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NABench: Large-Scale Benchmarks of Nucleotide Foundation Models for Fitness Prediction

Primary full-text snapshot retrieved 2026-09-17; exact bytes pinned by SHA-256

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Results

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Model or configurationMetricValueDatasetEvaluation
AIDO.RNASpearman0.218 unitlessNABench aptamer assays (NABench split)AIDO.RNA on NABench CCV-CORR-APTAMER: Fitness prediction on aptamer assays, supervised, contiguous cross validation
AIDO.RNASpearman0.015 unitlessNABench enhancer assays (NABench split)AIDO.RNA on NABench CCV-CORR-ENHANCER: Fitness prediction on enhancer assays, supervised, contiguous cross validation
AIDO.RNASpearman0.143 unitlessNABench mRNA assays (NABench split)AIDO.RNA on NABench CCV-CORR-MRNA: Fitness prediction on mRNA assays, supervised, contiguous cross validation
AIDO.RNASpearman0.095 unitlessNABench promoter assays (NABench split)AIDO.RNA on NABench CCV-CORR-PROMOTER: Fitness prediction on promoter assays, supervised, contiguous cross validation
AIDO.RNASpearman0.219 unitlessNABench ribozyme assays (NABench split)AIDO.RNA on NABench CCV-CORR-RIBOZYME: Fitness prediction on ribozyme assays, supervised, contiguous cross validation
AIDO.RNASpearman0.309 unitlessNABench tRNA assays (NABench split)AIDO.RNA on NABench CCV-CORR-TRNA: Fitness prediction on tRNA assays, supervised, contiguous cross validation
AIDO.RNASpearman0.207 unitlessNABench deep mutational scanning assays (NABench split)AIDO.RNA on NABench DMS-CCV: Overall fitness prediction on NABench deep mutational scanning assays, Contiguous cross validation Spearman ρ
AIDO.RNASpearman0.201 unitlessNABench deep mutational scanning assays (NABench split)AIDO.RNA on NABench DMS-FS: Overall fitness prediction on NABench deep mutational scanning assays, Few-shot Spearman ρ
AIDO.RNASpearman0.486 unitlessNABench deep mutational scanning assays (NABench split)AIDO.RNA on NABench DMS-RCV: Overall fitness prediction on NABench deep mutational scanning assays, Random cross validation Spearman ρ
AIDO.RNAAUROC0.472 unitlessNABench deep mutational scanning assays (NABench split)AIDO.RNA on NABench DMS-ZS-AUC: Overall fitness prediction on NABench deep mutational scanning assays, Zero-shot AUC
AIDO.RNASpearman0.098 unitlessNABench deep mutational scanning assays (NABench split)AIDO.RNA on NABench DMS-ZS-CORR: Overall fitness prediction on NABench deep mutational scanning assays, Zero-shot Spearman ρ
AIDO.RNAMCC0.049 unitlessNABench deep mutational scanning assays (NABench split)AIDO.RNA on NABench DMS-ZS-MCC: Overall fitness prediction on NABench deep mutational scanning assays, Zero-shot MCC
AIDO.RNANDCG (cutoff not stated)0.324 unitlessNABench deep mutational scanning assays (NABench split)AIDO.RNA on NABench DMS-ZS-NDCG: Overall fitness prediction on NABench deep mutational scanning assays, Zero-shot NDCG
AIDO.RNASpearman0.232 unitlessNABench aptamer assays (NABench split)AIDO.RNA on NABench FS-CORR-APTAMER: Fitness prediction on aptamer assays, few-shot
AIDO.RNASpearman0.033 unitlessNABench enhancer assays (NABench split)AIDO.RNA on NABench FS-CORR-ENHANCER: Fitness prediction on enhancer assays, few-shot
AIDO.RNASpearman0.297 unitlessNABench mRNA assays (NABench split)AIDO.RNA on NABench FS-CORR-MRNA: Fitness prediction on mRNA assays, few-shot
AIDO.RNASpearman0.126 unitlessNABench promoter assays (NABench split)AIDO.RNA on NABench FS-CORR-PROMOTER: Fitness prediction on promoter assays, few-shot
AIDO.RNASpearman0.201 unitlessNABench ribozyme assays (NABench split)AIDO.RNA on NABench FS-CORR-RIBOZYME: Fitness prediction on ribozyme assays, few-shot
AIDO.RNASpearman0.256 unitlessNABench tRNA assays (NABench split)AIDO.RNA on NABench FS-CORR-TRNA: Fitness prediction on tRNA assays, few-shot
AIDO.RNASpearman0.480 unitlessNABench aptamer assays (NABench split)AIDO.RNA on NABench RCV-CORR-APTAMER: Fitness prediction on aptamer assays, supervised, random cross validation
AIDO.RNASpearman0.200 unitlessNABench enhancer assays (NABench split)AIDO.RNA on NABench RCV-CORR-ENHANCER: Fitness prediction on enhancer assays, supervised, random cross validation
AIDO.RNASpearman0.565 unitlessNABench mRNA assays (NABench split)AIDO.RNA on NABench RCV-CORR-MRNA: Fitness prediction on mRNA assays, supervised, random cross validation
AIDO.RNASpearman0.481 unitlessNABench promoter assays (NABench split)AIDO.RNA on NABench RCV-CORR-PROMOTER: Fitness prediction on promoter assays, supervised, random cross validation
AIDO.RNASpearman0.495 unitlessNABench ribozyme assays (NABench split)AIDO.RNA on NABench RCV-CORR-RIBOZYME: Fitness prediction on ribozyme assays, supervised, random cross validation
AIDO.RNASpearman0.549 unitlessNABench tRNA assays (NABench split)AIDO.RNA on NABench RCV-CORR-TRNA: Fitness prediction on tRNA assays, supervised, random cross validation
AIDO.RNASpearman0.599 unitlessNABench SELEX assays (NABench split)AIDO.RNA on NABench SELEX-FS: Overall fitness prediction on NABench SELEX assays, Few-shot Spearman ρ
AIDO.RNASpearman0.687 unitlessNABench SELEX assays (NABench split)AIDO.RNA on NABench SELEX-RCV: Overall fitness prediction on NABench SELEX assays, Random cross validation Spearman ρ
AIDO.RNAAUROC0.547 unitlessNABench SELEX assays (NABench split)AIDO.RNA on NABench SELEX-ZS-AUC: Overall fitness prediction on NABench SELEX assays, Zero-shot AUC
AIDO.RNASpearman0.08 unitlessNABench SELEX assays (NABench split)AIDO.RNA on NABench SELEX-ZS-CORR: Overall fitness prediction on NABench SELEX assays, Zero-shot Spearman ρ
AIDO.RNAMCC0.045 unitlessNABench SELEX assays (NABench split)AIDO.RNA on NABench SELEX-ZS-MCC: Overall fitness prediction on NABench SELEX assays, Zero-shot MCC
AIDO.RNANDCG (cutoff not stated)0.266 unitlessNABench SELEX assays (NABench split)AIDO.RNA on NABench SELEX-ZS-NDCG: Overall fitness prediction on NABench SELEX assays, Zero-shot NDCG
AIDO.RNAAUROC0.578 unitlessNABench aptamer assays (NABench split)AIDO.RNA on NABench ZS-AUC-APTAMER: Fitness prediction on aptamer assays, zero-shot
AIDO.RNAAUROC0.551 unitlessNABench enhancer assays (NABench split)AIDO.RNA on NABench ZS-AUC-ENHANCER: Fitness prediction on enhancer assays, zero-shot
AIDO.RNAAUROC0.591 unitlessNABench mRNA assays (NABench split)AIDO.RNA on NABench ZS-AUC-MRNA: Fitness prediction on mRNA assays, zero-shot
AIDO.RNAAUROC0.546 unitlessNABench promoter assays (NABench split)AIDO.RNA on NABench ZS-AUC-PROMOTER: Fitness prediction on promoter assays, zero-shot
AIDO.RNAAUROC0.554 unitlessNABench ribozyme assays (NABench split)AIDO.RNA on NABench ZS-AUC-RIBOZYME: Fitness prediction on ribozyme assays, zero-shot
AIDO.RNAAUROC0.540 unitlessNABench tRNA assays (NABench split)AIDO.RNA on NABench ZS-AUC-TRNA: Fitness prediction on tRNA assays, zero-shot
AIDO.RNASpearman0.140 unitlessNABench aptamer assays (NABench split)AIDO.RNA on NABench ZS-CORR-APTAMER: Fitness prediction on aptamer assays, zero-shot
AIDO.RNASpearman0.057 unitlessNABench enhancer assays (NABench split)AIDO.RNA on NABench ZS-CORR-ENHANCER: Fitness prediction on enhancer assays, zero-shot
AIDO.RNASpearman0.069 unitlessNABench mRNA assays (NABench split)AIDO.RNA on NABench ZS-CORR-MRNA: Fitness prediction on mRNA assays, zero-shot
AIDO.RNASpearman0.059 unitlessNABench promoter assays (NABench split)AIDO.RNA on NABench ZS-CORR-PROMOTER: Fitness prediction on promoter assays, zero-shot
AIDO.RNASpearman0.109 unitlessNABench ribozyme assays (NABench split)AIDO.RNA on NABench ZS-CORR-RIBOZYME: Fitness prediction on ribozyme assays, zero-shot
AIDO.RNASpearman0.071 unitlessNABench tRNA assays (NABench split)AIDO.RNA on NABench ZS-CORR-TRNA: Fitness prediction on tRNA assays, zero-shot
BiRNA-BERTSpearman0.095 unitlessNABench aptamer assays (NABench split)BiRNA-BERT on NABench CCV-CORR-APTAMER: Fitness prediction on aptamer assays, supervised, contiguous cross validation
BiRNA-BERTSpearman0.057 unitlessNABench enhancer assays (NABench split)BiRNA-BERT on NABench CCV-CORR-ENHANCER: Fitness prediction on enhancer assays, supervised, contiguous cross validation
BiRNA-BERTSpearman0.238 unitlessNABench mRNA assays (NABench split)BiRNA-BERT on NABench CCV-CORR-MRNA: Fitness prediction on mRNA assays, supervised, contiguous cross validation
BiRNA-BERTSpearman0.031 unitlessNABench promoter assays (NABench split)BiRNA-BERT on NABench CCV-CORR-PROMOTER: Fitness prediction on promoter assays, supervised, contiguous cross validation
BiRNA-BERTSpearman0.193 unitlessNABench ribozyme assays (NABench split)BiRNA-BERT on NABench CCV-CORR-RIBOZYME: Fitness prediction on ribozyme assays, supervised, contiguous cross validation
BiRNA-BERTSpearman0.163 unitlessNABench tRNA assays (NABench split)BiRNA-BERT on NABench CCV-CORR-TRNA: Fitness prediction on tRNA assays, supervised, contiguous cross validation
BiRNA-BERTSpearman0.167 unitlessNABench deep mutational scanning assays (NABench split)BiRNA-BERT on NABench DMS-CCV: Overall fitness prediction on NABench deep mutational scanning assays, Contiguous cross validation Spearman ρ

Claims

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Models, benchmarks and other records

Configurations (27)

Benchmarks (1)

Tasks (43)

Dataset subsets (8)

Evaluations (1,101)

Evidence

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Claims, original sources and review scope · Release 2026-11-02-a7f03c9e55a5
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fefd48d53b1a7eadf9e14db96adacc8e646304c1b592562d9f136f4508941350
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NABench: Large-Scale Benchmarks of Nucleotide Foundation Models for Fitness Prediction

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NABench: Large-Scale Benchmarks of Nucleotide Foundation Models for Fitness Prediction

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NABench: Large-Scale Benchmarks of Nucleotide Foundation Models for Fitness Prediction

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NABench: Large-Scale Benchmarks of Nucleotide Foundation Models for Fitness Prediction

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NABench: Large-Scale Benchmarks of Nucleotide Foundation Models for Fitness Prediction

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NABench: Large-Scale Benchmarks of Nucleotide Foundation Models for Fitness Prediction

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NABench: Large-Scale Benchmarks of Nucleotide Foundation Models for Fitness Prediction

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NABench: Large-Scale Benchmarks of Nucleotide Foundation Models for Fitness Prediction

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NABench: Large-Scale Benchmarks of Nucleotide Foundation Models for Fitness Prediction

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NABench: Large-Scale Benchmarks of Nucleotide Foundation Models for Fitness Prediction

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url
https://arxiv.org/html/2511.02888v1
version
Primary full-text snapshot retrieved 2026-09-17; exact bytes pinned by SHA-256
retrieved at
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artifact sha256
fefd48d53b1a7eadf9e14db96adacc8e646304c1b592562d9f136f4508941350
artifact url
https://arxiv.org/html/2511.02888v1
hash scope
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review
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