GUANinE v1.1 cons30, Spearman rho x100 (Table 2)
GUANinE v1.1 task cons30: Sequence conservation, 30-way.
Overview
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Consult the linked sources for architecture or protocol details. Missing evidence is not evidence of a missing capability.
32 recorded evaluations, 32 metric rows. A comparison chart has not yet been validated for these results. The table retains the individual findings and their sources.
Results
Results are available, but no reviewed comparison panel is linked in this release.
All evaluations
32 evaluations · 32 results. Different protocols are not a single leaderboard.
Protocol: GUANinE v1.1 cons30, Spearman rho x100 (Table 2) · Dataset: GUANinE cons30 test set
Sorted by Spearman (GUANinE v1.1 test set) (higher is better). The best value in each column is highlighted. Decimals are rounded for display; each value links to the printed value and its source.
All 32 result rows with coverage, uncertainty and sources
Filter evaluations
Applied filters: All linked evaluations
| Tested configuration | Protocol and dataset | Finding | Evidence and details |
|---|---|---|---|
| Configuration: 5-mer kNN (fine-tuned, GUANinE v1.1) | Protocol: GUANinE v1.1 cons30, Spearman rho x100 (Table 2) Dataset: GUANinE cons30 test set | 52.6 Spearman (GUANinE v1.1 test set) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourcelit-genomics-20261011-guanine-protocol-cons30 Aggregation: Not reported GUANinE v1.1 reveals complementarity of supervised and genomic language models · Table 2, row '5-mer kNN', column 'cons30' (ρ) |
| Configuration: 5-mer LinSVR (fine-tuned, GUANinE v1.1) | Protocol: GUANinE v1.1 cons30, Spearman rho x100 (Table 2) Dataset: GUANinE cons30 test set | 49.4 Spearman (GUANinE v1.1 test set) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and source5-mer LinSVR on GUANinE cons30 lit-genomics-20261011-guanine-protocol-cons30 Aggregation: Not reported GUANinE v1.1 reveals complementarity of supervised and genomic language models · Table 2, row '5-mer LinSVR', column 'cons30' (ρ) |
| Configuration: AIDO.DNA_300m (1% eval (evaluated with 1% of the training set), GUANinE v1.1) | Protocol: GUANinE v1.1 cons30, Spearman rho x100 (Table 2) Dataset: GUANinE cons30 test set | 61 Spearman (GUANinE v1.1 test set) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceAIDO.DNA_300m on GUANinE cons30 lit-genomics-20261011-guanine-protocol-cons30 Aggregation: Not reported GUANinE v1.1 reveals complementarity of supervised and genomic language models · Table 2, row 'AIDO.DNA_300m', column 'cons30' (ρ) |
| Configuration: Borzoi (1% eval (evaluated with 1% of the training set), GUANinE v1.1) | Protocol: GUANinE v1.1 cons30, Spearman rho x100 (Table 2) Dataset: GUANinE cons30 test set | 71.5 Spearman (GUANinE v1.1 test set) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourcelit-genomics-20261011-guanine-protocol-cons30 Aggregation: Not reported GUANinE v1.1 reveals complementarity of supervised and genomic language models · Table 2, row 'Borzoi', column 'cons30' (ρ) |
| Configuration: Caduceus-PS (1% eval (evaluated with 1% of the training set), GUANinE v1.1) | Protocol: GUANinE v1.1 cons30, Spearman rho x100 (Table 2) Dataset: GUANinE cons30 test set | 74.4 Spearman (GUANinE v1.1 test set) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourcelit-genomics-20261011-guanine-protocol-cons30 Aggregation: Not reported GUANinE v1.1 reveals complementarity of supervised and genomic language models · Table 2, row 'Caduceus-PS', column 'cons30' (ρ) |
| Configuration: ChromBPNet-ATAC-F0 (1% eval (evaluated with 1% of the training set), GUANinE v1.1) | Protocol: GUANinE v1.1 cons30, Spearman rho x100 (Table 2) Dataset: GUANinE cons30 test set | 47.8 Spearman (GUANinE v1.1 test set) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceChromBPNet-ATAC-F0 on GUANinE cons30 lit-genomics-20261011-guanine-protocol-cons30 Aggregation: Not reported GUANinE v1.1 reveals complementarity of supervised and genomic language models · Table 2, row 'ChromBPNet-ATAC-F0', column 'cons30' (ρ) |
| Configuration: ChromBPNet-ATAC-F3 (1% eval (evaluated with 1% of the training set), GUANinE v1.1) | Protocol: GUANinE v1.1 cons30, Spearman rho x100 (Table 2) Dataset: GUANinE cons30 test set | 47.4 Spearman (GUANinE v1.1 test set) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceChromBPNet-ATAC-F3 on GUANinE cons30 lit-genomics-20261011-guanine-protocol-cons30 Aggregation: Not reported GUANinE v1.1 reveals complementarity of supervised and genomic language models · Table 2, row 'ChromBPNet-ATAC-F3', column 'cons30' (ρ) |
| Configuration: DeepSEA (1% eval (evaluated with 1% of the training set), GUANinE v1.1) | Protocol: GUANinE v1.1 cons30, Spearman rho x100 (Table 2) Dataset: GUANinE cons30 test set | 49.6 Spearman (GUANinE v1.1 test set) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourcelit-genomics-20261011-guanine-protocol-cons30 Aggregation: Not reported GUANinE v1.1 reveals complementarity of supervised and genomic language models · Table 2, row 'DeepSEA', column 'cons30' (ρ) |
| Configuration: DNABERT-2 (1% eval (evaluated with 1% of the training set), GUANinE v1.1) | Protocol: GUANinE v1.1 cons30, Spearman rho x100 (Table 2) Dataset: GUANinE cons30 test set | 60.6 Spearman (GUANinE v1.1 test set) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourcelit-genomics-20261011-guanine-protocol-cons30 Aggregation: Not reported GUANinE v1.1 reveals complementarity of supervised and genomic language models · Table 2, row 'DNABERT-2', column 'cons30' (ρ) |
| Configuration: ENCFF180XQC (zero-shot, GUANinE v1.1) | Protocol: GUANinE v1.1 cons30, Spearman rho x100 (Table 2) Dataset: GUANinE cons30 test set | 4.09 Spearman (GUANinE v1.1 test set) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourcelit-genomics-20261011-guanine-protocol-cons30 Aggregation: Not reported GUANinE v1.1 reveals complementarity of supervised and genomic language models · Table 2, row 'ENCFF180XQC', column 'cons30' (ρ) |
| Configuration: Enformer (1% eval (evaluated with 1% of the training set), GUANinE v1.1) | Protocol: GUANinE v1.1 cons30, Spearman rho x100 (Table 2) Dataset: GUANinE cons30 test set | 74.4 Spearman (GUANinE v1.1 test set) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourcelit-genomics-20261011-guanine-protocol-cons30 Aggregation: Not reported GUANinE v1.1 reveals complementarity of supervised and genomic language models · Table 2, row 'Enformer', column 'cons30' (ρ) |
| Configuration: Enformer (Pre-output) (1% eval (evaluated with 1% of the training set), GUANinE v1.1) | Protocol: GUANinE v1.1 cons30, Spearman rho x100 (Table 2) Dataset: GUANinE cons30 test set | 74.7 Spearman (GUANinE v1.1 test set) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceEnformer (Pre-output) on GUANinE cons30 lit-genomics-20261011-guanine-protocol-cons30 Aggregation: Not reported GUANinE v1.1 reveals complementarity of supervised and genomic language models · Table 2, row 'Enformer (Pre-output)', column 'cons30' (ρ) |
| Configuration: Enigma-Distilled (1% eval (evaluated with 1% of the training set), GUANinE v1.1) | Protocol: GUANinE v1.1 cons30, Spearman rho x100 (Table 2) Dataset: GUANinE cons30 test set | 63 Spearman (GUANinE v1.1 test set) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceEnigma-Distilled on GUANinE cons30 lit-genomics-20261011-guanine-protocol-cons30 Aggregation: Not reported GUANinE v1.1 reveals complementarity of supervised and genomic language models · Table 2, row 'Enigma-Distilled', column 'cons30' (ρ) |
| Configuration: ESA-dna2vec (1% eval (evaluated with 1% of the training set), GUANinE v1.1) | Protocol: GUANinE v1.1 cons30, Spearman rho x100 (Table 2) Dataset: GUANinE cons30 test set | 44.1 Spearman (GUANinE v1.1 test set) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourcelit-genomics-20261011-guanine-protocol-cons30 Aggregation: Not reported GUANinE v1.1 reveals complementarity of supervised and genomic language models · Table 2, row 'ESA-dna2vec', column 'cons30' (ρ) |
| Configuration: Evo2_1B_base (1% eval (evaluated with 1% of the training set), GUANinE v1.1) | Protocol: GUANinE v1.1 cons30, Spearman rho x100 (Table 2) Dataset: GUANinE cons30 test set | 68.5 Spearman (GUANinE v1.1 test set) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceEvo2_1B_base on GUANinE cons30 lit-genomics-20261011-guanine-protocol-cons30 Aggregation: Not reported GUANinE v1.1 reveals complementarity of supervised and genomic language models · Table 2, row 'Evo2_1B_base', column 'cons30' (ρ) |
| Configuration: Evo2_7B (1% eval (evaluated with 1% of the training set), GUANinE v1.1) | Protocol: GUANinE v1.1 cons30, Spearman rho x100 (Table 2) Dataset: GUANinE cons30 test set | 76.7 Spearman (GUANinE v1.1 test set) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourcelit-genomics-20261011-guanine-protocol-cons30 Aggregation: Not reported GUANinE v1.1 reveals complementarity of supervised and genomic language models · Table 2, row 'Evo2_7B', column 'cons30' (ρ) |
| Configuration: Evo2_7B_base (1% eval (evaluated with 1% of the training set), GUANinE v1.1) | Protocol: GUANinE v1.1 cons30, Spearman rho x100 (Table 2) Dataset: GUANinE cons30 test set | 74.1 Spearman (GUANinE v1.1 test set) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceEvo2_7B_base on GUANinE cons30 lit-genomics-20261011-guanine-protocol-cons30 Aggregation: Not reported GUANinE v1.1 reveals complementarity of supervised and genomic language models · Table 2, row 'Evo2_7B_base', column 'cons30' (ρ) |
| Configuration: GC-content (zero-shot, GUANinE v1.1) | Protocol: GUANinE v1.1 cons30, Spearman rho x100 (Table 2) Dataset: GUANinE cons30 test set | 38.1 Spearman (GUANinE v1.1 test set) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourcelit-genomics-20261011-guanine-protocol-cons30 Aggregation: Not reported GUANinE v1.1 reveals complementarity of supervised and genomic language models · Table 2, row 'GC-content', column 'cons30' (ρ) |
| Configuration: GENA-LM-bert-base-t2t (1% eval (evaluated with 1% of the training set), GUANinE v1.1) | Protocol: GUANinE v1.1 cons30, Spearman rho x100 (Table 2) Dataset: GUANinE cons30 test set | 66.7 Spearman (GUANinE v1.1 test set) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceGENA-LM-bert-base-t2t on GUANinE cons30 lit-genomics-20261011-guanine-protocol-cons30 Aggregation: Not reported GUANinE v1.1 reveals complementarity of supervised and genomic language models · Table 2, row 'GENA-LM-bert-base-t2t', column 'cons30' (ρ) |
| Configuration: GENA-LM-bert-base-t2t-enf (1% eval (evaluated with 1% of the training set), GUANinE v1.1) | Protocol: GUANinE v1.1 cons30, Spearman rho x100 (Table 2) Dataset: GUANinE cons30 test set | 68.2 Spearman (GUANinE v1.1 test set) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceGENA-LM-bert-base-t2t-enf on GUANinE cons30 lit-genomics-20261011-guanine-protocol-cons30 Aggregation: Not reported GUANinE v1.1 reveals complementarity of supervised and genomic language models · Table 2, row 'GENA-LM-bert-base-t2t-enf', column 'cons30' (ρ) |
| Configuration: GENA-LM-bert-large-t2t (1% eval (evaluated with 1% of the training set), GUANinE v1.1) | Protocol: GUANinE v1.1 cons30, Spearman rho x100 (Table 2) Dataset: GUANinE cons30 test set | 71.6 Spearman (GUANinE v1.1 test set) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceGENA-LM-bert-large-t2t on GUANinE cons30 lit-genomics-20261011-guanine-protocol-cons30 Aggregation: Not reported GUANinE v1.1 reveals complementarity of supervised and genomic language models · Table 2, row 'GENA-LM-bert-large-t2t', column 'cons30' (ρ) |
| Configuration: GENA-LM-bigbird-base-t2t (1% eval (evaluated with 1% of the training set), GUANinE v1.1) | Protocol: GUANinE v1.1 cons30, Spearman rho x100 (Table 2) Dataset: GUANinE cons30 test set | 73.6 Spearman (GUANinE v1.1 test set) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceGENA-LM-bigbird-base-t2t on GUANinE cons30 lit-genomics-20261011-guanine-protocol-cons30 Aggregation: Not reported GUANinE v1.1 reveals complementarity of supervised and genomic language models · Table 2, row 'GENA-LM-bigbird-base-t2t', column 'cons30' (ρ) |
| Configuration: hgT5-8195 (fine-tuned, GUANinE v1.1) | Protocol: GUANinE v1.1 cons30, Spearman rho x100 (Table 2) Dataset: GUANinE cons30 test set | 59.4 Spearman (GUANinE v1.1 test set) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourcelit-genomics-20261011-guanine-protocol-cons30 Aggregation: Not reported GUANinE v1.1 reveals complementarity of supervised and genomic language models · Table 2, row 'hgT5-8195', column 'cons30' (ρ) |
| Configuration: Mistral-DNA-422m-hg38 (1% eval (evaluated with 1% of the training set), GUANinE v1.1) | Protocol: GUANinE v1.1 cons30, Spearman rho x100 (Table 2) Dataset: GUANinE cons30 test set | 60.5 Spearman (GUANinE v1.1 test set) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceMistral-DNA-422m-hg38 on GUANinE cons30 lit-genomics-20261011-guanine-protocol-cons30 Aggregation: Not reported GUANinE v1.1 reveals complementarity of supervised and genomic language models · Table 2, row 'Mistral-DNA-422m-hg38', column 'cons30' (ρ) |
| Configuration: NTv2-100m (1% eval (evaluated with 1% of the training set), GUANinE v1.1) | Protocol: GUANinE v1.1 cons30, Spearman rho x100 (Table 2) Dataset: GUANinE cons30 test set | 69.2 Spearman (GUANinE v1.1 test set) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourcelit-genomics-20261011-guanine-protocol-cons30 Aggregation: Not reported GUANinE v1.1 reveals complementarity of supervised and genomic language models · Table 2, row 'NTv2-100m', column 'cons30' (ρ) |
Source checking is not independent reproduction. Release 2026-10-22-1b7cf027e4f6.
Methods and evaluation design
Procedure, tasks and evaluated configurations
Recorded evaluations
Each evaluation records what was tested and under which conditions.
- 5-mer kNN on GUANinE cons30
- 5-mer LinSVR on GUANinE cons30
- AIDO.DNA_300m on GUANinE cons30
- Borzoi on GUANinE cons30
- Caduceus-PS on GUANinE cons30
- ChromBPNet-ATAC-F0 on GUANinE cons30
- ChromBPNet-ATAC-F3 on GUANinE cons30
- DeepSEA on GUANinE cons30
- DNABERT-2 on GUANinE cons30
- ENCFF180XQC on GUANinE cons30
- Enformer on GUANinE cons30
- Enformer (Pre-output) on GUANinE cons30
Baseline coverage
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- Author-reported evaluations
- 5
- External evaluations
- 27
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Protocol coverage CSV (gzip) · Model evaluation matrix (gzip) · Source table (gzip) · Release and checksums (gzip)
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Evidence
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Evidence table
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Sources and history
Release 2026-10-22-1b7cf027e4f6 · Record review: source checked
1 source record and release history
- GUANinE v1.1 reveals complementarity of supervised and genomic language models · Original source · Bioinformatics 2026, btag427 (issue date 2026-08-01); PMC13501288 full-text XML
Technical metadata and extraction receipts
Stable ID: lit-genomics-20261011-guanine-protocol-cons30
- areas
- dna-genomes
- contexts
- research
- protocol
- GUANinE v1.1 cons30 test set; score is the printed column 'ρ'
- version
- GUANinE v1.1
- metric
- spearman-correlation
- metric direction
- higher
- unit
- unitless
- unit detail
- Printed as Spearman rho multiplied by 100
- limitations
- The benchmark authors evaluated the models; GUANinE v1.1 is by the developers of hgT5 and the T5 baseline.; Previously reported performances are marked in blue in the published table; the colour is not in the XML artifact, so prior and new cells are not distinguished here.; Many rows are '1% eval': models were evaluated with 1% of the training set (Table 2 footnote).
- source locator
- Table 2 column 'cons30'
Related records
- part of: GUANinE v1.1
- uses data: GUANinE cons30 test set
- assessment: 5-mer kNN on GUANinE cons30
- assessment: 5-mer LinSVR on GUANinE cons30
- assessment: AIDO.DNA_300m on GUANinE cons30
- assessment: Borzoi on GUANinE cons30
- assessment: Caduceus-PS on GUANinE cons30
- assessment: ChromBPNet-ATAC-F0 on GUANinE cons30
- assessment: ChromBPNet-ATAC-F3 on GUANinE cons30
- assessment: DeepSEA on GUANinE cons30
- assessment: DNABERT-2 on GUANinE cons30
- assessment: ENCFF180XQC on GUANinE cons30
- assessment: Enformer on GUANinE cons30
- assessment: Enformer (Pre-output) on GUANinE cons30
- assessment: Enigma-Distilled on GUANinE cons30
- assessment: ESA-dna2vec on GUANinE cons30
- assessment: Evo2_1B_base on GUANinE cons30
- assessment: Evo2_7B on GUANinE cons30
- assessment: Evo2_7B_base on GUANinE cons30
- assessment: GC-content on GUANinE cons30
- assessment: GENA-LM-bert-base-t2t on GUANinE cons30
- assessment: GENA-LM-bert-base-t2t-enf on GUANinE cons30
- assessment: GENA-LM-bert-large-t2t on GUANinE cons30
- assessment: GENA-LM-bigbird-base-t2t on GUANinE cons30
- assessment: hgT5-8195 on GUANinE cons30
- assessment: Mistral-DNA-422m-hg38 on GUANinE cons30
- assessment: NTv2-100m on GUANinE cons30
- assessment: NTv2-500m on GUANinE cons30
- assessment: NTv3-100m-post on GUANinE cons30
- assessment: NTv3-100m-pre on GUANinE cons30
- assessment: NTv3-650m-post on GUANinE cons30
- assessment: PhyloGPN on GUANinE cons30
- assessment: Sei on GUANinE cons30
- assessment: ⋆ T5 on GUANinE cons30