Model type
Multitrack generative protein transformer
Configuration
ESM3 open (1.4B) [ProteinGym 144fe22b snapshot]
ESM3 generates and completes protein sequence, structure and functional annotations using a shared multimodal representation.
Sources (3)
evolutionaryscale/esm: README.md; evolutionaryscale/esm: _assets/ESM3_README.md; evolutionaryscale/esm: THIRD_PARTY_NOTICE.md · _assets/ESM3_README.md: overview, ESM3 Family, Running Locally and LicensesHow it worksESM3 workflow
Conceptual summary of the documented data flow; optional inputs and configured downstream stages must be reported for a reproducible evaluation.
Sources (3)
evolutionaryscale/esm: README.md; evolutionaryscale/esm: _assets/ESM3_README.md; evolutionaryscale/esm: THIRD_PARTY_NOTICE.md · _assets/ESM3_README.md: overview, ESM3 Family, Running Locally and LicensesOverview
Inputs
Complete or partial protein sequence, structure and function-keyword tracks.
Outputs
Completed sequence, structure and functional tracks.
Access
Official project documentation and implementation: https://github.com/evolutionaryscale/esm
Sources (3)
evolutionaryscale/esm: README.md; evolutionaryscale/esm: _assets/ESM3_README.md; evolutionaryscale/esm: THIRD_PARTY_NOTICE.md · _assets/ESM3_README.md: overview, ESM3 Family, Running Locally and Licenseslimited source coverage · Automated source review, 2026-09-16. All specifications and missing details
Evaluations and results
1 evaluation · 1 result. Different protocols are not a single leaderboard.
Filter evaluations
Applied filters: All linked evaluations
| Tested configuration | Protocol and dataset | Finding | Evidence and details |
|---|---|---|---|
| Configuration: ESM3 open (1.4B) [ProteinGym 144fe22b snapshot] | Protocol: ProteinGym AMFR official zero-shot Spearman snapshot Dataset subset: ProteinGym AMFR 4G3O official snapshot cohort | 0.29 spearman_rho correlation · higher Uncertainty: type: unreported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceESM3 open (1.4B) AMFR official snapshot Not reported Aggregation: Not reported ProteinGym AMFR assay-level Spearman comparison · DMS_substitutions_Spearman_DMS_level.csv line 15, DMS ID=AMFR_HUMAN_Tsuboyama_2023_4G3O, column=ESM3 open (1.4B) |
Source checking is not independent reproduction. Release 2026-09-30-e37e3ab1284d.
Use this model
How it works, versions and access
Related profile: ESM3. This page retains the exact record and its evaluation context.
This configuration
Exact official CSV source-label configuration; checkpoint and per-assay scoring details are not inferred from similarly named methods.
- record
- ESM3 open (1.4B) [ProteinGym 144fe22b snapshot]
- configuration
- 144fe22b07dfaeec2b366f2346203a9838a55b4c
- entity type
- Configuration
How it works
How it works
ESM3 generates and completes protein sequence, structure and functional annotations using a shared multimodal representation. Transformer generative masked-language model with discrete sequence, structure and function tracks; generation iteratively fills masked positions. The documented inputs are complete or partial protein sequence, structure and function-keyword tracks. The output consists of completed sequence, structure and functional tracks.
Sources (3)
evolutionaryscale/esm: README.md; evolutionaryscale/esm: _assets/ESM3_README.md; evolutionaryscale/esm: THIRD_PARTY_NOTICE.md · _assets/ESM3_README.md: overview, ESM3 Family, Running Locally and LicensesVersions and reproducibility
Published March 2024 small/medium/large models, August 2024 small/medium models, and esm3-sm-open-v1 local weights. The applicable input limits require configuration-specific checking.
Sources (3)
evolutionaryscale/esm: README.md; evolutionaryscale/esm: _assets/ESM3_README.md; evolutionaryscale/esm: THIRD_PARTY_NOTICE.md · _assets/ESM3_README.md: overview, ESM3 Family, Running Locally and LicensesStrengths, limitations and unresolved questions
Strengths and limitations
Strengths and considerations
- Partial prompts can constrain more than one biological property in the same generation workflow.
Sources (3)
evolutionaryscale/esm: README.md; evolutionaryscale/esm: _assets/ESM3_README.md; evolutionaryscale/esm: THIRD_PARTY_NOTICE.md · _assets/ESM3_README.md: overview, ESM3 Family, Running Locally and Licenses
Limitations and conditions
- Open local weights and API model names refer to different released sizes and dates; results require the actual configuration, not only the ESM3 family name.
Sources (3)
evolutionaryscale/esm: README.md; evolutionaryscale/esm: _assets/ESM3_README.md; evolutionaryscale/esm: THIRD_PARTY_NOTICE.md · _assets/ESM3_README.md: overview, ESM3 Family, Running Locally and Licenses
Profile review details
Inspected pinned official documentation, relevant implementation files and named primary-paper sections. Claims are limited to those artifacts. Remaining field extraction and identity conflicts are explicit; no new performance claims, model runs or human review are implied.
Stable record: discovery-model-esm3Specifications
Inputs, training, access and other details
Explanatory profile: limited source coverage · Automated source review, 2026-09-16. Review applies to the cited claims; unresolved fields are listed below. Numerical results retain their own review status.
| Property | Description and evidence |
|---|---|
| Model type | Multitrack generative protein transformerSources (3)evolutionaryscale/esm: README.md; evolutionaryscale/esm: _assets/ESM3_README.md; evolutionaryscale/esm: THIRD_PARTY_NOTICE.md · _assets/ESM3_README.md: overview, ESM3 Family, Running Locally and Licenses |
| Architecture | Transformer generative masked-language model with discrete sequence, structure and function tracks; generation iteratively fills masked positions.Sources (3)evolutionaryscale/esm: README.md; evolutionaryscale/esm: _assets/ESM3_README.md; evolutionaryscale/esm: THIRD_PARTY_NOTICE.md · _assets/ESM3_README.md: overview, ESM3 Family, Running Locally and Licenses |
| Inputs | Complete or partial protein sequence, structure and function-keyword tracks.Sources (3)evolutionaryscale/esm: README.md; evolutionaryscale/esm: _assets/ESM3_README.md; evolutionaryscale/esm: THIRD_PARTY_NOTICE.md · _assets/ESM3_README.md: overview, ESM3 Family, Running Locally and Licenses |
| Outputs | Completed sequence, structure and functional tracks.Sources (3)evolutionaryscale/esm: README.md; evolutionaryscale/esm: _assets/ESM3_README.md; evolutionaryscale/esm: THIRD_PARTY_NOTICE.md · _assets/ESM3_README.md: overview, ESM3 Family, Running Locally and Licenses |
| Parameters | 1.4B small, 7B medium and 98B large variants.Sources (3)evolutionaryscale/esm: README.md; evolutionaryscale/esm: _assets/ESM3_README.md; evolutionaryscale/esm: THIRD_PARTY_NOTICE.md · _assets/ESM3_README.md: overview, ESM3 Family, Running Locally and Licenses |
| Known versions | Published March 2024 small/medium/large models, August 2024 small/medium models, and esm3-sm-open-v1 local weights.Sources (3)evolutionaryscale/esm: README.md; evolutionaryscale/esm: _assets/ESM3_README.md; evolutionaryscale/esm: THIRD_PARTY_NOTICE.md · _assets/ESM3_README.md: overview, ESM3 Family, Running Locally and Licenses |
| Training data | ESM3 overview reports 2.78 billion proteins and 771 billion unique tokens for the largest model; this is not a verified per-checkpoint manifest.Sources (3)evolutionaryscale/esm: README.md; evolutionaryscale/esm: _assets/ESM3_README.md; evolutionaryscale/esm: THIRD_PARTY_NOTICE.md · _assets/ESM3_README.md: overview, ESM3 Family, Running Locally and Licenses |
| Training cutoff | The inspected ESM3 release documentation does not supply one latest-data date shared across its sequence, structure and function tracks. · Not reported in inspected sourcesSources (3)evolutionaryscale/esm: README.md; evolutionaryscale/esm: _assets/ESM3_README.md; evolutionaryscale/esm: THIRD_PARTY_NOTICE.md · _assets/ESM3_README.md: overview, ESM3 Family, Running Locally and Licenses |
| Context limits | The inspected ESM3 family documentation does not establish one context limit for local small, hosted medium and hosted large models; a specific service/checkpoint is required. · Not reported in inspected sourcesSources (3)evolutionaryscale/esm: README.md; evolutionaryscale/esm: _assets/ESM3_README.md; evolutionaryscale/esm: THIRD_PARTY_NOTICE.md · _assets/ESM3_README.md: overview, ESM3 Family, Running Locally and Licenses |
| Weights licence | MIT stated in the inspected ESM3 README; model and API access conditions remain separate.Sources (3)evolutionaryscale/esm: README.md; evolutionaryscale/esm: _assets/ESM3_README.md; evolutionaryscale/esm: THIRD_PARTY_NOTICE.md · _assets/ESM3_README.md: overview, ESM3 Family, Running Locally and Licenses |
| Access | Official project documentation and implementation: https://github.com/evolutionaryscale/esmSources (3)evolutionaryscale/esm: README.md; evolutionaryscale/esm: _assets/ESM3_README.md; evolutionaryscale/esm: THIRD_PARTY_NOTICE.md · _assets/ESM3_README.md: overview, ESM3 Family, Running Locally and Licenses |
| Code licence | MITSourcesevolutionaryscale/esm: LICENSE.md · LICENSE.md: licence text |
Evidence
Source checking verifies the cited claim or transcription. It does not establish independent reproduction.
Evidence table
Inspect claims, sources and review details
Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.
One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.
1 evidence row matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|---|---|
| Relationship: variant of discovery-model-esm3 Individual claims | ProteinGym AMFR assay-level Spearman comparison Pinned ProteinGym Spearman CSV header: ESM3 open (1.4B) Version: 144fe22b07dfaeec2b366f2346203a9838a55b4c | source checked automated source review · 2026-09-30T21:40:59.576893+00:00 Audit detailsField: Claim: uc20260930-config-family-b2aa9ed7a7729807 Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
Sources and history
View linked audit checks and correction history
Release 2026-09-30-e37e3ab1284d · Record review: source checked
1 source records and release history
- ProteinGym AMFR assay-level Spearman comparison · Original source · 144fe22b07dfaeec2b366f2346203a9838a55b4c
Technical metadata and extraction receipts
Stable ID: uc20260930-proteingym-amfr-config-esm3-open-1-4b
- areas
- proteins-complexes
- source locator
- See linked evaluation and result locators
- missing metadata
- checkpoint hash: unextracted
- review
- method: automated_source_review; reviewer: Codex experimental-use-case curation; date: 2026-09-30; reviewed at: 2026-09-30T21:40:59.576893+00:00; scope: Primary-source transcription and catalogue applicability audit; not human scientific review or independent experimental reproduction.
- reported name
- ESM3 open (1.4B)
- version
- 144fe22b07dfaeec2b366f2346203a9838a55b4c
Related records
- variant of: ESM3
- subject: ESM3 open (1.4B) [ProteinGym 144fe22b snapshot] family identity
- configuration: ESM3 open (1.4B) AMFR official snapshot