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SpliceBERT (zero-shot, Wang et al. 2026)

SpliceBERT evaluated zero-shot by Wang et al. 2026.

36 evaluations · 36 results

Overview

An explanatory profile has not yet been reviewed for this record.

Consult the linked sources for architecture or protocol details. Missing evidence is not evidence of a missing capability.

Evaluations and results

36 evaluations · 36 results. Different protocols are not a single leaderboard.

Sorted by AUROC (CLS embedding; mean over random samplings of sequence pairs) (higher is better). The best value in each column is highlighted. Decimals are rounded for display; each value links to the printed value and its source.

Tested configurationProtocol and datasetAUROC (CLS embedding; mean over random samplings of sequence pairs)AUROC (FFT embedding; mean over random samplings of sequence pairs)F1 (attention; mean over structures)F1 (attention; median over structures)F1 (CLS embedding; mean over random samplings of sequence pairs)F1 (FFT embedding; mean over random samplings of sequence pairs)MCC (attention; mean over structures)MCC (attention; median over structures)MCC (CLS embedding; mean over random samplings of sequence pairs)MCC (FFT embedding; mean over random samplings of sequence pairs)One minus overlap ratio (CLS embedding; mean over random samplings of sequence pairs)One minus overlap ratio (FFT embedding; mean over random samplings of sequence pairs)Absolute spearman correlation (PLL-D; mean over assays)Absolute spearman correlation (PLL-D; median over assays)Absolute spearman correlation (WT-LLR; mean over assays)Absolute spearman correlation (WT-LLR; median over assays)AUROC (PLL-D; mean over assays)AUROC (PLL-D; median over assays)AUROC (WT-LLR; mean over assays)AUROC (WT-LLR; median over assays)MCC (PLL-D; mean over assays)MCC (PLL-D; median over assays)MCC (WT-LLR; mean over assays)MCC (WT-LLR; median over assays)
SpliceBERT (zero-shot, Wang et al. 2026)EvaluationWang et al. 2026 zero-shot family classification, RfamSample (561 Rfam families), CLS embedding, AUC (mean over repeated random samplings of sequence pairs), RfamSample (561 Rfam families) (Wang et al. 2026)0.804±0.001 (best in column)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
SpliceBERT (zero-shot, Wang et al. 2026)EvaluationWang et al. 2026 zero-shot RNA type classification, ArchiveII-Nr (1273 RNAs), CLS embedding, AUC (mean over repeated random samplings of sequence pairs), ArchiveII-Nr (1273 RNAs) (Wang et al. 2026)0.727±0.001Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
SpliceBERT (zero-shot, Wang et al. 2026)EvaluationWang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), WT-LLR, AUC (mean over assays), RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported0.631±0.074Not reportedNot reportedNot reportedNot reportedNot reported
SpliceBERT (zero-shot, Wang et al. 2026)EvaluationWang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), WT-LLR, AUC (median over assays), RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported0.612Not reportedNot reportedNot reportedNot reported
SpliceBERT (zero-shot, Wang et al. 2026)EvaluationWang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), WT-LLR, MCC (mean over assays), RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported0.194±0.109Not reported
SpliceBERT (zero-shot, Wang et al. 2026)EvaluationWang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), WT-LLR, MCC (median over assays), RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported0.176
SpliceBERT (zero-shot, Wang et al. 2026)EvaluationWang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), WT-LLR, SR (mean over assays), RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported0.268±0.149Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
SpliceBERT (zero-shot, Wang et al. 2026)EvaluationWang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), WT-LLR, SR (median over assays), RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported0.202Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
SpliceBERT (zero-shot, Wang et al. 2026)EvaluationWang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), PLL-D, AUC (mean over assays), RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported0.550±0.044Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
SpliceBERT (zero-shot, Wang et al. 2026)EvaluationWang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), PLL-D, AUC (median over assays), RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported0.543Not reportedNot reportedNot reportedNot reportedNot reportedNot reported
SpliceBERT (zero-shot, Wang et al. 2026)EvaluationWang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), PLL-D, MCC (mean over assays), RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported0.071±0.059Not reportedNot reportedNot reported
SpliceBERT (zero-shot, Wang et al. 2026)EvaluationWang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), PLL-D, MCC (median over assays), RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported0.063Not reportedNot reported
SpliceBERT (zero-shot, Wang et al. 2026)EvaluationWang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), PLL-D, SR (mean over assays), RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported0.097±0.088Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
SpliceBERT (zero-shot, Wang et al. 2026)EvaluationWang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), PLL-D, SR (median over assays), RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported0.079Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
SpliceBERT (zero-shot, Wang et al. 2026)EvaluationWang et al. 2026 zero-shot secondary structure, TS test set (70 PDB structures), attention, F1 score (mean over structures), TS test set (70 PDB structures) (Wang et al. 2026)Not reportedNot reported0.043±0.039 (best in column)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
SpliceBERT (zero-shot, Wang et al. 2026)EvaluationWang et al. 2026 zero-shot secondary structure, TS test set (70 PDB structures), attention, F1 score (median over structures), TS test set (70 PDB structures) (Wang et al. 2026)Not reportedNot reportedNot reported0.034 (best in column)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
SpliceBERT (zero-shot, Wang et al. 2026)EvaluationWang et al. 2026 zero-shot secondary structure, TS test set (70 PDB structures), attention, MCC (mean over structures), TS test set (70 PDB structures) (Wang et al. 2026)Not reportedNot reportedNot reportedNot reportedNot reportedNot reported0.033±0.045 (best in column)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
SpliceBERT (zero-shot, Wang et al. 2026)EvaluationWang et al. 2026 zero-shot secondary structure, TS test set (70 PDB structures), attention, MCC (median over structures), TS test set (70 PDB structures) (Wang et al. 2026)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported0.022Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
SpliceBERT (zero-shot, Wang et al. 2026)EvaluationWang et al. 2026 zero-shot secondary structure, TS-Hard test set (15 PDB structures), attention, F1 score (mean over structures), TS-Hard test set (15 PDB structures) (Wang et al. 2026)Not reportedNot reported0.030±0.023Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
SpliceBERT (zero-shot, Wang et al. 2026)EvaluationWang et al. 2026 zero-shot secondary structure, TS-Hard test set (15 PDB structures), attention, F1 score (median over structures), TS-Hard test set (15 PDB structures) (Wang et al. 2026)Not reportedNot reportedNot reported0.034 (best in column)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
SpliceBERT (zero-shot, Wang et al. 2026)EvaluationWang et al. 2026 zero-shot secondary structure, TS-Hard test set (15 PDB structures), attention, MCC (mean over structures), TS-Hard test set (15 PDB structures) (Wang et al. 2026)Not reportedNot reportedNot reportedNot reportedNot reportedNot reported0.020±0.026Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
SpliceBERT (zero-shot, Wang et al. 2026)EvaluationWang et al. 2026 zero-shot secondary structure, TS-Hard test set (15 PDB structures), attention, MCC (median over structures), TS-Hard test set (15 PDB structures) (Wang et al. 2026)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported0.025 (best in column)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
SpliceBERT (zero-shot, Wang et al. 2026)EvaluationWang et al. 2026 zero-shot family classification, RfamSample (561 Rfam families), FFT embedding, 1 − OR (mean over repeated random samplings of sequence pairs), RfamSample (561 Rfam families) (Wang et al. 2026)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported0.567±0.002 (best in column)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
SpliceBERT (zero-shot, Wang et al. 2026)EvaluationWang et al. 2026 zero-shot family classification, RfamSample (561 Rfam families), FFT embedding, AUC (mean over repeated random samplings of sequence pairs), RfamSample (561 Rfam families) (Wang et al. 2026)Not reported0.762±0.001 (best in column)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
SpliceBERT (zero-shot, Wang et al. 2026)EvaluationWang et al. 2026 zero-shot family classification, RfamSample (561 Rfam families), FFT embedding, F1 (mean over repeated random samplings of sequence pairs), RfamSample (561 Rfam families) (Wang et al. 2026)Not reportedNot reportedNot reportedNot reportedNot reported0.706±0.001Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
SpliceBERT (zero-shot, Wang et al. 2026)EvaluationWang et al. 2026 zero-shot family classification, RfamSample (561 Rfam families), FFT embedding, MCC (mean over repeated random samplings of sequence pairs), RfamSample (561 Rfam families) (Wang et al. 2026)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported0.341±0.001 (best in column)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
SpliceBERT (zero-shot, Wang et al. 2026)EvaluationWang et al. 2026 zero-shot RNA type classification, ArchiveII-Nr (1273 RNAs), FFT embedding, 1 − OR (mean over repeated random samplings of sequence pairs), ArchiveII-Nr (1273 RNAs) (Wang et al. 2026)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported0.487±0.003Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
SpliceBERT (zero-shot, Wang et al. 2026)EvaluationWang et al. 2026 zero-shot RNA type classification, ArchiveII-Nr (1273 RNAs), FFT embedding, AUC (mean over repeated random samplings of sequence pairs), ArchiveII-Nr (1273 RNAs) (Wang et al. 2026)Not reported0.731±0.002Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
SpliceBERT (zero-shot, Wang et al. 2026)EvaluationWang et al. 2026 zero-shot RNA type classification, ArchiveII-Nr (1273 RNAs), FFT embedding, F1 (mean over repeated random samplings of sequence pairs), ArchiveII-Nr (1273 RNAs) (Wang et al. 2026)Not reportedNot reportedNot reportedNot reportedNot reported0.712±0.000 (best in column)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
SpliceBERT (zero-shot, Wang et al. 2026)EvaluationWang et al. 2026 zero-shot RNA type classification, ArchiveII-Nr (1273 RNAs), FFT embedding, MCC (mean over repeated random samplings of sequence pairs), ArchiveII-Nr (1273 RNAs) (Wang et al. 2026)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported0.312±0.001Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
SpliceBERT (zero-shot, Wang et al. 2026)EvaluationWang et al. 2026 zero-shot family classification, RfamSample (561 Rfam families), CLS embedding, 1 − OR (mean over repeated random samplings of sequence pairs), RfamSample (561 Rfam families) (Wang et al. 2026)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported0.633±0.002 (best in column)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
SpliceBERT (zero-shot, Wang et al. 2026)EvaluationWang et al. 2026 zero-shot family classification, RfamSample (561 Rfam families), CLS embedding, F1 (mean over repeated random samplings of sequence pairs), RfamSample (561 Rfam families) (Wang et al. 2026)Not reportedNot reportedNot reportedNot reported0.735±0.001 (best in column)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
SpliceBERT (zero-shot, Wang et al. 2026)EvaluationWang et al. 2026 zero-shot family classification, RfamSample (561 Rfam families), CLS embedding, MCC (mean over repeated random samplings of sequence pairs), RfamSample (561 Rfam families) (Wang et al. 2026)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported0.426±0.002 (best in column)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
SpliceBERT (zero-shot, Wang et al. 2026)EvaluationWang et al. 2026 zero-shot RNA type classification, ArchiveII-Nr (1273 RNAs), CLS embedding, 1 − OR (mean over repeated random samplings of sequence pairs), ArchiveII-Nr (1273 RNAs) (Wang et al. 2026)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported0.469±0.002Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
SpliceBERT (zero-shot, Wang et al. 2026)EvaluationWang et al. 2026 zero-shot RNA type classification, ArchiveII-Nr (1273 RNAs), CLS embedding, F1 (mean over repeated random samplings of sequence pairs), ArchiveII-Nr (1273 RNAs) (Wang et al. 2026)Not reportedNot reportedNot reportedNot reported0.709±0.001Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
SpliceBERT (zero-shot, Wang et al. 2026)EvaluationWang et al. 2026 zero-shot RNA type classification, ArchiveII-Nr (1273 RNAs), CLS embedding, MCC (mean over repeated random samplings of sequence pairs), ArchiveII-Nr (1273 RNAs) (Wang et al. 2026)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported0.308±0.002Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
All 36 result rows with coverage, uncertainty and sources
Filter evaluations

Applied filters: All linked evaluations

Exact evaluated configurations and original reported results
Tested configurationProtocol and datasetFindingEvidence and details
Configuration: SpliceBERT (zero-shot, Wang et al. 2026)Protocol: Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), WT-LLR, AUC (mean over assays)
Dataset: RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026)
0.631±0.074 AUROC (WT-LLR; mean over assays)
unitless · higher

Uncertainty: SD 0.074

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

SpliceBERT zero-shot fitness on RNAGym ncRNA DMS assays (31 assays) (WT-LLR, AUC, mean)

lit-rna-20261011-rnalm-zeroshot-protocol-t10-auc-mean

Aggregation: Not reported

Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 10, row 'SpliceBERT', column 'AUC' (Mean ± Std)
Configuration: SpliceBERT (zero-shot, Wang et al. 2026)Protocol: Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), WT-LLR, AUC (median over assays)
Dataset: RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026)
0.612 AUROC (WT-LLR; median over assays)
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

SpliceBERT zero-shot fitness on RNAGym ncRNA DMS assays (31 assays) (WT-LLR, AUC, median)

lit-rna-20261011-rnalm-zeroshot-protocol-t10-auc-median

Aggregation: Not reported

Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 10, row 'SpliceBERT', column 'AUC' (Median)
Configuration: SpliceBERT (zero-shot, Wang et al. 2026)Protocol: Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), WT-LLR, MCC (mean over assays)
Dataset: RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026)
0.194±0.109 MCC (WT-LLR; mean over assays)
unitless · higher

Uncertainty: SD 0.109

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

SpliceBERT zero-shot fitness on RNAGym ncRNA DMS assays (31 assays) (WT-LLR, MCC, mean)

lit-rna-20261011-rnalm-zeroshot-protocol-t10-mcc-mean

Aggregation: Not reported

Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 10, row 'SpliceBERT', column 'MCC' (Mean ± Std)
Configuration: SpliceBERT (zero-shot, Wang et al. 2026)Protocol: Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), WT-LLR, MCC (median over assays)
Dataset: RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026)
0.176 MCC (WT-LLR; median over assays)
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

SpliceBERT zero-shot fitness on RNAGym ncRNA DMS assays (31 assays) (WT-LLR, MCC, median)

lit-rna-20261011-rnalm-zeroshot-protocol-t10-mcc-median

Aggregation: Not reported

Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 10, row 'SpliceBERT', column 'MCC' (Median)
Configuration: SpliceBERT (zero-shot, Wang et al. 2026)Protocol: Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), WT-LLR, SR (mean over assays)
Dataset: RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026)
0.268±0.149 Absolute spearman correlation (WT-LLR; mean over assays)
unitless · higher

Uncertainty: SD 0.149

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

SpliceBERT zero-shot fitness on RNAGym ncRNA DMS assays (31 assays) (WT-LLR, SR, mean)

lit-rna-20261011-rnalm-zeroshot-protocol-t10-sr-mean

Aggregation: Not reported

Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 10, row 'SpliceBERT', column 'SR' (Mean ± Std)
Configuration: SpliceBERT (zero-shot, Wang et al. 2026)Protocol: Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), WT-LLR, SR (median over assays)
Dataset: RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026)
0.202 Absolute spearman correlation (WT-LLR; median over assays)
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

SpliceBERT zero-shot fitness on RNAGym ncRNA DMS assays (31 assays) (WT-LLR, SR, median)

lit-rna-20261011-rnalm-zeroshot-protocol-t10-sr-median

Aggregation: Not reported

Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 10, row 'SpliceBERT', column 'SR' (Median)
Configuration: SpliceBERT (zero-shot, Wang et al. 2026)Protocol: Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), PLL-D, AUC (mean over assays)
Dataset: RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026)
0.550±0.044 AUROC (PLL-D; mean over assays)
unitless · higher

Uncertainty: SD 0.044

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

SpliceBERT zero-shot fitness on RNAGym ncRNA DMS assays (31 assays) (PLL-D, AUC, mean)

lit-rna-20261011-rnalm-zeroshot-protocol-t11-auc-mean

Aggregation: Not reported

Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 11, row 'SpliceBERT', column 'AUC' (Mean ± Std)
Configuration: SpliceBERT (zero-shot, Wang et al. 2026)Protocol: Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), PLL-D, AUC (median over assays)
Dataset: RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026)
0.543 AUROC (PLL-D; median over assays)
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

SpliceBERT zero-shot fitness on RNAGym ncRNA DMS assays (31 assays) (PLL-D, AUC, median)

lit-rna-20261011-rnalm-zeroshot-protocol-t11-auc-median

Aggregation: Not reported

Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 11, row 'SpliceBERT', column 'AUC' (Median)
Configuration: SpliceBERT (zero-shot, Wang et al. 2026)Protocol: Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), PLL-D, MCC (mean over assays)
Dataset: RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026)
0.071±0.059 MCC (PLL-D; mean over assays)
unitless · higher

Uncertainty: SD 0.059

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

SpliceBERT zero-shot fitness on RNAGym ncRNA DMS assays (31 assays) (PLL-D, MCC, mean)

lit-rna-20261011-rnalm-zeroshot-protocol-t11-mcc-mean

Aggregation: Not reported

Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 11, row 'SpliceBERT', column 'MCC' (Mean ± Std)
Configuration: SpliceBERT (zero-shot, Wang et al. 2026)Protocol: Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), PLL-D, MCC (median over assays)
Dataset: RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026)
0.063 MCC (PLL-D; median over assays)
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

SpliceBERT zero-shot fitness on RNAGym ncRNA DMS assays (31 assays) (PLL-D, MCC, median)

lit-rna-20261011-rnalm-zeroshot-protocol-t11-mcc-median

Aggregation: Not reported

Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 11, row 'SpliceBERT', column 'MCC' (Median)
Configuration: SpliceBERT (zero-shot, Wang et al. 2026)Protocol: Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), PLL-D, SR (mean over assays)
Dataset: RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026)
0.097±0.088 Absolute spearman correlation (PLL-D; mean over assays)
unitless · higher

Uncertainty: SD 0.088

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

SpliceBERT zero-shot fitness on RNAGym ncRNA DMS assays (31 assays) (PLL-D, SR, mean)

lit-rna-20261011-rnalm-zeroshot-protocol-t11-sr-mean

Aggregation: Not reported

Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 11, row 'SpliceBERT', column 'SR' (Mean ± Std)
Configuration: SpliceBERT (zero-shot, Wang et al. 2026)Protocol: Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), PLL-D, SR (median over assays)
Dataset: RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026)
0.079 Absolute spearman correlation (PLL-D; median over assays)
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

SpliceBERT zero-shot fitness on RNAGym ncRNA DMS assays (31 assays) (PLL-D, SR, median)

lit-rna-20261011-rnalm-zeroshot-protocol-t11-sr-median

Aggregation: Not reported

Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 11, row 'SpliceBERT', column 'SR' (Median)
Configuration: SpliceBERT (zero-shot, Wang et al. 2026)Protocol: Wang et al. 2026 zero-shot secondary structure, TS test set (70 PDB structures), attention, F1 score (mean over structures)
Dataset: TS test set (70 PDB structures) (Wang et al. 2026)
0.043±0.039 F1 (attention; mean over structures)
unitless · higher

Uncertainty: SD 0.039

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

SpliceBERT zero-shot secondary structure on TS test set (70 PDB structures) (attention, F1 score, mean)

lit-rna-20261011-rnalm-zeroshot-protocol-t4-f1-score-mean

Aggregation: Not reported

Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 4, row 'SpliceBERT', column 'F1 score' (Mean ± Std)
Configuration: SpliceBERT (zero-shot, Wang et al. 2026)Protocol: Wang et al. 2026 zero-shot secondary structure, TS test set (70 PDB structures), attention, F1 score (median over structures)
Dataset: TS test set (70 PDB structures) (Wang et al. 2026)
0.034 F1 (attention; median over structures)
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

SpliceBERT zero-shot secondary structure on TS test set (70 PDB structures) (attention, F1 score, median)

lit-rna-20261011-rnalm-zeroshot-protocol-t4-f1-score-median

Aggregation: Not reported

Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 4, row 'SpliceBERT', column 'F1 score' (Median)
Configuration: SpliceBERT (zero-shot, Wang et al. 2026)Protocol: Wang et al. 2026 zero-shot secondary structure, TS test set (70 PDB structures), attention, MCC (mean over structures)
Dataset: TS test set (70 PDB structures) (Wang et al. 2026)
0.033±0.045 MCC (attention; mean over structures)
unitless · higher

Uncertainty: SD 0.045

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

SpliceBERT zero-shot secondary structure on TS test set (70 PDB structures) (attention, MCC, mean)

lit-rna-20261011-rnalm-zeroshot-protocol-t4-mcc-mean

Aggregation: Not reported

Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 4, row 'SpliceBERT', column 'MCC' (Mean ± Std)
Configuration: SpliceBERT (zero-shot, Wang et al. 2026)Protocol: Wang et al. 2026 zero-shot secondary structure, TS test set (70 PDB structures), attention, MCC (median over structures)
Dataset: TS test set (70 PDB structures) (Wang et al. 2026)
0.022 MCC (attention; median over structures)
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

SpliceBERT zero-shot secondary structure on TS test set (70 PDB structures) (attention, MCC, median)

lit-rna-20261011-rnalm-zeroshot-protocol-t4-mcc-median

Aggregation: Not reported

Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 4, row 'SpliceBERT', column 'MCC' (Median)
Configuration: SpliceBERT (zero-shot, Wang et al. 2026)Protocol: Wang et al. 2026 zero-shot secondary structure, TS-Hard test set (15 PDB structures), attention, F1 score (mean over structures)
Dataset: TS-Hard test set (15 PDB structures) (Wang et al. 2026)
0.030±0.023 F1 (attention; mean over structures)
unitless · higher

Uncertainty: SD 0.023

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

SpliceBERT zero-shot secondary structure on TS-Hard test set (15 PDB structures) (attention, F1 score, mean)

lit-rna-20261011-rnalm-zeroshot-protocol-t5-f1-score-mean

Aggregation: Not reported

Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 5, row 'SpliceBERT', column 'F1 score' (Mean ± Std)
Configuration: SpliceBERT (zero-shot, Wang et al. 2026)Protocol: Wang et al. 2026 zero-shot secondary structure, TS-Hard test set (15 PDB structures), attention, F1 score (median over structures)
Dataset: TS-Hard test set (15 PDB structures) (Wang et al. 2026)
0.034 F1 (attention; median over structures)
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

SpliceBERT zero-shot secondary structure on TS-Hard test set (15 PDB structures) (attention, F1 score, median)

lit-rna-20261011-rnalm-zeroshot-protocol-t5-f1-score-median

Aggregation: Not reported

Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 5, row 'SpliceBERT', column 'F1 score' (Median)
Configuration: SpliceBERT (zero-shot, Wang et al. 2026)Protocol: Wang et al. 2026 zero-shot secondary structure, TS-Hard test set (15 PDB structures), attention, MCC (mean over structures)
Dataset: TS-Hard test set (15 PDB structures) (Wang et al. 2026)
0.020±0.026 MCC (attention; mean over structures)
unitless · higher

Uncertainty: SD 0.026

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

SpliceBERT zero-shot secondary structure on TS-Hard test set (15 PDB structures) (attention, MCC, mean)

lit-rna-20261011-rnalm-zeroshot-protocol-t5-mcc-mean

Aggregation: Not reported

Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 5, row 'SpliceBERT', column 'MCC' (Mean ± Std)
Configuration: SpliceBERT (zero-shot, Wang et al. 2026)Protocol: Wang et al. 2026 zero-shot secondary structure, TS-Hard test set (15 PDB structures), attention, MCC (median over structures)
Dataset: TS-Hard test set (15 PDB structures) (Wang et al. 2026)
0.025 MCC (attention; median over structures)
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

SpliceBERT zero-shot secondary structure on TS-Hard test set (15 PDB structures) (attention, MCC, median)

lit-rna-20261011-rnalm-zeroshot-protocol-t5-mcc-median

Aggregation: Not reported

Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 5, row 'SpliceBERT', column 'MCC' (Median)
Configuration: SpliceBERT (zero-shot, Wang et al. 2026)Protocol: Wang et al. 2026 zero-shot family classification, RfamSample (561 Rfam families), FFT embedding, 1 − OR (mean over repeated random samplings of sequence pairs)
Dataset: RfamSample (561 Rfam families) (Wang et al. 2026)
0.567±0.002 One minus overlap ratio (FFT embedding; mean over random samplings of sequence pairs)
unitless · higher

Uncertainty: SD 0.002

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

SpliceBERT zero-shot family classification on RfamSample (561 Rfam families) (FFT embedding, 1 − OR, sampled-mean)

lit-rna-20261011-rnalm-zeroshot-protocol-t6-1-or-sampled-mean

Aggregation: Not reported

Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 6, row 'SpliceBERT', column '1 − OR'
Configuration: SpliceBERT (zero-shot, Wang et al. 2026)Protocol: Wang et al. 2026 zero-shot family classification, RfamSample (561 Rfam families), FFT embedding, AUC (mean over repeated random samplings of sequence pairs)
Dataset: RfamSample (561 Rfam families) (Wang et al. 2026)
0.762±0.001 AUROC (FFT embedding; mean over random samplings of sequence pairs)
unitless · higher

Uncertainty: SD 0.001

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

SpliceBERT zero-shot family classification on RfamSample (561 Rfam families) (FFT embedding, AUC, sampled-mean)

lit-rna-20261011-rnalm-zeroshot-protocol-t6-auc-sampled-mean

Aggregation: Not reported

Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 6, row 'SpliceBERT', column 'AUC'
Configuration: SpliceBERT (zero-shot, Wang et al. 2026)Protocol: Wang et al. 2026 zero-shot family classification, RfamSample (561 Rfam families), FFT embedding, F1 (mean over repeated random samplings of sequence pairs)
Dataset: RfamSample (561 Rfam families) (Wang et al. 2026)
0.706±0.001 F1 (FFT embedding; mean over random samplings of sequence pairs)
unitless · higher

Uncertainty: SD 0.001

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

SpliceBERT zero-shot family classification on RfamSample (561 Rfam families) (FFT embedding, F1, sampled-mean)

lit-rna-20261011-rnalm-zeroshot-protocol-t6-f1-sampled-mean

Aggregation: Not reported

Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 6, row 'SpliceBERT', column 'F1'
Configuration: SpliceBERT (zero-shot, Wang et al. 2026)Protocol: Wang et al. 2026 zero-shot family classification, RfamSample (561 Rfam families), FFT embedding, MCC (mean over repeated random samplings of sequence pairs)
Dataset: RfamSample (561 Rfam families) (Wang et al. 2026)
0.341±0.001 MCC (FFT embedding; mean over random samplings of sequence pairs)
unitless · higher

Uncertainty: SD 0.001

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

SpliceBERT zero-shot family classification on RfamSample (561 Rfam families) (FFT embedding, MCC, sampled-mean)

lit-rna-20261011-rnalm-zeroshot-protocol-t6-mcc-sampled-mean

Aggregation: Not reported

Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 6, row 'SpliceBERT', column 'MCC'
Configuration: SpliceBERT (zero-shot, Wang et al. 2026)Protocol: Wang et al. 2026 zero-shot RNA type classification, ArchiveII-Nr (1273 RNAs), FFT embedding, 1 − OR (mean over repeated random samplings of sequence pairs)
Dataset: ArchiveII-Nr (1273 RNAs) (Wang et al. 2026)
0.487±0.003 One minus overlap ratio (FFT embedding; mean over random samplings of sequence pairs)
unitless · higher

Uncertainty: SD 0.003

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

SpliceBERT zero-shot RNA type classification on ArchiveII-Nr (1273 RNAs) (FFT embedding, 1 − OR, sampled-mean)

lit-rna-20261011-rnalm-zeroshot-protocol-t7-1-or-sampled-mean

Aggregation: Not reported

Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 7, row 'SpliceBERT', column '1 − OR'

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Stable ID: lit-rna-20261011-rnalm-zeroshot-config-splicebert-wang2026

areas
rna-transcriptomes
contexts
research
method types
foundation_model
reported name
SpliceBERT
foundation model eligible
true
parameters
Pretrained weights used without fine-tuning (zero-shot); attention maps, embeddings or token logits read out as described in the Methods
access reuse
Public download location listed in Supplementary Table 1
source locator
Supplementary Table 1 row 'SpliceBERT'
checkpoint
https://github.com/chenkenbio/SpliceBERT (downloaded 2024/8/11; version column 'SpliceBERT.1024nt'; variant label in results tables 'none')
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SpliceBERT.1024nt
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