Protocol

FASTQ-to-VCF runtime, core-hours and Azure cost of three Sentieon DNAscope pipelines on one 120-vCPU instance (Hu et al. 2026 Table 2)

Runtime by stage, core-hours and compute cost for DNAscope Hybrid, DNAscope LongRead and DNAscope short-read pipelines.

Overview

An explanatory profile has not yet been reviewed for this record.

Consult the linked sources for architecture or protocol details. Missing evidence is not evidence of a missing capability.

3 recorded evaluations, 21 metric rows. A comparison chart has not yet been validated for these results. The table retains the individual findings and their sources.

View coverage and remaining gaps across all benchmarks

Results

Results are available, but no reviewed comparison panel is linked in this release.

All evaluations

3 evaluations · 21 results. Different protocols are not a single leaderboard.

Protocol: FASTQ-to-VCF runtime, core-hours and Azure cost of three Sentieon DNAscope pipelines on one 120-vCPU instance (Hu et al. 2026 Table 2)

Sorted by Compute cost (Azure on-demand price, FASTQ to VCF; 10x PacBio HiFi plus 35x Illumina) (lower is better). The best value in each column is highlighted. Decimals are rounded for display; each value links to the printed value and its source.

Tested configuration	Protocol and dataset	Compute cost (Azure on-demand price, FASTQ to VCF; 10x PacBio HiFi plus 35x Illumina)	Compute cost (Azure on-demand price, FASTQ to VCF; 30x Illumina)	Compute cost (Azure on-demand price, FASTQ to VCF; 30x PacBio HiFi)	Compute cost (Azure spot price, FASTQ to VCF; 10x PacBio HiFi plus 35x Illumina)	Compute cost (Azure spot price, FASTQ to VCF; 30x Illumina)	Compute cost (Azure spot price, FASTQ to VCF; 30x PacBio HiFi)	CPU time (total, FASTQ to VCF; 10x PacBio HiFi plus 35x Illumina)	CPU time (total, FASTQ to VCF; 30x Illumina)	CPU time (total, FASTQ to VCF; 30x PacBio HiFi)	Runtime (alignment stage; 10x PacBio HiFi plus 35x Illumina)	Runtime (alignment stage; 30x Illumina)	Runtime (alignment stage; 30x PacBio HiFi)	Runtime (preprocessing stage; 10x PacBio HiFi plus 35x Illumina)	Runtime (preprocessing stage; 30x Illumina)	Runtime (preprocessing stage; 30x PacBio HiFi)	Runtime (total, FASTQ to VCF; 10x PacBio HiFi plus 35x Illumina)	Runtime (total, FASTQ to VCF; 30x Illumina)	Runtime (total, FASTQ to VCF; 30x PacBio HiFi)	Runtime (variant calling stage; 10x PacBio HiFi plus 35x Illumina)	Runtime (variant calling stage; 30x Illumina)	Runtime (variant calling stage; 30x PacBio HiFi)
Sentieon DNAscope Hybrid on Azure HB120rs v3 (Hu et al. 2026)Evaluation	10x PacBio HiFi plus 35x Illumina WGS input for DNAscope Hybrid (Hu et al. 2026 Table 2)	5.2	Not reported	Not reported	0.52	Not reported	Not reported	172	Not reported	Not reported	18.8	Not reported	Not reported	2	Not reported	Not reported	85.8	Not reported	Not reported	65	Not reported	Not reported
Sentieon DNAscope LongRead on Azure HB120rs v3 (Hu et al. 2026)Evaluation	30x PacBio HiFi WGS input for DNAscope LongRead (Hu et al. 2026 Table 2)	Not reported	Not reported	2.5	Not reported	Not reported	0.25	Not reported	Not reported	82.5	Not reported	Not reported	11.5	Not reported	Not reported	0	Not reported	Not reported	41.2	Not reported	Not reported	29.8
Sentieon DNAscope (short reads) on Azure HB120rs v3 (Hu et al. 2026)Evaluation	30x Illumina WGS input for DNAscope (short reads) (Hu et al. 2026 Table 2)	Not reported	1.1	Not reported	Not reported	0.11	Not reported	Not reported	37.8	Not reported	Not reported	9.7	Not reported	Not reported	1.4	Not reported	Not reported	18.9	Not reported	Not reported	7.8	Not reported

All 21 result rows with coverage, uncertainty and sources

Filter evaluations

Tested model or methodProtocolDatasetEvaluation setupMetricEvidence origin

Applied filters: All linked evaluations

Exact evaluated configurations and original reported results
Tested configuration	Protocol and dataset	Finding	Evidence and details
Configuration: Sentieon DNAscope Hybrid on Azure HB120rs v3 (Hu et al. 2026)	Protocol: FASTQ-to-VCF runtime, core-hours and Azure cost of three Sentieon DNAscope pipelines on one 120-vCPU instance (Hu et al. 2026 Table 2) Dataset: 10x PacBio HiFi plus 35x Illumina WGS input for DNAscope Hybrid (Hu et al. 2026 Table 2)	18.8 Runtime (alignment stage; 10x PacBio HiFi plus 35x Illumina) minute · lower Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source DNAscope Hybrid compute benchmark on Azure (Hu et al. 2026) model-execution-20261011-protocol-hu2026-dnascope-azure-compute Aggregation: Not reported A novel and accelerated method for integrated alignment and variant calling from short and long reads · Table 2, row 'Alignment (min)', column 'DNAscope Hybrid'
Configuration: Sentieon DNAscope Hybrid on Azure HB120rs v3 (Hu et al. 2026)	Protocol: FASTQ-to-VCF runtime, core-hours and Azure cost of three Sentieon DNAscope pipelines on one 120-vCPU instance (Hu et al. 2026 Table 2) Dataset: 10x PacBio HiFi plus 35x Illumina WGS input for DNAscope Hybrid (Hu et al. 2026 Table 2)	172 CPU time (total, FASTQ to VCF; 10x PacBio HiFi plus 35x Illumina) hour · lower Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source DNAscope Hybrid compute benchmark on Azure (Hu et al. 2026) model-execution-20261011-protocol-hu2026-dnascope-azure-compute Aggregation: Not reported A novel and accelerated method for integrated alignment and variant calling from short and long reads · Table 2, row 'Core-hours', column 'DNAscope Hybrid'
Configuration: Sentieon DNAscope Hybrid on Azure HB120rs v3 (Hu et al. 2026)	Protocol: FASTQ-to-VCF runtime, core-hours and Azure cost of three Sentieon DNAscope pipelines on one 120-vCPU instance (Hu et al. 2026 Table 2) Dataset: 10x PacBio HiFi plus 35x Illumina WGS input for DNAscope Hybrid (Hu et al. 2026 Table 2)	5.2 Compute cost (Azure on-demand price, FASTQ to VCF; 10x PacBio HiFi plus 35x Illumina) us-dollar · lower Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source DNAscope Hybrid compute benchmark on Azure (Hu et al. 2026) model-execution-20261011-protocol-hu2026-dnascope-azure-compute Aggregation: Not reported A novel and accelerated method for integrated alignment and variant calling from short and long reads · Table 2, row 'On-demand ($)', column 'DNAscope Hybrid'
Configuration: Sentieon DNAscope Hybrid on Azure HB120rs v3 (Hu et al. 2026)	Protocol: FASTQ-to-VCF runtime, core-hours and Azure cost of three Sentieon DNAscope pipelines on one 120-vCPU instance (Hu et al. 2026 Table 2) Dataset: 10x PacBio HiFi plus 35x Illumina WGS input for DNAscope Hybrid (Hu et al. 2026 Table 2)	2 Runtime (preprocessing stage; 10x PacBio HiFi plus 35x Illumina) minute · lower Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source DNAscope Hybrid compute benchmark on Azure (Hu et al. 2026) model-execution-20261011-protocol-hu2026-dnascope-azure-compute Aggregation: Not reported A novel and accelerated method for integrated alignment and variant calling from short and long reads · Table 2, row 'Preprocessing (min)', column 'DNAscope Hybrid'
Configuration: Sentieon DNAscope Hybrid on Azure HB120rs v3 (Hu et al. 2026)	Protocol: FASTQ-to-VCF runtime, core-hours and Azure cost of three Sentieon DNAscope pipelines on one 120-vCPU instance (Hu et al. 2026 Table 2) Dataset: 10x PacBio HiFi plus 35x Illumina WGS input for DNAscope Hybrid (Hu et al. 2026 Table 2)	0.52 Compute cost (Azure spot price, FASTQ to VCF; 10x PacBio HiFi plus 35x Illumina) us-dollar · lower Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source DNAscope Hybrid compute benchmark on Azure (Hu et al. 2026) model-execution-20261011-protocol-hu2026-dnascope-azure-compute Aggregation: Not reported A novel and accelerated method for integrated alignment and variant calling from short and long reads · Table 2, row 'Spot ($)', column 'DNAscope Hybrid'
Configuration: Sentieon DNAscope Hybrid on Azure HB120rs v3 (Hu et al. 2026)	Protocol: FASTQ-to-VCF runtime, core-hours and Azure cost of three Sentieon DNAscope pipelines on one 120-vCPU instance (Hu et al. 2026 Table 2) Dataset: 10x PacBio HiFi plus 35x Illumina WGS input for DNAscope Hybrid (Hu et al. 2026 Table 2)	85.8 Runtime (total, FASTQ to VCF; 10x PacBio HiFi plus 35x Illumina) minute · lower Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source DNAscope Hybrid compute benchmark on Azure (Hu et al. 2026) model-execution-20261011-protocol-hu2026-dnascope-azure-compute Aggregation: Not reported A novel and accelerated method for integrated alignment and variant calling from short and long reads · Table 2, row 'Total runtime (min)', column 'DNAscope Hybrid'
Configuration: Sentieon DNAscope Hybrid on Azure HB120rs v3 (Hu et al. 2026)	Protocol: FASTQ-to-VCF runtime, core-hours and Azure cost of three Sentieon DNAscope pipelines on one 120-vCPU instance (Hu et al. 2026 Table 2) Dataset: 10x PacBio HiFi plus 35x Illumina WGS input for DNAscope Hybrid (Hu et al. 2026 Table 2)	65 Runtime (variant calling stage; 10x PacBio HiFi plus 35x Illumina) minute · lower Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source DNAscope Hybrid compute benchmark on Azure (Hu et al. 2026) model-execution-20261011-protocol-hu2026-dnascope-azure-compute Aggregation: Not reported A novel and accelerated method for integrated alignment and variant calling from short and long reads · Table 2, row 'Variant calling (min)', column 'DNAscope Hybrid'
Configuration: Sentieon DNAscope LongRead on Azure HB120rs v3 (Hu et al. 2026)	Protocol: FASTQ-to-VCF runtime, core-hours and Azure cost of three Sentieon DNAscope pipelines on one 120-vCPU instance (Hu et al. 2026 Table 2) Dataset: 30x PacBio HiFi WGS input for DNAscope LongRead (Hu et al. 2026 Table 2)	11.5 Runtime (alignment stage; 30x PacBio HiFi) minute · lower Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source DNAscope LongRead compute benchmark on Azure (Hu et al. 2026) model-execution-20261011-protocol-hu2026-dnascope-azure-compute Aggregation: Not reported A novel and accelerated method for integrated alignment and variant calling from short and long reads · Table 2, row 'Alignment (min)', column 'DNAscope LongRead'
Configuration: Sentieon DNAscope LongRead on Azure HB120rs v3 (Hu et al. 2026)	Protocol: FASTQ-to-VCF runtime, core-hours and Azure cost of three Sentieon DNAscope pipelines on one 120-vCPU instance (Hu et al. 2026 Table 2) Dataset: 30x PacBio HiFi WGS input for DNAscope LongRead (Hu et al. 2026 Table 2)	82.5 CPU time (total, FASTQ to VCF; 30x PacBio HiFi) hour · lower Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source DNAscope LongRead compute benchmark on Azure (Hu et al. 2026) model-execution-20261011-protocol-hu2026-dnascope-azure-compute Aggregation: Not reported A novel and accelerated method for integrated alignment and variant calling from short and long reads · Table 2, row 'Core-hours', column 'DNAscope LongRead'
Configuration: Sentieon DNAscope LongRead on Azure HB120rs v3 (Hu et al. 2026)	Protocol: FASTQ-to-VCF runtime, core-hours and Azure cost of three Sentieon DNAscope pipelines on one 120-vCPU instance (Hu et al. 2026 Table 2) Dataset: 30x PacBio HiFi WGS input for DNAscope LongRead (Hu et al. 2026 Table 2)	2.5 Compute cost (Azure on-demand price, FASTQ to VCF; 30x PacBio HiFi) us-dollar · lower Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source DNAscope LongRead compute benchmark on Azure (Hu et al. 2026) model-execution-20261011-protocol-hu2026-dnascope-azure-compute Aggregation: Not reported A novel and accelerated method for integrated alignment and variant calling from short and long reads · Table 2, row 'On-demand ($)', column 'DNAscope LongRead'
Configuration: Sentieon DNAscope LongRead on Azure HB120rs v3 (Hu et al. 2026)	Protocol: FASTQ-to-VCF runtime, core-hours and Azure cost of three Sentieon DNAscope pipelines on one 120-vCPU instance (Hu et al. 2026 Table 2) Dataset: 30x PacBio HiFi WGS input for DNAscope LongRead (Hu et al. 2026 Table 2)	0 Runtime (preprocessing stage; 30x PacBio HiFi) minute · lower Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source DNAscope LongRead compute benchmark on Azure (Hu et al. 2026) model-execution-20261011-protocol-hu2026-dnascope-azure-compute Aggregation: Not reported A novel and accelerated method for integrated alignment and variant calling from short and long reads · Table 2, row 'Preprocessing (min)', column 'DNAscope LongRead'
Configuration: Sentieon DNAscope LongRead on Azure HB120rs v3 (Hu et al. 2026)	Protocol: FASTQ-to-VCF runtime, core-hours and Azure cost of three Sentieon DNAscope pipelines on one 120-vCPU instance (Hu et al. 2026 Table 2) Dataset: 30x PacBio HiFi WGS input for DNAscope LongRead (Hu et al. 2026 Table 2)	0.25 Compute cost (Azure spot price, FASTQ to VCF; 30x PacBio HiFi) us-dollar · lower Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source DNAscope LongRead compute benchmark on Azure (Hu et al. 2026) model-execution-20261011-protocol-hu2026-dnascope-azure-compute Aggregation: Not reported A novel and accelerated method for integrated alignment and variant calling from short and long reads · Table 2, row 'Spot ($)', column 'DNAscope LongRead'
Configuration: Sentieon DNAscope LongRead on Azure HB120rs v3 (Hu et al. 2026)	Protocol: FASTQ-to-VCF runtime, core-hours and Azure cost of three Sentieon DNAscope pipelines on one 120-vCPU instance (Hu et al. 2026 Table 2) Dataset: 30x PacBio HiFi WGS input for DNAscope LongRead (Hu et al. 2026 Table 2)	41.2 Runtime (total, FASTQ to VCF; 30x PacBio HiFi) minute · lower Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source DNAscope LongRead compute benchmark on Azure (Hu et al. 2026) model-execution-20261011-protocol-hu2026-dnascope-azure-compute Aggregation: Not reported A novel and accelerated method for integrated alignment and variant calling from short and long reads · Table 2, row 'Total runtime (min)', column 'DNAscope LongRead'
Configuration: Sentieon DNAscope LongRead on Azure HB120rs v3 (Hu et al. 2026)	Protocol: FASTQ-to-VCF runtime, core-hours and Azure cost of three Sentieon DNAscope pipelines on one 120-vCPU instance (Hu et al. 2026 Table 2) Dataset: 30x PacBio HiFi WGS input for DNAscope LongRead (Hu et al. 2026 Table 2)	29.8 Runtime (variant calling stage; 30x PacBio HiFi) minute · lower Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source DNAscope LongRead compute benchmark on Azure (Hu et al. 2026) model-execution-20261011-protocol-hu2026-dnascope-azure-compute Aggregation: Not reported A novel and accelerated method for integrated alignment and variant calling from short and long reads · Table 2, row 'Variant calling (min)', column 'DNAscope LongRead'
Configuration: Sentieon DNAscope (short reads) on Azure HB120rs v3 (Hu et al. 2026)	Protocol: FASTQ-to-VCF runtime, core-hours and Azure cost of three Sentieon DNAscope pipelines on one 120-vCPU instance (Hu et al. 2026 Table 2) Dataset: 30x Illumina WGS input for DNAscope (short reads) (Hu et al. 2026 Table 2)	9.7 Runtime (alignment stage; 30x Illumina) minute · lower Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source DNAscope (short reads) compute benchmark on Azure (Hu et al. 2026) model-execution-20261011-protocol-hu2026-dnascope-azure-compute Aggregation: Not reported A novel and accelerated method for integrated alignment and variant calling from short and long reads · Table 2, row 'Alignment (min)', column 'DNAscope (short reads)'
Configuration: Sentieon DNAscope (short reads) on Azure HB120rs v3 (Hu et al. 2026)	Protocol: FASTQ-to-VCF runtime, core-hours and Azure cost of three Sentieon DNAscope pipelines on one 120-vCPU instance (Hu et al. 2026 Table 2) Dataset: 30x Illumina WGS input for DNAscope (short reads) (Hu et al. 2026 Table 2)	37.8 CPU time (total, FASTQ to VCF; 30x Illumina) hour · lower Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source DNAscope (short reads) compute benchmark on Azure (Hu et al. 2026) model-execution-20261011-protocol-hu2026-dnascope-azure-compute Aggregation: Not reported A novel and accelerated method for integrated alignment and variant calling from short and long reads · Table 2, row 'Core-hours', column 'DNAscope (short reads)'
Configuration: Sentieon DNAscope (short reads) on Azure HB120rs v3 (Hu et al. 2026)	Protocol: FASTQ-to-VCF runtime, core-hours and Azure cost of three Sentieon DNAscope pipelines on one 120-vCPU instance (Hu et al. 2026 Table 2) Dataset: 30x Illumina WGS input for DNAscope (short reads) (Hu et al. 2026 Table 2)	1.1 Compute cost (Azure on-demand price, FASTQ to VCF; 30x Illumina) us-dollar · lower Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source DNAscope (short reads) compute benchmark on Azure (Hu et al. 2026) model-execution-20261011-protocol-hu2026-dnascope-azure-compute Aggregation: Not reported A novel and accelerated method for integrated alignment and variant calling from short and long reads · Table 2, row 'On-demand ($)', column 'DNAscope (short reads)'
Configuration: Sentieon DNAscope (short reads) on Azure HB120rs v3 (Hu et al. 2026)	Protocol: FASTQ-to-VCF runtime, core-hours and Azure cost of three Sentieon DNAscope pipelines on one 120-vCPU instance (Hu et al. 2026 Table 2) Dataset: 30x Illumina WGS input for DNAscope (short reads) (Hu et al. 2026 Table 2)	1.4 Runtime (preprocessing stage; 30x Illumina) minute · lower Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source DNAscope (short reads) compute benchmark on Azure (Hu et al. 2026) model-execution-20261011-protocol-hu2026-dnascope-azure-compute Aggregation: Not reported A novel and accelerated method for integrated alignment and variant calling from short and long reads · Table 2, row 'Preprocessing (min)', column 'DNAscope (short reads)'
Configuration: Sentieon DNAscope (short reads) on Azure HB120rs v3 (Hu et al. 2026)	Protocol: FASTQ-to-VCF runtime, core-hours and Azure cost of three Sentieon DNAscope pipelines on one 120-vCPU instance (Hu et al. 2026 Table 2) Dataset: 30x Illumina WGS input for DNAscope (short reads) (Hu et al. 2026 Table 2)	0.11 Compute cost (Azure spot price, FASTQ to VCF; 30x Illumina) us-dollar · lower Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source DNAscope (short reads) compute benchmark on Azure (Hu et al. 2026) model-execution-20261011-protocol-hu2026-dnascope-azure-compute Aggregation: Not reported A novel and accelerated method for integrated alignment and variant calling from short and long reads · Table 2, row 'Spot ($)', column 'DNAscope (short reads)'
Configuration: Sentieon DNAscope (short reads) on Azure HB120rs v3 (Hu et al. 2026)	Protocol: FASTQ-to-VCF runtime, core-hours and Azure cost of three Sentieon DNAscope pipelines on one 120-vCPU instance (Hu et al. 2026 Table 2) Dataset: 30x Illumina WGS input for DNAscope (short reads) (Hu et al. 2026 Table 2)	18.9 Runtime (total, FASTQ to VCF; 30x Illumina) minute · lower Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source DNAscope (short reads) compute benchmark on Azure (Hu et al. 2026) model-execution-20261011-protocol-hu2026-dnascope-azure-compute Aggregation: Not reported A novel and accelerated method for integrated alignment and variant calling from short and long reads · Table 2, row 'Total runtime (min)', column 'DNAscope (short reads)'
Configuration: Sentieon DNAscope (short reads) on Azure HB120rs v3 (Hu et al. 2026)	Protocol: FASTQ-to-VCF runtime, core-hours and Azure cost of three Sentieon DNAscope pipelines on one 120-vCPU instance (Hu et al. 2026 Table 2) Dataset: 30x Illumina WGS input for DNAscope (short reads) (Hu et al. 2026 Table 2)	7.8 Runtime (variant calling stage; 30x Illumina) minute · lower Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source DNAscope (short reads) compute benchmark on Azure (Hu et al. 2026) model-execution-20261011-protocol-hu2026-dnascope-azure-compute Aggregation: Not reported A novel and accelerated method for integrated alignment and variant calling from short and long reads · Table 2, row 'Variant calling (min)', column 'DNAscope (short reads)'

Source checking is not independent reproduction. Release 2026-10-22-1b7cf027e4f6.

Methods and evaluation design

Procedure, tasks and evaluated configurations

Recorded evaluations

Each evaluation records what was tested and under which conditions.

Baseline coverage

Reference methods help show what a model adds beyond simple controls. We track a null control and a conventional method for each protocol.

0 of 2 active baseline roles have published Rewire measurements in this release. Measurements on a selected protocol do not establish coverage of an entire suite.

No execution recipe linked to this protocol. Recipe availability does not establish a completed evaluation.

Author-reported evaluations: 3

Literature evidence is not a Rewire measurement. Executed but unpublished runs and private review status are not included.

Null control

Proposed control: requires review

Select a task-valid null control after reviewing inputs and metric

Protocol-specific applicability, permitted inputs, access, split, evaluator and execution requirements need review before implementation or execution.

This is a suggested selection rule, not a validated method or a measured score.

Conventional reference

Proposed control: requires review

Select an upstream conventional reference after reviewing the full protocol

Protocol-specific applicability, permitted inputs, access, split, evaluator and execution requirements need review before implementation or execution.

This is a suggested selection rule, not a validated method or a measured score.

Protocol coverage CSV (gzip) · Model evaluation matrix (gzip) · Source table (gzip) · Release and checksums (gzip)

Coverage is derived from release 2026-10-22-1b7cf027e4f6. Source citations describe the original records; they do not validate an unreviewed baseline proposal. No results have been generated by this audit.

Run instructions

No runnable recipe has been reviewed for this protocol. Dataset access, model requirements, licences and compute requirements must be checked against its sources before execution.

Strengths, limitations and unresolved questions

Evidence

Source checking verifies the cited claim or transcription. It does not establish independent reproduction.

Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

0 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-10-22-1b7cf027e4f6
Property and statement	Original source and location	Review and provenance

No evidence rows match these filters. Choose another scope or clear the search.

How to read the evidence

Sources and history

Release 2026-10-22-1b7cf027e4f6 · Record review: source checked

1 source record and release history

A novel and accelerated method for integrated alignment and variant calling from short and long reads · Original source · Frontiers in Bioinformatics 5:1691056, published 2026-01-05; PMC12813096 full-text XML

Download this release (gzip)

Technical metadata and extraction receipts

Stable ID: model-execution-20261011-protocol-hu2026-dnascope-azure-compute

areas: dna-genomes
contexts: clinical_research
protocol: Alignment, preprocessing and variant calling from FASTQ on an Azure Standard HB120rs v3 instance; runtime by stage in minutes, total core-hours, on-demand and spot compute cost.
version: Table 2
metric: runtime
limitations: Author-reported by the software vendor: all authors were employed by Sentieon Inc.; The three pipelines run on different inputs (hybrid, long-read and short-read data at different depths), so the table is not a like-for-like comparison.; The sample behind Table 2 is not named; the study's data are GIAB HG002 to HG004 (PacBio Revio and precisionFDA Truth Challenge V2 Illumina).; One value per pipeline is printed; the number of runs behind it is not stated and no spread is printed. The Sentieon software version is not stated for Table 2.; Costs are Azure on-demand and spot prices and exclude the Sentieon licence.; The LongRead and short-read runtimes were previously published in a Microsoft blog post (Results 'Compute resource benchmark').
source locator: Results 'Compute resource benchmark'; Table 2

Related records

uses data: 10x PacBio HiFi plus 35x Illumina WGS input for DNAscope Hybrid (Hu et al. 2026 Table 2)
uses data: 30x PacBio HiFi WGS input for DNAscope LongRead (Hu et al. 2026 Table 2)
uses data: 30x Illumina WGS input for DNAscope (short reads) (Hu et al. 2026 Table 2)
assessment: DNAscope Hybrid compute benchmark on Azure (Hu et al. 2026)
assessment: DNAscope LongRead compute benchmark on Azure (Hu et al. 2026)
assessment: DNAscope (short reads) compute benchmark on Azure (Hu et al. 2026)
assessed by: Select an execution workflow for large-scale diagnostic genomics

Suggest a correction