| Configuration: AIDO.RNA (1.6B) (zero-shot, Wang et al. 2026) | Protocol: Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), WT-LLR, SR (mean over assays) Dataset: RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026) | 0.237±0.166 Absolute spearman correlation (WT-LLR; mean over assays) unitless · higher Uncertainty: SD 0.166 Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceAIDO.RNA (1.6B) zero-shot fitness on RNAGym ncRNA DMS assays (31 assays) (WT-LLR, SR, mean) lit-rna-20261011-rnalm-zeroshot-protocol-t10-sr-mean Aggregation: Not reported Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 10, row 'AIDO.RNA (1.6B)', column 'SR' (Mean ± Std) |
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| Configuration: AIDO.RNA (650M) (zero-shot, Wang et al. 2026) | Protocol: Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), WT-LLR, SR (mean over assays) Dataset: RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026) | 0.218±0.183 Absolute spearman correlation (WT-LLR; mean over assays) unitless · higher Uncertainty: SD 0.183 Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceAIDO.RNA (650M) zero-shot fitness on RNAGym ncRNA DMS assays (31 assays) (WT-LLR, SR, mean) lit-rna-20261011-rnalm-zeroshot-protocol-t10-sr-mean Aggregation: Not reported Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 10, row 'AIDO.RNA (650M)', column 'SR' (Mean ± Std) |
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| Configuration: DGRNA (zero-shot, Wang et al. 2026) | Protocol: Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), WT-LLR, SR (mean over assays) Dataset: RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026) | 0.249±0.163 Absolute spearman correlation (WT-LLR; mean over assays) unitless · higher Uncertainty: SD 0.163 Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceDGRNA zero-shot fitness on RNAGym ncRNA DMS assays (31 assays) (WT-LLR, SR, mean) lit-rna-20261011-rnalm-zeroshot-protocol-t10-sr-mean Aggregation: Not reported Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 10, row 'DGRNA', column 'SR' (Mean ± Std) |
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| Configuration: LAMAR (2k) (zero-shot, Wang et al. 2026) | Protocol: Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), WT-LLR, SR (mean over assays) Dataset: RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026) | 0.093±0.078 Absolute spearman correlation (WT-LLR; mean over assays) unitless · higher Uncertainty: SD 0.078 Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceLAMAR (2k) zero-shot fitness on RNAGym ncRNA DMS assays (31 assays) (WT-LLR, SR, mean) lit-rna-20261011-rnalm-zeroshot-protocol-t10-sr-mean Aggregation: Not reported Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 10, row 'LAMAR (2k)', column 'SR' (Mean ± Std) |
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| Configuration: LAMAR (4k) (zero-shot, Wang et al. 2026) | Protocol: Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), WT-LLR, SR (mean over assays) Dataset: RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026) | 0.139±0.115 Absolute spearman correlation (WT-LLR; mean over assays) unitless · higher Uncertainty: SD 0.115 Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceLAMAR (4k) zero-shot fitness on RNAGym ncRNA DMS assays (31 assays) (WT-LLR, SR, mean) lit-rna-20261011-rnalm-zeroshot-protocol-t10-sr-mean Aggregation: Not reported Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 10, row 'LAMAR (4k)', column 'SR' (Mean ± Std) |
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| Configuration: LucaOne (D17.6M) (zero-shot, Wang et al. 2026) | Protocol: Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), WT-LLR, SR (mean over assays) Dataset: RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026) | 0.117±0.103 Absolute spearman correlation (WT-LLR; mean over assays) unitless · higher Uncertainty: SD 0.103 Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceLucaOne (D17.6M) zero-shot fitness on RNAGym ncRNA DMS assays (31 assays) (WT-LLR, SR, mean) lit-rna-20261011-rnalm-zeroshot-protocol-t10-sr-mean Aggregation: Not reported Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 10, row 'LucaOne (D17.6M)', column 'SR' (Mean ± Std) |
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| Configuration: LucaOne (D36.0M) (zero-shot, Wang et al. 2026) | Protocol: Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), WT-LLR, SR (mean over assays) Dataset: RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026) | 0.135±0.112 Absolute spearman correlation (WT-LLR; mean over assays) unitless · higher Uncertainty: SD 0.112 Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceLucaOne (D36.0M) zero-shot fitness on RNAGym ncRNA DMS assays (31 assays) (WT-LLR, SR, mean) lit-rna-20261011-rnalm-zeroshot-protocol-t10-sr-mean Aggregation: Not reported Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 10, row 'LucaOne (D36.0M)', column 'SR' (Mean ± Std) |
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| Configuration: LucaOne (G36.8M) (zero-shot, Wang et al. 2026) | Protocol: Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), WT-LLR, SR (mean over assays) Dataset: RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026) | 0.125±0.102 Absolute spearman correlation (WT-LLR; mean over assays) unitless · higher Uncertainty: SD 0.102 Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceLucaOne (G36.8M) zero-shot fitness on RNAGym ncRNA DMS assays (31 assays) (WT-LLR, SR, mean) lit-rna-20261011-rnalm-zeroshot-protocol-t10-sr-mean Aggregation: Not reported Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 10, row 'LucaOne (G36.8M)', column 'SR' (Mean ± Std) |
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| Configuration: MP-RNA (zero-shot, Wang et al. 2026) | Protocol: Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), WT-LLR, SR (mean over assays) Dataset: RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026) | 0.240±0.159 Absolute spearman correlation (WT-LLR; mean over assays) unitless · higher Uncertainty: SD 0.159 Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceMP-RNA zero-shot fitness on RNAGym ncRNA DMS assays (31 assays) (WT-LLR, SR, mean) lit-rna-20261011-rnalm-zeroshot-protocol-t10-sr-mean Aggregation: Not reported Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 10, row 'MP-RNA', column 'SR' (Mean ± Std) |
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| Configuration: PlantRNA-FM (zero-shot, Wang et al. 2026) | Protocol: Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), WT-LLR, SR (mean over assays) Dataset: RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026) | 0.187±0.148 Absolute spearman correlation (WT-LLR; mean over assays) unitless · higher Uncertainty: SD 0.148 Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourcePlantRNA-FM zero-shot fitness on RNAGym ncRNA DMS assays (31 assays) (WT-LLR, SR, mean) lit-rna-20261011-rnalm-zeroshot-protocol-t10-sr-mean Aggregation: Not reported Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 10, row 'PlantRNA-FM', column 'SR' (Mean ± Std) |
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| Configuration: ProtRNA (zero-shot, Wang et al. 2026) | Protocol: Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), WT-LLR, SR (mean over assays) Dataset: RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026) | 0.107±0.076 Absolute spearman correlation (WT-LLR; mean over assays) unitless · higher Uncertainty: SD 0.076 Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceProtRNA zero-shot fitness on RNAGym ncRNA DMS assays (31 assays) (WT-LLR, SR, mean) lit-rna-20261011-rnalm-zeroshot-protocol-t10-sr-mean Aggregation: Not reported Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 10, row 'ProtRNA', column 'SR' (Mean ± Std) |
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| Configuration: RiNALMo (giga) (zero-shot, Wang et al. 2026) | Protocol: Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), WT-LLR, SR (mean over assays) Dataset: RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026) | 0.175±0.165 Absolute spearman correlation (WT-LLR; mean over assays) unitless · higher Uncertainty: SD 0.165 Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceRiNALMo (giga) zero-shot fitness on RNAGym ncRNA DMS assays (31 assays) (WT-LLR, SR, mean) lit-rna-20261011-rnalm-zeroshot-protocol-t10-sr-mean Aggregation: Not reported Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 10, row 'RiNALMo (giga)', column 'SR' (Mean ± Std) |
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| Configuration: RiNALMo (mega) (zero-shot, Wang et al. 2026) | Protocol: Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), WT-LLR, SR (mean over assays) Dataset: RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026) | 0.178±0.152 Absolute spearman correlation (WT-LLR; mean over assays) unitless · higher Uncertainty: SD 0.152 Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceRiNALMo (mega) zero-shot fitness on RNAGym ncRNA DMS assays (31 assays) (WT-LLR, SR, mean) lit-rna-20261011-rnalm-zeroshot-protocol-t10-sr-mean Aggregation: Not reported Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 10, row 'RiNALMo (mega)', column 'SR' (Mean ± Std) |
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| Configuration: RiNALMo (micro) (zero-shot, Wang et al. 2026) | Protocol: Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), WT-LLR, SR (mean over assays) Dataset: RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026) | 0.175±0.158 Absolute spearman correlation (WT-LLR; mean over assays) unitless · higher Uncertainty: SD 0.158 Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceRiNALMo (micro) zero-shot fitness on RNAGym ncRNA DMS assays (31 assays) (WT-LLR, SR, mean) lit-rna-20261011-rnalm-zeroshot-protocol-t10-sr-mean Aggregation: Not reported Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 10, row 'RiNALMo (micro)', column 'SR' (Mean ± Std) |
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| Configuration: RNA-FM (zero-shot, Wang et al. 2026) | Protocol: Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), WT-LLR, SR (mean over assays) Dataset: RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026) | 0.226±0.170 Absolute spearman correlation (WT-LLR; mean over assays) unitless · higher Uncertainty: SD 0.170 Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceRNA-FM zero-shot fitness on RNAGym ncRNA DMS assays (31 assays) (WT-LLR, SR, mean) lit-rna-20261011-rnalm-zeroshot-protocol-t10-sr-mean Aggregation: Not reported Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 10, row 'RNA-FM', column 'SR' (Mean ± Std) |
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| Configuration: RNABERT (zero-shot, Wang et al. 2026) | Protocol: Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), WT-LLR, SR (mean over assays) Dataset: RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026) | 0.100±0.086 Absolute spearman correlation (WT-LLR; mean over assays) unitless · higher Uncertainty: SD 0.086 Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceRNABERT zero-shot fitness on RNAGym ncRNA DMS assays (31 assays) (WT-LLR, SR, mean) lit-rna-20261011-rnalm-zeroshot-protocol-t10-sr-mean Aggregation: Not reported Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 10, row 'RNABERT', column 'SR' (Mean ± Std) |
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| Configuration: RNAErnie (zero-shot, Wang et al. 2026) | Protocol: Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), WT-LLR, SR (mean over assays) Dataset: RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026) | 0.162±0.148 Absolute spearman correlation (WT-LLR; mean over assays) unitless · higher Uncertainty: SD 0.148 Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceRNAErnie zero-shot fitness on RNAGym ncRNA DMS assays (31 assays) (WT-LLR, SR, mean) lit-rna-20261011-rnalm-zeroshot-protocol-t10-sr-mean Aggregation: Not reported Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 10, row 'RNAErnie', column 'SR' (Mean ± Std) |
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| Configuration: SpliceBERT (zero-shot, Wang et al. 2026) | Protocol: Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), WT-LLR, SR (mean over assays) Dataset: RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026) | 0.268±0.149 Absolute spearman correlation (WT-LLR; mean over assays) unitless · higher Uncertainty: SD 0.149 Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceSpliceBERT zero-shot fitness on RNAGym ncRNA DMS assays (31 assays) (WT-LLR, SR, mean) lit-rna-20261011-rnalm-zeroshot-protocol-t10-sr-mean Aggregation: Not reported Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 10, row 'SpliceBERT', column 'SR' (Mean ± Std) |
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| Configuration: Uni-RNA (L12) (zero-shot, Wang et al. 2026) | Protocol: Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), WT-LLR, SR (mean over assays) Dataset: RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026) | 0.170±0.165 Absolute spearman correlation (WT-LLR; mean over assays) unitless · higher Uncertainty: SD 0.165 Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceUni-RNA (L12) zero-shot fitness on RNAGym ncRNA DMS assays (31 assays) (WT-LLR, SR, mean) lit-rna-20261011-rnalm-zeroshot-protocol-t10-sr-mean Aggregation: Not reported Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 10, row 'Uni-RNA (L12)', column 'SR' (Mean ± Std) |
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| Configuration: Uni-RNA (L16) (zero-shot, Wang et al. 2026) | Protocol: Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), WT-LLR, SR (mean over assays) Dataset: RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026) | 0.173±0.164 Absolute spearman correlation (WT-LLR; mean over assays) unitless · higher Uncertainty: SD 0.164 Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceUni-RNA (L16) zero-shot fitness on RNAGym ncRNA DMS assays (31 assays) (WT-LLR, SR, mean) lit-rna-20261011-rnalm-zeroshot-protocol-t10-sr-mean Aggregation: Not reported Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 10, row 'Uni-RNA (L16)', column 'SR' (Mean ± Std) |
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| Configuration: Uni-RNA (L8) (zero-shot, Wang et al. 2026) | Protocol: Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), WT-LLR, SR (mean over assays) Dataset: RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026) | 0.186±0.156 Absolute spearman correlation (WT-LLR; mean over assays) unitless · higher Uncertainty: SD 0.156 Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceUni-RNA (L8) zero-shot fitness on RNAGym ncRNA DMS assays (31 assays) (WT-LLR, SR, mean) lit-rna-20261011-rnalm-zeroshot-protocol-t10-sr-mean Aggregation: Not reported Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 10, row 'Uni-RNA (L8)', column 'SR' (Mean ± Std) |
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| Configuration: UTR_LM (zero-shot, Wang et al. 2026) | Protocol: Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), WT-LLR, SR (mean over assays) Dataset: RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026) | 0.116±0.097 Absolute spearman correlation (WT-LLR; mean over assays) unitless · higher Uncertainty: SD 0.097 Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceUTR_LM zero-shot fitness on RNAGym ncRNA DMS assays (31 assays) (WT-LLR, SR, mean) lit-rna-20261011-rnalm-zeroshot-protocol-t10-sr-mean Aggregation: Not reported Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 10, row 'UTR_LM', column 'SR' (Mean ± Std) |
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