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1 evaluation · 1 result. Different protocols are not a single leaderboard.
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| Tested configuration | Protocol and dataset | Finding | Evidence and details |
|---|---|---|---|
| Configuration: ESM-2 8M, the CLS token embedding, fine-tuned (PRIME) | Protocol: PRIME ACE2 binding regression, Position-stratified split holding out whole mutated positions, RMSE Dataset: SARS-CoV-2 RBD mutant binding and expression measurements | 1.9653 ± 0.03 RMSE (ACE2 binding; Position-stratified split holding out whole mutated positions; the CLS token embedding, fine-tuned) unit-unreported · lower Uncertainty: SD 0.03 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourcelit-protein-20261011-prime-protocol-position-stratified-binding-rmse Aggregation: Not reported PRIME: An evaluation framework for protein representation inference and generalization in viral mutation space · Table 1, row 'ESM-2 8M' / 'CLS' / '✓', columns 'Position-Stratified Split' / 'Binding' / 'RMSE' |
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PRIME ACE2 binding regression, Position-stratified split holding out whole mutated positions, RMSE
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18 evidence rows matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|---|---|
| Comparison: adaptation Supervised regression head on the representations; backbone fine-tuned Context-only references | PRIME: An evaluation framework for protein representation inference and generalization in viral mutation space Table 1, row 'ESM-2 8M' / 'CLS' / '✓', columns 'Position-Stratified Split' / 'Binding' / 'RMSE' Version: Version of record, BMC Genomics 2026 (PMC13425921 JATS full text) | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Comparison: aggregation Mean with standard deviation across random seeds, over five cross-validation folds (Table 1 footnote; Fig. 1C) Context-only references | PRIME: An evaluation framework for protein representation inference and generalization in viral mutation space Table 1, row 'ESM-2 8M' / 'CLS' / '✓', columns 'Position-Stratified Split' / 'Binding' / 'RMSE' Version: Version of record, BMC Genomics 2026 (PMC13425921 JATS full text) | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Comparison: budget Not reported Context-only references | PRIME: An evaluation framework for protein representation inference and generalization in viral mutation space Table 1, row 'ESM-2 8M' / 'CLS' / '✓', columns 'Position-Stratified Split' / 'Binding' / 'RMSE' Version: Version of record, BMC Genomics 2026 (PMC13425921 JATS full text) | missing or unspecified No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Comparison: dataset version Not reported Context-only references | PRIME: An evaluation framework for protein representation inference and generalization in viral mutation space Table 1, row 'ESM-2 8M' / 'CLS' / '✓', columns 'Position-Stratified Split' / 'Binding' / 'RMSE' Version: Version of record, BMC Genomics 2026 (PMC13425921 JATS full text) | missing or unspecified No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Comparison: inputs RBD mutant sequence; the CLS token embedding, fine-tuned Context-only references | PRIME: An evaluation framework for protein representation inference and generalization in viral mutation space Table 1, row 'ESM-2 8M' / 'CLS' / '✓', columns 'Position-Stratified Split' / 'Binding' / 'RMSE' Version: Version of record, BMC Genomics 2026 (PMC13425921 JATS full text) | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Comparison: metric implementation RMSE Context-only references | PRIME: An evaluation framework for protein representation inference and generalization in viral mutation space Table 1, row 'ESM-2 8M' / 'CLS' / '✓', columns 'Position-Stratified Split' / 'Binding' / 'RMSE' Version: Version of record, BMC Genomics 2026 (PMC13425921 JATS full text) | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Comparison: population RBD mutants with measured binding and expression Context-only references | PRIME: An evaluation framework for protein representation inference and generalization in viral mutation space Table 1, row 'ESM-2 8M' / 'CLS' / '✓', columns 'Position-Stratified Split' / 'Binding' / 'RMSE' Version: Version of record, BMC Genomics 2026 (PMC13425921 JATS full text) | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Comparison: protocol id lit-protein-20261011-prime-protocol-position-stratified-binding-rmse Context-only references | PRIME: An evaluation framework for protein representation inference and generalization in viral mutation space Table 1, row 'ESM-2 8M' / 'CLS' / '✓', columns 'Position-Stratified Split' / 'Binding' / 'RMSE' Version: Version of record, BMC Genomics 2026 (PMC13425921 JATS full text) | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Comparison: split Position-stratified split holding out whole mutated positions Context-only references | PRIME: An evaluation framework for protein representation inference and generalization in viral mutation space Table 1, row 'ESM-2 8M' / 'CLS' / '✓', columns 'Position-Stratified Split' / 'Binding' / 'RMSE' Version: Version of record, BMC Genomics 2026 (PMC13425921 JATS full text) | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Origin author_reported Context-only references | PRIME: An evaluation framework for protein representation inference and generalization in viral mutation space Table 1, row 'ESM-2 8M' / 'CLS' / '✓', columns 'Position-Stratified Split' / 'Binding' / 'RMSE' Version: Version of record, BMC Genomics 2026 (PMC13425921 JATS full text) | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
Release 2026-10-22-1b7cf027e4f6 · Record review: source checked
Stable ID: lit-protein-20261011-prime-eval-position-stratified-binding-rmse-esm-2-8m-cls-finetuned