Configuration

Sentieon DNAscope Hybrid on Azure HB120rs v3 (Hu et al. 2026)

DNAscope Hybrid pipeline; outputs SNP, indel, SV and CNV.

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Evaluations and results

1 evaluation · 7 results. Different protocols are not a single leaderboard.

Protocol: FASTQ-to-VCF runtime, core-hours and Azure cost of three Sentieon DNAscope pipelines on one 120-vCPU instance (Hu et al. 2026 Table 2) · Dataset: 10x PacBio HiFi plus 35x Illumina WGS input for DNAscope Hybrid (Hu et al. 2026 Table 2)

Sorted by Compute cost (Azure on-demand price, FASTQ to VCF; 10x PacBio HiFi plus 35x Illumina) (lower is better). The best value in each column is highlighted. Decimals are rounded for display; each value links to the printed value and its source.

Tested configuration	Compute cost (Azure on-demand price, FASTQ to VCF; 10x PacBio HiFi plus 35x Illumina)	Compute cost (Azure spot price, FASTQ to VCF; 10x PacBio HiFi plus 35x Illumina)	CPU time (total, FASTQ to VCF; 10x PacBio HiFi plus 35x Illumina)	Runtime (alignment stage; 10x PacBio HiFi plus 35x Illumina)	Runtime (preprocessing stage; 10x PacBio HiFi plus 35x Illumina)	Runtime (total, FASTQ to VCF; 10x PacBio HiFi plus 35x Illumina)	Runtime (variant calling stage; 10x PacBio HiFi plus 35x Illumina)
Sentieon DNAscope Hybrid on Azure HB120rs v3 (Hu et al. 2026)Evaluation	5.2	0.52	172	18.8	2	85.8	65

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Tested configuration	Protocol and dataset	Finding	Evidence and details
Configuration: Sentieon DNAscope Hybrid on Azure HB120rs v3 (Hu et al. 2026)	Protocol: FASTQ-to-VCF runtime, core-hours and Azure cost of three Sentieon DNAscope pipelines on one 120-vCPU instance (Hu et al. 2026 Table 2) Dataset: 10x PacBio HiFi plus 35x Illumina WGS input for DNAscope Hybrid (Hu et al. 2026 Table 2)	18.8 Runtime (alignment stage; 10x PacBio HiFi plus 35x Illumina) minute · lower Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source DNAscope Hybrid compute benchmark on Azure (Hu et al. 2026) model-execution-20261011-protocol-hu2026-dnascope-azure-compute Aggregation: Not reported A novel and accelerated method for integrated alignment and variant calling from short and long reads · Table 2, row 'Alignment (min)', column 'DNAscope Hybrid'
Configuration: Sentieon DNAscope Hybrid on Azure HB120rs v3 (Hu et al. 2026)	Protocol: FASTQ-to-VCF runtime, core-hours and Azure cost of three Sentieon DNAscope pipelines on one 120-vCPU instance (Hu et al. 2026 Table 2) Dataset: 10x PacBio HiFi plus 35x Illumina WGS input for DNAscope Hybrid (Hu et al. 2026 Table 2)	172 CPU time (total, FASTQ to VCF; 10x PacBio HiFi plus 35x Illumina) hour · lower Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source DNAscope Hybrid compute benchmark on Azure (Hu et al. 2026) model-execution-20261011-protocol-hu2026-dnascope-azure-compute Aggregation: Not reported A novel and accelerated method for integrated alignment and variant calling from short and long reads · Table 2, row 'Core-hours', column 'DNAscope Hybrid'
Configuration: Sentieon DNAscope Hybrid on Azure HB120rs v3 (Hu et al. 2026)	Protocol: FASTQ-to-VCF runtime, core-hours and Azure cost of three Sentieon DNAscope pipelines on one 120-vCPU instance (Hu et al. 2026 Table 2) Dataset: 10x PacBio HiFi plus 35x Illumina WGS input for DNAscope Hybrid (Hu et al. 2026 Table 2)	5.2 Compute cost (Azure on-demand price, FASTQ to VCF; 10x PacBio HiFi plus 35x Illumina) us-dollar · lower Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source DNAscope Hybrid compute benchmark on Azure (Hu et al. 2026) model-execution-20261011-protocol-hu2026-dnascope-azure-compute Aggregation: Not reported A novel and accelerated method for integrated alignment and variant calling from short and long reads · Table 2, row 'On-demand ($)', column 'DNAscope Hybrid'
Configuration: Sentieon DNAscope Hybrid on Azure HB120rs v3 (Hu et al. 2026)	Protocol: FASTQ-to-VCF runtime, core-hours and Azure cost of three Sentieon DNAscope pipelines on one 120-vCPU instance (Hu et al. 2026 Table 2) Dataset: 10x PacBio HiFi plus 35x Illumina WGS input for DNAscope Hybrid (Hu et al. 2026 Table 2)	2 Runtime (preprocessing stage; 10x PacBio HiFi plus 35x Illumina) minute · lower Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source DNAscope Hybrid compute benchmark on Azure (Hu et al. 2026) model-execution-20261011-protocol-hu2026-dnascope-azure-compute Aggregation: Not reported A novel and accelerated method for integrated alignment and variant calling from short and long reads · Table 2, row 'Preprocessing (min)', column 'DNAscope Hybrid'
Configuration: Sentieon DNAscope Hybrid on Azure HB120rs v3 (Hu et al. 2026)	Protocol: FASTQ-to-VCF runtime, core-hours and Azure cost of three Sentieon DNAscope pipelines on one 120-vCPU instance (Hu et al. 2026 Table 2) Dataset: 10x PacBio HiFi plus 35x Illumina WGS input for DNAscope Hybrid (Hu et al. 2026 Table 2)	0.52 Compute cost (Azure spot price, FASTQ to VCF; 10x PacBio HiFi plus 35x Illumina) us-dollar · lower Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source DNAscope Hybrid compute benchmark on Azure (Hu et al. 2026) model-execution-20261011-protocol-hu2026-dnascope-azure-compute Aggregation: Not reported A novel and accelerated method for integrated alignment and variant calling from short and long reads · Table 2, row 'Spot ($)', column 'DNAscope Hybrid'
Configuration: Sentieon DNAscope Hybrid on Azure HB120rs v3 (Hu et al. 2026)	Protocol: FASTQ-to-VCF runtime, core-hours and Azure cost of three Sentieon DNAscope pipelines on one 120-vCPU instance (Hu et al. 2026 Table 2) Dataset: 10x PacBio HiFi plus 35x Illumina WGS input for DNAscope Hybrid (Hu et al. 2026 Table 2)	85.8 Runtime (total, FASTQ to VCF; 10x PacBio HiFi plus 35x Illumina) minute · lower Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source DNAscope Hybrid compute benchmark on Azure (Hu et al. 2026) model-execution-20261011-protocol-hu2026-dnascope-azure-compute Aggregation: Not reported A novel and accelerated method for integrated alignment and variant calling from short and long reads · Table 2, row 'Total runtime (min)', column 'DNAscope Hybrid'
Configuration: Sentieon DNAscope Hybrid on Azure HB120rs v3 (Hu et al. 2026)	Protocol: FASTQ-to-VCF runtime, core-hours and Azure cost of three Sentieon DNAscope pipelines on one 120-vCPU instance (Hu et al. 2026 Table 2) Dataset: 10x PacBio HiFi plus 35x Illumina WGS input for DNAscope Hybrid (Hu et al. 2026 Table 2)	65 Runtime (variant calling stage; 10x PacBio HiFi plus 35x Illumina) minute · lower Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source DNAscope Hybrid compute benchmark on Azure (Hu et al. 2026) model-execution-20261011-protocol-hu2026-dnascope-azure-compute Aggregation: Not reported A novel and accelerated method for integrated alignment and variant calling from short and long reads · Table 2, row 'Variant calling (min)', column 'DNAscope Hybrid'

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A novel and accelerated method for integrated alignment and variant calling from short and long reads · Original source · Frontiers in Bioinformatics 5:1691056, published 2026-01-05; PMC12813096 full-text XML

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Technical metadata and extraction receipts

Stable ID: model-execution-20261011-config-hu2026-dnascope-hybrid-azure-hb120rs-v3

areas: dna-genomes
contexts: clinical_research
method types: conventional_pipeline
reported name: DNAscope Hybrid
foundation model eligible: false
hardware: description: Azure Standard HB120rs v3: 120 vCPUs, 456 GiB memory, 512 GB premium SSD (Table 2 caption)
protocol: DNAscope Hybrid pipeline from FASTQ; outputs SNP, indel, SV and CNV
access reuse: Commercial licensed software
source locator: Table 2 caption and column 'DNAscope Hybrid'
missing metadata: version: reason: unreported; note: Sentieon release not stated for Table 2

Related records

configuration of: Sentieon DNAscope
system: DNAscope Hybrid compute benchmark on Azure (Hu et al. 2026)

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