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MP-RNA (zero-shot, Wang et al. 2026)

MP-RNA evaluated zero-shot by Wang et al. 2026.

36 evaluations · 36 results

Overview

An explanatory profile has not yet been reviewed for this record.

Consult the linked sources for architecture or protocol details. Missing evidence is not evidence of a missing capability.

Evaluations and results

36 evaluations · 36 results. Different protocols are not a single leaderboard.

Sorted by AUROC (CLS embedding; mean over random samplings of sequence pairs) (higher is better). The best value in each column is highlighted. Decimals are rounded for display; each value links to the printed value and its source.

Tested configurationProtocol and datasetAUROC (CLS embedding; mean over random samplings of sequence pairs)AUROC (FFT embedding; mean over random samplings of sequence pairs)F1 (attention; mean over structures)F1 (attention; median over structures)F1 (CLS embedding; mean over random samplings of sequence pairs)F1 (FFT embedding; mean over random samplings of sequence pairs)MCC (attention; mean over structures)MCC (attention; median over structures)MCC (CLS embedding; mean over random samplings of sequence pairs)MCC (FFT embedding; mean over random samplings of sequence pairs)One minus overlap ratio (CLS embedding; mean over random samplings of sequence pairs)One minus overlap ratio (FFT embedding; mean over random samplings of sequence pairs)Absolute spearman correlation (PLL-D; mean over assays)Absolute spearman correlation (PLL-D; median over assays)Absolute spearman correlation (WT-LLR; mean over assays)Absolute spearman correlation (WT-LLR; median over assays)AUROC (PLL-D; mean over assays)AUROC (PLL-D; median over assays)AUROC (WT-LLR; mean over assays)AUROC (WT-LLR; median over assays)MCC (PLL-D; mean over assays)MCC (PLL-D; median over assays)MCC (WT-LLR; mean over assays)MCC (WT-LLR; median over assays)
MP-RNA (zero-shot, Wang et al. 2026)EvaluationWang et al. 2026 zero-shot family classification, RfamSample (561 Rfam families), CLS embedding, AUC (mean over repeated random samplings of sequence pairs), RfamSample (561 Rfam families) (Wang et al. 2026)0.817±0.000 (best in column)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
MP-RNA (zero-shot, Wang et al. 2026)EvaluationWang et al. 2026 zero-shot RNA type classification, ArchiveII-Nr (1273 RNAs), CLS embedding, AUC (mean over repeated random samplings of sequence pairs), ArchiveII-Nr (1273 RNAs) (Wang et al. 2026)0.798±0.001Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
MP-RNA (zero-shot, Wang et al. 2026)EvaluationWang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), WT-LLR, AUC (mean over assays), RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported0.617±0.076Not reportedNot reportedNot reportedNot reportedNot reported
MP-RNA (zero-shot, Wang et al. 2026)EvaluationWang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), WT-LLR, AUC (median over assays), RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported0.609Not reportedNot reportedNot reportedNot reported
MP-RNA (zero-shot, Wang et al. 2026)EvaluationWang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), WT-LLR, MCC (mean over assays), RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported0.165±0.105Not reported
MP-RNA (zero-shot, Wang et al. 2026)EvaluationWang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), WT-LLR, MCC (median over assays), RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported0.143
MP-RNA (zero-shot, Wang et al. 2026)EvaluationWang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), WT-LLR, SR (mean over assays), RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported0.240±0.159Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
MP-RNA (zero-shot, Wang et al. 2026)EvaluationWang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), WT-LLR, SR (median over assays), RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported0.215Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
MP-RNA (zero-shot, Wang et al. 2026)EvaluationWang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), PLL-D, AUC (mean over assays), RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported0.550±0.043Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
MP-RNA (zero-shot, Wang et al. 2026)EvaluationWang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), PLL-D, AUC (median over assays), RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported0.539Not reportedNot reportedNot reportedNot reportedNot reportedNot reported
MP-RNA (zero-shot, Wang et al. 2026)EvaluationWang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), PLL-D, MCC (mean over assays), RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported0.072±0.068Not reportedNot reportedNot reported
MP-RNA (zero-shot, Wang et al. 2026)EvaluationWang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), PLL-D, MCC (median over assays), RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported0.052Not reportedNot reported
MP-RNA (zero-shot, Wang et al. 2026)EvaluationWang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), PLL-D, SR (mean over assays), RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported0.098±0.084Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
MP-RNA (zero-shot, Wang et al. 2026)EvaluationWang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), PLL-D, SR (median over assays), RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported0.077Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
MP-RNA (zero-shot, Wang et al. 2026)EvaluationWang et al. 2026 zero-shot secondary structure, TS test set (70 PDB structures), attention, F1 score (mean over structures), TS test set (70 PDB structures) (Wang et al. 2026)Not reportedNot reported0.507±0.201Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
MP-RNA (zero-shot, Wang et al. 2026)EvaluationWang et al. 2026 zero-shot secondary structure, TS test set (70 PDB structures), attention, F1 score (median over structures), TS test set (70 PDB structures) (Wang et al. 2026)Not reportedNot reportedNot reported0.507Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
MP-RNA (zero-shot, Wang et al. 2026)EvaluationWang et al. 2026 zero-shot secondary structure, TS test set (70 PDB structures), attention, MCC (mean over structures), TS test set (70 PDB structures) (Wang et al. 2026)Not reportedNot reportedNot reportedNot reportedNot reportedNot reported0.510±0.200Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
MP-RNA (zero-shot, Wang et al. 2026)EvaluationWang et al. 2026 zero-shot secondary structure, TS test set (70 PDB structures), attention, MCC (median over structures), TS test set (70 PDB structures) (Wang et al. 2026)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported0.515Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
MP-RNA (zero-shot, Wang et al. 2026)EvaluationWang et al. 2026 zero-shot secondary structure, TS-Hard test set (15 PDB structures), attention, F1 score (mean over structures), TS-Hard test set (15 PDB structures) (Wang et al. 2026)Not reportedNot reported0.545±0.217 (best in column)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
MP-RNA (zero-shot, Wang et al. 2026)EvaluationWang et al. 2026 zero-shot secondary structure, TS-Hard test set (15 PDB structures), attention, F1 score (median over structures), TS-Hard test set (15 PDB structures) (Wang et al. 2026)Not reportedNot reportedNot reported0.519 (best in column)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
MP-RNA (zero-shot, Wang et al. 2026)EvaluationWang et al. 2026 zero-shot secondary structure, TS-Hard test set (15 PDB structures), attention, MCC (mean over structures), TS-Hard test set (15 PDB structures) (Wang et al. 2026)Not reportedNot reportedNot reportedNot reportedNot reportedNot reported0.547±0.215 (best in column)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
MP-RNA (zero-shot, Wang et al. 2026)EvaluationWang et al. 2026 zero-shot secondary structure, TS-Hard test set (15 PDB structures), attention, MCC (median over structures), TS-Hard test set (15 PDB structures) (Wang et al. 2026)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported0.516 (best in column)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
MP-RNA (zero-shot, Wang et al. 2026)EvaluationWang et al. 2026 zero-shot family classification, RfamSample (561 Rfam families), FFT embedding, 1 − OR (mean over repeated random samplings of sequence pairs), RfamSample (561 Rfam families) (Wang et al. 2026)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported0.619±0.000 (best in column)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
MP-RNA (zero-shot, Wang et al. 2026)EvaluationWang et al. 2026 zero-shot family classification, RfamSample (561 Rfam families), FFT embedding, AUC (mean over repeated random samplings of sequence pairs), RfamSample (561 Rfam families) (Wang et al. 2026)Not reported0.792±0.000 (best in column)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
MP-RNA (zero-shot, Wang et al. 2026)EvaluationWang et al. 2026 zero-shot family classification, RfamSample (561 Rfam families), FFT embedding, F1 (mean over repeated random samplings of sequence pairs), RfamSample (561 Rfam families) (Wang et al. 2026)Not reportedNot reportedNot reportedNot reportedNot reported0.731±0.001 (best in column)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
MP-RNA (zero-shot, Wang et al. 2026)EvaluationWang et al. 2026 zero-shot family classification, RfamSample (561 Rfam families), FFT embedding, MCC (mean over repeated random samplings of sequence pairs), RfamSample (561 Rfam families) (Wang et al. 2026)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported0.420±0.001 (best in column)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
MP-RNA (zero-shot, Wang et al. 2026)EvaluationWang et al. 2026 zero-shot RNA type classification, ArchiveII-Nr (1273 RNAs), FFT embedding, 1 − OR (mean over repeated random samplings of sequence pairs), ArchiveII-Nr (1273 RNAs) (Wang et al. 2026)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported0.539±0.001Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
MP-RNA (zero-shot, Wang et al. 2026)EvaluationWang et al. 2026 zero-shot RNA type classification, ArchiveII-Nr (1273 RNAs), FFT embedding, AUC (mean over repeated random samplings of sequence pairs), ArchiveII-Nr (1273 RNAs) (Wang et al. 2026)Not reported0.761±0.001Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
MP-RNA (zero-shot, Wang et al. 2026)EvaluationWang et al. 2026 zero-shot RNA type classification, ArchiveII-Nr (1273 RNAs), FFT embedding, F1 (mean over repeated random samplings of sequence pairs), ArchiveII-Nr (1273 RNAs) (Wang et al. 2026)Not reportedNot reportedNot reportedNot reportedNot reported0.719±0.001Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
MP-RNA (zero-shot, Wang et al. 2026)EvaluationWang et al. 2026 zero-shot RNA type classification, ArchiveII-Nr (1273 RNAs), FFT embedding, MCC (mean over repeated random samplings of sequence pairs), ArchiveII-Nr (1273 RNAs) (Wang et al. 2026)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported0.336±0.002Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
MP-RNA (zero-shot, Wang et al. 2026)EvaluationWang et al. 2026 zero-shot family classification, RfamSample (561 Rfam families), CLS embedding, 1 − OR (mean over repeated random samplings of sequence pairs), RfamSample (561 Rfam families) (Wang et al. 2026)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported0.652±0.001 (best in column)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
MP-RNA (zero-shot, Wang et al. 2026)EvaluationWang et al. 2026 zero-shot family classification, RfamSample (561 Rfam families), CLS embedding, F1 (mean over repeated random samplings of sequence pairs), RfamSample (561 Rfam families) (Wang et al. 2026)Not reportedNot reportedNot reportedNot reported0.745±0.001 (best in column)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
MP-RNA (zero-shot, Wang et al. 2026)EvaluationWang et al. 2026 zero-shot family classification, RfamSample (561 Rfam families), CLS embedding, MCC (mean over repeated random samplings of sequence pairs), RfamSample (561 Rfam families) (Wang et al. 2026)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported0.447±0.000 (best in column)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
MP-RNA (zero-shot, Wang et al. 2026)EvaluationWang et al. 2026 zero-shot RNA type classification, ArchiveII-Nr (1273 RNAs), CLS embedding, 1 − OR (mean over repeated random samplings of sequence pairs), ArchiveII-Nr (1273 RNAs) (Wang et al. 2026)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported0.613±0.002Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
MP-RNA (zero-shot, Wang et al. 2026)EvaluationWang et al. 2026 zero-shot RNA type classification, ArchiveII-Nr (1273 RNAs), CLS embedding, F1 (mean over repeated random samplings of sequence pairs), ArchiveII-Nr (1273 RNAs) (Wang et al. 2026)Not reportedNot reportedNot reportedNot reported0.733±0.001Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
MP-RNA (zero-shot, Wang et al. 2026)EvaluationWang et al. 2026 zero-shot RNA type classification, ArchiveII-Nr (1273 RNAs), CLS embedding, MCC (mean over repeated random samplings of sequence pairs), ArchiveII-Nr (1273 RNAs) (Wang et al. 2026)Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported0.388±0.002Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
All 36 result rows with coverage, uncertainty and sources
Filter evaluations

Applied filters: All linked evaluations

Exact evaluated configurations and original reported results
Tested configurationProtocol and datasetFindingEvidence and details
Configuration: MP-RNA (zero-shot, Wang et al. 2026)Protocol: Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), WT-LLR, AUC (mean over assays)
Dataset: RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026)
0.617±0.076 AUROC (WT-LLR; mean over assays)
unitless · higher

Uncertainty: SD 0.076

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

MP-RNA zero-shot fitness on RNAGym ncRNA DMS assays (31 assays) (WT-LLR, AUC, mean)

lit-rna-20261011-rnalm-zeroshot-protocol-t10-auc-mean

Aggregation: Not reported

Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 10, row 'MP-RNA', column 'AUC' (Mean ± Std)
Configuration: MP-RNA (zero-shot, Wang et al. 2026)Protocol: Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), WT-LLR, AUC (median over assays)
Dataset: RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026)
0.609 AUROC (WT-LLR; median over assays)
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

MP-RNA zero-shot fitness on RNAGym ncRNA DMS assays (31 assays) (WT-LLR, AUC, median)

lit-rna-20261011-rnalm-zeroshot-protocol-t10-auc-median

Aggregation: Not reported

Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 10, row 'MP-RNA', column 'AUC' (Median)
Configuration: MP-RNA (zero-shot, Wang et al. 2026)Protocol: Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), WT-LLR, MCC (mean over assays)
Dataset: RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026)
0.165±0.105 MCC (WT-LLR; mean over assays)
unitless · higher

Uncertainty: SD 0.105

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

MP-RNA zero-shot fitness on RNAGym ncRNA DMS assays (31 assays) (WT-LLR, MCC, mean)

lit-rna-20261011-rnalm-zeroshot-protocol-t10-mcc-mean

Aggregation: Not reported

Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 10, row 'MP-RNA', column 'MCC' (Mean ± Std)
Configuration: MP-RNA (zero-shot, Wang et al. 2026)Protocol: Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), WT-LLR, MCC (median over assays)
Dataset: RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026)
0.143 MCC (WT-LLR; median over assays)
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

MP-RNA zero-shot fitness on RNAGym ncRNA DMS assays (31 assays) (WT-LLR, MCC, median)

lit-rna-20261011-rnalm-zeroshot-protocol-t10-mcc-median

Aggregation: Not reported

Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 10, row 'MP-RNA', column 'MCC' (Median)
Configuration: MP-RNA (zero-shot, Wang et al. 2026)Protocol: Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), WT-LLR, SR (mean over assays)
Dataset: RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026)
0.240±0.159 Absolute spearman correlation (WT-LLR; mean over assays)
unitless · higher

Uncertainty: SD 0.159

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

MP-RNA zero-shot fitness on RNAGym ncRNA DMS assays (31 assays) (WT-LLR, SR, mean)

lit-rna-20261011-rnalm-zeroshot-protocol-t10-sr-mean

Aggregation: Not reported

Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 10, row 'MP-RNA', column 'SR' (Mean ± Std)
Configuration: MP-RNA (zero-shot, Wang et al. 2026)Protocol: Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), WT-LLR, SR (median over assays)
Dataset: RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026)
0.215 Absolute spearman correlation (WT-LLR; median over assays)
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

MP-RNA zero-shot fitness on RNAGym ncRNA DMS assays (31 assays) (WT-LLR, SR, median)

lit-rna-20261011-rnalm-zeroshot-protocol-t10-sr-median

Aggregation: Not reported

Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 10, row 'MP-RNA', column 'SR' (Median)
Configuration: MP-RNA (zero-shot, Wang et al. 2026)Protocol: Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), PLL-D, AUC (mean over assays)
Dataset: RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026)
0.550±0.043 AUROC (PLL-D; mean over assays)
unitless · higher

Uncertainty: SD 0.043

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

MP-RNA zero-shot fitness on RNAGym ncRNA DMS assays (31 assays) (PLL-D, AUC, mean)

lit-rna-20261011-rnalm-zeroshot-protocol-t11-auc-mean

Aggregation: Not reported

Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 11, row 'MP-RNA', column 'AUC' (Mean ± Std)
Configuration: MP-RNA (zero-shot, Wang et al. 2026)Protocol: Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), PLL-D, AUC (median over assays)
Dataset: RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026)
0.539 AUROC (PLL-D; median over assays)
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

MP-RNA zero-shot fitness on RNAGym ncRNA DMS assays (31 assays) (PLL-D, AUC, median)

lit-rna-20261011-rnalm-zeroshot-protocol-t11-auc-median

Aggregation: Not reported

Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 11, row 'MP-RNA', column 'AUC' (Median)
Configuration: MP-RNA (zero-shot, Wang et al. 2026)Protocol: Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), PLL-D, MCC (mean over assays)
Dataset: RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026)
0.072±0.068 MCC (PLL-D; mean over assays)
unitless · higher

Uncertainty: SD 0.068

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

MP-RNA zero-shot fitness on RNAGym ncRNA DMS assays (31 assays) (PLL-D, MCC, mean)

lit-rna-20261011-rnalm-zeroshot-protocol-t11-mcc-mean

Aggregation: Not reported

Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 11, row 'MP-RNA', column 'MCC' (Mean ± Std)
Configuration: MP-RNA (zero-shot, Wang et al. 2026)Protocol: Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), PLL-D, MCC (median over assays)
Dataset: RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026)
0.052 MCC (PLL-D; median over assays)
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

MP-RNA zero-shot fitness on RNAGym ncRNA DMS assays (31 assays) (PLL-D, MCC, median)

lit-rna-20261011-rnalm-zeroshot-protocol-t11-mcc-median

Aggregation: Not reported

Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 11, row 'MP-RNA', column 'MCC' (Median)
Configuration: MP-RNA (zero-shot, Wang et al. 2026)Protocol: Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), PLL-D, SR (mean over assays)
Dataset: RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026)
0.098±0.084 Absolute spearman correlation (PLL-D; mean over assays)
unitless · higher

Uncertainty: SD 0.084

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

MP-RNA zero-shot fitness on RNAGym ncRNA DMS assays (31 assays) (PLL-D, SR, mean)

lit-rna-20261011-rnalm-zeroshot-protocol-t11-sr-mean

Aggregation: Not reported

Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 11, row 'MP-RNA', column 'SR' (Mean ± Std)
Configuration: MP-RNA (zero-shot, Wang et al. 2026)Protocol: Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), PLL-D, SR (median over assays)
Dataset: RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026)
0.077 Absolute spearman correlation (PLL-D; median over assays)
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

MP-RNA zero-shot fitness on RNAGym ncRNA DMS assays (31 assays) (PLL-D, SR, median)

lit-rna-20261011-rnalm-zeroshot-protocol-t11-sr-median

Aggregation: Not reported

Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 11, row 'MP-RNA', column 'SR' (Median)
Configuration: MP-RNA (zero-shot, Wang et al. 2026)Protocol: Wang et al. 2026 zero-shot secondary structure, TS test set (70 PDB structures), attention, F1 score (mean over structures)
Dataset: TS test set (70 PDB structures) (Wang et al. 2026)
0.507±0.201 F1 (attention; mean over structures)
unitless · higher

Uncertainty: SD 0.201

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

MP-RNA zero-shot secondary structure on TS test set (70 PDB structures) (attention, F1 score, mean)

lit-rna-20261011-rnalm-zeroshot-protocol-t4-f1-score-mean

Aggregation: Not reported

Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 4, row 'MP-RNA', column 'F1 score' (Mean ± Std)
Configuration: MP-RNA (zero-shot, Wang et al. 2026)Protocol: Wang et al. 2026 zero-shot secondary structure, TS test set (70 PDB structures), attention, F1 score (median over structures)
Dataset: TS test set (70 PDB structures) (Wang et al. 2026)
0.507 F1 (attention; median over structures)
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

MP-RNA zero-shot secondary structure on TS test set (70 PDB structures) (attention, F1 score, median)

lit-rna-20261011-rnalm-zeroshot-protocol-t4-f1-score-median

Aggregation: Not reported

Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 4, row 'MP-RNA', column 'F1 score' (Median)
Configuration: MP-RNA (zero-shot, Wang et al. 2026)Protocol: Wang et al. 2026 zero-shot secondary structure, TS test set (70 PDB structures), attention, MCC (mean over structures)
Dataset: TS test set (70 PDB structures) (Wang et al. 2026)
0.510±0.200 MCC (attention; mean over structures)
unitless · higher

Uncertainty: SD 0.200

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

MP-RNA zero-shot secondary structure on TS test set (70 PDB structures) (attention, MCC, mean)

lit-rna-20261011-rnalm-zeroshot-protocol-t4-mcc-mean

Aggregation: Not reported

Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 4, row 'MP-RNA', column 'MCC' (Mean ± Std)
Configuration: MP-RNA (zero-shot, Wang et al. 2026)Protocol: Wang et al. 2026 zero-shot secondary structure, TS test set (70 PDB structures), attention, MCC (median over structures)
Dataset: TS test set (70 PDB structures) (Wang et al. 2026)
0.515 MCC (attention; median over structures)
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

MP-RNA zero-shot secondary structure on TS test set (70 PDB structures) (attention, MCC, median)

lit-rna-20261011-rnalm-zeroshot-protocol-t4-mcc-median

Aggregation: Not reported

Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 4, row 'MP-RNA', column 'MCC' (Median)
Configuration: MP-RNA (zero-shot, Wang et al. 2026)Protocol: Wang et al. 2026 zero-shot secondary structure, TS-Hard test set (15 PDB structures), attention, F1 score (mean over structures)
Dataset: TS-Hard test set (15 PDB structures) (Wang et al. 2026)
0.545±0.217 F1 (attention; mean over structures)
unitless · higher

Uncertainty: SD 0.217

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

MP-RNA zero-shot secondary structure on TS-Hard test set (15 PDB structures) (attention, F1 score, mean)

lit-rna-20261011-rnalm-zeroshot-protocol-t5-f1-score-mean

Aggregation: Not reported

Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 5, row 'MP-RNA', column 'F1 score' (Mean ± Std)
Configuration: MP-RNA (zero-shot, Wang et al. 2026)Protocol: Wang et al. 2026 zero-shot secondary structure, TS-Hard test set (15 PDB structures), attention, F1 score (median over structures)
Dataset: TS-Hard test set (15 PDB structures) (Wang et al. 2026)
0.519 F1 (attention; median over structures)
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

MP-RNA zero-shot secondary structure on TS-Hard test set (15 PDB structures) (attention, F1 score, median)

lit-rna-20261011-rnalm-zeroshot-protocol-t5-f1-score-median

Aggregation: Not reported

Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 5, row 'MP-RNA', column 'F1 score' (Median)
Configuration: MP-RNA (zero-shot, Wang et al. 2026)Protocol: Wang et al. 2026 zero-shot secondary structure, TS-Hard test set (15 PDB structures), attention, MCC (mean over structures)
Dataset: TS-Hard test set (15 PDB structures) (Wang et al. 2026)
0.547±0.215 MCC (attention; mean over structures)
unitless · higher

Uncertainty: SD 0.215

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

MP-RNA zero-shot secondary structure on TS-Hard test set (15 PDB structures) (attention, MCC, mean)

lit-rna-20261011-rnalm-zeroshot-protocol-t5-mcc-mean

Aggregation: Not reported

Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 5, row 'MP-RNA', column 'MCC' (Mean ± Std)
Configuration: MP-RNA (zero-shot, Wang et al. 2026)Protocol: Wang et al. 2026 zero-shot secondary structure, TS-Hard test set (15 PDB structures), attention, MCC (median over structures)
Dataset: TS-Hard test set (15 PDB structures) (Wang et al. 2026)
0.516 MCC (attention; median over structures)
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

MP-RNA zero-shot secondary structure on TS-Hard test set (15 PDB structures) (attention, MCC, median)

lit-rna-20261011-rnalm-zeroshot-protocol-t5-mcc-median

Aggregation: Not reported

Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 5, row 'MP-RNA', column 'MCC' (Median)
Configuration: MP-RNA (zero-shot, Wang et al. 2026)Protocol: Wang et al. 2026 zero-shot family classification, RfamSample (561 Rfam families), FFT embedding, 1 − OR (mean over repeated random samplings of sequence pairs)
Dataset: RfamSample (561 Rfam families) (Wang et al. 2026)
0.619±0.000 One minus overlap ratio (FFT embedding; mean over random samplings of sequence pairs)
unitless · higher

Uncertainty: SD 0.000

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

MP-RNA zero-shot family classification on RfamSample (561 Rfam families) (FFT embedding, 1 − OR, sampled-mean)

lit-rna-20261011-rnalm-zeroshot-protocol-t6-1-or-sampled-mean

Aggregation: Not reported

Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 6, row 'MP-RNA', column '1 − OR'
Configuration: MP-RNA (zero-shot, Wang et al. 2026)Protocol: Wang et al. 2026 zero-shot family classification, RfamSample (561 Rfam families), FFT embedding, AUC (mean over repeated random samplings of sequence pairs)
Dataset: RfamSample (561 Rfam families) (Wang et al. 2026)
0.792±0.000 AUROC (FFT embedding; mean over random samplings of sequence pairs)
unitless · higher

Uncertainty: SD 0.000

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

MP-RNA zero-shot family classification on RfamSample (561 Rfam families) (FFT embedding, AUC, sampled-mean)

lit-rna-20261011-rnalm-zeroshot-protocol-t6-auc-sampled-mean

Aggregation: Not reported

Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 6, row 'MP-RNA', column 'AUC'
Configuration: MP-RNA (zero-shot, Wang et al. 2026)Protocol: Wang et al. 2026 zero-shot family classification, RfamSample (561 Rfam families), FFT embedding, F1 (mean over repeated random samplings of sequence pairs)
Dataset: RfamSample (561 Rfam families) (Wang et al. 2026)
0.731±0.001 F1 (FFT embedding; mean over random samplings of sequence pairs)
unitless · higher

Uncertainty: SD 0.001

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

MP-RNA zero-shot family classification on RfamSample (561 Rfam families) (FFT embedding, F1, sampled-mean)

lit-rna-20261011-rnalm-zeroshot-protocol-t6-f1-sampled-mean

Aggregation: Not reported

Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 6, row 'MP-RNA', column 'F1'
Configuration: MP-RNA (zero-shot, Wang et al. 2026)Protocol: Wang et al. 2026 zero-shot family classification, RfamSample (561 Rfam families), FFT embedding, MCC (mean over repeated random samplings of sequence pairs)
Dataset: RfamSample (561 Rfam families) (Wang et al. 2026)
0.420±0.001 MCC (FFT embedding; mean over random samplings of sequence pairs)
unitless · higher

Uncertainty: SD 0.001

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

MP-RNA zero-shot family classification on RfamSample (561 Rfam families) (FFT embedding, MCC, sampled-mean)

lit-rna-20261011-rnalm-zeroshot-protocol-t6-mcc-sampled-mean

Aggregation: Not reported

Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 6, row 'MP-RNA', column 'MCC'
Configuration: MP-RNA (zero-shot, Wang et al. 2026)Protocol: Wang et al. 2026 zero-shot RNA type classification, ArchiveII-Nr (1273 RNAs), FFT embedding, 1 − OR (mean over repeated random samplings of sequence pairs)
Dataset: ArchiveII-Nr (1273 RNAs) (Wang et al. 2026)
0.539±0.001 One minus overlap ratio (FFT embedding; mean over random samplings of sequence pairs)
unitless · higher

Uncertainty: SD 0.001

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

MP-RNA zero-shot RNA type classification on ArchiveII-Nr (1273 RNAs) (FFT embedding, 1 − OR, sampled-mean)

lit-rna-20261011-rnalm-zeroshot-protocol-t7-1-or-sampled-mean

Aggregation: Not reported

Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 7, row 'MP-RNA', column '1 − OR'

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Stable ID: lit-rna-20261011-rnalm-zeroshot-config-mp-rna-wang2026

areas
rna-transcriptomes
contexts
research
method types
foundation_model
reported name
MP-RNA
foundation model eligible
true
parameters
Pretrained weights used without fine-tuning (zero-shot); attention maps, embeddings or token logits read out as described in the Methods
access reuse
Public download location listed in Supplementary Table 1
source locator
Supplementary Table 1 row 'MP-RNA'
checkpoint
https://huggingface.co/yangheng/MP-RNA (downloaded 2024/11/27; version column '-'; variant label in results tables 'none')
missing metadata
version: reason: unreported; note: No version column entry for this checkpoint in Supplementary Table 1
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