Extracted by deterministic parse of the PDF text layer (pdftotext -layout). Independent review 2026-10-10: value, interval and identity match the source.
- missing metadata
- uncertainty: reason: unreported
- numerator
- 95
- denominator
- 127
- reported p value
- p = 8 x 10^-9 against SCNA and p = 6.5 x 10^-12 against SNV-WBC, McNemar test