| Configuration: AIDO.RNA (1.6B) (zero-shot, Wang et al. 2026) | Protocol: Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), WT-LLR, SR (median over assays) Dataset: RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026) | 0.214 Absolute spearman correlation (WT-LLR; median over assays) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceAIDO.RNA (1.6B) zero-shot fitness on RNAGym ncRNA DMS assays (31 assays) (WT-LLR, SR, median) lit-rna-20261011-rnalm-zeroshot-protocol-t10-sr-median Aggregation: Not reported Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 10, row 'AIDO.RNA (1.6B)', column 'SR' (Median) |
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| Configuration: AIDO.RNA (650M) (zero-shot, Wang et al. 2026) | Protocol: Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), WT-LLR, SR (median over assays) Dataset: RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026) | 0.169 Absolute spearman correlation (WT-LLR; median over assays) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceAIDO.RNA (650M) zero-shot fitness on RNAGym ncRNA DMS assays (31 assays) (WT-LLR, SR, median) lit-rna-20261011-rnalm-zeroshot-protocol-t10-sr-median Aggregation: Not reported Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 10, row 'AIDO.RNA (650M)', column 'SR' (Median) |
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| Configuration: DGRNA (zero-shot, Wang et al. 2026) | Protocol: Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), WT-LLR, SR (median over assays) Dataset: RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026) | 0.2 Absolute spearman correlation (WT-LLR; median over assays) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceDGRNA zero-shot fitness on RNAGym ncRNA DMS assays (31 assays) (WT-LLR, SR, median) lit-rna-20261011-rnalm-zeroshot-protocol-t10-sr-median Aggregation: Not reported Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 10, row 'DGRNA', column 'SR' (Median) |
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| Configuration: LAMAR (2k) (zero-shot, Wang et al. 2026) | Protocol: Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), WT-LLR, SR (median over assays) Dataset: RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026) | 0.063 Absolute spearman correlation (WT-LLR; median over assays) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceLAMAR (2k) zero-shot fitness on RNAGym ncRNA DMS assays (31 assays) (WT-LLR, SR, median) lit-rna-20261011-rnalm-zeroshot-protocol-t10-sr-median Aggregation: Not reported Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 10, row 'LAMAR (2k)', column 'SR' (Median) |
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| Configuration: LAMAR (4k) (zero-shot, Wang et al. 2026) | Protocol: Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), WT-LLR, SR (median over assays) Dataset: RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026) | 0.1 Absolute spearman correlation (WT-LLR; median over assays) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceLAMAR (4k) zero-shot fitness on RNAGym ncRNA DMS assays (31 assays) (WT-LLR, SR, median) lit-rna-20261011-rnalm-zeroshot-protocol-t10-sr-median Aggregation: Not reported Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 10, row 'LAMAR (4k)', column 'SR' (Median) |
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| Configuration: LucaOne (D17.6M) (zero-shot, Wang et al. 2026) | Protocol: Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), WT-LLR, SR (median over assays) Dataset: RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026) | 0.092 Absolute spearman correlation (WT-LLR; median over assays) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceLucaOne (D17.6M) zero-shot fitness on RNAGym ncRNA DMS assays (31 assays) (WT-LLR, SR, median) lit-rna-20261011-rnalm-zeroshot-protocol-t10-sr-median Aggregation: Not reported Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 10, row 'LucaOne (D17.6M)', column 'SR' (Median) |
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| Configuration: LucaOne (D36.0M) (zero-shot, Wang et al. 2026) | Protocol: Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), WT-LLR, SR (median over assays) Dataset: RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026) | 0.116 Absolute spearman correlation (WT-LLR; median over assays) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceLucaOne (D36.0M) zero-shot fitness on RNAGym ncRNA DMS assays (31 assays) (WT-LLR, SR, median) lit-rna-20261011-rnalm-zeroshot-protocol-t10-sr-median Aggregation: Not reported Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 10, row 'LucaOne (D36.0M)', column 'SR' (Median) |
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| Configuration: LucaOne (G36.8M) (zero-shot, Wang et al. 2026) | Protocol: Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), WT-LLR, SR (median over assays) Dataset: RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026) | 0.104 Absolute spearman correlation (WT-LLR; median over assays) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceLucaOne (G36.8M) zero-shot fitness on RNAGym ncRNA DMS assays (31 assays) (WT-LLR, SR, median) lit-rna-20261011-rnalm-zeroshot-protocol-t10-sr-median Aggregation: Not reported Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 10, row 'LucaOne (G36.8M)', column 'SR' (Median) |
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| Configuration: MP-RNA (zero-shot, Wang et al. 2026) | Protocol: Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), WT-LLR, SR (median over assays) Dataset: RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026) | 0.215 Absolute spearman correlation (WT-LLR; median over assays) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceMP-RNA zero-shot fitness on RNAGym ncRNA DMS assays (31 assays) (WT-LLR, SR, median) lit-rna-20261011-rnalm-zeroshot-protocol-t10-sr-median Aggregation: Not reported Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 10, row 'MP-RNA', column 'SR' (Median) |
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| Configuration: PlantRNA-FM (zero-shot, Wang et al. 2026) | Protocol: Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), WT-LLR, SR (median over assays) Dataset: RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026) | 0.139 Absolute spearman correlation (WT-LLR; median over assays) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourcePlantRNA-FM zero-shot fitness on RNAGym ncRNA DMS assays (31 assays) (WT-LLR, SR, median) lit-rna-20261011-rnalm-zeroshot-protocol-t10-sr-median Aggregation: Not reported Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 10, row 'PlantRNA-FM', column 'SR' (Median) |
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| Configuration: ProtRNA (zero-shot, Wang et al. 2026) | Protocol: Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), WT-LLR, SR (median over assays) Dataset: RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026) | 0.089 Absolute spearman correlation (WT-LLR; median over assays) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceProtRNA zero-shot fitness on RNAGym ncRNA DMS assays (31 assays) (WT-LLR, SR, median) lit-rna-20261011-rnalm-zeroshot-protocol-t10-sr-median Aggregation: Not reported Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 10, row 'ProtRNA', column 'SR' (Median) |
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| Configuration: RiNALMo (giga) (zero-shot, Wang et al. 2026) | Protocol: Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), WT-LLR, SR (median over assays) Dataset: RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026) | 0.095 Absolute spearman correlation (WT-LLR; median over assays) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceRiNALMo (giga) zero-shot fitness on RNAGym ncRNA DMS assays (31 assays) (WT-LLR, SR, median) lit-rna-20261011-rnalm-zeroshot-protocol-t10-sr-median Aggregation: Not reported Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 10, row 'RiNALMo (giga)', column 'SR' (Median) |
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| Configuration: RiNALMo (mega) (zero-shot, Wang et al. 2026) | Protocol: Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), WT-LLR, SR (median over assays) Dataset: RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026) | 0.114 Absolute spearman correlation (WT-LLR; median over assays) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceRiNALMo (mega) zero-shot fitness on RNAGym ncRNA DMS assays (31 assays) (WT-LLR, SR, median) lit-rna-20261011-rnalm-zeroshot-protocol-t10-sr-median Aggregation: Not reported Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 10, row 'RiNALMo (mega)', column 'SR' (Median) |
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| Configuration: RiNALMo (micro) (zero-shot, Wang et al. 2026) | Protocol: Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), WT-LLR, SR (median over assays) Dataset: RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026) | 0.087 Absolute spearman correlation (WT-LLR; median over assays) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceRiNALMo (micro) zero-shot fitness on RNAGym ncRNA DMS assays (31 assays) (WT-LLR, SR, median) lit-rna-20261011-rnalm-zeroshot-protocol-t10-sr-median Aggregation: Not reported Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 10, row 'RiNALMo (micro)', column 'SR' (Median) |
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| Configuration: RNA-FM (zero-shot, Wang et al. 2026) | Protocol: Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), WT-LLR, SR (median over assays) Dataset: RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026) | 0.207 Absolute spearman correlation (WT-LLR; median over assays) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceRNA-FM zero-shot fitness on RNAGym ncRNA DMS assays (31 assays) (WT-LLR, SR, median) lit-rna-20261011-rnalm-zeroshot-protocol-t10-sr-median Aggregation: Not reported Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 10, row 'RNA-FM', column 'SR' (Median) |
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| Configuration: RNABERT (zero-shot, Wang et al. 2026) | Protocol: Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), WT-LLR, SR (median over assays) Dataset: RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026) | 0.075 Absolute spearman correlation (WT-LLR; median over assays) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceRNABERT zero-shot fitness on RNAGym ncRNA DMS assays (31 assays) (WT-LLR, SR, median) lit-rna-20261011-rnalm-zeroshot-protocol-t10-sr-median Aggregation: Not reported Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 10, row 'RNABERT', column 'SR' (Median) |
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| Configuration: RNAErnie (zero-shot, Wang et al. 2026) | Protocol: Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), WT-LLR, SR (median over assays) Dataset: RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026) | 0.133 Absolute spearman correlation (WT-LLR; median over assays) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceRNAErnie zero-shot fitness on RNAGym ncRNA DMS assays (31 assays) (WT-LLR, SR, median) lit-rna-20261011-rnalm-zeroshot-protocol-t10-sr-median Aggregation: Not reported Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 10, row 'RNAErnie', column 'SR' (Median) |
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| Configuration: SpliceBERT (zero-shot, Wang et al. 2026) | Protocol: Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), WT-LLR, SR (median over assays) Dataset: RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026) | 0.202 Absolute spearman correlation (WT-LLR; median over assays) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceSpliceBERT zero-shot fitness on RNAGym ncRNA DMS assays (31 assays) (WT-LLR, SR, median) lit-rna-20261011-rnalm-zeroshot-protocol-t10-sr-median Aggregation: Not reported Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 10, row 'SpliceBERT', column 'SR' (Median) |
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| Configuration: Uni-RNA (L12) (zero-shot, Wang et al. 2026) | Protocol: Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), WT-LLR, SR (median over assays) Dataset: RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026) | 0.096 Absolute spearman correlation (WT-LLR; median over assays) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceUni-RNA (L12) zero-shot fitness on RNAGym ncRNA DMS assays (31 assays) (WT-LLR, SR, median) lit-rna-20261011-rnalm-zeroshot-protocol-t10-sr-median Aggregation: Not reported Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 10, row 'Uni-RNA (L12)', column 'SR' (Median) |
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| Configuration: Uni-RNA (L16) (zero-shot, Wang et al. 2026) | Protocol: Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), WT-LLR, SR (median over assays) Dataset: RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026) | 0.111 Absolute spearman correlation (WT-LLR; median over assays) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceUni-RNA (L16) zero-shot fitness on RNAGym ncRNA DMS assays (31 assays) (WT-LLR, SR, median) lit-rna-20261011-rnalm-zeroshot-protocol-t10-sr-median Aggregation: Not reported Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 10, row 'Uni-RNA (L16)', column 'SR' (Median) |
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| Configuration: Uni-RNA (L8) (zero-shot, Wang et al. 2026) | Protocol: Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), WT-LLR, SR (median over assays) Dataset: RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026) | 0.135 Absolute spearman correlation (WT-LLR; median over assays) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceUni-RNA (L8) zero-shot fitness on RNAGym ncRNA DMS assays (31 assays) (WT-LLR, SR, median) lit-rna-20261011-rnalm-zeroshot-protocol-t10-sr-median Aggregation: Not reported Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 10, row 'Uni-RNA (L8)', column 'SR' (Median) |
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| Configuration: UTR_LM (zero-shot, Wang et al. 2026) | Protocol: Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), WT-LLR, SR (median over assays) Dataset: RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026) | 0.087 Absolute spearman correlation (WT-LLR; median over assays) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceUTR_LM zero-shot fitness on RNAGym ncRNA DMS assays (31 assays) (WT-LLR, SR, median) lit-rna-20261011-rnalm-zeroshot-protocol-t10-sr-median Aggregation: Not reported Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 10, row 'UTR_LM', column 'SR' (Median) |
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