Dataset

SARS-CoV-2 RBD mutant binding and expression measurements

Deep mutational scanning measurements of SARS-CoV-2 receptor-binding-domain mutants used by PRIME for binding and expression regression.

Evaluation results

168 evaluations · 168 results. Different protocols are not a single leaderboard.

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Exact evaluated configurations and original reported results
Tested configuration	Protocol and dataset	Finding	Evidence and details
Configuration: ESM-2 150M, the CLS token embedding, fine-tuned (PRIME)	Protocol: PRIME ACE2 binding regression, Position-stratified split holding out whole mutated positions, R² Dataset: SARS-CoV-2 RBD mutant binding and expression measurements	-0.2675 ± 0.07 R² (ACE2 binding; Position-stratified split holding out whole mutated positions; the CLS token embedding, fine-tuned) unitless · higher Uncertainty: SD 0.07 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESM-2 150M CLS finetuned: ACE2 binding R², Position-stratified split holding out whole mutated positions lit-protein-20261011-prime-protocol-position-stratified-binding-r2 Aggregation: Not reported PRIME: An evaluation framework for protein representation inference and generalization in viral mutation space · Table 1, row 'ESM-2 150M' / 'CLS' / '✓', columns 'Position-Stratified Split' / 'Binding' / 'R²'
Configuration: ESM-2 150M, the CLS token embedding, not fine-tuned (PRIME)	Protocol: PRIME ACE2 binding regression, Position-stratified split holding out whole mutated positions, R² Dataset: SARS-CoV-2 RBD mutant binding and expression measurements	-0.2449 ± 0.06 R² (ACE2 binding; Position-stratified split holding out whole mutated positions; the CLS token embedding, frozen) unitless · higher Uncertainty: SD 0.06 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESM-2 150M CLS frozen: ACE2 binding R², Position-stratified split holding out whole mutated positions lit-protein-20261011-prime-protocol-position-stratified-binding-r2 Aggregation: Not reported PRIME: An evaluation framework for protein representation inference and generalization in viral mutation space · Table 1, row 'ESM-2 150M' / 'CLS' / '×', columns 'Position-Stratified Split' / 'Binding' / 'R²'
Configuration: ESM-2 150M, the mean over residue embeddings, fine-tuned (PRIME)	Protocol: PRIME ACE2 binding regression, Position-stratified split holding out whole mutated positions, R² Dataset: SARS-CoV-2 RBD mutant binding and expression measurements	-0.0080 ± 0.00 R² (ACE2 binding; Position-stratified split holding out whole mutated positions; the mean over residue embeddings, fine-tuned) unitless · higher Uncertainty: SD 0.00 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESM-2 150M Mean finetuned: ACE2 binding R², Position-stratified split holding out whole mutated positions lit-protein-20261011-prime-protocol-position-stratified-binding-r2 Aggregation: Not reported PRIME: An evaluation framework for protein representation inference and generalization in viral mutation space · Table 1, row 'ESM-2 150M' / 'Mean' / '✓', columns 'Position-Stratified Split' / 'Binding' / 'R²'
Configuration: ESM-2 150M, the mean over residue embeddings, not fine-tuned (PRIME)	Protocol: PRIME ACE2 binding regression, Position-stratified split holding out whole mutated positions, R² Dataset: SARS-CoV-2 RBD mutant binding and expression measurements	-0.0695 ± 0.03 R² (ACE2 binding; Position-stratified split holding out whole mutated positions; the mean over residue embeddings, frozen) unitless · higher Uncertainty: SD 0.03 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESM-2 150M Mean frozen: ACE2 binding R², Position-stratified split holding out whole mutated positions lit-protein-20261011-prime-protocol-position-stratified-binding-r2 Aggregation: Not reported PRIME: An evaluation framework for protein representation inference and generalization in viral mutation space · Table 1, row 'ESM-2 150M' / 'Mean' / '×', columns 'Position-Stratified Split' / 'Binding' / 'R²'
Configuration: ESM-2 650M, the CLS token embedding, fine-tuned (PRIME)	Protocol: PRIME ACE2 binding regression, Position-stratified split holding out whole mutated positions, R² Dataset: SARS-CoV-2 RBD mutant binding and expression measurements	-0.0399 ± 0.06 R² (ACE2 binding; Position-stratified split holding out whole mutated positions; the CLS token embedding, fine-tuned) unitless · higher Uncertainty: SD 0.06 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESM-2 650M CLS finetuned: ACE2 binding R², Position-stratified split holding out whole mutated positions lit-protein-20261011-prime-protocol-position-stratified-binding-r2 Aggregation: Not reported PRIME: An evaluation framework for protein representation inference and generalization in viral mutation space · Table 1, row 'ESM-2 650M' / 'CLS' / '✓', columns 'Position-Stratified Split' / 'Binding' / 'R²'
Configuration: ESM-2 650M, the CLS token embedding, not fine-tuned (PRIME)	Protocol: PRIME ACE2 binding regression, Position-stratified split holding out whole mutated positions, R² Dataset: SARS-CoV-2 RBD mutant binding and expression measurements	-0.1591 ± 0.04 R² (ACE2 binding; Position-stratified split holding out whole mutated positions; the CLS token embedding, frozen) unitless · higher Uncertainty: SD 0.04 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESM-2 650M CLS frozen: ACE2 binding R², Position-stratified split holding out whole mutated positions lit-protein-20261011-prime-protocol-position-stratified-binding-r2 Aggregation: Not reported PRIME: An evaluation framework for protein representation inference and generalization in viral mutation space · Table 1, row 'ESM-2 650M' / 'CLS' / '×', columns 'Position-Stratified Split' / 'Binding' / 'R²'
Configuration: ESM-2 650M, the mean over residue embeddings, fine-tuned (PRIME)	Protocol: PRIME ACE2 binding regression, Position-stratified split holding out whole mutated positions, R² Dataset: SARS-CoV-2 RBD mutant binding and expression measurements	0.0588 ± 0.04 R² (ACE2 binding; Position-stratified split holding out whole mutated positions; the mean over residue embeddings, fine-tuned) unitless · higher Uncertainty: SD 0.04 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESM-2 650M Mean finetuned: ACE2 binding R², Position-stratified split holding out whole mutated positions lit-protein-20261011-prime-protocol-position-stratified-binding-r2 Aggregation: Not reported PRIME: An evaluation framework for protein representation inference and generalization in viral mutation space · Table 1, row 'ESM-2 650M' / 'Mean' / '✓', columns 'Position-Stratified Split' / 'Binding' / 'R²'
Configuration: ESM-2 650M, the mean over residue embeddings, not fine-tuned (PRIME)	Protocol: PRIME ACE2 binding regression, Position-stratified split holding out whole mutated positions, R² Dataset: SARS-CoV-2 RBD mutant binding and expression measurements	-0.0865 ± 0.04 R² (ACE2 binding; Position-stratified split holding out whole mutated positions; the mean over residue embeddings, frozen) unitless · higher Uncertainty: SD 0.04 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESM-2 650M Mean frozen: ACE2 binding R², Position-stratified split holding out whole mutated positions lit-protein-20261011-prime-protocol-position-stratified-binding-r2 Aggregation: Not reported PRIME: An evaluation framework for protein representation inference and generalization in viral mutation space · Table 1, row 'ESM-2 650M' / 'Mean' / '×', columns 'Position-Stratified Split' / 'Binding' / 'R²'
Configuration: ESM-2 8M, the CLS token embedding, fine-tuned (PRIME)	Protocol: PRIME ACE2 binding regression, Position-stratified split holding out whole mutated positions, R² Dataset: SARS-CoV-2 RBD mutant binding and expression measurements	-0.2294 ± 0.03 R² (ACE2 binding; Position-stratified split holding out whole mutated positions; the CLS token embedding, fine-tuned) unitless · higher Uncertainty: SD 0.03 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESM-2 8M CLS finetuned: ACE2 binding R², Position-stratified split holding out whole mutated positions lit-protein-20261011-prime-protocol-position-stratified-binding-r2 Aggregation: Not reported PRIME: An evaluation framework for protein representation inference and generalization in viral mutation space · Table 1, row 'ESM-2 8M' / 'CLS' / '✓', columns 'Position-Stratified Split' / 'Binding' / 'R²'
Configuration: ESM-2 8M, the CLS token embedding, not fine-tuned (PRIME)	Protocol: PRIME ACE2 binding regression, Position-stratified split holding out whole mutated positions, R² Dataset: SARS-CoV-2 RBD mutant binding and expression measurements	-0.2018 ± 0.04 R² (ACE2 binding; Position-stratified split holding out whole mutated positions; the CLS token embedding, frozen) unitless · higher Uncertainty: SD 0.04 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESM-2 8M CLS frozen: ACE2 binding R², Position-stratified split holding out whole mutated positions lit-protein-20261011-prime-protocol-position-stratified-binding-r2 Aggregation: Not reported PRIME: An evaluation framework for protein representation inference and generalization in viral mutation space · Table 1, row 'ESM-2 8M' / 'CLS' / '×', columns 'Position-Stratified Split' / 'Binding' / 'R²'
Configuration: ESM-2 8M, the mean over residue embeddings, fine-tuned (PRIME)	Protocol: PRIME ACE2 binding regression, Position-stratified split holding out whole mutated positions, R² Dataset: SARS-CoV-2 RBD mutant binding and expression measurements	0.0071 ± 0.05 R² (ACE2 binding; Position-stratified split holding out whole mutated positions; the mean over residue embeddings, fine-tuned) unitless · higher Uncertainty: SD 0.05 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESM-2 8M Mean finetuned: ACE2 binding R², Position-stratified split holding out whole mutated positions lit-protein-20261011-prime-protocol-position-stratified-binding-r2 Aggregation: Not reported PRIME: An evaluation framework for protein representation inference and generalization in viral mutation space · Table 1, row 'ESM-2 8M' / 'Mean' / '✓', columns 'Position-Stratified Split' / 'Binding' / 'R²'
Configuration: ESM-2 8M, the mean over residue embeddings, not fine-tuned (PRIME)	Protocol: PRIME ACE2 binding regression, Position-stratified split holding out whole mutated positions, R² Dataset: SARS-CoV-2 RBD mutant binding and expression measurements	0.0248 ± 0.01 R² (ACE2 binding; Position-stratified split holding out whole mutated positions; the mean over residue embeddings, frozen) unitless · higher Uncertainty: SD 0.01 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESM-2 8M Mean frozen: ACE2 binding R², Position-stratified split holding out whole mutated positions lit-protein-20261011-prime-protocol-position-stratified-binding-r2 Aggregation: Not reported PRIME: An evaluation framework for protein representation inference and generalization in viral mutation space · Table 1, row 'ESM-2 8M' / 'Mean' / '×', columns 'Position-Stratified Split' / 'Binding' / 'R²'
Configuration: ESM-C 300M, the CLS token embedding, fine-tuned (PRIME)	Protocol: PRIME ACE2 binding regression, Position-stratified split holding out whole mutated positions, R² Dataset: SARS-CoV-2 RBD mutant binding and expression measurements	0.0019 ± 0.05 R² (ACE2 binding; Position-stratified split holding out whole mutated positions; the CLS token embedding, fine-tuned) unitless · higher Uncertainty: SD 0.05 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESM-C 300M CLS finetuned: ACE2 binding R², Position-stratified split holding out whole mutated positions lit-protein-20261011-prime-protocol-position-stratified-binding-r2 Aggregation: Not reported PRIME: An evaluation framework for protein representation inference and generalization in viral mutation space · Table 1, row 'ESM-C 300M' / 'CLS' / '✓', columns 'Position-Stratified Split' / 'Binding' / 'R²'
Configuration: ESM-C 300M, the CLS token embedding, not fine-tuned (PRIME)	Protocol: PRIME ACE2 binding regression, Position-stratified split holding out whole mutated positions, R² Dataset: SARS-CoV-2 RBD mutant binding and expression measurements	-0.1954 ± 0.06 R² (ACE2 binding; Position-stratified split holding out whole mutated positions; the CLS token embedding, frozen) unitless · higher Uncertainty: SD 0.06 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESM-C 300M CLS frozen: ACE2 binding R², Position-stratified split holding out whole mutated positions lit-protein-20261011-prime-protocol-position-stratified-binding-r2 Aggregation: Not reported PRIME: An evaluation framework for protein representation inference and generalization in viral mutation space · Table 1, row 'ESM-C 300M' / 'CLS' / '×', columns 'Position-Stratified Split' / 'Binding' / 'R²'
Configuration: ESM-C 300M, the mean over residue embeddings, fine-tuned (PRIME)	Protocol: PRIME ACE2 binding regression, Position-stratified split holding out whole mutated positions, R² Dataset: SARS-CoV-2 RBD mutant binding and expression measurements	0.1949 ± 0.03 R² (ACE2 binding; Position-stratified split holding out whole mutated positions; the mean over residue embeddings, fine-tuned) unitless · higher Uncertainty: SD 0.03 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESM-C 300M Mean finetuned: ACE2 binding R², Position-stratified split holding out whole mutated positions lit-protein-20261011-prime-protocol-position-stratified-binding-r2 Aggregation: Not reported PRIME: An evaluation framework for protein representation inference and generalization in viral mutation space · Table 1, row 'ESM-C 300M' / 'Mean' / '✓', columns 'Position-Stratified Split' / 'Binding' / 'R²'
Configuration: ESM-C 300M, the mean over residue embeddings, not fine-tuned (PRIME)	Protocol: PRIME ACE2 binding regression, Position-stratified split holding out whole mutated positions, R² Dataset: SARS-CoV-2 RBD mutant binding and expression measurements	-0.0162 ± 0.01 R² (ACE2 binding; Position-stratified split holding out whole mutated positions; the mean over residue embeddings, frozen) unitless · higher Uncertainty: SD 0.01 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESM-C 300M Mean frozen: ACE2 binding R², Position-stratified split holding out whole mutated positions lit-protein-20261011-prime-protocol-position-stratified-binding-r2 Aggregation: Not reported PRIME: An evaluation framework for protein representation inference and generalization in viral mutation space · Table 1, row 'ESM-C 300M' / 'Mean' / '×', columns 'Position-Stratified Split' / 'Binding' / 'R²'
Configuration: ESM-C 600M, the CLS token embedding, fine-tuned (PRIME)	Protocol: PRIME ACE2 binding regression, Position-stratified split holding out whole mutated positions, R² Dataset: SARS-CoV-2 RBD mutant binding and expression measurements	0.1165 ± 0.06 R² (ACE2 binding; Position-stratified split holding out whole mutated positions; the CLS token embedding, fine-tuned) unitless · higher Uncertainty: SD 0.06 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESM-C 600M CLS finetuned: ACE2 binding R², Position-stratified split holding out whole mutated positions lit-protein-20261011-prime-protocol-position-stratified-binding-r2 Aggregation: Not reported PRIME: An evaluation framework for protein representation inference and generalization in viral mutation space · Table 1, row 'ESM-C 600M' / 'CLS' / '✓', columns 'Position-Stratified Split' / 'Binding' / 'R²'
Configuration: ESM-C 600M, the CLS token embedding, not fine-tuned (PRIME)	Protocol: PRIME ACE2 binding regression, Position-stratified split holding out whole mutated positions, R² Dataset: SARS-CoV-2 RBD mutant binding and expression measurements	-0.1106 ± 0.02 R² (ACE2 binding; Position-stratified split holding out whole mutated positions; the CLS token embedding, frozen) unitless · higher Uncertainty: SD 0.02 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESM-C 600M CLS frozen: ACE2 binding R², Position-stratified split holding out whole mutated positions lit-protein-20261011-prime-protocol-position-stratified-binding-r2 Aggregation: Not reported PRIME: An evaluation framework for protein representation inference and generalization in viral mutation space · Table 1, row 'ESM-C 600M' / 'CLS' / '×', columns 'Position-Stratified Split' / 'Binding' / 'R²'
Configuration: ESM-C 600M, the mean over residue embeddings, fine-tuned (PRIME)	Protocol: PRIME ACE2 binding regression, Position-stratified split holding out whole mutated positions, R² Dataset: SARS-CoV-2 RBD mutant binding and expression measurements	0.2120 ± 0.03 R² (ACE2 binding; Position-stratified split holding out whole mutated positions; the mean over residue embeddings, fine-tuned) unitless · higher Uncertainty: SD 0.03 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESM-C 600M Mean finetuned: ACE2 binding R², Position-stratified split holding out whole mutated positions lit-protein-20261011-prime-protocol-position-stratified-binding-r2 Aggregation: Not reported PRIME: An evaluation framework for protein representation inference and generalization in viral mutation space · Table 1, row 'ESM-C 600M' / 'Mean' / '✓', columns 'Position-Stratified Split' / 'Binding' / 'R²'
Configuration: ESM-C 600M, the mean over residue embeddings, not fine-tuned (PRIME)	Protocol: PRIME ACE2 binding regression, Position-stratified split holding out whole mutated positions, R² Dataset: SARS-CoV-2 RBD mutant binding and expression measurements	-0.0973 ± 0.03 R² (ACE2 binding; Position-stratified split holding out whole mutated positions; the mean over residue embeddings, frozen) unitless · higher Uncertainty: SD 0.03 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESM-C 600M Mean frozen: ACE2 binding R², Position-stratified split holding out whole mutated positions lit-protein-20261011-prime-protocol-position-stratified-binding-r2 Aggregation: Not reported PRIME: An evaluation framework for protein representation inference and generalization in viral mutation space · Table 1, row 'ESM-C 600M' / 'Mean' / '×', columns 'Position-Stratified Split' / 'Binding' / 'R²'
Configuration: One-hot mean representation (PRIME)	Protocol: PRIME ACE2 binding regression, Position-stratified split holding out whole mutated positions, R² Dataset: SARS-CoV-2 RBD mutant binding and expression measurements	-0.2397 ± 0.01 R² (ACE2 binding; Position-stratified split holding out whole mutated positions; one-hot mean representation) unitless · higher Uncertainty: SD 0.01 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source One-Hot Mean: ACE2 binding R², Position-stratified split holding out whole mutated positions lit-protein-20261011-prime-protocol-position-stratified-binding-r2 Aggregation: Not reported PRIME: An evaluation framework for protein representation inference and generalization in viral mutation space · Table 1, row 'One-Hot Mean', columns 'Position-Stratified Split' / 'Binding' / 'R²'
Configuration: ESM-2 150M, the CLS token embedding, fine-tuned (PRIME)	Protocol: PRIME ACE2 binding regression, Position-stratified split holding out whole mutated positions, RMSE Dataset: SARS-CoV-2 RBD mutant binding and expression measurements	2.0022 ± 0.04 RMSE (ACE2 binding; Position-stratified split holding out whole mutated positions; the CLS token embedding, fine-tuned) unit-unreported · lower Uncertainty: SD 0.04 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESM-2 150M CLS finetuned: ACE2 binding RMSE, Position-stratified split holding out whole mutated positions lit-protein-20261011-prime-protocol-position-stratified-binding-rmse Aggregation: Not reported PRIME: An evaluation framework for protein representation inference and generalization in viral mutation space · Table 1, row 'ESM-2 150M' / 'CLS' / '✓', columns 'Position-Stratified Split' / 'Binding' / 'RMSE'
Configuration: ESM-2 150M, the CLS token embedding, not fine-tuned (PRIME)	Protocol: PRIME ACE2 binding regression, Position-stratified split holding out whole mutated positions, RMSE Dataset: SARS-CoV-2 RBD mutant binding and expression measurements	1.9777 ± 0.03 RMSE (ACE2 binding; Position-stratified split holding out whole mutated positions; the CLS token embedding, frozen) unit-unreported · lower Uncertainty: SD 0.03 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESM-2 150M CLS frozen: ACE2 binding RMSE, Position-stratified split holding out whole mutated positions lit-protein-20261011-prime-protocol-position-stratified-binding-rmse Aggregation: Not reported PRIME: An evaluation framework for protein representation inference and generalization in viral mutation space · Table 1, row 'ESM-2 150M' / 'CLS' / '×', columns 'Position-Stratified Split' / 'Binding' / 'RMSE'
Configuration: ESM-2 150M, the mean over residue embeddings, fine-tuned (PRIME)	Protocol: PRIME ACE2 binding regression, Position-stratified split holding out whole mutated positions, RMSE Dataset: SARS-CoV-2 RBD mutant binding and expression measurements	1.7863 ± 0.01 RMSE (ACE2 binding; Position-stratified split holding out whole mutated positions; the mean over residue embeddings, fine-tuned) unit-unreported · lower Uncertainty: SD 0.01 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESM-2 150M Mean finetuned: ACE2 binding RMSE, Position-stratified split holding out whole mutated positions lit-protein-20261011-prime-protocol-position-stratified-binding-rmse Aggregation: Not reported PRIME: An evaluation framework for protein representation inference and generalization in viral mutation space · Table 1, row 'ESM-2 150M' / 'Mean' / '✓', columns 'Position-Stratified Split' / 'Binding' / 'RMSE'
Configuration: ESM-2 150M, the mean over residue embeddings, not fine-tuned (PRIME)	Protocol: PRIME ACE2 binding regression, Position-stratified split holding out whole mutated positions, RMSE Dataset: SARS-CoV-2 RBD mutant binding and expression measurements	1.8359 ± 0.02 RMSE (ACE2 binding; Position-stratified split holding out whole mutated positions; the mean over residue embeddings, frozen) unit-unreported · lower Uncertainty: SD 0.02 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESM-2 150M Mean frozen: ACE2 binding RMSE, Position-stratified split holding out whole mutated positions lit-protein-20261011-prime-protocol-position-stratified-binding-rmse Aggregation: Not reported PRIME: An evaluation framework for protein representation inference and generalization in viral mutation space · Table 1, row 'ESM-2 150M' / 'Mean' / '×', columns 'Position-Stratified Split' / 'Binding' / 'RMSE'

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Claims, original sources and review scope · Release 2026-10-22-1b7cf027e4f6
Property and statement	Original source and location	Review and provenance
Population Mutated SARS-CoV-2 RBD variants with ACE2 binding and expression measurements Context-only references	PRIME: An evaluation framework for protein representation inference and generalization in viral mutation space Original source ↗ Table 1 caption: 'Benchmarking PRIME across different model scales and validation regimes for mutated RBD binding and expression' Version: Version of record, BMC Genomics 2026 (PMC13425921 JATS full text) Retrieved: 2026-10-11T21:30:00Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.population` Source artifact SHA-256: `f6aac4c25dd93026f87ce9a2e327c95faf4c3014d7f9ae04bb11f208ce047971` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Source location Table 1 caption: 'Benchmarking PRIME across different model scales and validation regimes for mutated RBD binding and expression' Context-only references	PRIME: An evaluation framework for protein representation inference and generalization in viral mutation space Original source ↗ Table 1 caption: 'Benchmarking PRIME across different model scales and validation regimes for mutated RBD binding and expression' Version: Version of record, BMC Genomics 2026 (PMC13425921 JATS full text) Retrieved: 2026-10-11T21:30:00Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.source_locator` Source artifact SHA-256: `f6aac4c25dd93026f87ce9a2e327c95faf4c3014d7f9ae04bb11f208ce047971` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Split Random split and position-stratified split Context-only references	PRIME: An evaluation framework for protein representation inference and generalization in viral mutation space Original source ↗ Table 1 caption: 'Benchmarking PRIME across different model scales and validation regimes for mutated RBD binding and expression' Version: Version of record, BMC Genomics 2026 (PMC13425921 JATS full text) Retrieved: 2026-10-11T21:30:00Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.split` Source artifact SHA-256: `f6aac4c25dd93026f87ce9a2e327c95faf4c3014d7f9ae04bb11f208ce047971` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Description Deep mutational scanning measurements of SARS-CoV-2 receptor-binding-domain mutants used by PRIME for binding and expression regression. Context-only references	PRIME: An evaluation framework for protein representation inference and generalization in viral mutation space Original source ↗ Table 1 caption: 'Benchmarking PRIME across different model scales and validation regimes for mutated RBD binding and expression' Version: Version of record, BMC Genomics 2026 (PMC13425921 JATS full text) Retrieved: 2026-10-11T21:30:00Z	not individually reviewed No individual claim review recorded Audit details Field: `description` Source artifact SHA-256: `f6aac4c25dd93026f87ce9a2e327c95faf4c3014d7f9ae04bb11f208ce047971` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Name SARS-CoV-2 RBD mutant binding and expression measurements Context-only references	PRIME: An evaluation framework for protein representation inference and generalization in viral mutation space Original source ↗ Table 1 caption: 'Benchmarking PRIME across different model scales and validation regimes for mutated RBD binding and expression' Version: Version of record, BMC Genomics 2026 (PMC13425921 JATS full text) Retrieved: 2026-10-11T21:30:00Z	not individually reviewed No individual claim review recorded Audit details Field: `name` Source artifact SHA-256: `f6aac4c25dd93026f87ce9a2e327c95faf4c3014d7f9ae04bb11f208ce047971` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact

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Release 2026-10-22-1b7cf027e4f6 · Record review: source checked

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PRIME: An evaluation framework for protein representation inference and generalization in viral mutation space · Original source · Version of record, BMC Genomics 2026 (PMC13425921 JATS full text)

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Stable ID: lit-protein-20261011-prime-data-rbd-mutants

areas: protein-function
contexts: research
population: Mutated SARS-CoV-2 RBD variants with ACE2 binding and expression measurements
split: Random split and position-stratified split
source locator: Table 1 caption: 'Benchmarking PRIME across different model scales and validation regimes for mutated RBD binding and expression'
missing metadata: total: reason: unextracted; note: The variant count is in the Methods text, not in Table 1; version: reason: unreported

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