Zero-shot ClinVar 'Both' (coding and noncoding) microsatellite variants classification (Evo 2 paper, Supplementary Data 1); As published, Nature 652 (2026), Supplementary Data 1

Overview

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10 recorded evaluations, 20 metric rows. A comparison chart has not yet been validated for these results. The table retains the individual findings and their sources.

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Results

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All evaluations

10 evaluations · 20 results. Different protocols are not a single leaderboard.

Protocol: Zero-shot ClinVar 'Both' (coding and noncoding) microsatellite variants classification (Evo 2 paper, Supplementary Data 1) · Dataset: ClinVar October 2024 release, filtered (Brixi et al. 2026)

Sorted by AUPRC (zero-shot; ClinVar 'Both' (coding and noncoding) microsatellite variants) (higher is better). The best value in each column is highlighted. Decimals are rounded for display; each value links to the printed value and its source.

Tested configuration	AUPRC (zero-shot; ClinVar 'Both' (coding and noncoding) microsatellite variants)	AUROC (zero-shot; ClinVar 'Both' (coding and noncoding) microsatellite variants)
Evo 2 40B base (Evo 2 paper variant effect evaluations)Evaluation	0.989 (best in column)	0.985 (best in column)
Evo 2 40B (Evo 2 paper variant effect evaluations)Evaluation	0.987	0.982
Evo 2 7B base (Evo 2 paper variant effect evaluations)Evaluation	0.98	0.977
Evo 2 7B (Evo 2 paper variant effect evaluations)Evaluation	0.977	0.973
Evo 1 (Evo 2 paper variant effect evaluations)Evaluation	0.925	0.912
PhyloP 100 (Evo 2 paper variant effect evaluations)Evaluation	0.825	0.835
PhyloP 470 (Evo 2 paper variant effect evaluations)Evaluation	0.804	0.836
PhyloP 447 (Evo 2 paper variant effect evaluations)Evaluation	0.76	0.807
PhyloP 241 (Evo 2 paper variant effect evaluations)Evaluation	0.738	0.797
NT (Evo 2 paper variant effect evaluations)Evaluation	0.461	0.53

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Exact evaluated configurations and original reported results
Tested configuration	Protocol and dataset	Finding	Evidence and details
Configuration: Evo 1 (Evo 2 paper variant effect evaluations)	Protocol: Zero-shot ClinVar 'Both' (coding and noncoding) microsatellite variants classification (Evo 2 paper, Supplementary Data 1) Dataset: ClinVar October 2024 release, filtered (Brixi et al. 2026)	0.925 AUPRC (zero-shot; ClinVar 'Both' (coding and noncoding) microsatellite variants) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Evo 1 on ClinVar 'Both' (coding and noncoding) microsatellite variants (Evo 2 paper) gfm-guides-20261014-evo2-brixi2026-protocol-clinvar-both-microsatellite Aggregation: Not reported Genome modelling and design across all domains of life with Evo 2: Supplementary Data 1, human variant effect prediction results (Nature 2026); Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) · Supplementary Data 1 (sheet 'Sheet1') cell J601, row 601: Model 'Evo 1', Data 'ClinVar', Genomic_Feature 'Both', Variant_Type 'Microsatellite', Sub_category '', column 'AUPRC'
Configuration: Evo 1 (Evo 2 paper variant effect evaluations)	Protocol: Zero-shot ClinVar 'Both' (coding and noncoding) microsatellite variants classification (Evo 2 paper, Supplementary Data 1) Dataset: ClinVar October 2024 release, filtered (Brixi et al. 2026)	0.912 AUROC (zero-shot; ClinVar 'Both' (coding and noncoding) microsatellite variants) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Evo 1 on ClinVar 'Both' (coding and noncoding) microsatellite variants (Evo 2 paper) gfm-guides-20261014-evo2-brixi2026-protocol-clinvar-both-microsatellite Aggregation: Not reported Genome modelling and design across all domains of life with Evo 2: Supplementary Data 1, human variant effect prediction results (Nature 2026); Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) · Supplementary Data 1 (sheet 'Sheet1') cell I601, row 601: Model 'Evo 1', Data 'ClinVar', Genomic_Feature 'Both', Variant_Type 'Microsatellite', Sub_category '', column 'AUROC'
Configuration: Evo 2 40B base (Evo 2 paper variant effect evaluations)	Protocol: Zero-shot ClinVar 'Both' (coding and noncoding) microsatellite variants classification (Evo 2 paper, Supplementary Data 1) Dataset: ClinVar October 2024 release, filtered (Brixi et al. 2026)	0.989 AUPRC (zero-shot; ClinVar 'Both' (coding and noncoding) microsatellite variants) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Evo 2 40B base on ClinVar 'Both' (coding and noncoding) microsatellite variants (Evo 2 paper) gfm-guides-20261014-evo2-brixi2026-protocol-clinvar-both-microsatellite Aggregation: Not reported Genome modelling and design across all domains of life with Evo 2: Supplementary Data 1, human variant effect prediction results (Nature 2026); Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) · Supplementary Data 1 (sheet 'Sheet1') cell J597, row 597: Model 'Evo 2 40B base', Data 'ClinVar', Genomic_Feature 'Both', Variant_Type 'Microsatellite', Sub_category '', column 'AUPRC'
Configuration: Evo 2 40B base (Evo 2 paper variant effect evaluations)	Protocol: Zero-shot ClinVar 'Both' (coding and noncoding) microsatellite variants classification (Evo 2 paper, Supplementary Data 1) Dataset: ClinVar October 2024 release, filtered (Brixi et al. 2026)	0.985 AUROC (zero-shot; ClinVar 'Both' (coding and noncoding) microsatellite variants) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Evo 2 40B base on ClinVar 'Both' (coding and noncoding) microsatellite variants (Evo 2 paper) gfm-guides-20261014-evo2-brixi2026-protocol-clinvar-both-microsatellite Aggregation: Not reported Genome modelling and design across all domains of life with Evo 2: Supplementary Data 1, human variant effect prediction results (Nature 2026); Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) · Supplementary Data 1 (sheet 'Sheet1') cell I597, row 597: Model 'Evo 2 40B base', Data 'ClinVar', Genomic_Feature 'Both', Variant_Type 'Microsatellite', Sub_category '', column 'AUROC'
Configuration: Evo 2 40B (Evo 2 paper variant effect evaluations)	Protocol: Zero-shot ClinVar 'Both' (coding and noncoding) microsatellite variants classification (Evo 2 paper, Supplementary Data 1) Dataset: ClinVar October 2024 release, filtered (Brixi et al. 2026)	0.987 AUPRC (zero-shot; ClinVar 'Both' (coding and noncoding) microsatellite variants) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Evo 2 40B on ClinVar 'Both' (coding and noncoding) microsatellite variants (Evo 2 paper) gfm-guides-20261014-evo2-brixi2026-protocol-clinvar-both-microsatellite Aggregation: Not reported Genome modelling and design across all domains of life with Evo 2: Supplementary Data 1, human variant effect prediction results (Nature 2026); Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) · Supplementary Data 1 (sheet 'Sheet1') cell J598, row 598: Model 'Evo 2 40B', Data 'ClinVar', Genomic_Feature 'Both', Variant_Type 'Microsatellite', Sub_category '', column 'AUPRC'
Configuration: Evo 2 40B (Evo 2 paper variant effect evaluations)	Protocol: Zero-shot ClinVar 'Both' (coding and noncoding) microsatellite variants classification (Evo 2 paper, Supplementary Data 1) Dataset: ClinVar October 2024 release, filtered (Brixi et al. 2026)	0.982 AUROC (zero-shot; ClinVar 'Both' (coding and noncoding) microsatellite variants) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Evo 2 40B on ClinVar 'Both' (coding and noncoding) microsatellite variants (Evo 2 paper) gfm-guides-20261014-evo2-brixi2026-protocol-clinvar-both-microsatellite Aggregation: Not reported Genome modelling and design across all domains of life with Evo 2: Supplementary Data 1, human variant effect prediction results (Nature 2026); Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) · Supplementary Data 1 (sheet 'Sheet1') cell I598, row 598: Model 'Evo 2 40B', Data 'ClinVar', Genomic_Feature 'Both', Variant_Type 'Microsatellite', Sub_category '', column 'AUROC'
Configuration: Evo 2 7B base (Evo 2 paper variant effect evaluations)	Protocol: Zero-shot ClinVar 'Both' (coding and noncoding) microsatellite variants classification (Evo 2 paper, Supplementary Data 1) Dataset: ClinVar October 2024 release, filtered (Brixi et al. 2026)	0.98 AUPRC (zero-shot; ClinVar 'Both' (coding and noncoding) microsatellite variants) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Evo 2 7B base on ClinVar 'Both' (coding and noncoding) microsatellite variants (Evo 2 paper) gfm-guides-20261014-evo2-brixi2026-protocol-clinvar-both-microsatellite Aggregation: Not reported Genome modelling and design across all domains of life with Evo 2: Supplementary Data 1, human variant effect prediction results (Nature 2026); Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) · Supplementary Data 1 (sheet 'Sheet1') cell J599, row 599: Model 'Evo 2 7B base', Data 'ClinVar', Genomic_Feature 'Both', Variant_Type 'Microsatellite', Sub_category '', column 'AUPRC'
Configuration: Evo 2 7B base (Evo 2 paper variant effect evaluations)	Protocol: Zero-shot ClinVar 'Both' (coding and noncoding) microsatellite variants classification (Evo 2 paper, Supplementary Data 1) Dataset: ClinVar October 2024 release, filtered (Brixi et al. 2026)	0.977 AUROC (zero-shot; ClinVar 'Both' (coding and noncoding) microsatellite variants) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Evo 2 7B base on ClinVar 'Both' (coding and noncoding) microsatellite variants (Evo 2 paper) gfm-guides-20261014-evo2-brixi2026-protocol-clinvar-both-microsatellite Aggregation: Not reported Genome modelling and design across all domains of life with Evo 2: Supplementary Data 1, human variant effect prediction results (Nature 2026); Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) · Supplementary Data 1 (sheet 'Sheet1') cell I599, row 599: Model 'Evo 2 7B base', Data 'ClinVar', Genomic_Feature 'Both', Variant_Type 'Microsatellite', Sub_category '', column 'AUROC'
Configuration: Evo 2 7B (Evo 2 paper variant effect evaluations)	Protocol: Zero-shot ClinVar 'Both' (coding and noncoding) microsatellite variants classification (Evo 2 paper, Supplementary Data 1) Dataset: ClinVar October 2024 release, filtered (Brixi et al. 2026)	0.977 AUPRC (zero-shot; ClinVar 'Both' (coding and noncoding) microsatellite variants) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Evo 2 7B on ClinVar 'Both' (coding and noncoding) microsatellite variants (Evo 2 paper) gfm-guides-20261014-evo2-brixi2026-protocol-clinvar-both-microsatellite Aggregation: Not reported Genome modelling and design across all domains of life with Evo 2: Supplementary Data 1, human variant effect prediction results (Nature 2026); Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) · Supplementary Data 1 (sheet 'Sheet1') cell J600, row 600: Model 'Evo 2 7B', Data 'ClinVar', Genomic_Feature 'Both', Variant_Type 'Microsatellite', Sub_category '', column 'AUPRC'
Configuration: Evo 2 7B (Evo 2 paper variant effect evaluations)	Protocol: Zero-shot ClinVar 'Both' (coding and noncoding) microsatellite variants classification (Evo 2 paper, Supplementary Data 1) Dataset: ClinVar October 2024 release, filtered (Brixi et al. 2026)	0.973 AUROC (zero-shot; ClinVar 'Both' (coding and noncoding) microsatellite variants) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Evo 2 7B on ClinVar 'Both' (coding and noncoding) microsatellite variants (Evo 2 paper) gfm-guides-20261014-evo2-brixi2026-protocol-clinvar-both-microsatellite Aggregation: Not reported Genome modelling and design across all domains of life with Evo 2: Supplementary Data 1, human variant effect prediction results (Nature 2026); Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) · Supplementary Data 1 (sheet 'Sheet1') cell I600, row 600: Model 'Evo 2 7B', Data 'ClinVar', Genomic_Feature 'Both', Variant_Type 'Microsatellite', Sub_category '', column 'AUROC'
Configuration: NT (Evo 2 paper variant effect evaluations)	Protocol: Zero-shot ClinVar 'Both' (coding and noncoding) microsatellite variants classification (Evo 2 paper, Supplementary Data 1) Dataset: ClinVar October 2024 release, filtered (Brixi et al. 2026)	0.461 AUPRC (zero-shot; ClinVar 'Both' (coding and noncoding) microsatellite variants) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source NT on ClinVar 'Both' (coding and noncoding) microsatellite variants (Evo 2 paper) gfm-guides-20261014-evo2-brixi2026-protocol-clinvar-both-microsatellite Aggregation: Not reported Genome modelling and design across all domains of life with Evo 2: Supplementary Data 1, human variant effect prediction results (Nature 2026); Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) · Supplementary Data 1 (sheet 'Sheet1') cell J606, row 606: Model 'NT', Data 'ClinVar', Genomic_Feature 'Both', Variant_Type 'Microsatellite', Sub_category '', column 'AUPRC'
Configuration: NT (Evo 2 paper variant effect evaluations)	Protocol: Zero-shot ClinVar 'Both' (coding and noncoding) microsatellite variants classification (Evo 2 paper, Supplementary Data 1) Dataset: ClinVar October 2024 release, filtered (Brixi et al. 2026)	0.53 AUROC (zero-shot; ClinVar 'Both' (coding and noncoding) microsatellite variants) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source NT on ClinVar 'Both' (coding and noncoding) microsatellite variants (Evo 2 paper) gfm-guides-20261014-evo2-brixi2026-protocol-clinvar-both-microsatellite Aggregation: Not reported Genome modelling and design across all domains of life with Evo 2: Supplementary Data 1, human variant effect prediction results (Nature 2026); Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) · Supplementary Data 1 (sheet 'Sheet1') cell I606, row 606: Model 'NT', Data 'ClinVar', Genomic_Feature 'Both', Variant_Type 'Microsatellite', Sub_category '', column 'AUROC'
Configuration: PhyloP 100 (Evo 2 paper variant effect evaluations)	Protocol: Zero-shot ClinVar 'Both' (coding and noncoding) microsatellite variants classification (Evo 2 paper, Supplementary Data 1) Dataset: ClinVar October 2024 release, filtered (Brixi et al. 2026)	0.825 AUPRC (zero-shot; ClinVar 'Both' (coding and noncoding) microsatellite variants) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source PhyloP 100 on ClinVar 'Both' (coding and noncoding) microsatellite variants (Evo 2 paper) gfm-guides-20261014-evo2-brixi2026-protocol-clinvar-both-microsatellite Aggregation: Not reported Genome modelling and design across all domains of life with Evo 2: Supplementary Data 1, human variant effect prediction results (Nature 2026); Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) · Supplementary Data 1 (sheet 'Sheet1') cell J603, row 603: Model 'PhyloP 100', Data 'ClinVar', Genomic_Feature 'Both', Variant_Type 'Microsatellite', Sub_category '', column 'AUPRC'
Configuration: PhyloP 100 (Evo 2 paper variant effect evaluations)	Protocol: Zero-shot ClinVar 'Both' (coding and noncoding) microsatellite variants classification (Evo 2 paper, Supplementary Data 1) Dataset: ClinVar October 2024 release, filtered (Brixi et al. 2026)	0.835 AUROC (zero-shot; ClinVar 'Both' (coding and noncoding) microsatellite variants) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source PhyloP 100 on ClinVar 'Both' (coding and noncoding) microsatellite variants (Evo 2 paper) gfm-guides-20261014-evo2-brixi2026-protocol-clinvar-both-microsatellite Aggregation: Not reported Genome modelling and design across all domains of life with Evo 2: Supplementary Data 1, human variant effect prediction results (Nature 2026); Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) · Supplementary Data 1 (sheet 'Sheet1') cell I603, row 603: Model 'PhyloP 100', Data 'ClinVar', Genomic_Feature 'Both', Variant_Type 'Microsatellite', Sub_category '', column 'AUROC'
Configuration: PhyloP 241 (Evo 2 paper variant effect evaluations)	Protocol: Zero-shot ClinVar 'Both' (coding and noncoding) microsatellite variants classification (Evo 2 paper, Supplementary Data 1) Dataset: ClinVar October 2024 release, filtered (Brixi et al. 2026)	0.738 AUPRC (zero-shot; ClinVar 'Both' (coding and noncoding) microsatellite variants) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source PhyloP 241 on ClinVar 'Both' (coding and noncoding) microsatellite variants (Evo 2 paper) gfm-guides-20261014-evo2-brixi2026-protocol-clinvar-both-microsatellite Aggregation: Not reported Genome modelling and design across all domains of life with Evo 2: Supplementary Data 1, human variant effect prediction results (Nature 2026); Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) · Supplementary Data 1 (sheet 'Sheet1') cell J605, row 605: Model 'PhyloP 241', Data 'ClinVar', Genomic_Feature 'Both', Variant_Type 'Microsatellite', Sub_category '', column 'AUPRC'
Configuration: PhyloP 241 (Evo 2 paper variant effect evaluations)	Protocol: Zero-shot ClinVar 'Both' (coding and noncoding) microsatellite variants classification (Evo 2 paper, Supplementary Data 1) Dataset: ClinVar October 2024 release, filtered (Brixi et al. 2026)	0.797 AUROC (zero-shot; ClinVar 'Both' (coding and noncoding) microsatellite variants) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source PhyloP 241 on ClinVar 'Both' (coding and noncoding) microsatellite variants (Evo 2 paper) gfm-guides-20261014-evo2-brixi2026-protocol-clinvar-both-microsatellite Aggregation: Not reported Genome modelling and design across all domains of life with Evo 2: Supplementary Data 1, human variant effect prediction results (Nature 2026); Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) · Supplementary Data 1 (sheet 'Sheet1') cell I605, row 605: Model 'PhyloP 241', Data 'ClinVar', Genomic_Feature 'Both', Variant_Type 'Microsatellite', Sub_category '', column 'AUROC'
Configuration: PhyloP 447 (Evo 2 paper variant effect evaluations)	Protocol: Zero-shot ClinVar 'Both' (coding and noncoding) microsatellite variants classification (Evo 2 paper, Supplementary Data 1) Dataset: ClinVar October 2024 release, filtered (Brixi et al. 2026)	0.76 AUPRC (zero-shot; ClinVar 'Both' (coding and noncoding) microsatellite variants) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source PhyloP 447 on ClinVar 'Both' (coding and noncoding) microsatellite variants (Evo 2 paper) gfm-guides-20261014-evo2-brixi2026-protocol-clinvar-both-microsatellite Aggregation: Not reported Genome modelling and design across all domains of life with Evo 2: Supplementary Data 1, human variant effect prediction results (Nature 2026); Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) · Supplementary Data 1 (sheet 'Sheet1') cell J604, row 604: Model 'PhyloP 447', Data 'ClinVar', Genomic_Feature 'Both', Variant_Type 'Microsatellite', Sub_category '', column 'AUPRC'
Configuration: PhyloP 447 (Evo 2 paper variant effect evaluations)	Protocol: Zero-shot ClinVar 'Both' (coding and noncoding) microsatellite variants classification (Evo 2 paper, Supplementary Data 1) Dataset: ClinVar October 2024 release, filtered (Brixi et al. 2026)	0.807 AUROC (zero-shot; ClinVar 'Both' (coding and noncoding) microsatellite variants) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source PhyloP 447 on ClinVar 'Both' (coding and noncoding) microsatellite variants (Evo 2 paper) gfm-guides-20261014-evo2-brixi2026-protocol-clinvar-both-microsatellite Aggregation: Not reported Genome modelling and design across all domains of life with Evo 2: Supplementary Data 1, human variant effect prediction results (Nature 2026); Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) · Supplementary Data 1 (sheet 'Sheet1') cell I604, row 604: Model 'PhyloP 447', Data 'ClinVar', Genomic_Feature 'Both', Variant_Type 'Microsatellite', Sub_category '', column 'AUROC'
Configuration: PhyloP 470 (Evo 2 paper variant effect evaluations)	Protocol: Zero-shot ClinVar 'Both' (coding and noncoding) microsatellite variants classification (Evo 2 paper, Supplementary Data 1) Dataset: ClinVar October 2024 release, filtered (Brixi et al. 2026)	0.804 AUPRC (zero-shot; ClinVar 'Both' (coding and noncoding) microsatellite variants) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source PhyloP 470 on ClinVar 'Both' (coding and noncoding) microsatellite variants (Evo 2 paper) gfm-guides-20261014-evo2-brixi2026-protocol-clinvar-both-microsatellite Aggregation: Not reported Genome modelling and design across all domains of life with Evo 2: Supplementary Data 1, human variant effect prediction results (Nature 2026); Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) · Supplementary Data 1 (sheet 'Sheet1') cell J602, row 602: Model 'PhyloP 470', Data 'ClinVar', Genomic_Feature 'Both', Variant_Type 'Microsatellite', Sub_category '', column 'AUPRC'
Configuration: PhyloP 470 (Evo 2 paper variant effect evaluations)	Protocol: Zero-shot ClinVar 'Both' (coding and noncoding) microsatellite variants classification (Evo 2 paper, Supplementary Data 1) Dataset: ClinVar October 2024 release, filtered (Brixi et al. 2026)	0.836 AUROC (zero-shot; ClinVar 'Both' (coding and noncoding) microsatellite variants) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source PhyloP 470 on ClinVar 'Both' (coding and noncoding) microsatellite variants (Evo 2 paper) gfm-guides-20261014-evo2-brixi2026-protocol-clinvar-both-microsatellite Aggregation: Not reported Genome modelling and design across all domains of life with Evo 2: Supplementary Data 1, human variant effect prediction results (Nature 2026); Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) · Supplementary Data 1 (sheet 'Sheet1') cell I602, row 602: Model 'PhyloP 470', Data 'ClinVar', Genomic_Feature 'Both', Variant_Type 'Microsatellite', Sub_category '', column 'AUROC'

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evo2: Journal full-text XML · Original source · Retrieved page snapshot; no immutable publisher revision supplied
Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) · Original source · Nature 652 (2026), published 2026-03-04; Supplementary Information file 41586_2026_10176_MOESM1_ESM.pdf (73 pages)
Genome modelling and design across all domains of life with Evo 2: Supplementary Data 1, human variant effect prediction results (Nature 2026) · Original source · Nature 652 (2026), published 2026-03-04; Supplementary Data 1 file 41586_2026_10176_MOESM3_ESM.xlsx

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Technical metadata and extraction receipts

Stable ID: gfm-guides-20261014-evo2-brixi2026-protocol-clinvar-both-microsatellite

areas: dna-genomes
contexts: research
protocol: Score each variant zero-shot (for Evo 2, the log-likelihood of the variant sequence minus that of the reference over an 8,192-bp genomic window around the variant) and compute AUROC and AUPRC for pathogenic/likely pathogenic versus benign/likely benign variants in the stratum Data 'ClinVar', Genomic_Feature 'Both', Variant_Type 'Microsatellite'.
version: As published, Nature 652 (2026), Supplementary Data 1
source locator: Supplementary Data 1 rows with Data 'ClinVar', Genomic_Feature 'Both', Variant_Type 'Microsatellite', Sub_category ''; SI A.3.12 and A.3.13 (page 13)
limitations: Positives: 272 pathogenic/likely pathogenic; negatives: 346 benign/likely benign; total 618 variants (Supplementary Data 1).; The 'Both' rows are larger than the sum of the coding and noncoding rows; the population is not explained in the source.; No split: every model scores the same variants zero-shot (SI A.3.12: 'For each benchmark, we score the same variants with all models').; Supervised comparators (AlphaMissense, CADD, SpliceAI, Pangolin) may have been trained on overlapping variants; training overlap is not reported.; No uncertainty is reported.

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