GUANinE v1.1
Genome Understanding and ANnotation in silico Evaluation, version 1.1: functional genomics, conservation, gene-expression and variant tasks on hg38.
Results are recorded on the linked protocols, tasks or configurations listed below. Their settings and evaluations are kept separate.
Overview
An explanatory profile has not yet been reviewed for this record.
Consult the linked sources for architecture or protocol details. Missing evidence is not evidence of a missing capability.
Results on linked records
This benchmark has no results of its own in this release. 8 linked records have results. They are not assigned to the underlying benchmark: each record keeps its own settings and evaluations, and its scores are on its own page.
- GUANinE v1.1 cadd-snv, Spearman rho x100 (Table 3) Protocol · part of this benchmark · 23 evaluations · 23 results
- GUANinE v1.1 ccre-propensity, Spearman rho x100 (Table 2) Protocol · part of this benchmark · 32 evaluations · 32 results
- GUANinE v1.1 clinvar-snv, Spearman rho x100 (Table 4) Protocol · part of this benchmark · 12 evaluations · 12 results
- GUANinE v1.1 cons100, Spearman rho x100 (Table 2) Protocol · part of this benchmark · 32 evaluations · 32 results
- GUANinE v1.1 cons30, Spearman rho x100 (Table 2) Protocol · part of this benchmark · 32 evaluations · 32 results
- GUANinE v1.1 dnase-propensity, Spearman rho x100 (Table 2) Protocol · part of this benchmark · 32 evaluations · 32 results
- GUANinE v1.1 gpra-c, Spearman rho x100 (Table 2) Protocol · part of this benchmark · 31 evaluations · 31 results
- GUANinE v1.1 gpra-d, Spearman rho x100 (Table 2) Protocol · part of this benchmark · 31 evaluations · 31 results
Methods and evaluation design
Procedure, tasks and evaluated configurations
Baseline coverage
Reference methods help show what a model adds beyond simple controls. We track a null control and a conventional method for each protocol.
0 of 16 active baseline roles have published Rewire measurements in this release. Measurements on a selected protocol do not establish coverage of an entire suite.
Baseline status by linked protocol
- GUANinE v1.1 cadd-snv, Spearman rho x100 (Table 3) · 0/2 roles measured
- GUANinE v1.1 ccre-propensity, Spearman rho x100 (Table 2) · 0/2 roles measured
- GUANinE v1.1 clinvar-snv, Spearman rho x100 (Table 4) · 0/2 roles measured
- GUANinE v1.1 cons100, Spearman rho x100 (Table 2) · 0/2 roles measured
- GUANinE v1.1 cons30, Spearman rho x100 (Table 2) · 0/2 roles measured
- GUANinE v1.1 dnase-propensity, Spearman rho x100 (Table 2) · 0/2 roles measured
- GUANinE v1.1 gpra-c, Spearman rho x100 (Table 2) · 0/2 roles measured
- GUANinE v1.1 gpra-d, Spearman rho x100 (Table 2) · 0/2 roles measured
Protocol coverage CSV (gzip) · Model evaluation matrix (gzip) · Source table (gzip) · Release and checksums (gzip)
Coverage is derived from release 2026-10-22-1b7cf027e4f6. Source citations describe the original records; they do not validate an unreviewed baseline proposal. No results have been generated by this audit.
Run instructions
No runnable recipe has been reviewed for this benchmark. Dataset access, model requirements, licences and compute requirements must be checked against its sources before execution.
Strengths, limitations and unresolved questions
Evidence
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Evidence table
Inspect claims, sources and review details
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One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.
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Sources and history
Release 2026-10-22-1b7cf027e4f6 · Record review: source checked
1 source record and release history
- GUANinE v1.1 reveals complementarity of supervised and genomic language models · Original source · Bioinformatics 2026, btag427 (issue date 2026-08-01); PMC13501288 full-text XML
Technical metadata and extraction receipts
Stable ID: lit-genomics-20261011-guanine-benchmark-guanine-v1-1
- areas
- dna-genomes
- contexts
- research
- entity level
- suite
- version
- v1.1
- task
- Regulatory sequence, conservation, expression and variant-effect prediction
- scope note
- Tasks in this batch: dnase-propensity, ccre-propensity, cons30, cons100, gpra-c, gpra-d (Table 2), cadd-snv (Table 3), clinvar-snv (Table 4).
- source locator
- Abstract; Table 1; Tables 2-4
Related records
- part of: GUANinE v1.1 cadd-snv, Spearman rho x100 (Table 3)
- part of: GUANinE v1.1 ccre-propensity, Spearman rho x100 (Table 2)
- part of: GUANinE v1.1 clinvar-snv, Spearman rho x100 (Table 4)
- part of: GUANinE v1.1 cons100, Spearman rho x100 (Table 2)
- part of: GUANinE v1.1 cons30, Spearman rho x100 (Table 2)
- part of: GUANinE v1.1 dnase-propensity, Spearman rho x100 (Table 2)
- part of: GUANinE v1.1 gpra-c, Spearman rho x100 (Table 2)
- part of: GUANinE v1.1 gpra-d, Spearman rho x100 (Table 2)