Configuration

ESM-C (600M) [ProteinGym 144fe22b snapshot]

ESM C learns protein sequence representations for downstream analysis.

Sources (5)

evolutionaryscale/esm: README.md; evolutionaryscale/esm: _assets/ESM3_README.md; evolutionaryscale/esm: THIRD_PARTY_NOTICE.md; biohub/ESMC-6B: README.md; biohub/ESMC-6B: config.json · Official biohub/ESMC-6B card: Model Architecture, Parameters, Training Data, Training Procedure and Limitations; THIRD_PARTY_NOTICE.md

1 evaluation · 1 result

How it worksESMC workflow

Conceptual summary of the documented data flow; optional inputs and configured downstream stages must be reported for a reproducible evaluation.

Sources (5)

Overview

Model type

Protein representation transformer

Inputs

Protein amino-acid sequences.

Outputs

Final-layer or all-layer protein representations and masked-token outputs.

Access

Official project documentation and implementation: https://github.com/evolutionaryscale/esm

Sources (5)

limited source coverage · Automated source review, 2026-09-16. All specifications and missing details

Evaluations and results

1 evaluation · 1 result. Different protocols are not a single leaderboard.

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Tested model or methodProtocolDatasetEvaluation setupMetricEvidence origin

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Exact evaluated configurations and original reported results
Tested configuration	Protocol and dataset	Finding	Evidence and details
Configuration: ESM-C (600M) [ProteinGym 144fe22b snapshot]	Protocol: ProteinGym AMFR official zero-shot Spearman snapshot Dataset subset: ProteinGym AMFR 4G3O official snapshot cohort	0.262 spearman_rho correlation · higher Uncertainty: type: unreported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESM-C (600M) AMFR official snapshot Not reported Aggregation: Not reported ProteinGym AMFR assay-level Spearman comparison · DMS_substitutions_Spearman_DMS_level.csv line 15, DMS ID=AMFR_HUMAN_Tsuboyama_2023_4G3O, column=ESM-C (600M)

Source checking is not independent reproduction. Release 2026-09-30-e37e3ab1284d.

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How it works, versions and access

Related profile: ESMC. This page retains the exact record and its evaluation context.

This configuration

Exact official CSV source-label configuration; checkpoint and per-assay scoring details are not inferred from similarly named methods.

record: ESM-C (600M) [ProteinGym 144fe22b snapshot]
configuration: 144fe22b07dfaeec2b366f2346203a9838a55b4c
entity type: Configuration

How it works

ESM C learns protein sequence representations for downstream analysis. Pre-normalized transformer with rotary embeddings, SwiGLU feed-forward activations and no linear/layer-norm biases. The documented inputs are protein amino-acid sequences. The output consists of final-layer or all-layer protein representations and masked-token outputs.

Sources (5)

Versions and reproducibility

esmc-600m-2024-12 API identifier and biohub/ESMC-6B local example. The card specifies a2,048-token window after an initial 512-token training phase.

Sources (5)

Strengths, limitations and unresolved questions

Strengths and limitations

Strengths and considerations

The implementation supports local inference and a hosted interface, with downloadable model variants.
Sources (5)
evolutionaryscale/esm: README.md; evolutionaryscale/esm: _assets/ESM3_README.md; evolutionaryscale/esm: THIRD_PARTY_NOTICE.md; biohub/ESMC-6B: README.md; biohub/ESMC-6B: config.json · Official biohub/ESMC-6B card: Model Architecture, Parameters, Training Data, Training Procedure and Limitations; THIRD_PARTY_NOTICE.md

Limitations and conditions

Hosted API names and downloadable weights identify different versions. The main repository does not by itself provide a complete per-checkpoint training manifest.
Sources (5)
evolutionaryscale/esm: README.md; evolutionaryscale/esm: _assets/ESM3_README.md; evolutionaryscale/esm: THIRD_PARTY_NOTICE.md; biohub/ESMC-6B: README.md; biohub/ESMC-6B: config.json · Official biohub/ESMC-6B card: Model Architecture, Parameters, Training Data, Training Procedure and Limitations; THIRD_PARTY_NOTICE.md

Profile review details

Inspected pinned official documentation, relevant implementation files and named primary-paper sections. Claims are limited to those artifacts. Remaining field extraction and identity conflicts are explicit; no new performance claims, model runs or human review are implied.

Stable record: discovery-model-esmc

Specifications

Inputs, training, access and other details

Explanatory profile: limited source coverage · Automated source review, 2026-09-16. Review applies to the cited claims; unresolved fields are listed below. Numerical results retain their own review status.

Inputs, outputs and configuration
Property	Description and evidence
Model type	Protein representation transformer Sources (5) evolutionaryscale/esm: README.md; evolutionaryscale/esm: _assets/ESM3_README.md; evolutionaryscale/esm: THIRD_PARTY_NOTICE.md; biohub/ESMC-6B: README.md; biohub/ESMC-6B: config.json · Official biohub/ESMC-6B card: Model Architecture, Parameters, Training Data, Training Procedure and Limitations; THIRD_PARTY_NOTICE.md
Architecture	Pre-normalized transformer with rotary embeddings, SwiGLU feed-forward activations and no linear/layer-norm biases. Sources (5) evolutionaryscale/esm: README.md; evolutionaryscale/esm: _assets/ESM3_README.md; evolutionaryscale/esm: THIRD_PARTY_NOTICE.md; biohub/ESMC-6B: README.md; biohub/ESMC-6B: config.json · Official biohub/ESMC-6B card: Model Architecture, Parameters, Training Data, Training Procedure and Limitations; THIRD_PARTY_NOTICE.md
Inputs	Protein amino-acid sequences. Sources (5) evolutionaryscale/esm: README.md; evolutionaryscale/esm: _assets/ESM3_README.md; evolutionaryscale/esm: THIRD_PARTY_NOTICE.md; biohub/ESMC-6B: README.md; biohub/ESMC-6B: config.json · Official biohub/ESMC-6B card: Model Architecture, Parameters, Training Data, Training Procedure and Limitations; THIRD_PARTY_NOTICE.md
Outputs	Final-layer or all-layer protein representations and masked-token outputs. Sources (5) evolutionaryscale/esm: README.md; evolutionaryscale/esm: _assets/ESM3_README.md; evolutionaryscale/esm: THIRD_PARTY_NOTICE.md; biohub/ESMC-6B: README.md; biohub/ESMC-6B: config.json · Official biohub/ESMC-6B card: Model Architecture, Parameters, Training Data, Training Procedure and Limitations; THIRD_PARTY_NOTICE.md
Parameters	300M/30 layers, 600M/36 layers and 6B/80 layers in the checked model card. Sources (5) evolutionaryscale/esm: README.md; evolutionaryscale/esm: _assets/ESM3_README.md; evolutionaryscale/esm: THIRD_PARTY_NOTICE.md; biohub/ESMC-6B: README.md; biohub/ESMC-6B: config.json · Official biohub/ESMC-6B card: Model Architecture, Parameters, Training Data, Training Procedure and Limitations; THIRD_PARTY_NOTICE.md
Known versions	esmc-600m-2024-12 API identifier and biohub/ESMC-6B local example. Sources (5) evolutionaryscale/esm: README.md; evolutionaryscale/esm: _assets/ESM3_README.md; evolutionaryscale/esm: THIRD_PARTY_NOTICE.md; biohub/ESMC-6B: README.md; biohub/ESMC-6B: config.json · Official biohub/ESMC-6B card: Model Architecture, Parameters, Training Data, Training Procedure and Limitations; THIRD_PARTY_NOTICE.md
Training data	UniRef, MGnify and JGI protein sequences clustered at 70% identity. The card distinguishes83M, 372M and 2B clusters respectively from the number of repeated training tokens. Sources (5) evolutionaryscale/esm: README.md; evolutionaryscale/esm: _assets/ESM3_README.md; evolutionaryscale/esm: THIRD_PARTY_NOTICE.md; biohub/ESMC-6B: README.md; biohub/ESMC-6B: config.json · Official biohub/ESMC-6B card: Model Architecture, Parameters, Training Data, Training Procedure and Limitations; THIRD_PARTY_NOTICE.md
Training cutoff	The official ESMC-6B card identifies UniRef, MGnify and JGI clusters and training stages, but does not give a latest-sequence date shared across those corpora. · Not reported in inspected sources Sources (5) evolutionaryscale/esm: README.md; evolutionaryscale/esm: _assets/ESM3_README.md; evolutionaryscale/esm: THIRD_PARTY_NOTICE.md; biohub/ESMC-6B: README.md; biohub/ESMC-6B: config.json · Official biohub/ESMC-6B card: Model Architecture, Parameters, Training Data, Training Procedure and Limitations; THIRD_PARTY_NOTICE.md
Context limits	The card specifies a2,048-token window after an initial 512-token training phase. Sources (5) evolutionaryscale/esm: README.md; evolutionaryscale/esm: _assets/ESM3_README.md; evolutionaryscale/esm: THIRD_PARTY_NOTICE.md; biohub/ESMC-6B: README.md; biohub/ESMC-6B: config.json · Official biohub/ESMC-6B card: Model Architecture, Parameters, Training Data, Training Procedure and Limitations; THIRD_PARTY_NOTICE.md
Weights licence	MIT is declared alongside third-party notices in the checked6B card; THIRD_PARTY_NOTICE.md lists dependency licences. Sources (5) evolutionaryscale/esm: README.md; evolutionaryscale/esm: _assets/ESM3_README.md; evolutionaryscale/esm: THIRD_PARTY_NOTICE.md; biohub/ESMC-6B: README.md; biohub/ESMC-6B: config.json · Official biohub/ESMC-6B card: Model Architecture, Parameters, Training Data, Training Procedure and Limitations; THIRD_PARTY_NOTICE.md
Access	Official project documentation and implementation: https://github.com/evolutionaryscale/esm Sources (5) evolutionaryscale/esm: README.md; evolutionaryscale/esm: _assets/ESM3_README.md; evolutionaryscale/esm: THIRD_PARTY_NOTICE.md; biohub/ESMC-6B: README.md; biohub/ESMC-6B: config.json · Official biohub/ESMC-6B card: Model Architecture, Parameters, Training Data, Training Procedure and Limitations; THIRD_PARTY_NOTICE.md
Code licence	MIT Sources evolutionaryscale/esm: LICENSE.md · LICENSE.md: licence text

Evidence

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Evidence table

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1 evidence row matching the loaded filters

Claims, original sources and review scope · Release 2026-09-30-e37e3ab1284d
Property and statement	Original source and location	Review and provenance
Relationship: variant of discovery-model-esmc Individual claims	ProteinGym AMFR assay-level Spearman comparison Original source ↗ Pinned ProteinGym Spearman CSV header: ESM-C (600M) Version: 144fe22b07dfaeec2b366f2346203a9838a55b4c Retrieved: 2026-09-30	source checked automated source review · 2026-09-30T21:40:59.576893+00:00 Audit details Field: `links:variant_of:discovery-model-esmc` Claim: uc20260930-config-family-f503fc743c1b5ee2 Source artifact SHA-256: `f432423b87f79ac9778dfac86e3d95be041d246bc618dc0a406b35b0b7466437` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact

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Release 2026-09-30-e37e3ab1284d · Record review: source checked

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ProteinGym AMFR assay-level Spearman comparison · Original source · 144fe22b07dfaeec2b366f2346203a9838a55b4c

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Technical metadata and extraction receipts

Stable ID: uc20260930-proteingym-amfr-config-esm-c-600m

areas: proteins-complexes
source locator: See linked evaluation and result locators
missing metadata: checkpoint hash: unextracted
review: method: automated_source_review; reviewer: Codex experimental-use-case curation; date: 2026-09-30; reviewed at: 2026-09-30T21:40:59.576893+00:00; scope: Primary-source transcription and catalogue applicability audit; not human scientific review or independent experimental reproduction.
reported name: ESM-C (600M)
version: 144fe22b07dfaeec2b366f2346203a9838a55b4c

Related records

variant of: ESMC
subject: ESM-C (600M) [ProteinGym 144fe22b snapshot] family identity
configuration: ESM-C (600M) AMFR official snapshot

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