Model

ESM3

ESM3 generates and completes protein sequence, structure and functional annotations using a shared multimodal representation.

Sources (3)

evolutionaryscale/esm: README.md; evolutionaryscale/esm: _assets/ESM3_README.md; evolutionaryscale/esm: THIRD_PARTY_NOTICE.md · _assets/ESM3_README.md: overview, ESM3 Family, Running Locally and Licenses

58 evaluations · 58 results · 1 evaluated configuration using this model

How it worksESM3 workflow

Conceptual summary of the documented data flow; optional inputs and configured downstream stages must be reported for a reproducible evaluation.

Sources (3)

Overview

Model type

Multitrack generative protein transformer

Inputs

Complete or partial protein sequence, structure and function-keyword tracks.

Outputs

Completed sequence, structure and functional tracks.

Access

Official project documentation and implementation: https://github.com/evolutionaryscale/esm

Sources (3)

limited source coverage · Automated source review, 2026-09-16. All specifications and missing details

Evaluations and results

58 evaluations · 58 results. Different protocols are not a single leaderboard.

Filter evaluations

Tested model or methodProtocolDatasetEvaluation setupMetricEvidence origin

Applied filters: All linked evaluations

Exact evaluated configurations and original reported results
Tested configuration	Protocol and dataset	Finding	Evidence and details
Configuration: ESM3	Task: PFMBench ANTI-RES: Antibiotic resistance Dataset subset: Antibiotic resistance (PFMBench split)	0.584 accuracy fraction · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESM3 on PFMBench ANTI-RES: Antibiotic resistance Fine-tuned with an adapter under the PFMBench harness; train, validation and test counts are in Table 1. Aggregation: Not reported pfmbench primary benchmark evidence · Table 3, row(ESM3 [ 18 ]), column(Anti.Res.)
Configuration: ESM3	Task: PFMBench BINDING-DB: BindingDB Dataset subset: BindingDB (PFMBench split)	0.225 spearman correlation · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESM3 on PFMBench BINDING-DB: BindingDB Fine-tuned with an adapter under the PFMBench harness; train, validation and test counts are in Table 1. Aggregation: Not reported pfmbench primary benchmark evidence · Table 3, row(ESM3 [ 18 ]), column(Bind. DB)
Configuration: ESM3	Task: PFMBench CLONING-CLF: Cloning CLF Dataset subset: Cloning CLF (PFMBench split)	0.774 auroc fraction · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESM3 on PFMBench CLONING-CLF: Cloning CLF Fine-tuned with an adapter under the PFMBench harness; train, validation and test counts are in Table 1. Aggregation: Not reported pfmbench primary benchmark evidence · Table 3, row(ESM3 [ 18 ]), column(Clo. CLF)
Configuration: ESM3	Task: PFMBench DEEPLOC2: DeepLoc2 Multi Dataset subset: DeepLoc2 Multi (PFMBench split)	0.659 f1 fraction · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESM3 on PFMBench DEEPLOC2: DeepLoc2 Multi Fine-tuned with an adapter under the PFMBench harness; train, validation and test counts are in Table 1. Aggregation: Not reported pfmbench primary benchmark evidence · Table 3, row(ESM3 [ 18 ]), column(DL2 M.)
Configuration: ESM3	Task: PFMBench DEEPSOL: DeepSol Dataset subset: DeepSol (PFMBench split)	0.781 auroc fraction · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESM3 on PFMBench DEEPSOL: DeepSol Fine-tuned with an adapter under the PFMBench harness; train, validation and test counts are in Table 1. Aggregation: Not reported pfmbench primary benchmark evidence · Table 3, row(ESM3 [ 18 ]), column(DeepSol)
Configuration: ESM3	Task: PFMBench EC: Enzyme Commission Dataset subset: Enzyme Commission (PFMBench split)	0.648 f1 fraction · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESM3 on PFMBench EC: Enzyme Commission Fine-tuned with an adapter under the PFMBench harness; train, validation and test counts are in Table 1. Aggregation: Not reported pfmbench primary benchmark evidence · Table 3, row(ESM3 [ 18 ]), column(EC)
Configuration: ESM3	Task: PFMBench MAT-PROD: Material production Dataset subset: Material production (PFMBench split)	0.775 accuracy fraction · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESM3 on PFMBench MAT-PROD: Material production Fine-tuned with an adapter under the PFMBench harness; train, validation and test counts are in Table 1. Aggregation: Not reported pfmbench primary benchmark evidence · Table 3, row(ESM3 [ 18 ]), column(Mat.Pro.)
Configuration: ESM3	Task: PFMBench METAL-ION: Metal ion binding Dataset subset: Metal ion binding (PFMBench split)	0.703 accuracy fraction · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESM3 on PFMBench METAL-ION: Metal ion binding Fine-tuned with an adapter under the PFMBench harness; train, validation and test counts are in Table 1. Aggregation: Not reported pfmbench primary benchmark evidence · Table 3, row(ESM3 [ 18 ]), column(M. I. Bin.)
Configuration: ESM3	Task: PFMBench PDB-BIND: PDBbind Dataset subset: PDBbind (PFMBench split)	0.156 spearman correlation · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESM3 on PFMBench PDB-BIND: PDBbind Fine-tuned with an adapter under the PFMBench harness; train, validation and test counts are in Table 1. Aggregation: Not reported pfmbench primary benchmark evidence · Table 3, row(ESM3 [ 18 ]), column(PDBBind)
Configuration: ESM3	Task: PFMBench PROTEINGYM-ZS: ProteinGym zero-shot variant effect prediction Dataset subset: ProteinGym (PFMBench split)	0.414 spearman correlation · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESM3 on PFMBench PROTEINGYM-ZS: ProteinGym zero-shot variant effect prediction Scored zero-shot, with no fine-tuning, as reported in PFMBench Table 4. Aggregation: Not reported pfmbench primary benchmark evidence · Table 4, row(ESM3 [ 18 ]), column(ProteinGym)
Configuration: ESM3	Task: PFMBench SEC-STRUCT: Secondary structure Dataset subset: Secondary structure (PFMBench split)	0.813 accuracy fraction · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESM3 on PFMBench SEC-STRUCT: Secondary structure Fine-tuned with an adapter under the PFMBench harness; train, validation and test counts are in Table 1. Aggregation: Not reported pfmbench primary benchmark evidence · Table 3, row(ESM3 [ 18 ]), column(Sec. Str.)
Configuration: ESM3	Task: PFMBench STABILITY: TAPE_Stability Dataset subset: TAPE_Stability (PFMBench split)	0.157 spearman correlation · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESM3 on PFMBench STABILITY: TAPE_Stability Fine-tuned with an adapter under the PFMBench harness; train, validation and test counts are in Table 1. Aggregation: Not reported pfmbench primary benchmark evidence · Table 3, row(ESM3 [ 18 ]), column(Stability)
Configuration: ESM3 (1.4B)	Task: ProteinBench SEQ-LENGTH-100-DIVERSITY-MAX-CLUST: length 100, Diversity Max Clust. Dataset subset: Generated sequences at fixed lengths (ProteinBench split)	0.9 max-clust score · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESM3 (1.4B) on ProteinBench SEQ-LENGTH-100-DIVERSITY-MAX-CLUST: length 100, Diversity Max Clust. Unconditional sequence generation at a fixed length. Values are the mean and standard deviation over repeated runs. Aggregation: Not reported proteinbench primary benchmark evidence · Table 4, row(ESM3 (1.4B)), column(length 100, Diversity Max Clust. ↑)
Configuration: ESM3 (1.4B)	Task: ProteinBench SEQ-LENGTH-100-DIVERSITY-PAIRWISE-TM: length 100, Diversity pairwise TM Dataset subset: Generated sequences at fixed lengths (ProteinBench split)	0.45 ± 0.15 pairwise-tm score · lower Uncertainty: type: standard_deviation; value: 0.15 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESM3 (1.4B) on ProteinBench SEQ-LENGTH-100-DIVERSITY-PAIRWISE-TM: length 100, Diversity pairwise TM Unconditional sequence generation at a fixed length. Values are the mean and standard deviation over repeated runs. Aggregation: Not reported proteinbench primary benchmark evidence · Table 4, row(ESM3 (1.4B)), column(length 100, Diversity pairwise TM ↓)
Configuration: ESM3 (1.4B)	Task: ProteinBench SEQ-LENGTH-100-NOVELTY-MAX-TM: length 100, Novelty Max TM Dataset subset: Generated sequences at fixed lengths (ProteinBench split)	0.68 ± 0.07 max-tm score · lower Uncertainty: type: standard_deviation; value: 0.07 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESM3 (1.4B) on ProteinBench SEQ-LENGTH-100-NOVELTY-MAX-TM: length 100, Novelty Max TM Unconditional sequence generation at a fixed length. Values are the mean and standard deviation over repeated runs. Aggregation: Not reported proteinbench primary benchmark evidence · Table 4, row(ESM3 (1.4B)), column(length 100, Novelty Max TM ↓)
Configuration: ESM3 (1.4B)	Task: ProteinBench SEQ-LENGTH-100-QUALITY-PLDDT: length 100, Quality pLDDT Dataset subset: Generated sequences at fixed lengths (ProteinBench split)	54.26 ± 15.35 plddt score · higher Uncertainty: type: standard_deviation; value: 15.35 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESM3 (1.4B) on ProteinBench SEQ-LENGTH-100-QUALITY-PLDDT: length 100, Quality pLDDT Unconditional sequence generation at a fixed length. Values are the mean and standard deviation over repeated runs. Aggregation: Not reported proteinbench primary benchmark evidence · Table 4, row(ESM3 (1.4B)), column(length 100, Quality pLDDT ↑)
Configuration: ESM3 (1.4B)	Task: ProteinBench SEQ-LENGTH-100-QUALITY-PPL: length 100, Quality ppl Dataset subset: Generated sequences at fixed lengths (ProteinBench split)	14.79 ± 2.90 ppl score · lower Uncertainty: type: standard_deviation; value: 2.90 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESM3 (1.4B) on ProteinBench SEQ-LENGTH-100-QUALITY-PPL: length 100, Quality ppl Unconditional sequence generation at a fixed length. Values are the mean and standard deviation over repeated runs. Aggregation: Not reported proteinbench primary benchmark evidence · Table 4, row(ESM3 (1.4B)), column(length 100, Quality ppl ↓)
Configuration: ESM3 (1.4B)	Task: ProteinBench SEQ-LENGTH-200-DIVERSITY-MAX-CLUST: length 200, Diversity Max Clust. Dataset subset: Generated sequences at fixed lengths (ProteinBench split)	1 max-clust score · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESM3 (1.4B) on ProteinBench SEQ-LENGTH-200-DIVERSITY-MAX-CLUST: length 200, Diversity Max Clust. Unconditional sequence generation at a fixed length. Values are the mean and standard deviation over repeated runs. Aggregation: Not reported proteinbench primary benchmark evidence · Table 4, row(ESM3 (1.4B)), column(length 200, Diversity Max Clust. ↑)
Configuration: ESM3 (1.4B)	Task: ProteinBench SEQ-LENGTH-200-DIVERSITY-PAIRWISE-TM: length 200, Diversity pairwise TM Dataset subset: Generated sequences at fixed lengths (ProteinBench split)	0.35 ± 0.07 pairwise-tm score · lower Uncertainty: type: standard_deviation; value: 0.07 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESM3 (1.4B) on ProteinBench SEQ-LENGTH-200-DIVERSITY-PAIRWISE-TM: length 200, Diversity pairwise TM Unconditional sequence generation at a fixed length. Values are the mean and standard deviation over repeated runs. Aggregation: Not reported proteinbench primary benchmark evidence · Table 4, row(ESM3 (1.4B)), column(length 200, Diversity pairwise TM ↓)
Configuration: ESM3 (1.4B)	Task: ProteinBench SEQ-LENGTH-200-NOVELTY-MAX-TM: length 200, Novelty Max TM Dataset subset: Generated sequences at fixed lengths (ProteinBench split)	0.80 ± 0.01 max-tm score · lower Uncertainty: type: standard_deviation; value: 0.01 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESM3 (1.4B) on ProteinBench SEQ-LENGTH-200-NOVELTY-MAX-TM: length 200, Novelty Max TM Unconditional sequence generation at a fixed length. Values are the mean and standard deviation over repeated runs. Aggregation: Not reported proteinbench primary benchmark evidence · Table 4, row(ESM3 (1.4B)), column(length 200, Novelty Max TM ↓)
Configuration: ESM3 (1.4B)	Task: ProteinBench SEQ-LENGTH-200-QUALITY-PLDDT: length 200, Quality pLDDT Dataset subset: Generated sequences at fixed lengths (ProteinBench split)	58.45 ± 9.40 plddt score · higher Uncertainty: type: standard_deviation; value: 9.40 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESM3 (1.4B) on ProteinBench SEQ-LENGTH-200-QUALITY-PLDDT: length 200, Quality pLDDT Unconditional sequence generation at a fixed length. Values are the mean and standard deviation over repeated runs. Aggregation: Not reported proteinbench primary benchmark evidence · Table 4, row(ESM3 (1.4B)), column(length 200, Quality pLDDT↑)
Configuration: ESM3 (1.4B)	Task: ProteinBench SEQ-LENGTH-200-QUALITY-PPL: length 200, Quality ppl Dataset subset: Generated sequences at fixed lengths (ProteinBench split)	12.96 ± 2.38 ppl score · lower Uncertainty: type: standard_deviation; value: 2.38 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESM3 (1.4B) on ProteinBench SEQ-LENGTH-200-QUALITY-PPL: length 200, Quality ppl Unconditional sequence generation at a fixed length. Values are the mean and standard deviation over repeated runs. Aggregation: Not reported proteinbench primary benchmark evidence · Table 4, row(ESM3 (1.4B)), column(length 200, Quality ppl ↓)
Configuration: ESM3 (1.4B)	Task: ProteinBench SEQ-LENGTH-300-DIVERSITY-MAX-CLUST: length 300, Diversity Max Clust. Dataset subset: Generated sequences at fixed lengths (ProteinBench split)	1 max-clust score · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESM3 (1.4B) on ProteinBench SEQ-LENGTH-300-DIVERSITY-MAX-CLUST: length 300, Diversity Max Clust. Unconditional sequence generation at a fixed length. Values are the mean and standard deviation over repeated runs. Aggregation: Not reported proteinbench primary benchmark evidence · Table 4, row(ESM3 (1.4B)), column(length 300, Diversity Max Clust. ↑)
Configuration: ESM3 (1.4B)	Task: ProteinBench SEQ-LENGTH-300-DIVERSITY-PAIRWISE-TM: length 300, Diversity pairwise TM Dataset subset: Generated sequences at fixed lengths (ProteinBench split)	0.32 ± 0.03 pairwise-tm score · lower Uncertainty: type: standard_deviation; value: 0.03 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESM3 (1.4B) on ProteinBench SEQ-LENGTH-300-DIVERSITY-PAIRWISE-TM: length 300, Diversity pairwise TM Unconditional sequence generation at a fixed length. Values are the mean and standard deviation over repeated runs. Aggregation: Not reported proteinbench primary benchmark evidence · Table 4, row(ESM3 (1.4B)), column(length 300, Diversity pairwise TM ↓)
Configuration: ESM3 (1.4B)	Task: ProteinBench SEQ-LENGTH-300-NOVELTY-MAX-TM: length 300, Novelty Max TM Dataset subset: Generated sequences at fixed lengths (ProteinBench split)	0.75 ± 0.02 max-tm score · lower Uncertainty: type: standard_deviation; value: 0.02 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESM3 (1.4B) on ProteinBench SEQ-LENGTH-300-NOVELTY-MAX-TM: length 300, Novelty Max TM Unconditional sequence generation at a fixed length. Values are the mean and standard deviation over repeated runs. Aggregation: Not reported proteinbench primary benchmark evidence · Table 4, row(ESM3 (1.4B)), column(length 300, Novelty Max TM ↓)

Source checking is not independent reproduction. Release 2026-09-29-06401fd5b220.

Related configurations, pipelines and services

These configurations, services and pipelines use this model within their own configurations. Their results, where available, are not assigned to the underlying model.

MegSite + ESM3 Pipeline · 1 result

Use this model

How it works, versions and access

Versions and evaluated configurations

ESM3 · family
ESM3 · family
ESM3 (1.4B) · family

How it works

ESM3 generates and completes protein sequence, structure and functional annotations using a shared multimodal representation. Transformer generative masked-language model with discrete sequence, structure and function tracks; generation iteratively fills masked positions. The documented inputs are complete or partial protein sequence, structure and function-keyword tracks. The output consists of completed sequence, structure and functional tracks.

Sources (3)

Versions and reproducibility

Published March 2024 small/medium/large models, August 2024 small/medium models, and esm3-sm-open-v1 local weights. The applicable input limits require configuration-specific checking.

Sources (3)

Strengths, limitations and unresolved questions

Strengths and limitations

Strengths and considerations

Partial prompts can constrain more than one biological property in the same generation workflow.
Sources (3)
evolutionaryscale/esm: README.md; evolutionaryscale/esm: _assets/ESM3_README.md; evolutionaryscale/esm: THIRD_PARTY_NOTICE.md · _assets/ESM3_README.md: overview, ESM3 Family, Running Locally and Licenses

Limitations and conditions

Open local weights and API model names refer to different released sizes and dates; results require the actual configuration, not only the ESM3 family name.
Sources (3)
evolutionaryscale/esm: README.md; evolutionaryscale/esm: _assets/ESM3_README.md; evolutionaryscale/esm: THIRD_PARTY_NOTICE.md · _assets/ESM3_README.md: overview, ESM3 Family, Running Locally and Licenses

Profile review details

Inspected pinned official documentation, relevant implementation files and named primary-paper sections. Claims are limited to those artifacts. Remaining field extraction and identity conflicts are explicit; no new performance claims, model runs or human review are implied.

Stable record: discovery-model-esm3

Specifications

Inputs, training, access and other details

Explanatory profile: limited source coverage · Automated source review, 2026-09-16. Review applies to the cited claims; unresolved fields are listed below. Numerical results retain their own review status.

Inputs, outputs and configuration
Property	Description and evidence
Model type	Multitrack generative protein transformer Sources (3) evolutionaryscale/esm: README.md; evolutionaryscale/esm: _assets/ESM3_README.md; evolutionaryscale/esm: THIRD_PARTY_NOTICE.md · _assets/ESM3_README.md: overview, ESM3 Family, Running Locally and Licenses
Architecture	Transformer generative masked-language model with discrete sequence, structure and function tracks; generation iteratively fills masked positions. Sources (3) evolutionaryscale/esm: README.md; evolutionaryscale/esm: _assets/ESM3_README.md; evolutionaryscale/esm: THIRD_PARTY_NOTICE.md · _assets/ESM3_README.md: overview, ESM3 Family, Running Locally and Licenses
Inputs	Complete or partial protein sequence, structure and function-keyword tracks. Sources (3) evolutionaryscale/esm: README.md; evolutionaryscale/esm: _assets/ESM3_README.md; evolutionaryscale/esm: THIRD_PARTY_NOTICE.md · _assets/ESM3_README.md: overview, ESM3 Family, Running Locally and Licenses
Outputs	Completed sequence, structure and functional tracks. Sources (3) evolutionaryscale/esm: README.md; evolutionaryscale/esm: _assets/ESM3_README.md; evolutionaryscale/esm: THIRD_PARTY_NOTICE.md · _assets/ESM3_README.md: overview, ESM3 Family, Running Locally and Licenses
Parameters	1.4B small, 7B medium and 98B large variants. Sources (3) evolutionaryscale/esm: README.md; evolutionaryscale/esm: _assets/ESM3_README.md; evolutionaryscale/esm: THIRD_PARTY_NOTICE.md · _assets/ESM3_README.md: overview, ESM3 Family, Running Locally and Licenses
Known versions	Published March 2024 small/medium/large models, August 2024 small/medium models, and esm3-sm-open-v1 local weights. Sources (3) evolutionaryscale/esm: README.md; evolutionaryscale/esm: _assets/ESM3_README.md; evolutionaryscale/esm: THIRD_PARTY_NOTICE.md · _assets/ESM3_README.md: overview, ESM3 Family, Running Locally and Licenses
Training data	ESM3 overview reports 2.78 billion proteins and 771 billion unique tokens for the largest model; this is not a verified per-checkpoint manifest. Sources (3) evolutionaryscale/esm: README.md; evolutionaryscale/esm: _assets/ESM3_README.md; evolutionaryscale/esm: THIRD_PARTY_NOTICE.md · _assets/ESM3_README.md: overview, ESM3 Family, Running Locally and Licenses
Training cutoff	The inspected ESM3 release documentation does not supply one latest-data date shared across its sequence, structure and function tracks. · Not reported in inspected sources Sources (3) evolutionaryscale/esm: README.md; evolutionaryscale/esm: _assets/ESM3_README.md; evolutionaryscale/esm: THIRD_PARTY_NOTICE.md · _assets/ESM3_README.md: overview, ESM3 Family, Running Locally and Licenses
Context limits	The inspected ESM3 family documentation does not establish one context limit for local small, hosted medium and hosted large models; a specific service/checkpoint is required. · Not reported in inspected sources Sources (3) evolutionaryscale/esm: README.md; evolutionaryscale/esm: _assets/ESM3_README.md; evolutionaryscale/esm: THIRD_PARTY_NOTICE.md · _assets/ESM3_README.md: overview, ESM3 Family, Running Locally and Licenses
Weights licence	MIT stated in the inspected ESM3 README; model and API access conditions remain separate. Sources (3) evolutionaryscale/esm: README.md; evolutionaryscale/esm: _assets/ESM3_README.md; evolutionaryscale/esm: THIRD_PARTY_NOTICE.md · _assets/ESM3_README.md: overview, ESM3 Family, Running Locally and Licenses
Access	Official project documentation and implementation: https://github.com/evolutionaryscale/esm Sources (3) evolutionaryscale/esm: README.md; evolutionaryscale/esm: _assets/ESM3_README.md; evolutionaryscale/esm: THIRD_PARTY_NOTICE.md · _assets/ESM3_README.md: overview, ESM3 Family, Running Locally and Licenses
Code licence	MIT Sources evolutionaryscale/esm: LICENSE.md · LICENSE.md: licence text

Applicable tests and references

Applicability is distinct from a completed evaluation.

ProteinBench · Proposed association

Evidence

Source checking verifies the cited claim or transcription. It does not establish independent reproduction.

Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

58 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-09-29-06401fd5b220
Property and statement	Original source and location	Review and provenance
Diagram caption Conceptual summary of the documented data flow; optional inputs and configured downstream stages must be reported for a reproducible evaluation. Individual claims	evolutionaryscale/esm: _assets/ESM3_README.md Original source ↗ _assets/ESM3_README.md: overview, ESM3 Family, Running Locally and Licenses Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: bf343ba264b650dff7a073643725f9aaa1fdbe8d Retrieved: 2026-09-16T19:46:18.983347+00:00	source checked automated source review · 2026-09-16 Audit details Inspected pinned official documentation, relevant implementation files and named primary-paper sections. Claims are limited to those artifacts. Remaining field extraction and identity conflicts are explicit; no new performance claims, model runs or human review are implied. Field: `attributes.profile.diagram.caption` Source artifact SHA-256: `2f564153712e32ad668f1586b6e78599d1a7fd6a3b3b7049718d85f9b33f79a6` Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact Inspected artifact
Diagram caption Conceptual summary of the documented data flow; optional inputs and configured downstream stages must be reported for a reproducible evaluation. Individual claims	evolutionaryscale/esm: THIRD_PARTY_NOTICE.md Original source ↗ _assets/ESM3_README.md: overview, ESM3 Family, Running Locally and Licenses Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: bf343ba264b650dff7a073643725f9aaa1fdbe8d Retrieved: 2026-09-16T19:46:18.983347+00:00	source checked automated source review · 2026-09-16 Audit details Inspected pinned official documentation, relevant implementation files and named primary-paper sections. Claims are limited to those artifacts. Remaining field extraction and identity conflicts are explicit; no new performance claims, model runs or human review are implied. Field: `attributes.profile.diagram.caption` Source artifact SHA-256: `5bff8515ba4e0f53abdc43714c180b79c5b606160497d98de741a369cb9b6a23` Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact Inspected artifact
Diagram caption Conceptual summary of the documented data flow; optional inputs and configured downstream stages must be reported for a reproducible evaluation. Individual claims	evolutionaryscale/esm: README.md Original source ↗ _assets/ESM3_README.md: overview, ESM3 Family, Running Locally and Licenses Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: bf343ba264b650dff7a073643725f9aaa1fdbe8d Retrieved: 2026-09-16T19:46:18.983347+00:00	source checked automated source review · 2026-09-16 Audit details Inspected pinned official documentation, relevant implementation files and named primary-paper sections. Claims are limited to those artifacts. Remaining field extraction and identity conflicts are explicit; no new performance claims, model runs or human review are implied. Field: `attributes.profile.diagram.caption` Source artifact SHA-256: `74a897f0e97e3d4256f7cff11424dd264df4daaf8cabd9a6fb74b661421de038` Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact Inspected artifact
Diagram steps Partial protein tracks Multitrack transformer Iterative unmasking Completed sequence or structure Individual claims	evolutionaryscale/esm: _assets/ESM3_README.md Original source ↗ _assets/ESM3_README.md: overview, ESM3 Family, Running Locally and Licenses Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: bf343ba264b650dff7a073643725f9aaa1fdbe8d Retrieved: 2026-09-16T19:46:18.983347+00:00	source checked automated source review · 2026-09-16 Audit details Inspected pinned official documentation, relevant implementation files and named primary-paper sections. Claims are limited to those artifacts. Remaining field extraction and identity conflicts are explicit; no new performance claims, model runs or human review are implied. Field: `attributes.profile.diagram.steps` Source artifact SHA-256: `2f564153712e32ad668f1586b6e78599d1a7fd6a3b3b7049718d85f9b33f79a6` Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact Inspected artifact
Diagram steps Partial protein tracks Multitrack transformer Iterative unmasking Completed sequence or structure Individual claims	evolutionaryscale/esm: THIRD_PARTY_NOTICE.md Original source ↗ _assets/ESM3_README.md: overview, ESM3 Family, Running Locally and Licenses Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: bf343ba264b650dff7a073643725f9aaa1fdbe8d Retrieved: 2026-09-16T19:46:18.983347+00:00	source checked automated source review · 2026-09-16 Audit details Inspected pinned official documentation, relevant implementation files and named primary-paper sections. Claims are limited to those artifacts. Remaining field extraction and identity conflicts are explicit; no new performance claims, model runs or human review are implied. Field: `attributes.profile.diagram.steps` Source artifact SHA-256: `5bff8515ba4e0f53abdc43714c180b79c5b606160497d98de741a369cb9b6a23` Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact Inspected artifact
Diagram steps Partial protein tracks Multitrack transformer Iterative unmasking Completed sequence or structure Individual claims	evolutionaryscale/esm: README.md Original source ↗ _assets/ESM3_README.md: overview, ESM3 Family, Running Locally and Licenses Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: bf343ba264b650dff7a073643725f9aaa1fdbe8d Retrieved: 2026-09-16T19:46:18.983347+00:00	source checked automated source review · 2026-09-16 Audit details Inspected pinned official documentation, relevant implementation files and named primary-paper sections. Claims are limited to those artifacts. Remaining field extraction and identity conflicts are explicit; no new performance claims, model runs or human review are implied. Field: `attributes.profile.diagram.steps` Source artifact SHA-256: `74a897f0e97e3d4256f7cff11424dd264df4daaf8cabd9a6fb74b661421de038` Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact Inspected artifact
Diagram title ESM3 workflow Individual claims	evolutionaryscale/esm: _assets/ESM3_README.md Original source ↗ _assets/ESM3_README.md: overview, ESM3 Family, Running Locally and Licenses Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: bf343ba264b650dff7a073643725f9aaa1fdbe8d Retrieved: 2026-09-16T19:46:18.983347+00:00	source checked automated source review · 2026-09-16 Audit details Inspected pinned official documentation, relevant implementation files and named primary-paper sections. Claims are limited to those artifacts. Remaining field extraction and identity conflicts are explicit; no new performance claims, model runs or human review are implied. Field: `attributes.profile.diagram.title` Source artifact SHA-256: `2f564153712e32ad668f1586b6e78599d1a7fd6a3b3b7049718d85f9b33f79a6` Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact Inspected artifact
Diagram title ESM3 workflow Individual claims	evolutionaryscale/esm: THIRD_PARTY_NOTICE.md Original source ↗ _assets/ESM3_README.md: overview, ESM3 Family, Running Locally and Licenses Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: bf343ba264b650dff7a073643725f9aaa1fdbe8d Retrieved: 2026-09-16T19:46:18.983347+00:00	source checked automated source review · 2026-09-16 Audit details Inspected pinned official documentation, relevant implementation files and named primary-paper sections. Claims are limited to those artifacts. Remaining field extraction and identity conflicts are explicit; no new performance claims, model runs or human review are implied. Field: `attributes.profile.diagram.title` Source artifact SHA-256: `5bff8515ba4e0f53abdc43714c180b79c5b606160497d98de741a369cb9b6a23` Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact Inspected artifact
Diagram title ESM3 workflow Individual claims	evolutionaryscale/esm: README.md Original source ↗ _assets/ESM3_README.md: overview, ESM3 Family, Running Locally and Licenses Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: bf343ba264b650dff7a073643725f9aaa1fdbe8d Retrieved: 2026-09-16T19:46:18.983347+00:00	source checked automated source review · 2026-09-16 Audit details Inspected pinned official documentation, relevant implementation files and named primary-paper sections. Claims are limited to those artifacts. Remaining field extraction and identity conflicts are explicit; no new performance claims, model runs or human review are implied. Field: `attributes.profile.diagram.title` Source artifact SHA-256: `74a897f0e97e3d4256f7cff11424dd264df4daaf8cabd9a6fb74b661421de038` Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact Inspected artifact
Model type Multitrack generative protein transformer Individual claims	evolutionaryscale/esm: _assets/ESM3_README.md Original source ↗ _assets/ESM3_README.md: overview, ESM3 Family, Running Locally and Licenses Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: bf343ba264b650dff7a073643725f9aaa1fdbe8d Retrieved: 2026-09-16T19:46:18.983347+00:00	source checked automated source review · 2026-09-16 Audit details Inspected pinned official documentation, relevant implementation files and named primary-paper sections. Claims are limited to those artifacts. Remaining field extraction and identity conflicts are explicit; no new performance claims, model runs or human review are implied. Field: `attributes.profile.facts.0.value` Source artifact SHA-256: `2f564153712e32ad668f1586b6e78599d1a7fd6a3b3b7049718d85f9b33f79a6` Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact Inspected artifact

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Sources and history

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Release 2026-09-29-06401fd5b220 · Record review: discovered

5 source records and release history

evolutionaryscale/esm official source · Original source · bf343ba264b650dff7a073643725f9aaa1fdbe8d
evolutionaryscale/esm: README.md · Original source · bf343ba264b650dff7a073643725f9aaa1fdbe8d
evolutionaryscale/esm: _assets/ESM3_README.md · Original source · bf343ba264b650dff7a073643725f9aaa1fdbe8d
evolutionaryscale/esm: THIRD_PARTY_NOTICE.md · Original source · bf343ba264b650dff7a073643725f9aaa1fdbe8d
evolutionaryscale/esm: LICENSE.md · Original source · bf343ba264b650dff7a073643725f9aaa1fdbe8d

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Technical metadata and extraction receipts

Stable ID: discovery-model-esm3

areas: protein-structure
access: official_source_linked
benchmark applicability: candidate; not evidence of a reported evaluation
candidate benchmark ids: discovery-benchmark-proteinbench
entity level: family
reported name: ESM3
version: Not reported
historical missing metadata: checkpoint: unextracted; code licence: unextracted; parameters: unextracted; training cutoff: unextracted; training data: unextracted; version: unextracted; weights licence: unextracted
metadata review scope: historical_missing_metadata preserves the original discovery state. Current descriptive evidence and missingness are recorded in profile.facts; numerical-result review is separate.
entity classification: review date: 2026-09-17; rationale: The cited profile describes a named learned biological predictor or representation model/family. Preserve this identity separately from task-specific fitting, individual checkpoints, pipelines and hosted access.; source ids: evidence-official-4bf005200ebfb2586b78; evidence-official-0437be6150a3da9f8efc; evidence-official-1f027f8ecc53decdeec8; source locator: _assets/ESM3_README.md: overview, ESM3 Family, Running Locally and Licenses; ambiguities: None recorded

Related records

applicable to: ProteinBench
family: ESM3
family: ESM3
family: ESM3 (1.4B)
uses model: MegSite + ESM3

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