Source

evo2: Journal full-text XML

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Records in this release that cite this source. A record can cite several sources.

2 models
21 configurations
1 benchmark
49 protocols
4 datasets
705 evaluations
1,296 results
4 evidence claims

Results

Values as the source printed them. Compare results only under compatible protocols, datasets and metrics.

Model or configuration	Metric	Value	Dataset	Evaluation
AlphaMissense (Evo 2 paper variant effect evaluations)	AUPRC (zero-shot; BRCA1 coding SNVs)	0.690 unitless	BRCA1 saturation genome editing SNVs, Findlay et al. 2018 classes (Brixi et al. 2026)	AlphaMissense on BRCA1 coding SNVs (Evo 2 paper)
AlphaMissense (Evo 2 paper variant effect evaluations)	AUROC (zero-shot; BRCA1 coding SNVs)	0.889 unitless	BRCA1 saturation genome editing SNVs, Findlay et al. 2018 classes (Brixi et al. 2026)	AlphaMissense on BRCA1 coding SNVs (Evo 2 paper)
AlphaMissense (Evo 2 paper variant effect evaluations)	AUPRC (zero-shot; BRCA2 coding SNVs)	0.527 unitless	BRCA2 SNVs with functional classifications, Huang et al. 2025 (Brixi et al. 2026)	AlphaMissense on BRCA2 coding SNVs (Evo 2 paper)
AlphaMissense (Evo 2 paper variant effect evaluations)	AUROC (zero-shot; BRCA2 coding SNVs)	0.831 unitless	BRCA2 SNVs with functional classifications, Huang et al. 2025 (Brixi et al. 2026)	AlphaMissense on BRCA2 coding SNVs (Evo 2 paper)
AlphaMissense (Evo 2 paper variant effect evaluations)	AUPRC (zero-shot; ClinVar coding SNVs)	0.977 unitless	ClinVar October 2024 release, filtered (Brixi et al. 2026)	AlphaMissense on ClinVar coding SNVs (Evo 2 paper)
AlphaMissense (Evo 2 paper variant effect evaluations)	AUROC (zero-shot; ClinVar coding SNVs)	0.958 unitless	ClinVar October 2024 release, filtered (Brixi et al. 2026)	AlphaMissense on ClinVar coding SNVs (Evo 2 paper)
AlphaMissense (Evo 2 paper variant effect evaluations)	AUPRC (zero-shot; ClinVar coding SNVs, far from splice site)	0.977 unitless	ClinVar October 2024 release, filtered (Brixi et al. 2026)	AlphaMissense on ClinVar coding SNVs, far from splice site (Evo 2 paper)
AlphaMissense (Evo 2 paper variant effect evaluations)	AUROC (zero-shot; ClinVar coding SNVs, far from splice site)	0.961 unitless	ClinVar October 2024 release, filtered (Brixi et al. 2026)	AlphaMissense on ClinVar coding SNVs, far from splice site (Evo 2 paper)
AlphaMissense (Evo 2 paper variant effect evaluations)	AUPRC (zero-shot; ClinVar coding SNVs, highly conserved)	0.981 unitless	ClinVar October 2024 release, filtered (Brixi et al. 2026)	AlphaMissense on ClinVar coding SNVs, highly conserved (Evo 2 paper)
AlphaMissense (Evo 2 paper variant effect evaluations)	AUROC (zero-shot; ClinVar coding SNVs, highly conserved)	0.935 unitless	ClinVar October 2024 release, filtered (Brixi et al. 2026)	AlphaMissense on ClinVar coding SNVs, highly conserved (Evo 2 paper)
AlphaMissense (Evo 2 paper variant effect evaluations)	AUPRC (zero-shot; ClinVar coding SNVs, moderately conserved)	0.914 unitless	ClinVar October 2024 release, filtered (Brixi et al. 2026)	AlphaMissense on ClinVar coding SNVs, moderately conserved (Evo 2 paper)
AlphaMissense (Evo 2 paper variant effect evaluations)	AUROC (zero-shot; ClinVar coding SNVs, moderately conserved)	0.947 unitless	ClinVar October 2024 release, filtered (Brixi et al. 2026)	AlphaMissense on ClinVar coding SNVs, moderately conserved (Evo 2 paper)
AlphaMissense (Evo 2 paper variant effect evaluations)	AUPRC (zero-shot; ClinVar coding SNVs, near splice site)	0.980 unitless	ClinVar October 2024 release, filtered (Brixi et al. 2026)	AlphaMissense on ClinVar coding SNVs, near splice site (Evo 2 paper)
AlphaMissense (Evo 2 paper variant effect evaluations)	AUROC (zero-shot; ClinVar coding SNVs, near splice site)	0.931 unitless	ClinVar October 2024 release, filtered (Brixi et al. 2026)	AlphaMissense on ClinVar coding SNVs, near splice site (Evo 2 paper)
AlphaMissense (Evo 2 paper variant effect evaluations)	AUPRC (zero-shot; ClinVar coding SNVs, not conserved)	0.900 unitless	ClinVar October 2024 release, filtered (Brixi et al. 2026)	AlphaMissense on ClinVar coding SNVs, not conserved (Evo 2 paper)
AlphaMissense (Evo 2 paper variant effect evaluations)	AUROC (zero-shot; ClinVar coding SNVs, not conserved)	0.964 unitless	ClinVar October 2024 release, filtered (Brixi et al. 2026)	AlphaMissense on ClinVar coding SNVs, not conserved (Evo 2 paper)
AlphaMissense (Evo 2 paper variant effect evaluations)	AUPRC (zero-shot; ClinVar coding SNVs, poorly conserved)	0.883 unitless	ClinVar October 2024 release, filtered (Brixi et al. 2026)	AlphaMissense on ClinVar coding SNVs, poorly conserved (Evo 2 paper)
AlphaMissense (Evo 2 paper variant effect evaluations)	AUROC (zero-shot; ClinVar coding SNVs, poorly conserved)	0.957 unitless	ClinVar October 2024 release, filtered (Brixi et al. 2026)	AlphaMissense on ClinVar coding SNVs, poorly conserved (Evo 2 paper)
AlphaMissense (Evo 2 paper variant effect evaluations)	AUPRC (zero-shot; SpliceVarDB exonic SNVs)	0.449 unitless	SpliceVarDB experimentally validated splice variants (Brixi et al. 2026)	AlphaMissense on SpliceVarDB exonic SNVs (Evo 2 paper)
AlphaMissense (Evo 2 paper variant effect evaluations)	AUROC (zero-shot; SpliceVarDB exonic SNVs)	0.594 unitless	SpliceVarDB experimentally validated splice variants (Brixi et al. 2026)	AlphaMissense on SpliceVarDB exonic SNVs (Evo 2 paper)
CADD (Evo 2 paper variant effect evaluations)	AUPRC (zero-shot; BRCA1 'Both' (coding and noncoding) SNVs)	0.730 unitless	BRCA1 saturation genome editing SNVs, Findlay et al. 2018 classes (Brixi et al. 2026)	CADD on BRCA1 'Both' (coding and noncoding) SNVs (Evo 2 paper)
CADD (Evo 2 paper variant effect evaluations)	AUROC (zero-shot; BRCA1 'Both' (coding and noncoding) SNVs)	0.876 unitless	BRCA1 saturation genome editing SNVs, Findlay et al. 2018 classes (Brixi et al. 2026)	CADD on BRCA1 'Both' (coding and noncoding) SNVs (Evo 2 paper)
CADD (Evo 2 paper variant effect evaluations)	AUPRC (zero-shot; BRCA1 coding SNVs)	0.521 unitless	BRCA1 saturation genome editing SNVs, Findlay et al. 2018 classes (Brixi et al. 2026)	CADD on BRCA1 coding SNVs (Evo 2 paper)
CADD (Evo 2 paper variant effect evaluations)	AUROC (zero-shot; BRCA1 coding SNVs)	0.814 unitless	BRCA1 saturation genome editing SNVs, Findlay et al. 2018 classes (Brixi et al. 2026)	CADD on BRCA1 coding SNVs (Evo 2 paper)
CADD (Evo 2 paper variant effect evaluations)	AUPRC (zero-shot; BRCA1 intronic SNVs)	0.362 unitless	BRCA1 saturation genome editing SNVs, Findlay et al. 2018 classes (Brixi et al. 2026)	CADD on BRCA1 intronic SNVs (Evo 2 paper)
CADD (Evo 2 paper variant effect evaluations)	AUROC (zero-shot; BRCA1 intronic SNVs)	0.813 unitless	BRCA1 saturation genome editing SNVs, Findlay et al. 2018 classes (Brixi et al. 2026)	CADD on BRCA1 intronic SNVs (Evo 2 paper)
CADD (Evo 2 paper variant effect evaluations)	AUPRC (zero-shot; BRCA1 noncoding SNVs)	0.800 unitless	BRCA1 saturation genome editing SNVs, Findlay et al. 2018 classes (Brixi et al. 2026)	CADD on BRCA1 noncoding SNVs (Evo 2 paper)
CADD (Evo 2 paper variant effect evaluations)	AUROC (zero-shot; BRCA1 noncoding SNVs)	0.909 unitless	BRCA1 saturation genome editing SNVs, Findlay et al. 2018 classes (Brixi et al. 2026)	CADD on BRCA1 noncoding SNVs (Evo 2 paper)
CADD (Evo 2 paper variant effect evaluations)	AUPRC (zero-shot; BRCA1 splice region SNVs)	0.856 unitless	BRCA1 saturation genome editing SNVs, Findlay et al. 2018 classes (Brixi et al. 2026)	CADD on BRCA1 splice region SNVs (Evo 2 paper)
CADD (Evo 2 paper variant effect evaluations)	AUROC (zero-shot; BRCA1 splice region SNVs)	0.890 unitless	BRCA1 saturation genome editing SNVs, Findlay et al. 2018 classes (Brixi et al. 2026)	CADD on BRCA1 splice region SNVs (Evo 2 paper)
CADD (Evo 2 paper variant effect evaluations)	AUPRC (zero-shot; BRCA2 'Both' (coding and noncoding) SNVs)	0.739 unitless	BRCA2 SNVs with functional classifications, Huang et al. 2025 (Brixi et al. 2026)	CADD on BRCA2 'Both' (coding and noncoding) SNVs (Evo 2 paper)
CADD (Evo 2 paper variant effect evaluations)	AUROC (zero-shot; BRCA2 'Both' (coding and noncoding) SNVs)	0.884 unitless	BRCA2 SNVs with functional classifications, Huang et al. 2025 (Brixi et al. 2026)	CADD on BRCA2 'Both' (coding and noncoding) SNVs (Evo 2 paper)
CADD (Evo 2 paper variant effect evaluations)	AUPRC (zero-shot; BRCA2 coding SNVs)	0.402 unitless	BRCA2 SNVs with functional classifications, Huang et al. 2025 (Brixi et al. 2026)	CADD on BRCA2 coding SNVs (Evo 2 paper)
CADD (Evo 2 paper variant effect evaluations)	AUROC (zero-shot; BRCA2 coding SNVs)	0.787 unitless	BRCA2 SNVs with functional classifications, Huang et al. 2025 (Brixi et al. 2026)	CADD on BRCA2 coding SNVs (Evo 2 paper)
CADD (Evo 2 paper variant effect evaluations)	AUPRC (zero-shot; BRCA2 noncoding SNVs)	0.867 unitless	BRCA2 SNVs with functional classifications, Huang et al. 2025 (Brixi et al. 2026)	CADD on BRCA2 noncoding SNVs (Evo 2 paper)
CADD (Evo 2 paper variant effect evaluations)	AUROC (zero-shot; BRCA2 noncoding SNVs)	0.924 unitless	BRCA2 SNVs with functional classifications, Huang et al. 2025 (Brixi et al. 2026)	CADD on BRCA2 noncoding SNVs (Evo 2 paper)
CADD (Evo 2 paper variant effect evaluations)	AUPRC (zero-shot; ClinVar 'Both' (coding and noncoding) SNVs)	0.984 unitless	ClinVar October 2024 release, filtered (Brixi et al. 2026)	CADD on ClinVar 'Both' (coding and noncoding) SNVs (Evo 2 paper)
CADD (Evo 2 paper variant effect evaluations)	AUROC (zero-shot; ClinVar 'Both' (coding and noncoding) SNVs)	0.988 unitless	ClinVar October 2024 release, filtered (Brixi et al. 2026)	CADD on ClinVar 'Both' (coding and noncoding) SNVs (Evo 2 paper)
CADD (Evo 2 paper variant effect evaluations)	AUPRC (zero-shot; ClinVar coding SNVs)	0.952 unitless	ClinVar October 2024 release, filtered (Brixi et al. 2026)	CADD on ClinVar coding SNVs (Evo 2 paper)
CADD (Evo 2 paper variant effect evaluations)	AUROC (zero-shot; ClinVar coding SNVs)	0.927 unitless	ClinVar October 2024 release, filtered (Brixi et al. 2026)	CADD on ClinVar coding SNVs (Evo 2 paper)
CADD (Evo 2 paper variant effect evaluations)	AUPRC (zero-shot; ClinVar coding SNVs, far from splice site)	0.949 unitless	ClinVar October 2024 release, filtered (Brixi et al. 2026)	CADD on ClinVar coding SNVs, far from splice site (Evo 2 paper)
CADD (Evo 2 paper variant effect evaluations)	AUROC (zero-shot; ClinVar coding SNVs, far from splice site)	0.925 unitless	ClinVar October 2024 release, filtered (Brixi et al. 2026)	CADD on ClinVar coding SNVs, far from splice site (Evo 2 paper)
CADD (Evo 2 paper variant effect evaluations)	AUPRC (zero-shot; ClinVar coding SNVs, highly conserved)	0.961 unitless	ClinVar October 2024 release, filtered (Brixi et al. 2026)	CADD on ClinVar coding SNVs, highly conserved (Evo 2 paper)
CADD (Evo 2 paper variant effect evaluations)	AUROC (zero-shot; ClinVar coding SNVs, highly conserved)	0.883 unitless	ClinVar October 2024 release, filtered (Brixi et al. 2026)	CADD on ClinVar coding SNVs, highly conserved (Evo 2 paper)
CADD (Evo 2 paper variant effect evaluations)	AUPRC (zero-shot; ClinVar coding SNVs, moderately conserved)	0.818 unitless	ClinVar October 2024 release, filtered (Brixi et al. 2026)	CADD on ClinVar coding SNVs, moderately conserved (Evo 2 paper)
CADD (Evo 2 paper variant effect evaluations)	AUROC (zero-shot; ClinVar coding SNVs, moderately conserved)	0.905 unitless	ClinVar October 2024 release, filtered (Brixi et al. 2026)	CADD on ClinVar coding SNVs, moderately conserved (Evo 2 paper)
CADD (Evo 2 paper variant effect evaluations)	AUPRC (zero-shot; ClinVar coding SNVs, near splice site)	0.977 unitless	ClinVar October 2024 release, filtered (Brixi et al. 2026)	CADD on ClinVar coding SNVs, near splice site (Evo 2 paper)
CADD (Evo 2 paper variant effect evaluations)	AUROC (zero-shot; ClinVar coding SNVs, near splice site)	0.934 unitless	ClinVar October 2024 release, filtered (Brixi et al. 2026)	CADD on ClinVar coding SNVs, near splice site (Evo 2 paper)
CADD (Evo 2 paper variant effect evaluations)	AUPRC (zero-shot; ClinVar coding SNVs, not conserved)	0.623 unitless	ClinVar October 2024 release, filtered (Brixi et al. 2026)	CADD on ClinVar coding SNVs, not conserved (Evo 2 paper)
CADD (Evo 2 paper variant effect evaluations)	AUROC (zero-shot; ClinVar coding SNVs, not conserved)	0.880 unitless	ClinVar October 2024 release, filtered (Brixi et al. 2026)	CADD on ClinVar coding SNVs, not conserved (Evo 2 paper)

Claims

Statements this source supports, each with where in the source it was checked.

Evo 2: alias of Evo 2: Alias of Evo 2 (Both records cite the same official Evo 2 artifacts (evidence-official-a248990b44d481814f47, -849b751ed4bf88622749, -b8df803e8f55324a4eb5, -8717ffb993cc8f7eddec) and carry the same profile. Configurations linked to catalog-model-evo-2 include Evo 2 40B (Alavi 2026) and Evo 2 7B (NABench), so it describes the family, not the 7B checkpoint.)
Evo 2: description: Description Evo 2 models and generates DNA over long contexts at single-nucleotide resolution. (Reviewed profile summary (2026-09-16): evidence-official-a248990b44d481814f47, evidence-official-849b751ed4bf88622749, evidence-official-b8df803e8f55324a4eb5, evidence-official-8717ffb993cc8f7eddec: Evo 2 paper: architecture, training, and data, Figure 1 and Discussion; official checkpoints table and evo2_7b licence metadata)
Evo 2: variant of Evo 2: Variant of Evo 2 (Official Evo2 README checkpoint list: evo2_7b and evo2_7b_base; catalogue card cites evo2_7b | Existing reviewed locator: Evo 2 paper: architecture, training, and data, Figure 1 and Discussion; official checkpoints table and evo2_7b licence metadata)
Evo 2: version: Version absent; missing_metadata.version is inapplicable for a family record (Records linked to catalog-model-evo-2 by configuration_of and family in the canonical store, release 2026-10-14-a2714d701935)

Models, benchmarks and other records

Models (2)

Configurations (21)

Benchmarks (1)

Evo 2 paper zero-shot human variant effect evaluations (Brixi et al. 2026)

Protocols (49)

Datasets (4)

Evaluations (705)

Evidence

Source checking verifies the cited claim or transcription. It does not establish independent reproduction.

Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

18 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-11-02-a7f03c9e55a5
Property and statement	Original source and location	Review and provenance
Artifact format original_artifact Source metadata	evo2: Journal full-text XML Original source ↗ No field-specific location recorded Version: Retrieved page snapshot; no immutable publisher revision supplied Retrieved: 2026-09-16T20:16:14.422554+00:00	catalogued No individual claim review recorded Audit details Field: `attributes.artifact_format` Source artifact SHA-256: `d043dbda49e023ef6b70e36e7ca7832bda6b7af6c5934368e8778a7f23cda8bd` Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact Inspected artifact
Artifact SHA-256 d043dbda49e023ef6b70e36e7ca7832bda6b7af6c5934368e8778a7f23cda8bd Source metadata	evo2: Journal full-text XML Original source ↗ No field-specific location recorded Version: Retrieved page snapshot; no immutable publisher revision supplied Retrieved: 2026-09-16T20:16:14.422554+00:00	catalogued No individual claim review recorded Audit details Field: `attributes.artifact_sha256` Source artifact SHA-256: `d043dbda49e023ef6b70e36e7ca7832bda6b7af6c5934368e8778a7f23cda8bd` Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact Inspected artifact
Artifact url https://www.ebi.ac.uk/europepmc/webservices/rest/PMC13128491/fullTextXML Source metadata	evo2: Journal full-text XML Original source ↗ No field-specific location recorded Version: Retrieved page snapshot; no immutable publisher revision supplied Retrieved: 2026-09-16T20:16:14.422554+00:00	catalogued No individual claim review recorded Audit details Field: `attributes.artifact_url` Source artifact SHA-256: `d043dbda49e023ef6b70e36e7ca7832bda6b7af6c5934368e8778a7f23cda8bd` Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact Inspected artifact
Hash scope SHA-256 of retrieved original artifact bytes Source metadata	evo2: Journal full-text XML Original source ↗ No field-specific location recorded Version: Retrieved page snapshot; no immutable publisher revision supplied Retrieved: 2026-09-16T20:16:14.422554+00:00	catalogued No individual claim review recorded Audit details Field: `attributes.hash_scope` Source artifact SHA-256: `d043dbda49e023ef6b70e36e7ca7832bda6b7af6c5934368e8778a7f23cda8bd` Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact Inspected artifact
Retrieval note Direct source retrieval Source metadata	evo2: Journal full-text XML Original source ↗ No field-specific location recorded Version: Retrieved page snapshot; no immutable publisher revision supplied Retrieved: 2026-09-16T20:16:14.422554+00:00	catalogued No individual claim review recorded Audit details Field: `attributes.retrieval_note` Source artifact SHA-256: `d043dbda49e023ef6b70e36e7ca7832bda6b7af6c5934368e8778a7f23cda8bd` Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact Inspected artifact
Retrieved at 2026-09-16T20:16:14.422554+00:00 Source metadata	evo2: Journal full-text XML Original source ↗ No field-specific location recorded Version: Retrieved page snapshot; no immutable publisher revision supplied Retrieved: 2026-09-16T20:16:14.422554+00:00	catalogued No individual claim review recorded Audit details Field: `attributes.retrieved_at` Source artifact SHA-256: `d043dbda49e023ef6b70e36e7ca7832bda6b7af6c5934368e8778a7f23cda8bd` Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact Inspected artifact
Review method 1 values automated-source-review Source metadata	evo2: Journal full-text XML Original source ↗ No field-specific location recorded Version: Retrieved page snapshot; no immutable publisher revision supplied Retrieved: 2026-09-16T20:16:14.422554+00:00	catalogued No individual claim review recorded Audit details Field: `attributes.review.method` Source artifact SHA-256: `d043dbda49e023ef6b70e36e7ca7832bda6b7af6c5934368e8778a7f23cda8bd` Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact Inspected artifact
Review: scope Only cited profile claims; no numerical performance result added or independently reproduced. Source metadata	evo2: Journal full-text XML Original source ↗ No field-specific location recorded Version: Retrieved page snapshot; no immutable publisher revision supplied Retrieved: 2026-09-16T20:16:14.422554+00:00	catalogued No individual claim review recorded Audit details Field: `attributes.review.scope` Source artifact SHA-256: `d043dbda49e023ef6b70e36e7ca7832bda6b7af6c5934368e8778a7f23cda8bd` Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact Inspected artifact
Source location Journal full-text XML Source metadata	evo2: Journal full-text XML Original source ↗ No field-specific location recorded Version: Retrieved page snapshot; no immutable publisher revision supplied Retrieved: 2026-09-16T20:16:14.422554+00:00	catalogued No individual claim review recorded Audit details Field: `attributes.source_locator` Source artifact SHA-256: `d043dbda49e023ef6b70e36e7ca7832bda6b7af6c5934368e8778a7f23cda8bd` Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact Inspected artifact
Url https://pmc.ncbi.nlm.nih.gov/articles/PMC13128491/ Source metadata	evo2: Journal full-text XML Original source ↗ No field-specific location recorded Version: Retrieved page snapshot; no immutable publisher revision supplied Retrieved: 2026-09-16T20:16:14.422554+00:00	catalogued No individual claim review recorded Audit details Field: `attributes.url` Source artifact SHA-256: `d043dbda49e023ef6b70e36e7ca7832bda6b7af6c5934368e8778a7f23cda8bd` Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact Inspected artifact

How to read the evidence

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Release 2026-11-02-a7f03c9e55a5 · Record review: source checked

Primary-source artifact retrieved for field-level model-profile review. Source inspection is not independent model reproduction.

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Technical metadata and extraction receipts

Stable ID: evidence-official-8717ffb993cc8f7eddec

url: https://pmc.ncbi.nlm.nih.gov/articles/PMC13128491/
artifact url: https://www.ebi.ac.uk/europepmc/webservices/rest/PMC13128491/fullTextXML
version: Retrieved page snapshot; no immutable publisher revision supplied
retrieved at: 2026-09-16T20:16:14.422554+00:00
artifact sha256: d043dbda49e023ef6b70e36e7ca7832bda6b7af6c5934368e8778a7f23cda8bd
artifact format: original_artifact
hash scope: SHA-256 of retrieved original artifact bytes
retrieval note: Direct source retrieval
source locator: Journal full-text XML
review: method: automated-source-review; scope: Only cited profile claims; no numerical performance result added or independently reproduced.

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