Dataset

BRCA2 SNVs with functional classifications, Huang et al. 2025 (Brixi et al. 2026)

BRCA2 SNVs with experimental functional scores and classifications (Huang et al. 2025, reference 27): P strong, P moderate and P supporting (1,156) versus B strong, B moderate and B supporting (5,681).

Evaluation results

44 evaluations · 88 results. Different protocols are not a single leaderboard.

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Tested model or methodProtocolDatasetEvaluation setupMetricEvidence origin

Applied filters: All linked evaluations

Exact evaluated configurations and original reported results
Tested configuration	Protocol and dataset	Finding	Evidence and details
Configuration: AlphaMissense (Evo 2 paper variant effect evaluations)	Protocol: Zero-shot BRCA2 coding SNVs classification (Evo 2 paper, Supplementary Data 1) Dataset: BRCA2 SNVs with functional classifications, Huang et al. 2025 (Brixi et al. 2026)	0.527 AUPRC (zero-shot; BRCA2 coding SNVs) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source AlphaMissense on BRCA2 coding SNVs (Evo 2 paper) gfm-guides-20261014-evo2-brixi2026-protocol-brca2-coding-snv Aggregation: Not reported Genome modelling and design across all domains of life with Evo 2: Supplementary Data 1, human variant effect prediction results (Nature 2026); Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) · Supplementary Data 1 (sheet 'Sheet1') cell J531, row 531: Model 'AlphaMissense', Data 'BRCA2', Genomic_Feature 'Coding', Variant_Type 'SNV', Sub_category '', column 'AUPRC'
Configuration: AlphaMissense (Evo 2 paper variant effect evaluations)	Protocol: Zero-shot BRCA2 coding SNVs classification (Evo 2 paper, Supplementary Data 1) Dataset: BRCA2 SNVs with functional classifications, Huang et al. 2025 (Brixi et al. 2026)	0.831 AUROC (zero-shot; BRCA2 coding SNVs) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source AlphaMissense on BRCA2 coding SNVs (Evo 2 paper) gfm-guides-20261014-evo2-brixi2026-protocol-brca2-coding-snv Aggregation: Not reported Genome modelling and design across all domains of life with Evo 2: Supplementary Data 1, human variant effect prediction results (Nature 2026); Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) · Supplementary Data 1 (sheet 'Sheet1') cell I531, row 531: Model 'AlphaMissense', Data 'BRCA2', Genomic_Feature 'Coding', Variant_Type 'SNV', Sub_category '', column 'AUROC'
Configuration: CADD (Evo 2 paper variant effect evaluations)	Protocol: Zero-shot BRCA2 'Both' (coding and noncoding) SNVs classification (Evo 2 paper, Supplementary Data 1) Dataset: BRCA2 SNVs with functional classifications, Huang et al. 2025 (Brixi et al. 2026)	0.739 AUPRC (zero-shot; BRCA2 'Both' (coding and noncoding) SNVs) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source CADD on BRCA2 'Both' (coding and noncoding) SNVs (Evo 2 paper) gfm-guides-20261014-evo2-brixi2026-protocol-brca2-both-snv Aggregation: Not reported Genome modelling and design across all domains of life with Evo 2: Supplementary Data 1, human variant effect prediction results (Nature 2026); Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) · Supplementary Data 1 (sheet 'Sheet1') cell J561, row 561: Model 'CADD', Data 'BRCA2', Genomic_Feature 'Both', Variant_Type 'SNV', Sub_category '', column 'AUPRC'
Configuration: CADD (Evo 2 paper variant effect evaluations)	Protocol: Zero-shot BRCA2 'Both' (coding and noncoding) SNVs classification (Evo 2 paper, Supplementary Data 1) Dataset: BRCA2 SNVs with functional classifications, Huang et al. 2025 (Brixi et al. 2026)	0.884 AUROC (zero-shot; BRCA2 'Both' (coding and noncoding) SNVs) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source CADD on BRCA2 'Both' (coding and noncoding) SNVs (Evo 2 paper) gfm-guides-20261014-evo2-brixi2026-protocol-brca2-both-snv Aggregation: Not reported Genome modelling and design across all domains of life with Evo 2: Supplementary Data 1, human variant effect prediction results (Nature 2026); Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) · Supplementary Data 1 (sheet 'Sheet1') cell I561, row 561: Model 'CADD', Data 'BRCA2', Genomic_Feature 'Both', Variant_Type 'SNV', Sub_category '', column 'AUROC'
Configuration: CADD (Evo 2 paper variant effect evaluations)	Protocol: Zero-shot BRCA2 coding SNVs classification (Evo 2 paper, Supplementary Data 1) Dataset: BRCA2 SNVs with functional classifications, Huang et al. 2025 (Brixi et al. 2026)	0.402 AUPRC (zero-shot; BRCA2 coding SNVs) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source CADD on BRCA2 coding SNVs (Evo 2 paper) gfm-guides-20261014-evo2-brixi2026-protocol-brca2-coding-snv Aggregation: Not reported Genome modelling and design across all domains of life with Evo 2: Supplementary Data 1, human variant effect prediction results (Nature 2026); Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) · Supplementary Data 1 (sheet 'Sheet1') cell J533, row 533: Model 'CADD', Data 'BRCA2', Genomic_Feature 'Coding', Variant_Type 'SNV', Sub_category '', column 'AUPRC'
Configuration: CADD (Evo 2 paper variant effect evaluations)	Protocol: Zero-shot BRCA2 coding SNVs classification (Evo 2 paper, Supplementary Data 1) Dataset: BRCA2 SNVs with functional classifications, Huang et al. 2025 (Brixi et al. 2026)	0.787 AUROC (zero-shot; BRCA2 coding SNVs) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source CADD on BRCA2 coding SNVs (Evo 2 paper) gfm-guides-20261014-evo2-brixi2026-protocol-brca2-coding-snv Aggregation: Not reported Genome modelling and design across all domains of life with Evo 2: Supplementary Data 1, human variant effect prediction results (Nature 2026); Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) · Supplementary Data 1 (sheet 'Sheet1') cell I533, row 533: Model 'CADD', Data 'BRCA2', Genomic_Feature 'Coding', Variant_Type 'SNV', Sub_category '', column 'AUROC'
Configuration: CADD (Evo 2 paper variant effect evaluations)	Protocol: Zero-shot BRCA2 noncoding SNVs classification (Evo 2 paper, Supplementary Data 1) Dataset: BRCA2 SNVs with functional classifications, Huang et al. 2025 (Brixi et al. 2026)	0.867 AUPRC (zero-shot; BRCA2 noncoding SNVs) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source CADD on BRCA2 noncoding SNVs (Evo 2 paper) gfm-guides-20261014-evo2-brixi2026-protocol-brca2-noncoding-snv Aggregation: Not reported Genome modelling and design across all domains of life with Evo 2: Supplementary Data 1, human variant effect prediction results (Nature 2026); Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) · Supplementary Data 1 (sheet 'Sheet1') cell J547, row 547: Model 'CADD', Data 'BRCA2', Genomic_Feature 'Noncoding', Variant_Type 'SNV', Sub_category '', column 'AUPRC'
Configuration: CADD (Evo 2 paper variant effect evaluations)	Protocol: Zero-shot BRCA2 noncoding SNVs classification (Evo 2 paper, Supplementary Data 1) Dataset: BRCA2 SNVs with functional classifications, Huang et al. 2025 (Brixi et al. 2026)	0.924 AUROC (zero-shot; BRCA2 noncoding SNVs) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source CADD on BRCA2 noncoding SNVs (Evo 2 paper) gfm-guides-20261014-evo2-brixi2026-protocol-brca2-noncoding-snv Aggregation: Not reported Genome modelling and design across all domains of life with Evo 2: Supplementary Data 1, human variant effect prediction results (Nature 2026); Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) · Supplementary Data 1 (sheet 'Sheet1') cell I547, row 547: Model 'CADD', Data 'BRCA2', Genomic_Feature 'Noncoding', Variant_Type 'SNV', Sub_category '', column 'AUROC'
Configuration: Evo 1 (Evo 2 paper variant effect evaluations)	Protocol: Zero-shot BRCA2 'Both' (coding and noncoding) SNVs classification (Evo 2 paper, Supplementary Data 1) Dataset: BRCA2 SNVs with functional classifications, Huang et al. 2025 (Brixi et al. 2026)	0.228 AUPRC (zero-shot; BRCA2 'Both' (coding and noncoding) SNVs) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Evo 1 on BRCA2 'Both' (coding and noncoding) SNVs (Evo 2 paper) gfm-guides-20261014-evo2-brixi2026-protocol-brca2-both-snv Aggregation: Not reported Genome modelling and design across all domains of life with Evo 2: Supplementary Data 1, human variant effect prediction results (Nature 2026); Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) · Supplementary Data 1 (sheet 'Sheet1') cell J573, row 573: Model 'Evo 1', Data 'BRCA2', Genomic_Feature 'Both', Variant_Type 'SNV', Sub_category '', column 'AUPRC'
Configuration: Evo 1 (Evo 2 paper variant effect evaluations)	Protocol: Zero-shot BRCA2 'Both' (coding and noncoding) SNVs classification (Evo 2 paper, Supplementary Data 1) Dataset: BRCA2 SNVs with functional classifications, Huang et al. 2025 (Brixi et al. 2026)	0.54 AUROC (zero-shot; BRCA2 'Both' (coding and noncoding) SNVs) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Evo 1 on BRCA2 'Both' (coding and noncoding) SNVs (Evo 2 paper) gfm-guides-20261014-evo2-brixi2026-protocol-brca2-both-snv Aggregation: Not reported Genome modelling and design across all domains of life with Evo 2: Supplementary Data 1, human variant effect prediction results (Nature 2026); Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) · Supplementary Data 1 (sheet 'Sheet1') cell I573, row 573: Model 'Evo 1', Data 'BRCA2', Genomic_Feature 'Both', Variant_Type 'SNV', Sub_category '', column 'AUROC'
Configuration: Evo 1 (Evo 2 paper variant effect evaluations)	Protocol: Zero-shot BRCA2 coding SNVs classification (Evo 2 paper, Supplementary Data 1) Dataset: BRCA2 SNVs with functional classifications, Huang et al. 2025 (Brixi et al. 2026)	0.157 AUPRC (zero-shot; BRCA2 coding SNVs) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Evo 1 on BRCA2 coding SNVs (Evo 2 paper) gfm-guides-20261014-evo2-brixi2026-protocol-brca2-coding-snv Aggregation: Not reported Genome modelling and design across all domains of life with Evo 2: Supplementary Data 1, human variant effect prediction results (Nature 2026); Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) · Supplementary Data 1 (sheet 'Sheet1') cell J544, row 544: Model 'Evo 1', Data 'BRCA2', Genomic_Feature 'Coding', Variant_Type 'SNV', Sub_category '', column 'AUPRC'
Configuration: Evo 1 (Evo 2 paper variant effect evaluations)	Protocol: Zero-shot BRCA2 coding SNVs classification (Evo 2 paper, Supplementary Data 1) Dataset: BRCA2 SNVs with functional classifications, Huang et al. 2025 (Brixi et al. 2026)	0.535 AUROC (zero-shot; BRCA2 coding SNVs) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Evo 1 on BRCA2 coding SNVs (Evo 2 paper) gfm-guides-20261014-evo2-brixi2026-protocol-brca2-coding-snv Aggregation: Not reported Genome modelling and design across all domains of life with Evo 2: Supplementary Data 1, human variant effect prediction results (Nature 2026); Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) · Supplementary Data 1 (sheet 'Sheet1') cell I544, row 544: Model 'Evo 1', Data 'BRCA2', Genomic_Feature 'Coding', Variant_Type 'SNV', Sub_category '', column 'AUROC'
Configuration: Evo 1 (Evo 2 paper variant effect evaluations)	Protocol: Zero-shot BRCA2 noncoding SNVs classification (Evo 2 paper, Supplementary Data 1) Dataset: BRCA2 SNVs with functional classifications, Huang et al. 2025 (Brixi et al. 2026)	0.265 AUPRC (zero-shot; BRCA2 noncoding SNVs) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Evo 1 on BRCA2 noncoding SNVs (Evo 2 paper) gfm-guides-20261014-evo2-brixi2026-protocol-brca2-noncoding-snv Aggregation: Not reported Genome modelling and design across all domains of life with Evo 2: Supplementary Data 1, human variant effect prediction results (Nature 2026); Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) · Supplementary Data 1 (sheet 'Sheet1') cell J559, row 559: Model 'Evo 1', Data 'BRCA2', Genomic_Feature 'Noncoding', Variant_Type 'SNV', Sub_category '', column 'AUPRC'
Configuration: Evo 1 (Evo 2 paper variant effect evaluations)	Protocol: Zero-shot BRCA2 noncoding SNVs classification (Evo 2 paper, Supplementary Data 1) Dataset: BRCA2 SNVs with functional classifications, Huang et al. 2025 (Brixi et al. 2026)	0.545 AUROC (zero-shot; BRCA2 noncoding SNVs) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Evo 1 on BRCA2 noncoding SNVs (Evo 2 paper) gfm-guides-20261014-evo2-brixi2026-protocol-brca2-noncoding-snv Aggregation: Not reported Genome modelling and design across all domains of life with Evo 2: Supplementary Data 1, human variant effect prediction results (Nature 2026); Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) · Supplementary Data 1 (sheet 'Sheet1') cell I559, row 559: Model 'Evo 1', Data 'BRCA2', Genomic_Feature 'Noncoding', Variant_Type 'SNV', Sub_category '', column 'AUROC'
Configuration: Evo 2 40B base (Evo 2 paper variant effect evaluations)	Protocol: Zero-shot BRCA2 'Both' (coding and noncoding) SNVs classification (Evo 2 paper, Supplementary Data 1) Dataset: BRCA2 SNVs with functional classifications, Huang et al. 2025 (Brixi et al. 2026)	0.558 AUPRC (zero-shot; BRCA2 'Both' (coding and noncoding) SNVs) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Evo 2 40B base on BRCA2 'Both' (coding and noncoding) SNVs (Evo 2 paper) gfm-guides-20261014-evo2-brixi2026-protocol-brca2-both-snv Aggregation: Not reported Genome modelling and design across all domains of life with Evo 2: Supplementary Data 1, human variant effect prediction results (Nature 2026); Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) · Supplementary Data 1 (sheet 'Sheet1') cell J562, row 562: Model 'Evo 2 40B base', Data 'BRCA2', Genomic_Feature 'Both', Variant_Type 'SNV', Sub_category '', column 'AUPRC'
Configuration: Evo 2 40B base (Evo 2 paper variant effect evaluations)	Protocol: Zero-shot BRCA2 'Both' (coding and noncoding) SNVs classification (Evo 2 paper, Supplementary Data 1) Dataset: BRCA2 SNVs with functional classifications, Huang et al. 2025 (Brixi et al. 2026)	0.847 AUROC (zero-shot; BRCA2 'Both' (coding and noncoding) SNVs) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Evo 2 40B base on BRCA2 'Both' (coding and noncoding) SNVs (Evo 2 paper) gfm-guides-20261014-evo2-brixi2026-protocol-brca2-both-snv Aggregation: Not reported Genome modelling and design across all domains of life with Evo 2: Supplementary Data 1, human variant effect prediction results (Nature 2026); Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) · Supplementary Data 1 (sheet 'Sheet1') cell I562, row 562: Model 'Evo 2 40B base', Data 'BRCA2', Genomic_Feature 'Both', Variant_Type 'SNV', Sub_category '', column 'AUROC'
Configuration: Evo 2 40B base (Evo 2 paper variant effect evaluations)	Protocol: Zero-shot BRCA2 coding SNVs classification (Evo 2 paper, Supplementary Data 1) Dataset: BRCA2 SNVs with functional classifications, Huang et al. 2025 (Brixi et al. 2026)	0.346 AUPRC (zero-shot; BRCA2 coding SNVs) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Evo 2 40B base on BRCA2 coding SNVs (Evo 2 paper) gfm-guides-20261014-evo2-brixi2026-protocol-brca2-coding-snv Aggregation: Not reported Genome modelling and design across all domains of life with Evo 2: Supplementary Data 1, human variant effect prediction results (Nature 2026); Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) · Supplementary Data 1 (sheet 'Sheet1') cell J534, row 534: Model 'Evo 2 40B base', Data 'BRCA2', Genomic_Feature 'Coding', Variant_Type 'SNV', Sub_category '', column 'AUPRC'
Configuration: Evo 2 40B base (Evo 2 paper variant effect evaluations)	Protocol: Zero-shot BRCA2 coding SNVs classification (Evo 2 paper, Supplementary Data 1) Dataset: BRCA2 SNVs with functional classifications, Huang et al. 2025 (Brixi et al. 2026)	0.77 AUROC (zero-shot; BRCA2 coding SNVs) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Evo 2 40B base on BRCA2 coding SNVs (Evo 2 paper) gfm-guides-20261014-evo2-brixi2026-protocol-brca2-coding-snv Aggregation: Not reported Genome modelling and design across all domains of life with Evo 2: Supplementary Data 1, human variant effect prediction results (Nature 2026); Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) · Supplementary Data 1 (sheet 'Sheet1') cell I534, row 534: Model 'Evo 2 40B base', Data 'BRCA2', Genomic_Feature 'Coding', Variant_Type 'SNV', Sub_category '', column 'AUROC'
Configuration: Evo 2 40B base (Evo 2 paper variant effect evaluations)	Protocol: Zero-shot BRCA2 noncoding SNVs classification (Evo 2 paper, Supplementary Data 1) Dataset: BRCA2 SNVs with functional classifications, Huang et al. 2025 (Brixi et al. 2026)	0.784 AUPRC (zero-shot; BRCA2 noncoding SNVs) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Evo 2 40B base on BRCA2 noncoding SNVs (Evo 2 paper) gfm-guides-20261014-evo2-brixi2026-protocol-brca2-noncoding-snv Aggregation: Not reported Genome modelling and design across all domains of life with Evo 2: Supplementary Data 1, human variant effect prediction results (Nature 2026); Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) · Supplementary Data 1 (sheet 'Sheet1') cell J550, row 550: Model 'Evo 2 40B base', Data 'BRCA2', Genomic_Feature 'Noncoding', Variant_Type 'SNV', Sub_category '', column 'AUPRC'
Configuration: Evo 2 40B base (Evo 2 paper variant effect evaluations)	Protocol: Zero-shot BRCA2 noncoding SNVs classification (Evo 2 paper, Supplementary Data 1) Dataset: BRCA2 SNVs with functional classifications, Huang et al. 2025 (Brixi et al. 2026)	0.903 AUROC (zero-shot; BRCA2 noncoding SNVs) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Evo 2 40B base on BRCA2 noncoding SNVs (Evo 2 paper) gfm-guides-20261014-evo2-brixi2026-protocol-brca2-noncoding-snv Aggregation: Not reported Genome modelling and design across all domains of life with Evo 2: Supplementary Data 1, human variant effect prediction results (Nature 2026); Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) · Supplementary Data 1 (sheet 'Sheet1') cell I550, row 550: Model 'Evo 2 40B base', Data 'BRCA2', Genomic_Feature 'Noncoding', Variant_Type 'SNV', Sub_category '', column 'AUROC'
Configuration: Evo 2 40B (Evo 2 paper variant effect evaluations)	Protocol: Zero-shot BRCA2 'Both' (coding and noncoding) SNVs classification (Evo 2 paper, Supplementary Data 1) Dataset: BRCA2 SNVs with functional classifications, Huang et al. 2025 (Brixi et al. 2026)	0.533 AUPRC (zero-shot; BRCA2 'Both' (coding and noncoding) SNVs) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Evo 2 40B on BRCA2 'Both' (coding and noncoding) SNVs (Evo 2 paper) gfm-guides-20261014-evo2-brixi2026-protocol-brca2-both-snv Aggregation: Not reported Genome modelling and design across all domains of life with Evo 2: Supplementary Data 1, human variant effect prediction results (Nature 2026); Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) · Supplementary Data 1 (sheet 'Sheet1') cell J563, row 563: Model 'Evo 2 40B', Data 'BRCA2', Genomic_Feature 'Both', Variant_Type 'SNV', Sub_category '', column 'AUPRC'
Configuration: Evo 2 40B (Evo 2 paper variant effect evaluations)	Protocol: Zero-shot BRCA2 'Both' (coding and noncoding) SNVs classification (Evo 2 paper, Supplementary Data 1) Dataset: BRCA2 SNVs with functional classifications, Huang et al. 2025 (Brixi et al. 2026)	0.845 AUROC (zero-shot; BRCA2 'Both' (coding and noncoding) SNVs) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Evo 2 40B on BRCA2 'Both' (coding and noncoding) SNVs (Evo 2 paper) gfm-guides-20261014-evo2-brixi2026-protocol-brca2-both-snv Aggregation: Not reported Genome modelling and design across all domains of life with Evo 2: Supplementary Data 1, human variant effect prediction results (Nature 2026); Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) · Supplementary Data 1 (sheet 'Sheet1') cell I563, row 563: Model 'Evo 2 40B', Data 'BRCA2', Genomic_Feature 'Both', Variant_Type 'SNV', Sub_category '', column 'AUROC'
Configuration: Evo 2 40B (Evo 2 paper variant effect evaluations)	Protocol: Zero-shot BRCA2 coding SNVs classification (Evo 2 paper, Supplementary Data 1) Dataset: BRCA2 SNVs with functional classifications, Huang et al. 2025 (Brixi et al. 2026)	0.333 AUPRC (zero-shot; BRCA2 coding SNVs) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Evo 2 40B on BRCA2 coding SNVs (Evo 2 paper) gfm-guides-20261014-evo2-brixi2026-protocol-brca2-coding-snv Aggregation: Not reported Genome modelling and design across all domains of life with Evo 2: Supplementary Data 1, human variant effect prediction results (Nature 2026); Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) · Supplementary Data 1 (sheet 'Sheet1') cell J535, row 535: Model 'Evo 2 40B', Data 'BRCA2', Genomic_Feature 'Coding', Variant_Type 'SNV', Sub_category '', column 'AUPRC'
Configuration: Evo 2 40B (Evo 2 paper variant effect evaluations)	Protocol: Zero-shot BRCA2 coding SNVs classification (Evo 2 paper, Supplementary Data 1) Dataset: BRCA2 SNVs with functional classifications, Huang et al. 2025 (Brixi et al. 2026)	0.768 AUROC (zero-shot; BRCA2 coding SNVs) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Evo 2 40B on BRCA2 coding SNVs (Evo 2 paper) gfm-guides-20261014-evo2-brixi2026-protocol-brca2-coding-snv Aggregation: Not reported Genome modelling and design across all domains of life with Evo 2: Supplementary Data 1, human variant effect prediction results (Nature 2026); Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) · Supplementary Data 1 (sheet 'Sheet1') cell I535, row 535: Model 'Evo 2 40B', Data 'BRCA2', Genomic_Feature 'Coding', Variant_Type 'SNV', Sub_category '', column 'AUROC'
Configuration: Evo 2 40B (Evo 2 paper variant effect evaluations)	Protocol: Zero-shot BRCA2 noncoding SNVs classification (Evo 2 paper, Supplementary Data 1) Dataset: BRCA2 SNVs with functional classifications, Huang et al. 2025 (Brixi et al. 2026)	0.786 AUPRC (zero-shot; BRCA2 noncoding SNVs) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Evo 2 40B on BRCA2 noncoding SNVs (Evo 2 paper) gfm-guides-20261014-evo2-brixi2026-protocol-brca2-noncoding-snv Aggregation: Not reported Genome modelling and design across all domains of life with Evo 2: Supplementary Data 1, human variant effect prediction results (Nature 2026); Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) · Supplementary Data 1 (sheet 'Sheet1') cell J548, row 548: Model 'Evo 2 40B', Data 'BRCA2', Genomic_Feature 'Noncoding', Variant_Type 'SNV', Sub_category '', column 'AUPRC'

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Release 2026-10-22-1b7cf027e4f6 · Evidence verified: Not verified

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24 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-10-22-1b7cf027e4f6
Property and statement	Original source and location	Review and provenance
Label semantics P strong, P moderate, P supporting versus B strong, B moderate, B supporting Context-only references	evo2: Journal full-text XML Original source ↗ Supplementary Information A.3.15 (page 14); main text 'Human variant effect prediction' Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Retrieved page snapshot; no immutable publisher revision supplied Retrieved: 2026-09-16T20:16:14.422554+00:00	not individually reviewed No individual claim review recorded Audit details Field: `attributes.label_semantics` Source artifact SHA-256: `d043dbda49e023ef6b70e36e7ca7832bda6b7af6c5934368e8778a7f23cda8bd` Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact Inspected artifact
Label semantics P strong, P moderate, P supporting versus B strong, B moderate, B supporting Context-only references	Genome modelling and design across all domains of life with Evo 2: Supplementary Data 1, human variant effect prediction results (Nature 2026) Original source ↗ Supplementary Information A.3.15 (page 14); main text 'Human variant effect prediction' Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Nature 652 (2026), published 2026-03-04; Supplementary Data 1 file 41586_2026_10176_MOESM3_ESM.xlsx Retrieved: 2026-10-14T12:01:04Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.label_semantics` Source artifact SHA-256: `159f321775d634d9ed53b7a81c5cc1b5ef3d407880997e0f8c69bb8315a20a51` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Label semantics P strong, P moderate, P supporting versus B strong, B moderate, B supporting Context-only references	Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) Original source ↗ Supplementary Information A.3.15 (page 14); main text 'Human variant effect prediction' Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Nature 652 (2026), published 2026-03-04; Supplementary Information file 41586_2026_10176_MOESM1_ESM.pdf (73 pages) Retrieved: 2026-10-14T12:01:04Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.label_semantics` Source artifact SHA-256: `fe2a99108a4ce5c0f4ef1595605eaec709fa86204410d5b66c1384327eb7b925` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Negatives 5681 Context-only references	evo2: Journal full-text XML Original source ↗ Supplementary Information A.3.15 (page 14); main text 'Human variant effect prediction' Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Retrieved page snapshot; no immutable publisher revision supplied Retrieved: 2026-09-16T20:16:14.422554+00:00	not individually reviewed No individual claim review recorded Audit details Field: `attributes.negatives` Source artifact SHA-256: `d043dbda49e023ef6b70e36e7ca7832bda6b7af6c5934368e8778a7f23cda8bd` Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact Inspected artifact
Negatives 5681 Context-only references	Genome modelling and design across all domains of life with Evo 2: Supplementary Data 1, human variant effect prediction results (Nature 2026) Original source ↗ Supplementary Information A.3.15 (page 14); main text 'Human variant effect prediction' Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Nature 652 (2026), published 2026-03-04; Supplementary Data 1 file 41586_2026_10176_MOESM3_ESM.xlsx Retrieved: 2026-10-14T12:01:04Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.negatives` Source artifact SHA-256: `159f321775d634d9ed53b7a81c5cc1b5ef3d407880997e0f8c69bb8315a20a51` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Negatives 5681 Context-only references	Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) Original source ↗ Supplementary Information A.3.15 (page 14); main text 'Human variant effect prediction' Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Nature 652 (2026), published 2026-03-04; Supplementary Information file 41586_2026_10176_MOESM1_ESM.pdf (73 pages) Retrieved: 2026-10-14T12:01:04Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.negatives` Source artifact SHA-256: `fe2a99108a4ce5c0f4ef1595605eaec709fa86204410d5b66c1384327eb7b925` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Positives 1156 Context-only references	evo2: Journal full-text XML Original source ↗ Supplementary Information A.3.15 (page 14); main text 'Human variant effect prediction' Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Retrieved page snapshot; no immutable publisher revision supplied Retrieved: 2026-09-16T20:16:14.422554+00:00	not individually reviewed No individual claim review recorded Audit details Field: `attributes.positives` Source artifact SHA-256: `d043dbda49e023ef6b70e36e7ca7832bda6b7af6c5934368e8778a7f23cda8bd` Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact Inspected artifact
Positives 1156 Context-only references	Genome modelling and design across all domains of life with Evo 2: Supplementary Data 1, human variant effect prediction results (Nature 2026) Original source ↗ Supplementary Information A.3.15 (page 14); main text 'Human variant effect prediction' Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Nature 652 (2026), published 2026-03-04; Supplementary Data 1 file 41586_2026_10176_MOESM3_ESM.xlsx Retrieved: 2026-10-14T12:01:04Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.positives` Source artifact SHA-256: `159f321775d634d9ed53b7a81c5cc1b5ef3d407880997e0f8c69bb8315a20a51` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Positives 1156 Context-only references	Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) Original source ↗ Supplementary Information A.3.15 (page 14); main text 'Human variant effect prediction' Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Nature 652 (2026), published 2026-03-04; Supplementary Information file 41586_2026_10176_MOESM1_ESM.pdf (73 pages) Retrieved: 2026-10-14T12:01:04Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.positives` Source artifact SHA-256: `fe2a99108a4ce5c0f4ef1595605eaec709fa86204410d5b66c1384327eb7b925` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Source location Supplementary Information A.3.15 (page 14); main text 'Human variant effect prediction' Context-only references	evo2: Journal full-text XML Original source ↗ Supplementary Information A.3.15 (page 14); main text 'Human variant effect prediction' Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Retrieved page snapshot; no immutable publisher revision supplied Retrieved: 2026-09-16T20:16:14.422554+00:00	not individually reviewed No individual claim review recorded Audit details Field: `attributes.source_locator` Source artifact SHA-256: `d043dbda49e023ef6b70e36e7ca7832bda6b7af6c5934368e8778a7f23cda8bd` Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact Inspected artifact

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Sources and history

Release 2026-10-22-1b7cf027e4f6 · Record review: source checked

3 source records and release history

evo2: Journal full-text XML · Original source · Retrieved page snapshot; no immutable publisher revision supplied
Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) · Original source · Nature 652 (2026), published 2026-03-04; Supplementary Information file 41586_2026_10176_MOESM1_ESM.pdf (73 pages)
Genome modelling and design across all domains of life with Evo 2: Supplementary Data 1, human variant effect prediction results (Nature 2026) · Original source · Nature 652 (2026), published 2026-03-04; Supplementary Data 1 file 41586_2026_10176_MOESM3_ESM.xlsx

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Technical metadata and extraction receipts

Stable ID: gfm-guides-20261014-evo2-brixi2026-data-brca2-huang2025

areas: dna-genomes
contexts: research
version: Huang et al. 2025 (Nature 638, 528-537) classifications
positives: 1156
negatives: 5681
split: No split for zero-shot scoring
label semantics: P strong, P moderate, P supporting versus B strong, B moderate, B supporting
source locator: Supplementary Information A.3.15 (page 14); main text 'Human variant effect prediction'

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