rewirebio.iobenchmarks
Protocol

GUANinE v1.1 cons100, Spearman rho x100 (Table 2)

GUANinE v1.1 task cons100: Sequence conservation, 100-way.

32 evaluations · 32 results

Overview

An explanatory profile has not yet been reviewed for this record.

Consult the linked sources for architecture or protocol details. Missing evidence is not evidence of a missing capability.

32 recorded evaluations, 32 metric rows. A comparison chart has not yet been validated for these results. The table retains the individual findings and their sources.

View coverage and remaining gaps across all benchmarks

Results

Results are available, but no reviewed comparison panel is linked in this release.

All evaluations

32 evaluations · 32 results. Different protocols are not a single leaderboard.

Protocol: GUANinE v1.1 cons100, Spearman rho x100 (Table 2) · Dataset: GUANinE cons100 test set

Sorted by Spearman (GUANinE v1.1 test set) (higher is better). The best value in each column is highlighted. Decimals are rounded for display; each value links to the printed value and its source.

Tested configurationSpearman (GUANinE v1.1 test set)
Evo2_7B (1% eval (evaluated with 1% of the training set), GUANinE v1.1)Evaluation65.3 (best in column)
NTv2-500m (1% eval (evaluated with 1% of the training set), GUANinE v1.1)Evaluation63.5
Enformer (Pre-output) (1% eval (evaluated with 1% of the training set), GUANinE v1.1)Evaluation62.4
Caduceus-PS (1% eval (evaluated with 1% of the training set), GUANinE v1.1)Evaluation62.4
Enformer (1% eval (evaluated with 1% of the training set), GUANinE v1.1)Evaluation62.2
Evo2_7B_base (1% eval (evaluated with 1% of the training set), GUANinE v1.1)Evaluation61.9
GENA-LM-bigbird-base-t2t (1% eval (evaluated with 1% of the training set), GUANinE v1.1)Evaluation61.5
NTv3-650m-post (1% eval (evaluated with 1% of the training set), GUANinE v1.1)Evaluation60.6
GENA-LM-bert-large-t2t (1% eval (evaluated with 1% of the training set), GUANinE v1.1)Evaluation59.9
Borzoi (1% eval (evaluated with 1% of the training set), GUANinE v1.1)Evaluation59.7
NTv3-100m-post (1% eval (evaluated with 1% of the training set), GUANinE v1.1)Evaluation59.6
NTv2-100m (1% eval (evaluated with 1% of the training set), GUANinE v1.1)Evaluation57.9
GENA-LM-bert-base-t2t-enf (1% eval (evaluated with 1% of the training set), GUANinE v1.1)Evaluation56.5
GENA-LM-bert-base-t2t (1% eval (evaluated with 1% of the training set), GUANinE v1.1)Evaluation56
Evo2_1B_base (1% eval (evaluated with 1% of the training set), GUANinE v1.1)Evaluation55.2
NTv3-100m-pre (1% eval (evaluated with 1% of the training set), GUANinE v1.1)Evaluation52.9
Sei (1% eval (evaluated with 1% of the training set), GUANinE v1.1)Evaluation51.6
AIDO.DNA_300m (1% eval (evaluated with 1% of the training set), GUANinE v1.1)Evaluation51.5
Mistral-DNA-422m-hg38 (1% eval (evaluated with 1% of the training set), GUANinE v1.1)Evaluation50.7
DNABERT-2 (1% eval (evaluated with 1% of the training set), GUANinE v1.1)Evaluation50.4
hgT5-8195 (fine-tuned, GUANinE v1.1)Evaluation46.2
Enigma-Distilled (1% eval (evaluated with 1% of the training set), GUANinE v1.1)Evaluation45.8
5-mer LinSVR (fine-tuned, GUANinE v1.1)Evaluation45
5-mer kNN (fine-tuned, GUANinE v1.1)Evaluation44.5
⋆ T5 (fine-tuned, GUANinE v1.1)Evaluation44
DeepSEA (1% eval (evaluated with 1% of the training set), GUANinE v1.1)Evaluation43.4
PhyloGPN (1% eval (evaluated with 1% of the training set), GUANinE v1.1)Evaluation43.1
ChromBPNet-ATAC-F0 (1% eval (evaluated with 1% of the training set), GUANinE v1.1)Evaluation41.5
ChromBPNet-ATAC-F3 (1% eval (evaluated with 1% of the training set), GUANinE v1.1)Evaluation40.3
ESA-dna2vec (1% eval (evaluated with 1% of the training set), GUANinE v1.1)Evaluation39.8
GC-content (zero-shot, GUANinE v1.1)Evaluation39.6
ENCFF180XQC (zero-shot, GUANinE v1.1)Evaluation6.46
All 32 result rows with coverage, uncertainty and sources
Filter evaluations

Applied filters: All linked evaluations

Exact evaluated configurations and original reported results
Tested configurationProtocol and datasetFindingEvidence and details
Configuration: 5-mer kNN (fine-tuned, GUANinE v1.1)Protocol: GUANinE v1.1 cons100, Spearman rho x100 (Table 2)
Dataset: GUANinE cons100 test set
44.5 Spearman (GUANinE v1.1 test set)
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

5-mer kNN on GUANinE cons100

lit-genomics-20261011-guanine-protocol-cons100

Aggregation: Not reported

GUANinE v1.1 reveals complementarity of supervised and genomic language models · Table 2, row '5-mer kNN', column 'cons100' (ρ)
Configuration: 5-mer LinSVR (fine-tuned, GUANinE v1.1)Protocol: GUANinE v1.1 cons100, Spearman rho x100 (Table 2)
Dataset: GUANinE cons100 test set
45 Spearman (GUANinE v1.1 test set)
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

5-mer LinSVR on GUANinE cons100

lit-genomics-20261011-guanine-protocol-cons100

Aggregation: Not reported

GUANinE v1.1 reveals complementarity of supervised and genomic language models · Table 2, row '5-mer LinSVR', column 'cons100' (ρ)
Configuration: AIDO.DNA_300m (1% eval (evaluated with 1% of the training set), GUANinE v1.1)Protocol: GUANinE v1.1 cons100, Spearman rho x100 (Table 2)
Dataset: GUANinE cons100 test set
51.5 Spearman (GUANinE v1.1 test set)
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

AIDO.DNA_300m on GUANinE cons100

lit-genomics-20261011-guanine-protocol-cons100

Aggregation: Not reported

GUANinE v1.1 reveals complementarity of supervised and genomic language models · Table 2, row 'AIDO.DNA_300m', column 'cons100' (ρ)
Configuration: Borzoi (1% eval (evaluated with 1% of the training set), GUANinE v1.1)Protocol: GUANinE v1.1 cons100, Spearman rho x100 (Table 2)
Dataset: GUANinE cons100 test set
59.7 Spearman (GUANinE v1.1 test set)
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Borzoi on GUANinE cons100

lit-genomics-20261011-guanine-protocol-cons100

Aggregation: Not reported

GUANinE v1.1 reveals complementarity of supervised and genomic language models · Table 2, row 'Borzoi', column 'cons100' (ρ)
Configuration: Caduceus-PS (1% eval (evaluated with 1% of the training set), GUANinE v1.1)Protocol: GUANinE v1.1 cons100, Spearman rho x100 (Table 2)
Dataset: GUANinE cons100 test set
62.4 Spearman (GUANinE v1.1 test set)
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Caduceus-PS on GUANinE cons100

lit-genomics-20261011-guanine-protocol-cons100

Aggregation: Not reported

GUANinE v1.1 reveals complementarity of supervised and genomic language models · Table 2, row 'Caduceus-PS', column 'cons100' (ρ)
Configuration: ChromBPNet-ATAC-F0 (1% eval (evaluated with 1% of the training set), GUANinE v1.1)Protocol: GUANinE v1.1 cons100, Spearman rho x100 (Table 2)
Dataset: GUANinE cons100 test set
41.5 Spearman (GUANinE v1.1 test set)
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

ChromBPNet-ATAC-F0 on GUANinE cons100

lit-genomics-20261011-guanine-protocol-cons100

Aggregation: Not reported

GUANinE v1.1 reveals complementarity of supervised and genomic language models · Table 2, row 'ChromBPNet-ATAC-F0', column 'cons100' (ρ)
Configuration: ChromBPNet-ATAC-F3 (1% eval (evaluated with 1% of the training set), GUANinE v1.1)Protocol: GUANinE v1.1 cons100, Spearman rho x100 (Table 2)
Dataset: GUANinE cons100 test set
40.3 Spearman (GUANinE v1.1 test set)
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

ChromBPNet-ATAC-F3 on GUANinE cons100

lit-genomics-20261011-guanine-protocol-cons100

Aggregation: Not reported

GUANinE v1.1 reveals complementarity of supervised and genomic language models · Table 2, row 'ChromBPNet-ATAC-F3', column 'cons100' (ρ)
Configuration: DeepSEA (1% eval (evaluated with 1% of the training set), GUANinE v1.1)Protocol: GUANinE v1.1 cons100, Spearman rho x100 (Table 2)
Dataset: GUANinE cons100 test set
43.4 Spearman (GUANinE v1.1 test set)
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

DeepSEA on GUANinE cons100

lit-genomics-20261011-guanine-protocol-cons100

Aggregation: Not reported

GUANinE v1.1 reveals complementarity of supervised and genomic language models · Table 2, row 'DeepSEA', column 'cons100' (ρ)
Configuration: DNABERT-2 (1% eval (evaluated with 1% of the training set), GUANinE v1.1)Protocol: GUANinE v1.1 cons100, Spearman rho x100 (Table 2)
Dataset: GUANinE cons100 test set
50.4 Spearman (GUANinE v1.1 test set)
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

DNABERT-2 on GUANinE cons100

lit-genomics-20261011-guanine-protocol-cons100

Aggregation: Not reported

GUANinE v1.1 reveals complementarity of supervised and genomic language models · Table 2, row 'DNABERT-2', column 'cons100' (ρ)
Configuration: ENCFF180XQC (zero-shot, GUANinE v1.1)Protocol: GUANinE v1.1 cons100, Spearman rho x100 (Table 2)
Dataset: GUANinE cons100 test set
6.46 Spearman (GUANinE v1.1 test set)
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

ENCFF180XQC on GUANinE cons100

lit-genomics-20261011-guanine-protocol-cons100

Aggregation: Not reported

GUANinE v1.1 reveals complementarity of supervised and genomic language models · Table 2, row 'ENCFF180XQC', column 'cons100' (ρ)
Configuration: Enformer (1% eval (evaluated with 1% of the training set), GUANinE v1.1)Protocol: GUANinE v1.1 cons100, Spearman rho x100 (Table 2)
Dataset: GUANinE cons100 test set
62.2 Spearman (GUANinE v1.1 test set)
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Enformer on GUANinE cons100

lit-genomics-20261011-guanine-protocol-cons100

Aggregation: Not reported

GUANinE v1.1 reveals complementarity of supervised and genomic language models · Table 2, row 'Enformer', column 'cons100' (ρ)
Configuration: Enformer (Pre-output) (1% eval (evaluated with 1% of the training set), GUANinE v1.1)Protocol: GUANinE v1.1 cons100, Spearman rho x100 (Table 2)
Dataset: GUANinE cons100 test set
62.4 Spearman (GUANinE v1.1 test set)
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Enformer (Pre-output) on GUANinE cons100

lit-genomics-20261011-guanine-protocol-cons100

Aggregation: Not reported

GUANinE v1.1 reveals complementarity of supervised and genomic language models · Table 2, row 'Enformer (Pre-output)', column 'cons100' (ρ)
Configuration: Enigma-Distilled (1% eval (evaluated with 1% of the training set), GUANinE v1.1)Protocol: GUANinE v1.1 cons100, Spearman rho x100 (Table 2)
Dataset: GUANinE cons100 test set
45.8 Spearman (GUANinE v1.1 test set)
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Enigma-Distilled on GUANinE cons100

lit-genomics-20261011-guanine-protocol-cons100

Aggregation: Not reported

GUANinE v1.1 reveals complementarity of supervised and genomic language models · Table 2, row 'Enigma-Distilled', column 'cons100' (ρ)
Configuration: ESA-dna2vec (1% eval (evaluated with 1% of the training set), GUANinE v1.1)Protocol: GUANinE v1.1 cons100, Spearman rho x100 (Table 2)
Dataset: GUANinE cons100 test set
39.8 Spearman (GUANinE v1.1 test set)
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

ESA-dna2vec on GUANinE cons100

lit-genomics-20261011-guanine-protocol-cons100

Aggregation: Not reported

GUANinE v1.1 reveals complementarity of supervised and genomic language models · Table 2, row 'ESA-dna2vec', column 'cons100' (ρ)
Configuration: Evo2_1B_base (1% eval (evaluated with 1% of the training set), GUANinE v1.1)Protocol: GUANinE v1.1 cons100, Spearman rho x100 (Table 2)
Dataset: GUANinE cons100 test set
55.2 Spearman (GUANinE v1.1 test set)
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Evo2_1B_base on GUANinE cons100

lit-genomics-20261011-guanine-protocol-cons100

Aggregation: Not reported

GUANinE v1.1 reveals complementarity of supervised and genomic language models · Table 2, row 'Evo2_1B_base', column 'cons100' (ρ)
Configuration: Evo2_7B (1% eval (evaluated with 1% of the training set), GUANinE v1.1)Protocol: GUANinE v1.1 cons100, Spearman rho x100 (Table 2)
Dataset: GUANinE cons100 test set
65.3 Spearman (GUANinE v1.1 test set)
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Evo2_7B on GUANinE cons100

lit-genomics-20261011-guanine-protocol-cons100

Aggregation: Not reported

GUANinE v1.1 reveals complementarity of supervised and genomic language models · Table 2, row 'Evo2_7B', column 'cons100' (ρ)
Configuration: Evo2_7B_base (1% eval (evaluated with 1% of the training set), GUANinE v1.1)Protocol: GUANinE v1.1 cons100, Spearman rho x100 (Table 2)
Dataset: GUANinE cons100 test set
61.9 Spearman (GUANinE v1.1 test set)
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Evo2_7B_base on GUANinE cons100

lit-genomics-20261011-guanine-protocol-cons100

Aggregation: Not reported

GUANinE v1.1 reveals complementarity of supervised and genomic language models · Table 2, row 'Evo2_7B_base', column 'cons100' (ρ)
Configuration: GC-content (zero-shot, GUANinE v1.1)Protocol: GUANinE v1.1 cons100, Spearman rho x100 (Table 2)
Dataset: GUANinE cons100 test set
39.6 Spearman (GUANinE v1.1 test set)
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

GC-content on GUANinE cons100

lit-genomics-20261011-guanine-protocol-cons100

Aggregation: Not reported

GUANinE v1.1 reveals complementarity of supervised and genomic language models · Table 2, row 'GC-content', column 'cons100' (ρ)
Configuration: GENA-LM-bert-base-t2t (1% eval (evaluated with 1% of the training set), GUANinE v1.1)Protocol: GUANinE v1.1 cons100, Spearman rho x100 (Table 2)
Dataset: GUANinE cons100 test set
56 Spearman (GUANinE v1.1 test set)
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

GENA-LM-bert-base-t2t on GUANinE cons100

lit-genomics-20261011-guanine-protocol-cons100

Aggregation: Not reported

GUANinE v1.1 reveals complementarity of supervised and genomic language models · Table 2, row 'GENA-LM-bert-base-t2t', column 'cons100' (ρ)
Configuration: GENA-LM-bert-base-t2t-enf (1% eval (evaluated with 1% of the training set), GUANinE v1.1)Protocol: GUANinE v1.1 cons100, Spearman rho x100 (Table 2)
Dataset: GUANinE cons100 test set
56.5 Spearman (GUANinE v1.1 test set)
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

GENA-LM-bert-base-t2t-enf on GUANinE cons100

lit-genomics-20261011-guanine-protocol-cons100

Aggregation: Not reported

GUANinE v1.1 reveals complementarity of supervised and genomic language models · Table 2, row 'GENA-LM-bert-base-t2t-enf', column 'cons100' (ρ)
Configuration: GENA-LM-bert-large-t2t (1% eval (evaluated with 1% of the training set), GUANinE v1.1)Protocol: GUANinE v1.1 cons100, Spearman rho x100 (Table 2)
Dataset: GUANinE cons100 test set
59.9 Spearman (GUANinE v1.1 test set)
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

GENA-LM-bert-large-t2t on GUANinE cons100

lit-genomics-20261011-guanine-protocol-cons100

Aggregation: Not reported

GUANinE v1.1 reveals complementarity of supervised and genomic language models · Table 2, row 'GENA-LM-bert-large-t2t', column 'cons100' (ρ)
Configuration: GENA-LM-bigbird-base-t2t (1% eval (evaluated with 1% of the training set), GUANinE v1.1)Protocol: GUANinE v1.1 cons100, Spearman rho x100 (Table 2)
Dataset: GUANinE cons100 test set
61.5 Spearman (GUANinE v1.1 test set)
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

GENA-LM-bigbird-base-t2t on GUANinE cons100

lit-genomics-20261011-guanine-protocol-cons100

Aggregation: Not reported

GUANinE v1.1 reveals complementarity of supervised and genomic language models · Table 2, row 'GENA-LM-bigbird-base-t2t', column 'cons100' (ρ)
Configuration: hgT5-8195 (fine-tuned, GUANinE v1.1)Protocol: GUANinE v1.1 cons100, Spearman rho x100 (Table 2)
Dataset: GUANinE cons100 test set
46.2 Spearman (GUANinE v1.1 test set)
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

hgT5-8195 on GUANinE cons100

lit-genomics-20261011-guanine-protocol-cons100

Aggregation: Not reported

GUANinE v1.1 reveals complementarity of supervised and genomic language models · Table 2, row 'hgT5-8195', column 'cons100' (ρ)
Configuration: Mistral-DNA-422m-hg38 (1% eval (evaluated with 1% of the training set), GUANinE v1.1)Protocol: GUANinE v1.1 cons100, Spearman rho x100 (Table 2)
Dataset: GUANinE cons100 test set
50.7 Spearman (GUANinE v1.1 test set)
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Mistral-DNA-422m-hg38 on GUANinE cons100

lit-genomics-20261011-guanine-protocol-cons100

Aggregation: Not reported

GUANinE v1.1 reveals complementarity of supervised and genomic language models · Table 2, row 'Mistral-DNA-422m-hg38', column 'cons100' (ρ)
Configuration: NTv2-100m (1% eval (evaluated with 1% of the training set), GUANinE v1.1)Protocol: GUANinE v1.1 cons100, Spearman rho x100 (Table 2)
Dataset: GUANinE cons100 test set
57.9 Spearman (GUANinE v1.1 test set)
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

NTv2-100m on GUANinE cons100

lit-genomics-20261011-guanine-protocol-cons100

Aggregation: Not reported

GUANinE v1.1 reveals complementarity of supervised and genomic language models · Table 2, row 'NTv2-100m', column 'cons100' (ρ)

Source checking is not independent reproduction. Release 2026-10-22-1b7cf027e4f6.

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External evaluations
27

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Stable ID: lit-genomics-20261011-guanine-protocol-cons100

areas
dna-genomes
contexts
research
protocol
GUANinE v1.1 cons100 test set; score is the printed column 'ρ'
version
GUANinE v1.1
metric
spearman-correlation
metric direction
higher
unit
unitless
unit detail
Printed as Spearman rho multiplied by 100
limitations
The benchmark authors evaluated the models; GUANinE v1.1 is by the developers of hgT5 and the T5 baseline.; Previously reported performances are marked in blue in the published table; the colour is not in the XML artifact, so prior and new cells are not distinguished here.; Many rows are '1% eval': models were evaluated with 1% of the training set (Table 2 footnote).
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Table 2 column 'cons100'
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