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1 evaluation · 1 result. Different protocols are not a single leaderboard.
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| Tested configuration | Protocol and dataset | Finding | Evidence and details |
|---|---|---|---|
| Configuration: Whole-genome methylation classifier (GRAIL prototype), CCGA substudy 1 | Protocol: CCGA substudy 1 validation set: cancer signal origin accuracy among jointly detected cancers Dataset: CCGA substudy 1 validation cancers detected by all three representative classifiers (127) | 75% Accuracy (cancer signal origin among 127 jointly detected validation cancers) percent · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourcectdnajam-20261010-protocol-ccga1-validation-cso-accuracy Aggregation: Not reported Evaluation of cell-free DNA approaches for multi-cancer early detection · Results, cancer signal origin prediction: 75% (95/127) |
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CCGA substudy 1 validation set: cancer signal origin accuracy among jointly detected cancers
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19 evidence rows matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|---|---|
| Comparison: adaptation Separate multinomial origin classifier trained on the training set, using the detection classifier's features Context-only references | Evaluation of cell-free DNA approaches for multi-cancer early detection Results, cancer signal origin prediction, paragraph 1 Version: Cancer Cell 40(12):1537-1549.e12, published 2022-12-12; publisher PDF (1-s2.0-S153561082200513X-main.pdf) as deposited by the Francis Crick Institute on figshare, 10.25418/crick.21731870.v1 | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: pdftotext -layout text layer, parsed by extract/extract_ctdna_jamshidi.py |
| Comparison: aggregation Pooled over participants Context-only references | Evaluation of cell-free DNA approaches for multi-cancer early detection Results, cancer signal origin prediction, paragraph 1 Version: Cancer Cell 40(12):1537-1549.e12, published 2022-12-12; publisher PDF (1-s2.0-S153561082200513X-main.pdf) as deposited by the Francis Crick Institute on figshare, 10.25418/crick.21731870.v1 | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: pdftotext -layout text layer, parsed by extract/extract_ctdna_jamshidi.py |
| Comparison: budget Not reported Context-only references | Evaluation of cell-free DNA approaches for multi-cancer early detection Results, cancer signal origin prediction, paragraph 1 Version: Cancer Cell 40(12):1537-1549.e12, published 2022-12-12; publisher PDF (1-s2.0-S153561082200513X-main.pdf) as deposited by the Francis Crick Institute on figshare, 10.25418/crick.21731870.v1 | missing or unspecified No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: pdftotext -layout text layer, parsed by extract/extract_ctdna_jamshidi.py |
| Comparison: dataset version CCGA substudy 1 validation set, jointly detected cancers Context-only references | Evaluation of cell-free DNA approaches for multi-cancer early detection Results, cancer signal origin prediction, paragraph 1 Version: Cancer Cell 40(12):1537-1549.e12, published 2022-12-12; publisher PDF (1-s2.0-S153561082200513X-main.pdf) as deposited by the Francis Crick Institute on figshare, 10.25418/crick.21731870.v1 | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: pdftotext -layout text layer, parsed by extract/extract_ctdna_jamshidi.py |
| Comparison: inputs Whole-genome bisulfite sequencing of cfDNA, about 30x Context-only references | Evaluation of cell-free DNA approaches for multi-cancer early detection Results, cancer signal origin prediction, paragraph 1 Version: Cancer Cell 40(12):1537-1549.e12, published 2022-12-12; publisher PDF (1-s2.0-S153561082200513X-main.pdf) as deposited by the Francis Crick Institute on figshare, 10.25418/crick.21731870.v1 | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: pdftotext -layout text layer, parsed by extract/extract_ctdna_jamshidi.py |
| Comparison: metric implementation Share of correct origin labels; 'other' counted as correct for six cancer types Context-only references | Evaluation of cell-free DNA approaches for multi-cancer early detection Results, cancer signal origin prediction, paragraph 1 Version: Cancer Cell 40(12):1537-1549.e12, published 2022-12-12; publisher PDF (1-s2.0-S153561082200513X-main.pdf) as deposited by the Francis Crick Institute on figshare, 10.25418/crick.21731870.v1 | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: pdftotext -layout text layer, parsed by extract/extract_ctdna_jamshidi.py |
| Comparison: population 127 cancers Context-only references | Evaluation of cell-free DNA approaches for multi-cancer early detection Results, cancer signal origin prediction, paragraph 1 Version: Cancer Cell 40(12):1537-1549.e12, published 2022-12-12; publisher PDF (1-s2.0-S153561082200513X-main.pdf) as deposited by the Francis Crick Institute on figshare, 10.25418/crick.21731870.v1 | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: pdftotext -layout text layer, parsed by extract/extract_ctdna_jamshidi.py |
| Comparison: protocol id ctdnajam-20261010-protocol-ccga1-validation-cso-accuracy Context-only references | Evaluation of cell-free DNA approaches for multi-cancer early detection Results, cancer signal origin prediction, paragraph 1 Version: Cancer Cell 40(12):1537-1549.e12, published 2022-12-12; publisher PDF (1-s2.0-S153561082200513X-main.pdf) as deposited by the Francis Crick Institute on figshare, 10.25418/crick.21731870.v1 | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: pdftotext -layout text layer, parsed by extract/extract_ctdna_jamshidi.py |
| Comparison: split Independent validation set Context-only references | Evaluation of cell-free DNA approaches for multi-cancer early detection Results, cancer signal origin prediction, paragraph 1 Version: Cancer Cell 40(12):1537-1549.e12, published 2022-12-12; publisher PDF (1-s2.0-S153561082200513X-main.pdf) as deposited by the Francis Crick Institute on figshare, 10.25418/crick.21731870.v1 | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: pdftotext -layout text layer, parsed by extract/extract_ctdna_jamshidi.py |
Limitations2 values
| Evaluation of cell-free DNA approaches for multi-cancer early detection Results, cancer signal origin prediction, paragraph 1 Version: Cancer Cell 40(12):1537-1549.e12, published 2022-12-12; publisher PDF (1-s2.0-S153561082200513X-main.pdf) as deposited by the Francis Crick Institute on figshare, 10.25418/crick.21731870.v1 | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: pdftotext -layout text layer, parsed by extract/extract_ctdna_jamshidi.py |
Release 2026-10-10-cbb3da59bc08 · Record review: source checked
Stable ID: ctdnajam-20261010-eval-cso-wg-methylation