Configuration

AIDO.RNA (650M) (zero-shot, Wang et al. 2026)

AIDO.RNA (650M) evaluated zero-shot by Wang et al. 2026.

Overview

An explanatory profile has not yet been reviewed for this record.

Consult the linked sources for architecture or protocol details. Missing evidence is not evidence of a missing capability.

Evaluations and results

36 evaluations · 36 results. Different protocols are not a single leaderboard.

Sorted by AUROC (CLS embedding; mean over random samplings of sequence pairs) (higher is better). The best value in each column is highlighted. Decimals are rounded for display; each value links to the printed value and its source.

Tested configuration	Protocol and dataset	AUROC (CLS embedding; mean over random samplings of sequence pairs)	AUROC (FFT embedding; mean over random samplings of sequence pairs)	F1 (attention; mean over structures)	F1 (attention; median over structures)	F1 (CLS embedding; mean over random samplings of sequence pairs)	F1 (FFT embedding; mean over random samplings of sequence pairs)	MCC (attention; mean over structures)	MCC (attention; median over structures)	MCC (CLS embedding; mean over random samplings of sequence pairs)	MCC (FFT embedding; mean over random samplings of sequence pairs)	One minus overlap ratio (CLS embedding; mean over random samplings of sequence pairs)	One minus overlap ratio (FFT embedding; mean over random samplings of sequence pairs)	Absolute spearman correlation (PLL-D; mean over assays)	Absolute spearman correlation (PLL-D; median over assays)	Absolute spearman correlation (WT-LLR; mean over assays)	Absolute spearman correlation (WT-LLR; median over assays)	AUROC (PLL-D; mean over assays)	AUROC (PLL-D; median over assays)	AUROC (WT-LLR; mean over assays)	AUROC (WT-LLR; median over assays)	MCC (PLL-D; mean over assays)	MCC (PLL-D; median over assays)	MCC (WT-LLR; mean over assays)	MCC (WT-LLR; median over assays)
AIDO.RNA (650M) (zero-shot, Wang et al. 2026)Evaluation	Wang et al. 2026 zero-shot family classification, RfamSample (561 Rfam families), CLS embedding, AUC (mean over repeated random samplings of sequence pairs), RfamSample (561 Rfam families) (Wang et al. 2026)	0.964±0.001 (best in column)	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported
AIDO.RNA (650M) (zero-shot, Wang et al. 2026)Evaluation	Wang et al. 2026 zero-shot RNA type classification, ArchiveII-Nr (1273 RNAs), CLS embedding, AUC (mean over repeated random samplings of sequence pairs), ArchiveII-Nr (1273 RNAs) (Wang et al. 2026)	0.897±0.001	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported
AIDO.RNA (650M) (zero-shot, Wang et al. 2026)Evaluation	Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), WT-LLR, AUC (mean over assays), RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026)	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	0.606±0.088	Not reported	Not reported	Not reported	Not reported	Not reported
AIDO.RNA (650M) (zero-shot, Wang et al. 2026)Evaluation	Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), WT-LLR, AUC (median over assays), RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026)	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	0.577	Not reported	Not reported	Not reported	Not reported
AIDO.RNA (650M) (zero-shot, Wang et al. 2026)Evaluation	Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), WT-LLR, MCC (mean over assays), RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026)	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	0.152±0.126	Not reported
AIDO.RNA (650M) (zero-shot, Wang et al. 2026)Evaluation	Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), WT-LLR, MCC (median over assays), RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026)	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	0.122
AIDO.RNA (650M) (zero-shot, Wang et al. 2026)Evaluation	Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), WT-LLR, SR (mean over assays), RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026)	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	0.218±0.183	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported
AIDO.RNA (650M) (zero-shot, Wang et al. 2026)Evaluation	Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), WT-LLR, SR (median over assays), RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026)	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	0.169	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported
AIDO.RNA (650M) (zero-shot, Wang et al. 2026)Evaluation	Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), PLL-D, AUC (mean over assays), RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026)	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	0.584±0.070	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported
AIDO.RNA (650M) (zero-shot, Wang et al. 2026)Evaluation	Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), PLL-D, AUC (median over assays), RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026)	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	0.558	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported
AIDO.RNA (650M) (zero-shot, Wang et al. 2026)Evaluation	Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), PLL-D, MCC (mean over assays), RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026)	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	0.122±0.107	Not reported	Not reported	Not reported
AIDO.RNA (650M) (zero-shot, Wang et al. 2026)Evaluation	Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), PLL-D, MCC (median over assays), RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026)	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	0.088	Not reported	Not reported
AIDO.RNA (650M) (zero-shot, Wang et al. 2026)Evaluation	Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), PLL-D, SR (mean over assays), RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026)	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	0.169±0.143	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported
AIDO.RNA (650M) (zero-shot, Wang et al. 2026)Evaluation	Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), PLL-D, SR (median over assays), RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026)	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	0.106	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported
AIDO.RNA (650M) (zero-shot, Wang et al. 2026)Evaluation	Wang et al. 2026 zero-shot secondary structure, TS test set (70 PDB structures), attention, F1 score (mean over structures), TS test set (70 PDB structures) (Wang et al. 2026)	Not reported	Not reported	0.402±0.234 (best in column)	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported
AIDO.RNA (650M) (zero-shot, Wang et al. 2026)Evaluation	Wang et al. 2026 zero-shot secondary structure, TS test set (70 PDB structures), attention, F1 score (median over structures), TS test set (70 PDB structures) (Wang et al. 2026)	Not reported	Not reported	Not reported	0.438 (best in column)	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported
AIDO.RNA (650M) (zero-shot, Wang et al. 2026)Evaluation	Wang et al. 2026 zero-shot secondary structure, TS test set (70 PDB structures), attention, MCC (mean over structures), TS test set (70 PDB structures) (Wang et al. 2026)	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	0.427±0.235 (best in column)	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported
AIDO.RNA (650M) (zero-shot, Wang et al. 2026)Evaluation	Wang et al. 2026 zero-shot secondary structure, TS test set (70 PDB structures), attention, MCC (median over structures), TS test set (70 PDB structures) (Wang et al. 2026)	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	0.469 (best in column)	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported
AIDO.RNA (650M) (zero-shot, Wang et al. 2026)Evaluation	Wang et al. 2026 zero-shot secondary structure, TS-Hard test set (15 PDB structures), attention, F1 score (mean over structures), TS-Hard test set (15 PDB structures) (Wang et al. 2026)	Not reported	Not reported	0.331±0.217	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported
AIDO.RNA (650M) (zero-shot, Wang et al. 2026)Evaluation	Wang et al. 2026 zero-shot secondary structure, TS-Hard test set (15 PDB structures), attention, F1 score (median over structures), TS-Hard test set (15 PDB structures) (Wang et al. 2026)	Not reported	Not reported	Not reported	0.331	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported
AIDO.RNA (650M) (zero-shot, Wang et al. 2026)Evaluation	Wang et al. 2026 zero-shot secondary structure, TS-Hard test set (15 PDB structures), attention, MCC (mean over structures), TS-Hard test set (15 PDB structures) (Wang et al. 2026)	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	0.365±0.227	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported
AIDO.RNA (650M) (zero-shot, Wang et al. 2026)Evaluation	Wang et al. 2026 zero-shot secondary structure, TS-Hard test set (15 PDB structures), attention, MCC (median over structures), TS-Hard test set (15 PDB structures) (Wang et al. 2026)	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	0.412	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported
AIDO.RNA (650M) (zero-shot, Wang et al. 2026)Evaluation	Wang et al. 2026 zero-shot family classification, RfamSample (561 Rfam families), FFT embedding, 1 − OR (mean over repeated random samplings of sequence pairs), RfamSample (561 Rfam families) (Wang et al. 2026)	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	0.854±0.002 (best in column)	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported
AIDO.RNA (650M) (zero-shot, Wang et al. 2026)Evaluation	Wang et al. 2026 zero-shot family classification, RfamSample (561 Rfam families), FFT embedding, AUC (mean over repeated random samplings of sequence pairs), RfamSample (561 Rfam families) (Wang et al. 2026)	Not reported	0.944±0.001 (best in column)	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported
AIDO.RNA (650M) (zero-shot, Wang et al. 2026)Evaluation	Wang et al. 2026 zero-shot family classification, RfamSample (561 Rfam families), FFT embedding, F1 (mean over repeated random samplings of sequence pairs), RfamSample (561 Rfam families) (Wang et al. 2026)	Not reported	Not reported	Not reported	Not reported	Not reported	0.873±0.002 (best in column)	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported
AIDO.RNA (650M) (zero-shot, Wang et al. 2026)Evaluation	Wang et al. 2026 zero-shot family classification, RfamSample (561 Rfam families), FFT embedding, MCC (mean over repeated random samplings of sequence pairs), RfamSample (561 Rfam families) (Wang et al. 2026)	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	0.745±0.002 (best in column)	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported
AIDO.RNA (650M) (zero-shot, Wang et al. 2026)Evaluation	Wang et al. 2026 zero-shot RNA type classification, ArchiveII-Nr (1273 RNAs), FFT embedding, 1 − OR (mean over repeated random samplings of sequence pairs), ArchiveII-Nr (1273 RNAs) (Wang et al. 2026)	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	0.728±0.001	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported
AIDO.RNA (650M) (zero-shot, Wang et al. 2026)Evaluation	Wang et al. 2026 zero-shot RNA type classification, ArchiveII-Nr (1273 RNAs), FFT embedding, AUC (mean over repeated random samplings of sequence pairs), ArchiveII-Nr (1273 RNAs) (Wang et al. 2026)	Not reported	0.840±0.001	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported
AIDO.RNA (650M) (zero-shot, Wang et al. 2026)Evaluation	Wang et al. 2026 zero-shot RNA type classification, ArchiveII-Nr (1273 RNAs), FFT embedding, F1 (mean over repeated random samplings of sequence pairs), ArchiveII-Nr (1273 RNAs) (Wang et al. 2026)	Not reported	Not reported	Not reported	Not reported	Not reported	0.782±0.001	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported
AIDO.RNA (650M) (zero-shot, Wang et al. 2026)Evaluation	Wang et al. 2026 zero-shot RNA type classification, ArchiveII-Nr (1273 RNAs), FFT embedding, MCC (mean over repeated random samplings of sequence pairs), ArchiveII-Nr (1273 RNAs) (Wang et al. 2026)	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	0.555±0.001	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported
AIDO.RNA (650M) (zero-shot, Wang et al. 2026)Evaluation	Wang et al. 2026 zero-shot family classification, RfamSample (561 Rfam families), CLS embedding, 1 − OR (mean over repeated random samplings of sequence pairs), RfamSample (561 Rfam families) (Wang et al. 2026)	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	0.889±0.001 (best in column)	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported
AIDO.RNA (650M) (zero-shot, Wang et al. 2026)Evaluation	Wang et al. 2026 zero-shot family classification, RfamSample (561 Rfam families), CLS embedding, F1 (mean over repeated random samplings of sequence pairs), RfamSample (561 Rfam families) (Wang et al. 2026)	Not reported	Not reported	Not reported	Not reported	0.901±0.001 (best in column)	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported
AIDO.RNA (650M) (zero-shot, Wang et al. 2026)Evaluation	Wang et al. 2026 zero-shot family classification, RfamSample (561 Rfam families), CLS embedding, MCC (mean over repeated random samplings of sequence pairs), RfamSample (561 Rfam families) (Wang et al. 2026)	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	0.802±0.002 (best in column)	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported
AIDO.RNA (650M) (zero-shot, Wang et al. 2026)Evaluation	Wang et al. 2026 zero-shot RNA type classification, ArchiveII-Nr (1273 RNAs), CLS embedding, 1 − OR (mean over repeated random samplings of sequence pairs), ArchiveII-Nr (1273 RNAs) (Wang et al. 2026)	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	0.767±0.001	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported
AIDO.RNA (650M) (zero-shot, Wang et al. 2026)Evaluation	Wang et al. 2026 zero-shot RNA type classification, ArchiveII-Nr (1273 RNAs), CLS embedding, F1 (mean over repeated random samplings of sequence pairs), ArchiveII-Nr (1273 RNAs) (Wang et al. 2026)	Not reported	Not reported	Not reported	Not reported	0.810±0.001	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported
AIDO.RNA (650M) (zero-shot, Wang et al. 2026)Evaluation	Wang et al. 2026 zero-shot RNA type classification, ArchiveII-Nr (1273 RNAs), CLS embedding, MCC (mean over repeated random samplings of sequence pairs), ArchiveII-Nr (1273 RNAs) (Wang et al. 2026)	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	0.615±0.001	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported

All 36 result rows with coverage, uncertainty and sources

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Tested model or methodProtocolDatasetEvaluation setupMetricEvidence origin

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Exact evaluated configurations and original reported results
Tested configuration	Protocol and dataset	Finding	Evidence and details
Configuration: AIDO.RNA (650M) (zero-shot, Wang et al. 2026)	Protocol: Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), WT-LLR, AUC (mean over assays) Dataset: RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026)	0.606±0.088 AUROC (WT-LLR; mean over assays) unitless · higher Uncertainty: SD 0.088 Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source AIDO.RNA (650M) zero-shot fitness on RNAGym ncRNA DMS assays (31 assays) (WT-LLR, AUC, mean) lit-rna-20261011-rnalm-zeroshot-protocol-t10-auc-mean Aggregation: Not reported Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 10, row 'AIDO.RNA (650M)', column 'AUC' (Mean ± Std)
Configuration: AIDO.RNA (650M) (zero-shot, Wang et al. 2026)	Protocol: Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), WT-LLR, AUC (median over assays) Dataset: RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026)	0.577 AUROC (WT-LLR; median over assays) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source AIDO.RNA (650M) zero-shot fitness on RNAGym ncRNA DMS assays (31 assays) (WT-LLR, AUC, median) lit-rna-20261011-rnalm-zeroshot-protocol-t10-auc-median Aggregation: Not reported Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 10, row 'AIDO.RNA (650M)', column 'AUC' (Median)
Configuration: AIDO.RNA (650M) (zero-shot, Wang et al. 2026)	Protocol: Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), WT-LLR, MCC (mean over assays) Dataset: RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026)	0.152±0.126 MCC (WT-LLR; mean over assays) unitless · higher Uncertainty: SD 0.126 Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source AIDO.RNA (650M) zero-shot fitness on RNAGym ncRNA DMS assays (31 assays) (WT-LLR, MCC, mean) lit-rna-20261011-rnalm-zeroshot-protocol-t10-mcc-mean Aggregation: Not reported Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 10, row 'AIDO.RNA (650M)', column 'MCC' (Mean ± Std)
Configuration: AIDO.RNA (650M) (zero-shot, Wang et al. 2026)	Protocol: Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), WT-LLR, MCC (median over assays) Dataset: RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026)	0.122 MCC (WT-LLR; median over assays) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source AIDO.RNA (650M) zero-shot fitness on RNAGym ncRNA DMS assays (31 assays) (WT-LLR, MCC, median) lit-rna-20261011-rnalm-zeroshot-protocol-t10-mcc-median Aggregation: Not reported Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 10, row 'AIDO.RNA (650M)', column 'MCC' (Median)
Configuration: AIDO.RNA (650M) (zero-shot, Wang et al. 2026)	Protocol: Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), WT-LLR, SR (mean over assays) Dataset: RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026)	0.218±0.183 Absolute spearman correlation (WT-LLR; mean over assays) unitless · higher Uncertainty: SD 0.183 Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source AIDO.RNA (650M) zero-shot fitness on RNAGym ncRNA DMS assays (31 assays) (WT-LLR, SR, mean) lit-rna-20261011-rnalm-zeroshot-protocol-t10-sr-mean Aggregation: Not reported Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 10, row 'AIDO.RNA (650M)', column 'SR' (Mean ± Std)
Configuration: AIDO.RNA (650M) (zero-shot, Wang et al. 2026)	Protocol: Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), WT-LLR, SR (median over assays) Dataset: RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026)	0.169 Absolute spearman correlation (WT-LLR; median over assays) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source AIDO.RNA (650M) zero-shot fitness on RNAGym ncRNA DMS assays (31 assays) (WT-LLR, SR, median) lit-rna-20261011-rnalm-zeroshot-protocol-t10-sr-median Aggregation: Not reported Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 10, row 'AIDO.RNA (650M)', column 'SR' (Median)
Configuration: AIDO.RNA (650M) (zero-shot, Wang et al. 2026)	Protocol: Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), PLL-D, AUC (mean over assays) Dataset: RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026)	0.584±0.070 AUROC (PLL-D; mean over assays) unitless · higher Uncertainty: SD 0.070 Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source AIDO.RNA (650M) zero-shot fitness on RNAGym ncRNA DMS assays (31 assays) (PLL-D, AUC, mean) lit-rna-20261011-rnalm-zeroshot-protocol-t11-auc-mean Aggregation: Not reported Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 11, row 'AIDO.RNA (650M)', column 'AUC' (Mean ± Std)
Configuration: AIDO.RNA (650M) (zero-shot, Wang et al. 2026)	Protocol: Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), PLL-D, AUC (median over assays) Dataset: RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026)	0.558 AUROC (PLL-D; median over assays) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source AIDO.RNA (650M) zero-shot fitness on RNAGym ncRNA DMS assays (31 assays) (PLL-D, AUC, median) lit-rna-20261011-rnalm-zeroshot-protocol-t11-auc-median Aggregation: Not reported Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 11, row 'AIDO.RNA (650M)', column 'AUC' (Median)
Configuration: AIDO.RNA (650M) (zero-shot, Wang et al. 2026)	Protocol: Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), PLL-D, MCC (mean over assays) Dataset: RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026)	0.122±0.107 MCC (PLL-D; mean over assays) unitless · higher Uncertainty: SD 0.107 Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source AIDO.RNA (650M) zero-shot fitness on RNAGym ncRNA DMS assays (31 assays) (PLL-D, MCC, mean) lit-rna-20261011-rnalm-zeroshot-protocol-t11-mcc-mean Aggregation: Not reported Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 11, row 'AIDO.RNA (650M)', column 'MCC' (Mean ± Std)
Configuration: AIDO.RNA (650M) (zero-shot, Wang et al. 2026)	Protocol: Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), PLL-D, MCC (median over assays) Dataset: RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026)	0.088 MCC (PLL-D; median over assays) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source AIDO.RNA (650M) zero-shot fitness on RNAGym ncRNA DMS assays (31 assays) (PLL-D, MCC, median) lit-rna-20261011-rnalm-zeroshot-protocol-t11-mcc-median Aggregation: Not reported Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 11, row 'AIDO.RNA (650M)', column 'MCC' (Median)
Configuration: AIDO.RNA (650M) (zero-shot, Wang et al. 2026)	Protocol: Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), PLL-D, SR (mean over assays) Dataset: RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026)	0.169±0.143 Absolute spearman correlation (PLL-D; mean over assays) unitless · higher Uncertainty: SD 0.143 Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source AIDO.RNA (650M) zero-shot fitness on RNAGym ncRNA DMS assays (31 assays) (PLL-D, SR, mean) lit-rna-20261011-rnalm-zeroshot-protocol-t11-sr-mean Aggregation: Not reported Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 11, row 'AIDO.RNA (650M)', column 'SR' (Mean ± Std)
Configuration: AIDO.RNA (650M) (zero-shot, Wang et al. 2026)	Protocol: Wang et al. 2026 zero-shot fitness, RNAGym ncRNA DMS assays (31 assays), PLL-D, SR (median over assays) Dataset: RNAGym ncRNA DMS assays (31 assays) (Wang et al. 2026)	0.106 Absolute spearman correlation (PLL-D; median over assays) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source AIDO.RNA (650M) zero-shot fitness on RNAGym ncRNA DMS assays (31 assays) (PLL-D, SR, median) lit-rna-20261011-rnalm-zeroshot-protocol-t11-sr-median Aggregation: Not reported Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 11, row 'AIDO.RNA (650M)', column 'SR' (Median)
Configuration: AIDO.RNA (650M) (zero-shot, Wang et al. 2026)	Protocol: Wang et al. 2026 zero-shot secondary structure, TS test set (70 PDB structures), attention, F1 score (mean over structures) Dataset: TS test set (70 PDB structures) (Wang et al. 2026)	0.402±0.234 F1 (attention; mean over structures) unitless · higher Uncertainty: SD 0.234 Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source AIDO.RNA (650M) zero-shot secondary structure on TS test set (70 PDB structures) (attention, F1 score, mean) lit-rna-20261011-rnalm-zeroshot-protocol-t4-f1-score-mean Aggregation: Not reported Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 4, row 'AIDO.RNA (650M)', column 'F1 score' (Mean ± Std)
Configuration: AIDO.RNA (650M) (zero-shot, Wang et al. 2026)	Protocol: Wang et al. 2026 zero-shot secondary structure, TS test set (70 PDB structures), attention, F1 score (median over structures) Dataset: TS test set (70 PDB structures) (Wang et al. 2026)	0.438 F1 (attention; median over structures) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source AIDO.RNA (650M) zero-shot secondary structure on TS test set (70 PDB structures) (attention, F1 score, median) lit-rna-20261011-rnalm-zeroshot-protocol-t4-f1-score-median Aggregation: Not reported Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 4, row 'AIDO.RNA (650M)', column 'F1 score' (Median)
Configuration: AIDO.RNA (650M) (zero-shot, Wang et al. 2026)	Protocol: Wang et al. 2026 zero-shot secondary structure, TS test set (70 PDB structures), attention, MCC (mean over structures) Dataset: TS test set (70 PDB structures) (Wang et al. 2026)	0.427±0.235 MCC (attention; mean over structures) unitless · higher Uncertainty: SD 0.235 Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source AIDO.RNA (650M) zero-shot secondary structure on TS test set (70 PDB structures) (attention, MCC, mean) lit-rna-20261011-rnalm-zeroshot-protocol-t4-mcc-mean Aggregation: Not reported Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 4, row 'AIDO.RNA (650M)', column 'MCC' (Mean ± Std)
Configuration: AIDO.RNA (650M) (zero-shot, Wang et al. 2026)	Protocol: Wang et al. 2026 zero-shot secondary structure, TS test set (70 PDB structures), attention, MCC (median over structures) Dataset: TS test set (70 PDB structures) (Wang et al. 2026)	0.469 MCC (attention; median over structures) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source AIDO.RNA (650M) zero-shot secondary structure on TS test set (70 PDB structures) (attention, MCC, median) lit-rna-20261011-rnalm-zeroshot-protocol-t4-mcc-median Aggregation: Not reported Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 4, row 'AIDO.RNA (650M)', column 'MCC' (Median)
Configuration: AIDO.RNA (650M) (zero-shot, Wang et al. 2026)	Protocol: Wang et al. 2026 zero-shot secondary structure, TS-Hard test set (15 PDB structures), attention, F1 score (mean over structures) Dataset: TS-Hard test set (15 PDB structures) (Wang et al. 2026)	0.331±0.217 F1 (attention; mean over structures) unitless · higher Uncertainty: SD 0.217 Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source AIDO.RNA (650M) zero-shot secondary structure on TS-Hard test set (15 PDB structures) (attention, F1 score, mean) lit-rna-20261011-rnalm-zeroshot-protocol-t5-f1-score-mean Aggregation: Not reported Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 5, row 'AIDO.RNA (650M)', column 'F1 score' (Mean ± Std)
Configuration: AIDO.RNA (650M) (zero-shot, Wang et al. 2026)	Protocol: Wang et al. 2026 zero-shot secondary structure, TS-Hard test set (15 PDB structures), attention, F1 score (median over structures) Dataset: TS-Hard test set (15 PDB structures) (Wang et al. 2026)	0.331 F1 (attention; median over structures) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source AIDO.RNA (650M) zero-shot secondary structure on TS-Hard test set (15 PDB structures) (attention, F1 score, median) lit-rna-20261011-rnalm-zeroshot-protocol-t5-f1-score-median Aggregation: Not reported Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 5, row 'AIDO.RNA (650M)', column 'F1 score' (Median)
Configuration: AIDO.RNA (650M) (zero-shot, Wang et al. 2026)	Protocol: Wang et al. 2026 zero-shot secondary structure, TS-Hard test set (15 PDB structures), attention, MCC (mean over structures) Dataset: TS-Hard test set (15 PDB structures) (Wang et al. 2026)	0.365±0.227 MCC (attention; mean over structures) unitless · higher Uncertainty: SD 0.227 Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source AIDO.RNA (650M) zero-shot secondary structure on TS-Hard test set (15 PDB structures) (attention, MCC, mean) lit-rna-20261011-rnalm-zeroshot-protocol-t5-mcc-mean Aggregation: Not reported Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 5, row 'AIDO.RNA (650M)', column 'MCC' (Mean ± Std)
Configuration: AIDO.RNA (650M) (zero-shot, Wang et al. 2026)	Protocol: Wang et al. 2026 zero-shot secondary structure, TS-Hard test set (15 PDB structures), attention, MCC (median over structures) Dataset: TS-Hard test set (15 PDB structures) (Wang et al. 2026)	0.412 MCC (attention; median over structures) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source AIDO.RNA (650M) zero-shot secondary structure on TS-Hard test set (15 PDB structures) (attention, MCC, median) lit-rna-20261011-rnalm-zeroshot-protocol-t5-mcc-median Aggregation: Not reported Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 5, row 'AIDO.RNA (650M)', column 'MCC' (Median)
Configuration: AIDO.RNA (650M) (zero-shot, Wang et al. 2026)	Protocol: Wang et al. 2026 zero-shot family classification, RfamSample (561 Rfam families), FFT embedding, 1 − OR (mean over repeated random samplings of sequence pairs) Dataset: RfamSample (561 Rfam families) (Wang et al. 2026)	0.854±0.002 One minus overlap ratio (FFT embedding; mean over random samplings of sequence pairs) unitless · higher Uncertainty: SD 0.002 Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source AIDO.RNA (650M) zero-shot family classification on RfamSample (561 Rfam families) (FFT embedding, 1 − OR, sampled-mean) lit-rna-20261011-rnalm-zeroshot-protocol-t6-1-or-sampled-mean Aggregation: Not reported Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 6, row 'AIDO.RNA (650M)', column '1 − OR'
Configuration: AIDO.RNA (650M) (zero-shot, Wang et al. 2026)	Protocol: Wang et al. 2026 zero-shot family classification, RfamSample (561 Rfam families), FFT embedding, AUC (mean over repeated random samplings of sequence pairs) Dataset: RfamSample (561 Rfam families) (Wang et al. 2026)	0.944±0.001 AUROC (FFT embedding; mean over random samplings of sequence pairs) unitless · higher Uncertainty: SD 0.001 Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source AIDO.RNA (650M) zero-shot family classification on RfamSample (561 Rfam families) (FFT embedding, AUC, sampled-mean) lit-rna-20261011-rnalm-zeroshot-protocol-t6-auc-sampled-mean Aggregation: Not reported Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 6, row 'AIDO.RNA (650M)', column 'AUC'
Configuration: AIDO.RNA (650M) (zero-shot, Wang et al. 2026)	Protocol: Wang et al. 2026 zero-shot family classification, RfamSample (561 Rfam families), FFT embedding, F1 (mean over repeated random samplings of sequence pairs) Dataset: RfamSample (561 Rfam families) (Wang et al. 2026)	0.873±0.002 F1 (FFT embedding; mean over random samplings of sequence pairs) unitless · higher Uncertainty: SD 0.002 Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source AIDO.RNA (650M) zero-shot family classification on RfamSample (561 Rfam families) (FFT embedding, F1, sampled-mean) lit-rna-20261011-rnalm-zeroshot-protocol-t6-f1-sampled-mean Aggregation: Not reported Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 6, row 'AIDO.RNA (650M)', column 'F1'
Configuration: AIDO.RNA (650M) (zero-shot, Wang et al. 2026)	Protocol: Wang et al. 2026 zero-shot family classification, RfamSample (561 Rfam families), FFT embedding, MCC (mean over repeated random samplings of sequence pairs) Dataset: RfamSample (561 Rfam families) (Wang et al. 2026)	0.745±0.002 MCC (FFT embedding; mean over random samplings of sequence pairs) unitless · higher Uncertainty: SD 0.002 Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source AIDO.RNA (650M) zero-shot family classification on RfamSample (561 Rfam families) (FFT embedding, MCC, sampled-mean) lit-rna-20261011-rnalm-zeroshot-protocol-t6-mcc-sampled-mean Aggregation: Not reported Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 6, row 'AIDO.RNA (650M)', column 'MCC'
Configuration: AIDO.RNA (650M) (zero-shot, Wang et al. 2026)	Protocol: Wang et al. 2026 zero-shot RNA type classification, ArchiveII-Nr (1273 RNAs), FFT embedding, 1 − OR (mean over repeated random samplings of sequence pairs) Dataset: ArchiveII-Nr (1273 RNAs) (Wang et al. 2026)	0.728±0.001 One minus overlap ratio (FFT embedding; mean over random samplings of sequence pairs) unitless · higher Uncertainty: SD 0.001 Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source AIDO.RNA (650M) zero-shot RNA type classification on ArchiveII-Nr (1273 RNAs) (FFT embedding, 1 − OR, sampled-mean) lit-rna-20261011-rnalm-zeroshot-protocol-t7-1-or-sampled-mean Aggregation: Not reported Zero-shot benchmarking of RNA language models: Supplementary Information; Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning · Supplementary Table 7, row 'AIDO.RNA (650M)', column '1 − OR'

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Stable ID: lit-rna-20261011-rnalm-zeroshot-config-aido-rna-650m-wang2026

areas: rna-transcriptomes
contexts: research
method types: foundation_model
reported name: AIDO.RNA (650M)
foundation model eligible: true
parameters: Pretrained weights used without fine-tuning (zero-shot); attention maps, embeddings or token logits read out as described in the Methods
access reuse: Public download location listed in Supplementary Table 1
source locator: Supplementary Table 1 row 'AIDO.RNA'
checkpoint: https://github.com/genbio-ai/AIDO (downloaded 2024/12/11; version column 'AIDO.RNA-650M (650M)/AIDO.RNA-1B600M (1.6B)'; variant label in results tables '650M')
version: 650M

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