47-residue AMFR construct; cDNA-display proteolysis folding-stability endpoint; 2,972 assay variants comprising 820 single and 2,152 double substitutions.
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Release 2026-09-30-e37e3ab1284d · Evidence verified: Not verified
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Missing or unresolved evidence
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97 evaluations · 97 results. Different protocols are not a single leaderboard.
Applied filters: All linked evaluations
| Tested configuration | Protocol and dataset | Finding | Evidence and details |
|---|---|---|---|
| Configuration: AIDO Protein-RAG (16B) [ProteinGym 144fe22b snapshot] | Protocol: ProteinGym AMFR official zero-shot Spearman snapshot Dataset subset: ProteinGym AMFR 4G3O official snapshot cohort | 0.445 spearman_rho correlation · higher Uncertainty: type: unreported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceAIDO Protein-RAG (16B) AMFR official snapshot Not reported Aggregation: Not reported ProteinGym AMFR assay-level Spearman comparison · DMS_substitutions_Spearman_DMS_level.csv line 15, DMS ID=AMFR_HUMAN_Tsuboyama_2023_4G3O, column=AIDO Protein-RAG (16B) |
| Configuration: CARP (38M) [ProteinGym 144fe22b snapshot] | Protocol: ProteinGym AMFR official zero-shot Spearman snapshot Dataset subset: ProteinGym AMFR 4G3O official snapshot cohort | -0.185 spearman_rho correlation · higher Uncertainty: type: unreported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceCARP (38M) AMFR official snapshot Not reported Aggregation: Not reported ProteinGym AMFR assay-level Spearman comparison · DMS_substitutions_Spearman_DMS_level.csv line 15, DMS ID=AMFR_HUMAN_Tsuboyama_2023_4G3O, column=CARP (38M) |
| Configuration: CARP (600K) [ProteinGym 144fe22b snapshot] | Protocol: ProteinGym AMFR official zero-shot Spearman snapshot Dataset subset: ProteinGym AMFR 4G3O official snapshot cohort | -0.194 spearman_rho correlation · higher Uncertainty: type: unreported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceCARP (600K) AMFR official snapshot Not reported Aggregation: Not reported ProteinGym AMFR assay-level Spearman comparison · DMS_substitutions_Spearman_DMS_level.csv line 15, DMS ID=AMFR_HUMAN_Tsuboyama_2023_4G3O, column=CARP (600K) |
| Configuration: CARP (640M) [ProteinGym 144fe22b snapshot] | Protocol: ProteinGym AMFR official zero-shot Spearman snapshot Dataset subset: ProteinGym AMFR 4G3O official snapshot cohort | 0.165 spearman_rho correlation · higher Uncertainty: type: unreported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceCARP (640M) AMFR official snapshot Not reported Aggregation: Not reported ProteinGym AMFR assay-level Spearman comparison · DMS_substitutions_Spearman_DMS_level.csv line 15, DMS ID=AMFR_HUMAN_Tsuboyama_2023_4G3O, column=CARP (640M) |
| Configuration: CARP (76M) [ProteinGym 144fe22b snapshot] | Protocol: ProteinGym AMFR official zero-shot Spearman snapshot Dataset subset: ProteinGym AMFR 4G3O official snapshot cohort | 0.114 spearman_rho correlation · higher Uncertainty: type: unreported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceCARP (76M) AMFR official snapshot Not reported Aggregation: Not reported ProteinGym AMFR assay-level Spearman comparison · DMS_substitutions_Spearman_DMS_level.csv line 15, DMS ID=AMFR_HUMAN_Tsuboyama_2023_4G3O, column=CARP (76M) |
| Configuration: DeepSequence (ensemble) [ProteinGym 144fe22b snapshot] | Protocol: ProteinGym AMFR official zero-shot Spearman snapshot Dataset subset: ProteinGym AMFR 4G3O official snapshot cohort | 0.407 spearman_rho correlation · higher Uncertainty: type: unreported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceDeepSequence (ensemble) AMFR official snapshot Not reported Aggregation: Not reported ProteinGym AMFR assay-level Spearman comparison · DMS_substitutions_Spearman_DMS_level.csv line 15, DMS ID=AMFR_HUMAN_Tsuboyama_2023_4G3O, column=DeepSequence (ensemble) |
| Configuration: DeepSequence (single) [ProteinGym 144fe22b snapshot] | Protocol: ProteinGym AMFR official zero-shot Spearman snapshot Dataset subset: ProteinGym AMFR 4G3O official snapshot cohort | 0.419 spearman_rho correlation · higher Uncertainty: type: unreported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceDeepSequence (single) AMFR official snapshot Not reported Aggregation: Not reported ProteinGym AMFR assay-level Spearman comparison · DMS_substitutions_Spearman_DMS_level.csv line 15, DMS ID=AMFR_HUMAN_Tsuboyama_2023_4G3O, column=DeepSequence (single) |
| Configuration: ESCOTT [ProteinGym 144fe22b snapshot] | Protocol: ProteinGym AMFR official zero-shot Spearman snapshot Dataset subset: ProteinGym AMFR 4G3O official snapshot cohort | 0.41 spearman_rho correlation · higher Uncertainty: type: unreported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceNot reported Aggregation: Not reported ProteinGym AMFR assay-level Spearman comparison · DMS_substitutions_Spearman_DMS_level.csv line 15, DMS ID=AMFR_HUMAN_Tsuboyama_2023_4G3O, column=ESCOTT |
| Configuration: ESM-1b [ProteinGym 144fe22b snapshot] | Protocol: ProteinGym AMFR official zero-shot Spearman snapshot Dataset subset: ProteinGym AMFR 4G3O official snapshot cohort | 0.374 spearman_rho correlation · higher Uncertainty: type: unreported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceNot reported Aggregation: Not reported ProteinGym AMFR assay-level Spearman comparison · DMS_substitutions_Spearman_DMS_level.csv line 15, DMS ID=AMFR_HUMAN_Tsuboyama_2023_4G3O, column=ESM-1b |
| Configuration: ESM-1v (ensemble) [ProteinGym 144fe22b snapshot] | Protocol: ProteinGym AMFR official zero-shot Spearman snapshot Dataset subset: ProteinGym AMFR 4G3O official snapshot cohort | 0.423 spearman_rho correlation · higher Uncertainty: type: unreported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceESM-1v (ensemble) AMFR official snapshot Not reported Aggregation: Not reported ProteinGym AMFR assay-level Spearman comparison · DMS_substitutions_Spearman_DMS_level.csv line 15, DMS ID=AMFR_HUMAN_Tsuboyama_2023_4G3O, column=ESM-1v (ensemble) |
| Configuration: ESM-1v (single) [ProteinGym 144fe22b snapshot] | Protocol: ProteinGym AMFR official zero-shot Spearman snapshot Dataset subset: ProteinGym AMFR 4G3O official snapshot cohort | 0.07 spearman_rho correlation · higher Uncertainty: type: unreported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceESM-1v (single) AMFR official snapshot Not reported Aggregation: Not reported ProteinGym AMFR assay-level Spearman comparison · DMS_substitutions_Spearman_DMS_level.csv line 15, DMS ID=AMFR_HUMAN_Tsuboyama_2023_4G3O, column=ESM-1v (single) |
| Configuration: ESM-C (300M) [ProteinGym 144fe22b snapshot] | Protocol: ProteinGym AMFR official zero-shot Spearman snapshot Dataset subset: ProteinGym AMFR 4G3O official snapshot cohort | 0.364 spearman_rho correlation · higher Uncertainty: type: unreported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceESM-C (300M) AMFR official snapshot Not reported Aggregation: Not reported ProteinGym AMFR assay-level Spearman comparison · DMS_substitutions_Spearman_DMS_level.csv line 15, DMS ID=AMFR_HUMAN_Tsuboyama_2023_4G3O, column=ESM-C (300M) |
| Configuration: ESM-C (600M) [ProteinGym 144fe22b snapshot] | Protocol: ProteinGym AMFR official zero-shot Spearman snapshot Dataset subset: ProteinGym AMFR 4G3O official snapshot cohort | 0.262 spearman_rho correlation · higher Uncertainty: type: unreported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceESM-C (600M) AMFR official snapshot Not reported Aggregation: Not reported ProteinGym AMFR assay-level Spearman comparison · DMS_substitutions_Spearman_DMS_level.csv line 15, DMS ID=AMFR_HUMAN_Tsuboyama_2023_4G3O, column=ESM-C (600M) |
| Configuration: ESM-IF1 [ProteinGym 144fe22b snapshot] | Protocol: ProteinGym AMFR official zero-shot Spearman snapshot Dataset subset: ProteinGym AMFR 4G3O official snapshot cohort | 0.433 spearman_rho correlation · higher Uncertainty: type: unreported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceESM-IF1 AMFR official snapshot Not reported Aggregation: Not reported ProteinGym AMFR assay-level Spearman comparison · DMS_substitutions_Spearman_DMS_level.csv line 15, DMS ID=AMFR_HUMAN_Tsuboyama_2023_4G3O, column=ESM-IF1 |
| Configuration: ESM2 (150M) [ProteinGym 144fe22b snapshot] | Protocol: ProteinGym AMFR official zero-shot Spearman snapshot Dataset subset: ProteinGym AMFR 4G3O official snapshot cohort | 0.321 spearman_rho correlation · higher Uncertainty: type: unreported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceESM2 (150M) AMFR official snapshot Not reported Aggregation: Not reported ProteinGym AMFR assay-level Spearman comparison · DMS_substitutions_Spearman_DMS_level.csv line 15, DMS ID=AMFR_HUMAN_Tsuboyama_2023_4G3O, column=ESM2 (150M) |
| Configuration: ESM2 (15B) [ProteinGym 144fe22b snapshot] | Protocol: ProteinGym AMFR official zero-shot Spearman snapshot Dataset subset: ProteinGym AMFR 4G3O official snapshot cohort | 0.26 spearman_rho correlation · higher Uncertainty: type: unreported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceESM2 (15B) AMFR official snapshot Not reported Aggregation: Not reported ProteinGym AMFR assay-level Spearman comparison · DMS_substitutions_Spearman_DMS_level.csv line 15, DMS ID=AMFR_HUMAN_Tsuboyama_2023_4G3O, column=ESM2 (15B) |
| Configuration: ESM2 (35M) [ProteinGym 144fe22b snapshot] | Protocol: ProteinGym AMFR official zero-shot Spearman snapshot Dataset subset: ProteinGym AMFR 4G3O official snapshot cohort | 0.286 spearman_rho correlation · higher Uncertainty: type: unreported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceESM2 (35M) AMFR official snapshot Not reported Aggregation: Not reported ProteinGym AMFR assay-level Spearman comparison · DMS_substitutions_Spearman_DMS_level.csv line 15, DMS ID=AMFR_HUMAN_Tsuboyama_2023_4G3O, column=ESM2 (35M) |
| Configuration: ESM2 (3B) [ProteinGym 144fe22b snapshot] | Protocol: ProteinGym AMFR official zero-shot Spearman snapshot Dataset subset: ProteinGym AMFR 4G3O official snapshot cohort | 0.297 spearman_rho correlation · higher Uncertainty: type: unreported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceESM2 (3B) AMFR official snapshot Not reported Aggregation: Not reported ProteinGym AMFR assay-level Spearman comparison · DMS_substitutions_Spearman_DMS_level.csv line 15, DMS ID=AMFR_HUMAN_Tsuboyama_2023_4G3O, column=ESM2 (3B) |
| Configuration: ESM2 (650M) [ProteinGym 144fe22b snapshot] | Protocol: ProteinGym AMFR official zero-shot Spearman snapshot Dataset subset: ProteinGym AMFR 4G3O official snapshot cohort | 0.261 spearman_rho correlation · higher Uncertainty: type: unreported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceESM2 (650M) AMFR official snapshot Not reported Aggregation: Not reported ProteinGym AMFR assay-level Spearman comparison · DMS_substitutions_Spearman_DMS_level.csv line 15, DMS ID=AMFR_HUMAN_Tsuboyama_2023_4G3O, column=ESM2 (650M) |
| Configuration: ESM2 (8M) [ProteinGym 144fe22b snapshot] | Protocol: ProteinGym AMFR official zero-shot Spearman snapshot Dataset subset: ProteinGym AMFR 4G3O official snapshot cohort | -0.209 spearman_rho correlation · higher Uncertainty: type: unreported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceESM2 (8M) AMFR official snapshot Not reported Aggregation: Not reported ProteinGym AMFR assay-level Spearman comparison · DMS_substitutions_Spearman_DMS_level.csv line 15, DMS ID=AMFR_HUMAN_Tsuboyama_2023_4G3O, column=ESM2 (8M) |
| Configuration: ESM3 open (1.4B) [ProteinGym 144fe22b snapshot] | Protocol: ProteinGym AMFR official zero-shot Spearman snapshot Dataset subset: ProteinGym AMFR 4G3O official snapshot cohort | 0.29 spearman_rho correlation · higher Uncertainty: type: unreported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceESM3 open (1.4B) AMFR official snapshot Not reported Aggregation: Not reported ProteinGym AMFR assay-level Spearman comparison · DMS_substitutions_Spearman_DMS_level.csv line 15, DMS ID=AMFR_HUMAN_Tsuboyama_2023_4G3O, column=ESM3 open (1.4B) |
| Configuration: EVE (ensemble) [ProteinGym 144fe22b snapshot] | Protocol: ProteinGym AMFR official zero-shot Spearman snapshot Dataset subset: ProteinGym AMFR 4G3O official snapshot cohort | 0.398 spearman_rho correlation · higher Uncertainty: type: unreported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceEVE (ensemble) AMFR official snapshot Not reported Aggregation: Not reported ProteinGym AMFR assay-level Spearman comparison · DMS_substitutions_Spearman_DMS_level.csv line 15, DMS ID=AMFR_HUMAN_Tsuboyama_2023_4G3O, column=EVE (ensemble) |
| Configuration: EVE (single) [ProteinGym 144fe22b snapshot] | Protocol: ProteinGym AMFR official zero-shot Spearman snapshot Dataset subset: ProteinGym AMFR 4G3O official snapshot cohort | 0.386 spearman_rho correlation · higher Uncertainty: type: unreported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceEVE (single) AMFR official snapshot Not reported Aggregation: Not reported ProteinGym AMFR assay-level Spearman comparison · DMS_substitutions_Spearman_DMS_level.csv line 15, DMS ID=AMFR_HUMAN_Tsuboyama_2023_4G3O, column=EVE (single) |
| Configuration: EVmutation [ProteinGym 144fe22b snapshot] | Protocol: ProteinGym AMFR official zero-shot Spearman snapshot Dataset subset: ProteinGym AMFR 4G3O official snapshot cohort | 0.418 spearman_rho correlation · higher Uncertainty: type: unreported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceEVmutation AMFR official snapshot Not reported Aggregation: Not reported ProteinGym AMFR assay-level Spearman comparison · DMS_substitutions_Spearman_DMS_level.csv line 15, DMS ID=AMFR_HUMAN_Tsuboyama_2023_4G3O, column=EVmutation |
| Configuration: GEMME [ProteinGym 144fe22b snapshot] | Protocol: ProteinGym AMFR official zero-shot Spearman snapshot Dataset subset: ProteinGym AMFR 4G3O official snapshot cohort | 0.396 spearman_rho correlation · higher Uncertainty: type: unreported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceNot reported Aggregation: Not reported ProteinGym AMFR assay-level Spearman comparison · DMS_substitutions_Spearman_DMS_level.csv line 15, DMS ID=AMFR_HUMAN_Tsuboyama_2023_4G3O, column=GEMME |
Source checking is not independent reproduction. Release 2026-09-30-e37e3ab1284d.
This record describes a particular subset or cohort used in an evaluation. Its results do not describe the full dataset.
Source checking verifies the cited claim or transcription. It does not establish independent reproduction.
Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.
One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.
12 evidence rows matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|---|---|
| attributes.assay_count 2972 Context-only references | Protocol metadata evidence: proteingym-reference_files-DMS_substitutions.csv CSV row AMFR_HUMAN_Tsuboyama_2023_4G3O; pinned DMS metadata row Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: 144fe22b07dfaeec2b366f2346203a9838a55b4c | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| attributes.assay_count 2972 Context-only references | ProteinGym AMFR assay-level Spearman comparison CSV row AMFR_HUMAN_Tsuboyama_2023_4G3O; pinned DMS metadata row Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: 144fe22b07dfaeec2b366f2346203a9838a55b4c | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| attributes.double_substitutions 2152 Context-only references | Protocol metadata evidence: proteingym-reference_files-DMS_substitutions.csv CSV row AMFR_HUMAN_Tsuboyama_2023_4G3O; pinned DMS metadata row Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: 144fe22b07dfaeec2b366f2346203a9838a55b4c | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| attributes.double_substitutions 2152 Context-only references | ProteinGym AMFR assay-level Spearman comparison CSV row AMFR_HUMAN_Tsuboyama_2023_4G3O; pinned DMS metadata row Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: 144fe22b07dfaeec2b366f2346203a9838a55b4c | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| attributes.single_substitutions 820 Context-only references | Protocol metadata evidence: proteingym-reference_files-DMS_substitutions.csv CSV row AMFR_HUMAN_Tsuboyama_2023_4G3O; pinned DMS metadata row Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: 144fe22b07dfaeec2b366f2346203a9838a55b4c | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| attributes.single_substitutions 820 Context-only references | ProteinGym AMFR assay-level Spearman comparison CSV row AMFR_HUMAN_Tsuboyama_2023_4G3O; pinned DMS metadata row Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: 144fe22b07dfaeec2b366f2346203a9838a55b4c | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| attributes.source_locator CSV row AMFR_HUMAN_Tsuboyama_2023_4G3O; pinned DMS metadata row Context-only references | Protocol metadata evidence: proteingym-reference_files-DMS_substitutions.csv CSV row AMFR_HUMAN_Tsuboyama_2023_4G3O; pinned DMS metadata row Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: 144fe22b07dfaeec2b366f2346203a9838a55b4c | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| attributes.source_locator CSV row AMFR_HUMAN_Tsuboyama_2023_4G3O; pinned DMS metadata row Context-only references | ProteinGym AMFR assay-level Spearman comparison CSV row AMFR_HUMAN_Tsuboyama_2023_4G3O; pinned DMS metadata row Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: 144fe22b07dfaeec2b366f2346203a9838a55b4c | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| description 47-residue AMFR construct; cDNA-display proteolysis folding-stability endpoint; 2,972 assay variants comprising 820 single and 2,152 double substitutions. Context-only references | Protocol metadata evidence: proteingym-reference_files-DMS_substitutions.csv CSV row AMFR_HUMAN_Tsuboyama_2023_4G3O; pinned DMS metadata row Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: 144fe22b07dfaeec2b366f2346203a9838a55b4c | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| description 47-residue AMFR construct; cDNA-display proteolysis folding-stability endpoint; 2,972 assay variants comprising 820 single and 2,152 double substitutions. Context-only references | ProteinGym AMFR assay-level Spearman comparison CSV row AMFR_HUMAN_Tsuboyama_2023_4G3O; pinned DMS metadata row Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: 144fe22b07dfaeec2b366f2346203a9838a55b4c | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
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Release 2026-09-30-e37e3ab1284d · Record review: source checked
Stable ID: uc20260930-proteingym-amfr-data