rewirebio.iobenchmarks
Evaluation

DNAscope (short reads) compute benchmark on Azure (Hu et al. 2026)

Published pipeline execution benchmark; transcribed, not reproduced.

Evaluation results

1 evaluation · 7 results. Different protocols are not a single leaderboard.

Protocol: FASTQ-to-VCF runtime, core-hours and Azure cost of three Sentieon DNAscope pipelines on one 120-vCPU instance (Hu et al. 2026 Table 2) · Dataset: 30x Illumina WGS input for DNAscope (short reads) (Hu et al. 2026 Table 2)

Sorted by Compute cost (Azure on-demand price, FASTQ to VCF; 30x Illumina) (lower is better). The best value in each column is highlighted. Decimals are rounded for display; each value links to the printed value and its source.

Tested configurationCompute cost (Azure on-demand price, FASTQ to VCF; 30x Illumina)Compute cost (Azure spot price, FASTQ to VCF; 30x Illumina)CPU time (total, FASTQ to VCF; 30x Illumina)Runtime (alignment stage; 30x Illumina)Runtime (preprocessing stage; 30x Illumina)Runtime (total, FASTQ to VCF; 30x Illumina)Runtime (variant calling stage; 30x Illumina)
Sentieon DNAscope (short reads) on Azure HB120rs v3 (Hu et al. 2026)Evaluation1.10.1137.89.71.418.97.8
All 7 result rows with coverage, uncertainty and sources
Filter evaluations

Applied filters: All linked evaluations

Exact evaluated configurations and original reported results
Tested configurationProtocol and datasetFindingEvidence and details
Configuration: Sentieon DNAscope (short reads) on Azure HB120rs v3 (Hu et al. 2026)Protocol: FASTQ-to-VCF runtime, core-hours and Azure cost of three Sentieon DNAscope pipelines on one 120-vCPU instance (Hu et al. 2026 Table 2)
Dataset: 30x Illumina WGS input for DNAscope (short reads) (Hu et al. 2026 Table 2)
9.7 Runtime (alignment stage; 30x Illumina)
minute · lower

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

DNAscope (short reads) compute benchmark on Azure (Hu et al. 2026)

model-execution-20261011-protocol-hu2026-dnascope-azure-compute

Aggregation: Not reported

A novel and accelerated method for integrated alignment and variant calling from short and long reads · Table 2, row 'Alignment (min)', column 'DNAscope (short reads)'
Configuration: Sentieon DNAscope (short reads) on Azure HB120rs v3 (Hu et al. 2026)Protocol: FASTQ-to-VCF runtime, core-hours and Azure cost of three Sentieon DNAscope pipelines on one 120-vCPU instance (Hu et al. 2026 Table 2)
Dataset: 30x Illumina WGS input for DNAscope (short reads) (Hu et al. 2026 Table 2)
37.8 CPU time (total, FASTQ to VCF; 30x Illumina)
hour · lower

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

DNAscope (short reads) compute benchmark on Azure (Hu et al. 2026)

model-execution-20261011-protocol-hu2026-dnascope-azure-compute

Aggregation: Not reported

A novel and accelerated method for integrated alignment and variant calling from short and long reads · Table 2, row 'Core-hours', column 'DNAscope (short reads)'
Configuration: Sentieon DNAscope (short reads) on Azure HB120rs v3 (Hu et al. 2026)Protocol: FASTQ-to-VCF runtime, core-hours and Azure cost of three Sentieon DNAscope pipelines on one 120-vCPU instance (Hu et al. 2026 Table 2)
Dataset: 30x Illumina WGS input for DNAscope (short reads) (Hu et al. 2026 Table 2)
1.1 Compute cost (Azure on-demand price, FASTQ to VCF; 30x Illumina)
us-dollar · lower

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

DNAscope (short reads) compute benchmark on Azure (Hu et al. 2026)

model-execution-20261011-protocol-hu2026-dnascope-azure-compute

Aggregation: Not reported

A novel and accelerated method for integrated alignment and variant calling from short and long reads · Table 2, row 'On-demand ($)', column 'DNAscope (short reads)'
Configuration: Sentieon DNAscope (short reads) on Azure HB120rs v3 (Hu et al. 2026)Protocol: FASTQ-to-VCF runtime, core-hours and Azure cost of three Sentieon DNAscope pipelines on one 120-vCPU instance (Hu et al. 2026 Table 2)
Dataset: 30x Illumina WGS input for DNAscope (short reads) (Hu et al. 2026 Table 2)
1.4 Runtime (preprocessing stage; 30x Illumina)
minute · lower

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

DNAscope (short reads) compute benchmark on Azure (Hu et al. 2026)

model-execution-20261011-protocol-hu2026-dnascope-azure-compute

Aggregation: Not reported

A novel and accelerated method for integrated alignment and variant calling from short and long reads · Table 2, row 'Preprocessing (min)', column 'DNAscope (short reads)'
Configuration: Sentieon DNAscope (short reads) on Azure HB120rs v3 (Hu et al. 2026)Protocol: FASTQ-to-VCF runtime, core-hours and Azure cost of three Sentieon DNAscope pipelines on one 120-vCPU instance (Hu et al. 2026 Table 2)
Dataset: 30x Illumina WGS input for DNAscope (short reads) (Hu et al. 2026 Table 2)
0.11 Compute cost (Azure spot price, FASTQ to VCF; 30x Illumina)
us-dollar · lower

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

DNAscope (short reads) compute benchmark on Azure (Hu et al. 2026)

model-execution-20261011-protocol-hu2026-dnascope-azure-compute

Aggregation: Not reported

A novel and accelerated method for integrated alignment and variant calling from short and long reads · Table 2, row 'Spot ($)', column 'DNAscope (short reads)'
Configuration: Sentieon DNAscope (short reads) on Azure HB120rs v3 (Hu et al. 2026)Protocol: FASTQ-to-VCF runtime, core-hours and Azure cost of three Sentieon DNAscope pipelines on one 120-vCPU instance (Hu et al. 2026 Table 2)
Dataset: 30x Illumina WGS input for DNAscope (short reads) (Hu et al. 2026 Table 2)
18.9 Runtime (total, FASTQ to VCF; 30x Illumina)
minute · lower

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

DNAscope (short reads) compute benchmark on Azure (Hu et al. 2026)

model-execution-20261011-protocol-hu2026-dnascope-azure-compute

Aggregation: Not reported

A novel and accelerated method for integrated alignment and variant calling from short and long reads · Table 2, row 'Total runtime (min)', column 'DNAscope (short reads)'
Configuration: Sentieon DNAscope (short reads) on Azure HB120rs v3 (Hu et al. 2026)Protocol: FASTQ-to-VCF runtime, core-hours and Azure cost of three Sentieon DNAscope pipelines on one 120-vCPU instance (Hu et al. 2026 Table 2)
Dataset: 30x Illumina WGS input for DNAscope (short reads) (Hu et al. 2026 Table 2)
7.8 Runtime (variant calling stage; 30x Illumina)
minute · lower

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

DNAscope (short reads) compute benchmark on Azure (Hu et al. 2026)

model-execution-20261011-protocol-hu2026-dnascope-azure-compute

Aggregation: Not reported

A novel and accelerated method for integrated alignment and variant calling from short and long reads · Table 2, row 'Variant calling (min)', column 'DNAscope (short reads)'

Source checking is not independent reproduction. Release 2026-10-22-1b7cf027e4f6.

Research readiness

0 of 4 readiness checks met. These checks assess whether the evidence supports a reproducible investigation; a source-checked score alone does not meet them.

Readiness checks, gaps and artifacts

Release 2026-10-22-1b7cf027e4f6 · Evidence verified: Not verified

Evidence incomplete

Replay metrics

Exact outcomes, predictions, identifiers and evaluator are connected.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • File checksums match the recorded files: not yet verified
  • Predictions are matched to the right samples: not yet verified
  • Score meaning and direction are confirmed: not yet verified
  • Metrics are recomputed from the saved predictions: not yet verified

Verified: Not verified

Evidence incomplete

Investigate discrepancies

Replay evidence includes annotations and an assessment of dependence. Unknown independence permits descriptive analysis only.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • File checksums match the recorded files: not yet verified
  • Predictions are matched to the right samples: not yet verified
  • Score meaning and direction are confirmed: not yet verified
  • Metrics are recomputed from the saved predictions: not yet verified
  • Sample annotations are recorded: not yet verified
  • Dependence between samples is assessed: not yet verified

Verified: Not verified

Evidence incomplete

Run locally

A pinned recipe describes the inputs, environment and resource requirements.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • File checksums match the recorded files: not yet verified
  • Predictions are matched to the right samples: not yet verified
  • Score meaning and direction are confirmed: not yet verified
  • A pinned run recipe exists: not yet verified
  • Compute requirements are estimated: not yet verified

Verified: Not verified

Evidence incomplete

Validate independently

Separate data and exposure records support an independent test.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • File checksums match the recorded files: not yet verified
  • Predictions are matched to the right samples: not yet verified
  • Score meaning and direction are confirmed: not yet verified
  • Independent validation data exist: not yet verified
  • Overlap with training data is checked: not yet verified

Verified: Not verified

Readiness describes the evidence in this release. Availability on your computer is checked separately when an investigation runs. Existing data exposure can prevent independent validation even when files are available.

Artifacts and reproduction

No verified artifact manifest is connected to this record yet. The gaps above identify what is needed before analysis can begin.

Evaluation procedure

FASTQ-to-VCF runtime, core-hours and Azure cost of three Sentieon DNAscope pipelines on one 120-vCPU instance (Hu et al. 2026 Table 2)

Configuration
Sentieon DNAscope (short reads) on Azure HB120rs v3 (Hu et al. 2026)
Protocol
FASTQ-to-VCF runtime, core-hours and Azure cost of three Sentieon DNAscope pipelines on one 120-vCPU instance (Hu et al. 2026 Table 2)
Dataset
30x Illumina WGS input for DNAscope (short reads) (Hu et al. 2026 Table 2)
origin
Author-reported evaluation
configuration
Primary source as retrieved 2026-10-11
protocol id
model-execution-20261011-protocol-hu2026-dnascope-azure-compute
dataset version
Not reported
split
One value; number of runs not stated
population
30x Illumina WGS (sample not named)
inputs
FASTQ
adaptation
Not reported
metric implementation
Not reported
aggregation
One value per pipeline; number of runs not stated
budget
One Azure Standard HB120rs v3 instance (120 vCPUs)

Metadata review: source checked. Unreported conditions prevent automatic comparisons.

Reproduction

Split
One value; number of runs not stated
Adaptation
Not reported
Scoring implementation
Not reported

No execution recipe has been verified for this exact configuration and evaluation. A benchmark's general instructions may use different inputs, splits or model settings.

Reproducing this published result requires matching its model configuration, data, split and scorer. Source checking or a successful smoke test does not establish score reproduction.

Evidence

Source checking verifies the cited claim or transcription. It does not establish independent reproduction.

Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

18 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-10-22-1b7cf027e4f6
Property and statementOriginal source and locationReview and provenance
Comparison: adaptation
Not reported
Context-only references
A novel and accelerated method for integrated alignment and variant calling from short and long reads

Original source ↗

Table 2 column 'DNAscope (short reads)'

Version: Frontiers in Bioinformatics 5:1691056, published 2026-01-05; PMC12813096 full-text XML
Retrieved: 2026-10-11T21:42:46Z

missing or unspecified

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.adaptation

Source artifact SHA-256: b138dd8976f01b4ff50f72669dea3a7062f564a9cb359417aad0dc72a8b6c859

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Comparison: aggregation
One value per pipeline; number of runs not stated
Context-only references
A novel and accelerated method for integrated alignment and variant calling from short and long reads

Original source ↗

Table 2 column 'DNAscope (short reads)'

Version: Frontiers in Bioinformatics 5:1691056, published 2026-01-05; PMC12813096 full-text XML
Retrieved: 2026-10-11T21:42:46Z

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.aggregation

Source artifact SHA-256: b138dd8976f01b4ff50f72669dea3a7062f564a9cb359417aad0dc72a8b6c859

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Comparison: budget
One Azure Standard HB120rs v3 instance (120 vCPUs)
Context-only references
A novel and accelerated method for integrated alignment and variant calling from short and long reads

Original source ↗

Table 2 column 'DNAscope (short reads)'

Version: Frontiers in Bioinformatics 5:1691056, published 2026-01-05; PMC12813096 full-text XML
Retrieved: 2026-10-11T21:42:46Z

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.budget

Source artifact SHA-256: b138dd8976f01b4ff50f72669dea3a7062f564a9cb359417aad0dc72a8b6c859

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Comparison: dataset version
Not reported
Context-only references
A novel and accelerated method for integrated alignment and variant calling from short and long reads

Original source ↗

Table 2 column 'DNAscope (short reads)'

Version: Frontiers in Bioinformatics 5:1691056, published 2026-01-05; PMC12813096 full-text XML
Retrieved: 2026-10-11T21:42:46Z

missing or unspecified

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.dataset_version

Source artifact SHA-256: b138dd8976f01b4ff50f72669dea3a7062f564a9cb359417aad0dc72a8b6c859

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Comparison: inputs
FASTQ
Context-only references
A novel and accelerated method for integrated alignment and variant calling from short and long reads

Original source ↗

Table 2 column 'DNAscope (short reads)'

Version: Frontiers in Bioinformatics 5:1691056, published 2026-01-05; PMC12813096 full-text XML
Retrieved: 2026-10-11T21:42:46Z

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.inputs

Source artifact SHA-256: b138dd8976f01b4ff50f72669dea3a7062f564a9cb359417aad0dc72a8b6c859

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Comparison: metric implementation
Not reported
Context-only references
A novel and accelerated method for integrated alignment and variant calling from short and long reads

Original source ↗

Table 2 column 'DNAscope (short reads)'

Version: Frontiers in Bioinformatics 5:1691056, published 2026-01-05; PMC12813096 full-text XML
Retrieved: 2026-10-11T21:42:46Z

missing or unspecified

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.metric_implementation

Source artifact SHA-256: b138dd8976f01b4ff50f72669dea3a7062f564a9cb359417aad0dc72a8b6c859

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Comparison: population
30x Illumina WGS (sample not named)
Context-only references
A novel and accelerated method for integrated alignment and variant calling from short and long reads

Original source ↗

Table 2 column 'DNAscope (short reads)'

Version: Frontiers in Bioinformatics 5:1691056, published 2026-01-05; PMC12813096 full-text XML
Retrieved: 2026-10-11T21:42:46Z

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.population

Source artifact SHA-256: b138dd8976f01b4ff50f72669dea3a7062f564a9cb359417aad0dc72a8b6c859

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Comparison: protocol id
model-execution-20261011-protocol-hu2026-dnascope-azure-compute
Context-only references
A novel and accelerated method for integrated alignment and variant calling from short and long reads

Original source ↗

Table 2 column 'DNAscope (short reads)'

Version: Frontiers in Bioinformatics 5:1691056, published 2026-01-05; PMC12813096 full-text XML
Retrieved: 2026-10-11T21:42:46Z

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.protocol_id

Source artifact SHA-256: b138dd8976f01b4ff50f72669dea3a7062f564a9cb359417aad0dc72a8b6c859

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Comparison: split
One value; number of runs not stated
Context-only references
A novel and accelerated method for integrated alignment and variant calling from short and long reads

Original source ↗

Table 2 column 'DNAscope (short reads)'

Version: Frontiers in Bioinformatics 5:1691056, published 2026-01-05; PMC12813096 full-text XML
Retrieved: 2026-10-11T21:42:46Z

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.split

Source artifact SHA-256: b138dd8976f01b4ff50f72669dea3a7062f564a9cb359417aad0dc72a8b6c859

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Origin
author_reported
Context-only references
A novel and accelerated method for integrated alignment and variant calling from short and long reads

Original source ↗

Table 2 column 'DNAscope (short reads)'

Version: Frontiers in Bioinformatics 5:1691056, published 2026-01-05; PMC12813096 full-text XML
Retrieved: 2026-10-11T21:42:46Z

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: attributes.origin

Source artifact SHA-256: b138dd8976f01b4ff50f72669dea3a7062f564a9cb359417aad0dc72a8b6c859

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

How to read the evidence

Sources and history

Release 2026-10-22-1b7cf027e4f6 · Record review: source checked

1 source record and release historyDownload this release (gzip)
Technical metadata and extraction receipts

Stable ID: model-execution-20261011-eval-hu2026-dnascope-short-read-azure

areas
dna-genomes
contexts
clinical_research
origin
author_reported
protocol
model-execution-20261011-protocol-hu2026-dnascope-azure-compute
version
Primary source as retrieved 2026-10-11
comparison
protocol id: model-execution-20261011-protocol-hu2026-dnascope-azure-compute; dataset version: Not reported; split: One value; number of runs not stated; population: 30x Illumina WGS (sample not named); inputs: FASTQ; adaptation: Not reported; metric implementation: Not reported; aggregation: One value per pipeline; number of runs not stated; budget: One Azure Standard HB120rs v3 instance (120 vCPUs)
source locator
Table 2 column 'DNAscope (short reads)'
missing metadata
comparison.dataset version: reason: unreported; comparison.metric implementation: reason: unreported; note: How runtime and cost were measured is not stated
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