Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026)
Nature 652 (2026), published 2026-03-04; Supplementary Information file 41586_2026_10176_MOESM1_ESM.pdf (73 pages) · Peer-reviewed
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Records in this release that cite this source. A record can cite several sources.
Results
Values as the source printed them. Compare results only under compatible protocols, datasets and metrics.
Models, benchmarks and other records
Models (3)
Configurations (21)
- AlphaMissense (Evo 2 paper variant effect evaluations)
- CADD (Evo 2 paper variant effect evaluations)
- CodonBERT 87M (Evo 2 paper variant effect evaluations)
- DeCodon 200M (Evo 2 paper variant effect evaluations)
- EnCodon 620M (Evo 2 paper variant effect evaluations)
- ESM-1b (Evo 2 paper variant effect evaluations)
- ESM-2 650M (Evo 2 paper variant effect evaluations)
- Evo 1 (Evo 2 paper variant effect evaluations)
- Evo 2 7B (Evo 2 paper variant effect evaluations)
- Evo 2 7B base (Evo 2 paper variant effect evaluations)
- Evo 2 40B (Evo 2 paper variant effect evaluations)
- Evo 2 40B base (Evo 2 paper variant effect evaluations)
- GPN-MSA (Evo 2 paper variant effect evaluations)
- NT (Evo 2 paper variant effect evaluations)
- Pangolin (Evo 2 paper variant effect evaluations)
- PhyloP 100 (Evo 2 paper variant effect evaluations)
- PhyloP 241 (Evo 2 paper variant effect evaluations)
- PhyloP 447 (Evo 2 paper variant effect evaluations)
- PhyloP 470 (Evo 2 paper variant effect evaluations)
- RNA-FM (Evo 2 paper variant effect evaluations)
- SpliceAI (Evo 2 paper variant effect evaluations)
Benchmarks (1)
Protocols (49)
- Zero-shot BRCA1 'Both' (coding and noncoding) SNVs classification (Evo 2 paper, Supplementary Data 1)
- Zero-shot BRCA1 coding SNVs classification (Evo 2 paper, Supplementary Data 1)
- Zero-shot BRCA1 intronic SNVs classification (Evo 2 paper, Supplementary Data 1)
- Zero-shot BRCA1 noncoding SNVs classification (Evo 2 paper, Supplementary Data 1)
- Zero-shot BRCA1 splice region SNVs classification (Evo 2 paper, Supplementary Data 1)
- Zero-shot BRCA2 'Both' (coding and noncoding) SNVs classification (Evo 2 paper, Supplementary Data 1)
- Zero-shot BRCA2 coding SNVs classification (Evo 2 paper, Supplementary Data 1)
- Zero-shot BRCA2 noncoding SNVs classification (Evo 2 paper, Supplementary Data 1)
- Zero-shot ClinVar 'Both' (coding and noncoding) indels classification (Evo 2 paper, Supplementary Data 1)
- Zero-shot ClinVar 'Both' (coding and noncoding) microsatellite variants classification (Evo 2 paper, Supplementary Data 1)
- Zero-shot ClinVar 'Both' (coding and noncoding) SNVs classification (Evo 2 paper, Supplementary Data 1)
- Zero-shot ClinVar coding indels classification (Evo 2 paper, Supplementary Data 1)
- Zero-shot ClinVar coding microsatellite variants classification (Evo 2 paper, Supplementary Data 1)
- Zero-shot ClinVar coding non-SNVs classification (Evo 2 paper, Supplementary Data 1)
- Zero-shot ClinVar coding non-SNVs, far from splice site classification (Evo 2 paper, Supplementary Data 1)
- Zero-shot ClinVar coding non-SNVs, highly conserved classification (Evo 2 paper, Supplementary Data 1)
- Zero-shot ClinVar coding non-SNVs, moderately conserved classification (Evo 2 paper, Supplementary Data 1)
- Zero-shot ClinVar coding non-SNVs, not conserved classification (Evo 2 paper, Supplementary Data 1)
- Zero-shot ClinVar coding non-SNVs, poorly conserved classification (Evo 2 paper, Supplementary Data 1)
- Zero-shot ClinVar coding SNVs classification (Evo 2 paper, Supplementary Data 1)
- Zero-shot ClinVar coding SNVs, far from splice site classification (Evo 2 paper, Supplementary Data 1)
- Zero-shot ClinVar coding SNVs, highly conserved classification (Evo 2 paper, Supplementary Data 1)
- Zero-shot ClinVar coding SNVs, moderately conserved classification (Evo 2 paper, Supplementary Data 1)
- Zero-shot ClinVar coding SNVs, near splice site classification (Evo 2 paper, Supplementary Data 1)
- Zero-shot ClinVar coding SNVs, not conserved classification (Evo 2 paper, Supplementary Data 1)
Datasets (4)
Evaluations (705)
- AlphaMissense on BRCA1 coding SNVs (Evo 2 paper)
- AlphaMissense on BRCA2 coding SNVs (Evo 2 paper)
- AlphaMissense on ClinVar coding SNVs (Evo 2 paper)
- AlphaMissense on ClinVar coding SNVs, far from splice site (Evo 2 paper)
- AlphaMissense on ClinVar coding SNVs, highly conserved (Evo 2 paper)
- AlphaMissense on ClinVar coding SNVs, moderately conserved (Evo 2 paper)
- AlphaMissense on ClinVar coding SNVs, near splice site (Evo 2 paper)
- AlphaMissense on ClinVar coding SNVs, not conserved (Evo 2 paper)
- AlphaMissense on ClinVar coding SNVs, poorly conserved (Evo 2 paper)
- AlphaMissense on SpliceVarDB exonic SNVs (Evo 2 paper)
- CADD on BRCA1 'Both' (coding and noncoding) SNVs (Evo 2 paper)
- CADD on BRCA1 coding SNVs (Evo 2 paper)
- CADD on BRCA1 intronic SNVs (Evo 2 paper)
- CADD on BRCA1 noncoding SNVs (Evo 2 paper)
- CADD on BRCA1 splice region SNVs (Evo 2 paper)
- CADD on BRCA2 'Both' (coding and noncoding) SNVs (Evo 2 paper)
- CADD on BRCA2 coding SNVs (Evo 2 paper)
- CADD on BRCA2 noncoding SNVs (Evo 2 paper)
- CADD on ClinVar 'Both' (coding and noncoding) SNVs (Evo 2 paper)
- CADD on ClinVar coding SNVs (Evo 2 paper)
- CADD on ClinVar coding SNVs, far from splice site (Evo 2 paper)
- CADD on ClinVar coding SNVs, highly conserved (Evo 2 paper)
- CADD on ClinVar coding SNVs, moderately conserved (Evo 2 paper)
- CADD on ClinVar coding SNVs, near splice site (Evo 2 paper)
- CADD on ClinVar coding SNVs, not conserved (Evo 2 paper)
Evidence
Source checking verifies the cited claim or transcription. It does not establish independent reproduction.
Evidence table
Inspect claims, sources and review details
Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.
One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.
26 evidence rows matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|---|---|
| attributes.artifact_sha256 fe2a99108a4ce5c0f4ef1595605eaec709fa86204410d5b66c1384327eb7b925 Source metadata | Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) No field-specific location recorded Version: Nature 652 (2026), published 2026-03-04; Supplementary Information file 41586_2026_10176_MOESM1_ESM.pdf (73 pages) | catalogued No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Artifact url https://static-content.springer.com/esm/art%3A10.1038%2Fs41586-026-10176-5/MediaObjects/41586_2026_10176_MOESM1_ESM.pdf Source metadata | Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) No field-specific location recorded Version: Nature 652 (2026), published 2026-03-04; Supplementary Information file 41586_2026_10176_MOESM1_ESM.pdf (73 pages) | catalogued No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Doi 10.1038/s41586-026-10176-5 Source metadata | Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) No field-specific location recorded Version: Nature 652 (2026), published 2026-03-04; Supplementary Information file 41586_2026_10176_MOESM1_ESM.pdf (73 pages) | catalogued No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Licence CC-BY-NC-ND-4.0 Source metadata | Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) No field-specific location recorded Version: Nature 652 (2026), published 2026-03-04; Supplementary Information file 41586_2026_10176_MOESM1_ESM.pdf (73 pages) | catalogued No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
Limitations2 values
| Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) No field-specific location recorded Version: Nature 652 (2026), published 2026-03-04; Supplementary Information file 41586_2026_10176_MOESM1_ESM.pdf (73 pages) | catalogued No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Media type application/pdf Source metadata | Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) No field-specific location recorded Version: Nature 652 (2026), published 2026-03-04; Supplementary Information file 41586_2026_10176_MOESM1_ESM.pdf (73 pages) | catalogued No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Publication status peer_reviewed Source metadata | Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) No field-specific location recorded Version: Nature 652 (2026), published 2026-03-04; Supplementary Information file 41586_2026_10176_MOESM1_ESM.pdf (73 pages) | catalogued No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Retrieved at 2026-10-14T12:01:04Z Source metadata | Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) No field-specific location recorded Version: Nature 652 (2026), published 2026-03-04; Supplementary Information file 41586_2026_10176_MOESM1_ESM.pdf (73 pages) | catalogued No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| attributes.review.artifact_sha256 fe2a99108a4ce5c0f4ef1595605eaec709fa86204410d5b66c1384327eb7b925 Source metadata | Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) No field-specific location recorded Version: Nature 652 (2026), published 2026-03-04; Supplementary Information file 41586_2026_10176_MOESM1_ESM.pdf (73 pages) | catalogued No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Review: date 2026-10-14 Source metadata | Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) No field-specific location recorded Version: Nature 652 (2026), published 2026-03-04; Supplementary Information file 41586_2026_10176_MOESM1_ESM.pdf (73 pages) | catalogued No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
Sources and history
Release 2026-10-22-1b7cf027e4f6 · Record review: source checked
Primary source retrieved and hashed for the issue #129 Evo 2 evidence pass.
Technical metadata and extraction receipts
Stable ID: gfm-guides-20261014-evo2-brixi2026-source-supplementary-information
- areas
- dna-genomes
- contexts
- research
- url
- https://doi.org/10.1038/s41586-026-10176-5
- artifact url
- https://static-content.springer.com/esm/art%3A10.1038%2Fs41586-026-10176-5/MediaObjects/41586_2026_10176_MOESM1_ESM.pdf
- version
- Nature 652 (2026), published 2026-03-04; Supplementary Information file 41586_2026_10176_MOESM1_ESM.pdf (73 pages)
- retrieved at
- 2026-10-14T12:01:04Z
- artifact sha256
- fe2a99108a4ce5c0f4ef1595605eaec709fa86204410d5b66c1384327eb7b925
- doi
- 10.1038/s41586-026-10176-5
- publication status
- peer_reviewed
- licence
- CC-BY-NC-ND-4.0
- media type
- application/pdf
- limitations
- Supplementary Tables 6 to 8 print Evo 2 7B base zero-shot AUROC and AUPRC against a 7B data-ablation model on ClinVar, SpliceVarDB and BRCA1. Several Evo 2 7B base values differ from Supplementary Data 1: ClinVar all SNV AUROC 0.957 and AUPRC 0.927 (Supplementary Data 1 'Both' SNV 0.960 and 0.944), coding non-SNV AUROC 0.918 (0.865), SpliceVarDB intronic AUROC 0.923 (0.925). BRCA1 values match. The tables were not extracted.; Licence CC BY-NC-ND 4.0 (article licence statement); no archived copy kept in the batch folder.
- review
- method: source-hash-verification; method note: Re-downloaded from the publisher on 2026-10-14; SHA-256 matches.; reviewer: claude; reviewer note: Claude (Opus 5.5) research agent, independent of the extractor; no human review claimed; date: 2026-10-14; artifact sha256: fe2a99108a4ce5c0f4ef1595605eaec709fa86204410d5b66c1384327eb7b925; retrieval url: https://static-content.springer.com/esm/art%3A10.1038%2Fs41586-026-10176-5/MediaObjects/41586_2026_10176_MOESM1_ESM.pdf; note: Independent review 2026-10-14.