Dataset

SpliceVarDB experimentally validated splice variants (Brixi et al. 2026)

SpliceVarDB variants with experimentally validated splicing effects, excluding variants labelled 'low frequency'.

Evaluation results

31 evaluations · 62 results. Different protocols are not a single leaderboard.

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Tested model or methodProtocolDatasetEvaluation setupMetricEvidence origin

Applied filters: All linked evaluations

Exact evaluated configurations and original reported results
Tested configuration	Protocol and dataset	Finding	Evidence and details
Configuration: AlphaMissense (Evo 2 paper variant effect evaluations)	Protocol: Zero-shot SpliceVarDB exonic SNVs classification (Evo 2 paper, Supplementary Data 1) Dataset: SpliceVarDB experimentally validated splice variants (Brixi et al. 2026)	0.449 AUPRC (zero-shot; SpliceVarDB exonic SNVs) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source AlphaMissense on SpliceVarDB exonic SNVs (Evo 2 paper) gfm-guides-20261014-evo2-brixi2026-protocol-splicevardb-exonic-snv Aggregation: Not reported Genome modelling and design across all domains of life with Evo 2: Supplementary Data 1, human variant effect prediction results (Nature 2026); Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) · Supplementary Data 1 (sheet 'Sheet1') cell J497, row 497: Model 'AlphaMissense', Data 'SpliceVarDB', Genomic_Feature 'Exonic', Variant_Type 'SNV', Sub_category '', column 'AUPRC'
Configuration: AlphaMissense (Evo 2 paper variant effect evaluations)	Protocol: Zero-shot SpliceVarDB exonic SNVs classification (Evo 2 paper, Supplementary Data 1) Dataset: SpliceVarDB experimentally validated splice variants (Brixi et al. 2026)	0.594 AUROC (zero-shot; SpliceVarDB exonic SNVs) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source AlphaMissense on SpliceVarDB exonic SNVs (Evo 2 paper) gfm-guides-20261014-evo2-brixi2026-protocol-splicevardb-exonic-snv Aggregation: Not reported Genome modelling and design across all domains of life with Evo 2: Supplementary Data 1, human variant effect prediction results (Nature 2026); Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) · Supplementary Data 1 (sheet 'Sheet1') cell I497, row 497: Model 'AlphaMissense', Data 'SpliceVarDB', Genomic_Feature 'Exonic', Variant_Type 'SNV', Sub_category '', column 'AUROC'
Configuration: CADD (Evo 2 paper variant effect evaluations)	Protocol: Zero-shot SpliceVarDB 'Both' (coding and noncoding) SNVs classification (Evo 2 paper, Supplementary Data 1) Dataset: SpliceVarDB experimentally validated splice variants (Brixi et al. 2026)	0.874 AUPRC (zero-shot; SpliceVarDB 'Both' (coding and noncoding) SNVs) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source CADD on SpliceVarDB 'Both' (coding and noncoding) SNVs (Evo 2 paper) gfm-guides-20261014-evo2-brixi2026-protocol-splicevardb-both-snv Aggregation: Not reported Genome modelling and design across all domains of life with Evo 2: Supplementary Data 1, human variant effect prediction results (Nature 2026); Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) · Supplementary Data 1 (sheet 'Sheet1') cell J518, row 518: Model 'CADD', Data 'SpliceVarDB', Genomic_Feature 'Both', Variant_Type 'SNV', Sub_category '', column 'AUPRC'
Configuration: CADD (Evo 2 paper variant effect evaluations)	Protocol: Zero-shot SpliceVarDB 'Both' (coding and noncoding) SNVs classification (Evo 2 paper, Supplementary Data 1) Dataset: SpliceVarDB experimentally validated splice variants (Brixi et al. 2026)	0.832 AUROC (zero-shot; SpliceVarDB 'Both' (coding and noncoding) SNVs) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source CADD on SpliceVarDB 'Both' (coding and noncoding) SNVs (Evo 2 paper) gfm-guides-20261014-evo2-brixi2026-protocol-splicevardb-both-snv Aggregation: Not reported Genome modelling and design across all domains of life with Evo 2: Supplementary Data 1, human variant effect prediction results (Nature 2026); Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) · Supplementary Data 1 (sheet 'Sheet1') cell I518, row 518: Model 'CADD', Data 'SpliceVarDB', Genomic_Feature 'Both', Variant_Type 'SNV', Sub_category '', column 'AUROC'
Configuration: CADD (Evo 2 paper variant effect evaluations)	Protocol: Zero-shot SpliceVarDB exonic SNVs classification (Evo 2 paper, Supplementary Data 1) Dataset: SpliceVarDB experimentally validated splice variants (Brixi et al. 2026)	0.784 AUPRC (zero-shot; SpliceVarDB exonic SNVs) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source CADD on SpliceVarDB exonic SNVs (Evo 2 paper) gfm-guides-20261014-evo2-brixi2026-protocol-splicevardb-exonic-snv Aggregation: Not reported Genome modelling and design across all domains of life with Evo 2: Supplementary Data 1, human variant effect prediction results (Nature 2026); Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) · Supplementary Data 1 (sheet 'Sheet1') cell J487, row 487: Model 'CADD', Data 'SpliceVarDB', Genomic_Feature 'Exonic', Variant_Type 'SNV', Sub_category '', column 'AUPRC'
Configuration: CADD (Evo 2 paper variant effect evaluations)	Protocol: Zero-shot SpliceVarDB exonic SNVs classification (Evo 2 paper, Supplementary Data 1) Dataset: SpliceVarDB experimentally validated splice variants (Brixi et al. 2026)	0.799 AUROC (zero-shot; SpliceVarDB exonic SNVs) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source CADD on SpliceVarDB exonic SNVs (Evo 2 paper) gfm-guides-20261014-evo2-brixi2026-protocol-splicevardb-exonic-snv Aggregation: Not reported Genome modelling and design across all domains of life with Evo 2: Supplementary Data 1, human variant effect prediction results (Nature 2026); Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) · Supplementary Data 1 (sheet 'Sheet1') cell I487, row 487: Model 'CADD', Data 'SpliceVarDB', Genomic_Feature 'Exonic', Variant_Type 'SNV', Sub_category '', column 'AUROC'
Configuration: Evo 1 (Evo 2 paper variant effect evaluations)	Protocol: Zero-shot SpliceVarDB 'Both' (coding and noncoding) SNVs classification (Evo 2 paper, Supplementary Data 1) Dataset: SpliceVarDB experimentally validated splice variants (Brixi et al. 2026)	0.621 AUPRC (zero-shot; SpliceVarDB 'Both' (coding and noncoding) SNVs) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Evo 1 on SpliceVarDB 'Both' (coding and noncoding) SNVs (Evo 2 paper) gfm-guides-20261014-evo2-brixi2026-protocol-splicevardb-both-snv Aggregation: Not reported Genome modelling and design across all domains of life with Evo 2: Supplementary Data 1, human variant effect prediction results (Nature 2026); Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) · Supplementary Data 1 (sheet 'Sheet1') cell J528, row 528: Model 'Evo 1', Data 'SpliceVarDB', Genomic_Feature 'Both', Variant_Type 'SNV', Sub_category '', column 'AUPRC'
Configuration: Evo 1 (Evo 2 paper variant effect evaluations)	Protocol: Zero-shot SpliceVarDB 'Both' (coding and noncoding) SNVs classification (Evo 2 paper, Supplementary Data 1) Dataset: SpliceVarDB experimentally validated splice variants (Brixi et al. 2026)	0.534 AUROC (zero-shot; SpliceVarDB 'Both' (coding and noncoding) SNVs) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Evo 1 on SpliceVarDB 'Both' (coding and noncoding) SNVs (Evo 2 paper) gfm-guides-20261014-evo2-brixi2026-protocol-splicevardb-both-snv Aggregation: Not reported Genome modelling and design across all domains of life with Evo 2: Supplementary Data 1, human variant effect prediction results (Nature 2026); Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) · Supplementary Data 1 (sheet 'Sheet1') cell I528, row 528: Model 'Evo 1', Data 'SpliceVarDB', Genomic_Feature 'Both', Variant_Type 'SNV', Sub_category '', column 'AUROC'
Configuration: Evo 1 (Evo 2 paper variant effect evaluations)	Protocol: Zero-shot SpliceVarDB exonic SNVs classification (Evo 2 paper, Supplementary Data 1) Dataset: SpliceVarDB experimentally validated splice variants (Brixi et al. 2026)	0.414 AUPRC (zero-shot; SpliceVarDB exonic SNVs) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Evo 1 on SpliceVarDB exonic SNVs (Evo 2 paper) gfm-guides-20261014-evo2-brixi2026-protocol-splicevardb-exonic-snv Aggregation: Not reported Genome modelling and design across all domains of life with Evo 2: Supplementary Data 1, human variant effect prediction results (Nature 2026); Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) · Supplementary Data 1 (sheet 'Sheet1') cell J499, row 499: Model 'Evo 1', Data 'SpliceVarDB', Genomic_Feature 'Exonic', Variant_Type 'SNV', Sub_category '', column 'AUPRC'
Configuration: Evo 1 (Evo 2 paper variant effect evaluations)	Protocol: Zero-shot SpliceVarDB exonic SNVs classification (Evo 2 paper, Supplementary Data 1) Dataset: SpliceVarDB experimentally validated splice variants (Brixi et al. 2026)	0.558 AUROC (zero-shot; SpliceVarDB exonic SNVs) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Evo 1 on SpliceVarDB exonic SNVs (Evo 2 paper) gfm-guides-20261014-evo2-brixi2026-protocol-splicevardb-exonic-snv Aggregation: Not reported Genome modelling and design across all domains of life with Evo 2: Supplementary Data 1, human variant effect prediction results (Nature 2026); Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) · Supplementary Data 1 (sheet 'Sheet1') cell I499, row 499: Model 'Evo 1', Data 'SpliceVarDB', Genomic_Feature 'Exonic', Variant_Type 'SNV', Sub_category '', column 'AUROC'
Configuration: Evo 2 40B base (Evo 2 paper variant effect evaluations)	Protocol: Zero-shot SpliceVarDB 'Both' (coding and noncoding) SNVs classification (Evo 2 paper, Supplementary Data 1) Dataset: SpliceVarDB experimentally validated splice variants (Brixi et al. 2026)	0.855 AUPRC (zero-shot; SpliceVarDB 'Both' (coding and noncoding) SNVs) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Evo 2 40B base on SpliceVarDB 'Both' (coding and noncoding) SNVs (Evo 2 paper) gfm-guides-20261014-evo2-brixi2026-protocol-splicevardb-both-snv Aggregation: Not reported Genome modelling and design across all domains of life with Evo 2: Supplementary Data 1, human variant effect prediction results (Nature 2026); Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) · Supplementary Data 1 (sheet 'Sheet1') cell J521, row 521: Model 'Evo 2 40B base', Data 'SpliceVarDB', Genomic_Feature 'Both', Variant_Type 'SNV', Sub_category '', column 'AUPRC'
Configuration: Evo 2 40B base (Evo 2 paper variant effect evaluations)	Protocol: Zero-shot SpliceVarDB 'Both' (coding and noncoding) SNVs classification (Evo 2 paper, Supplementary Data 1) Dataset: SpliceVarDB experimentally validated splice variants (Brixi et al. 2026)	0.818 AUROC (zero-shot; SpliceVarDB 'Both' (coding and noncoding) SNVs) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Evo 2 40B base on SpliceVarDB 'Both' (coding and noncoding) SNVs (Evo 2 paper) gfm-guides-20261014-evo2-brixi2026-protocol-splicevardb-both-snv Aggregation: Not reported Genome modelling and design across all domains of life with Evo 2: Supplementary Data 1, human variant effect prediction results (Nature 2026); Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) · Supplementary Data 1 (sheet 'Sheet1') cell I521, row 521: Model 'Evo 2 40B base', Data 'SpliceVarDB', Genomic_Feature 'Both', Variant_Type 'SNV', Sub_category '', column 'AUROC'
Configuration: Evo 2 40B base (Evo 2 paper variant effect evaluations)	Protocol: Zero-shot SpliceVarDB exonic SNVs classification (Evo 2 paper, Supplementary Data 1) Dataset: SpliceVarDB experimentally validated splice variants (Brixi et al. 2026)	0.534 AUPRC (zero-shot; SpliceVarDB exonic SNVs) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Evo 2 40B base on SpliceVarDB exonic SNVs (Evo 2 paper) gfm-guides-20261014-evo2-brixi2026-protocol-splicevardb-exonic-snv Aggregation: Not reported Genome modelling and design across all domains of life with Evo 2: Supplementary Data 1, human variant effect prediction results (Nature 2026); Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) · Supplementary Data 1 (sheet 'Sheet1') cell J488, row 488: Model 'Evo 2 40B base', Data 'SpliceVarDB', Genomic_Feature 'Exonic', Variant_Type 'SNV', Sub_category '', column 'AUPRC'
Configuration: Evo 2 40B base (Evo 2 paper variant effect evaluations)	Protocol: Zero-shot SpliceVarDB exonic SNVs classification (Evo 2 paper, Supplementary Data 1) Dataset: SpliceVarDB experimentally validated splice variants (Brixi et al. 2026)	0.688 AUROC (zero-shot; SpliceVarDB exonic SNVs) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Evo 2 40B base on SpliceVarDB exonic SNVs (Evo 2 paper) gfm-guides-20261014-evo2-brixi2026-protocol-splicevardb-exonic-snv Aggregation: Not reported Genome modelling and design across all domains of life with Evo 2: Supplementary Data 1, human variant effect prediction results (Nature 2026); Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) · Supplementary Data 1 (sheet 'Sheet1') cell I488, row 488: Model 'Evo 2 40B base', Data 'SpliceVarDB', Genomic_Feature 'Exonic', Variant_Type 'SNV', Sub_category '', column 'AUROC'
Configuration: Evo 2 40B (Evo 2 paper variant effect evaluations)	Protocol: Zero-shot SpliceVarDB 'Both' (coding and noncoding) SNVs classification (Evo 2 paper, Supplementary Data 1) Dataset: SpliceVarDB experimentally validated splice variants (Brixi et al. 2026)	0.85 AUPRC (zero-shot; SpliceVarDB 'Both' (coding and noncoding) SNVs) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Evo 2 40B on SpliceVarDB 'Both' (coding and noncoding) SNVs (Evo 2 paper) gfm-guides-20261014-evo2-brixi2026-protocol-splicevardb-both-snv Aggregation: Not reported Genome modelling and design across all domains of life with Evo 2: Supplementary Data 1, human variant effect prediction results (Nature 2026); Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) · Supplementary Data 1 (sheet 'Sheet1') cell J522, row 522: Model 'Evo 2 40B', Data 'SpliceVarDB', Genomic_Feature 'Both', Variant_Type 'SNV', Sub_category '', column 'AUPRC'
Configuration: Evo 2 40B (Evo 2 paper variant effect evaluations)	Protocol: Zero-shot SpliceVarDB 'Both' (coding and noncoding) SNVs classification (Evo 2 paper, Supplementary Data 1) Dataset: SpliceVarDB experimentally validated splice variants (Brixi et al. 2026)	0.815 AUROC (zero-shot; SpliceVarDB 'Both' (coding and noncoding) SNVs) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Evo 2 40B on SpliceVarDB 'Both' (coding and noncoding) SNVs (Evo 2 paper) gfm-guides-20261014-evo2-brixi2026-protocol-splicevardb-both-snv Aggregation: Not reported Genome modelling and design across all domains of life with Evo 2: Supplementary Data 1, human variant effect prediction results (Nature 2026); Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) · Supplementary Data 1 (sheet 'Sheet1') cell I522, row 522: Model 'Evo 2 40B', Data 'SpliceVarDB', Genomic_Feature 'Both', Variant_Type 'SNV', Sub_category '', column 'AUROC'
Configuration: Evo 2 40B (Evo 2 paper variant effect evaluations)	Protocol: Zero-shot SpliceVarDB exonic SNVs classification (Evo 2 paper, Supplementary Data 1) Dataset: SpliceVarDB experimentally validated splice variants (Brixi et al. 2026)	0.523 AUPRC (zero-shot; SpliceVarDB exonic SNVs) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Evo 2 40B on SpliceVarDB exonic SNVs (Evo 2 paper) gfm-guides-20261014-evo2-brixi2026-protocol-splicevardb-exonic-snv Aggregation: Not reported Genome modelling and design across all domains of life with Evo 2: Supplementary Data 1, human variant effect prediction results (Nature 2026); Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) · Supplementary Data 1 (sheet 'Sheet1') cell J490, row 490: Model 'Evo 2 40B', Data 'SpliceVarDB', Genomic_Feature 'Exonic', Variant_Type 'SNV', Sub_category '', column 'AUPRC'
Configuration: Evo 2 40B (Evo 2 paper variant effect evaluations)	Protocol: Zero-shot SpliceVarDB exonic SNVs classification (Evo 2 paper, Supplementary Data 1) Dataset: SpliceVarDB experimentally validated splice variants (Brixi et al. 2026)	0.684 AUROC (zero-shot; SpliceVarDB exonic SNVs) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Evo 2 40B on SpliceVarDB exonic SNVs (Evo 2 paper) gfm-guides-20261014-evo2-brixi2026-protocol-splicevardb-exonic-snv Aggregation: Not reported Genome modelling and design across all domains of life with Evo 2: Supplementary Data 1, human variant effect prediction results (Nature 2026); Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) · Supplementary Data 1 (sheet 'Sheet1') cell I490, row 490: Model 'Evo 2 40B', Data 'SpliceVarDB', Genomic_Feature 'Exonic', Variant_Type 'SNV', Sub_category '', column 'AUROC'
Configuration: Evo 2 7B base (Evo 2 paper variant effect evaluations)	Protocol: Zero-shot SpliceVarDB 'Both' (coding and noncoding) SNVs classification (Evo 2 paper, Supplementary Data 1) Dataset: SpliceVarDB experimentally validated splice variants (Brixi et al. 2026)	0.873 AUPRC (zero-shot; SpliceVarDB 'Both' (coding and noncoding) SNVs) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Evo 2 7B base on SpliceVarDB 'Both' (coding and noncoding) SNVs (Evo 2 paper) gfm-guides-20261014-evo2-brixi2026-protocol-splicevardb-both-snv Aggregation: Not reported Genome modelling and design across all domains of life with Evo 2: Supplementary Data 1, human variant effect prediction results (Nature 2026); Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) · Supplementary Data 1 (sheet 'Sheet1') cell J519, row 519: Model 'Evo 2 7B base', Data 'SpliceVarDB', Genomic_Feature 'Both', Variant_Type 'SNV', Sub_category '', column 'AUPRC'
Configuration: Evo 2 7B base (Evo 2 paper variant effect evaluations)	Protocol: Zero-shot SpliceVarDB 'Both' (coding and noncoding) SNVs classification (Evo 2 paper, Supplementary Data 1) Dataset: SpliceVarDB experimentally validated splice variants (Brixi et al. 2026)	0.827 AUROC (zero-shot; SpliceVarDB 'Both' (coding and noncoding) SNVs) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Evo 2 7B base on SpliceVarDB 'Both' (coding and noncoding) SNVs (Evo 2 paper) gfm-guides-20261014-evo2-brixi2026-protocol-splicevardb-both-snv Aggregation: Not reported Genome modelling and design across all domains of life with Evo 2: Supplementary Data 1, human variant effect prediction results (Nature 2026); Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) · Supplementary Data 1 (sheet 'Sheet1') cell I519, row 519: Model 'Evo 2 7B base', Data 'SpliceVarDB', Genomic_Feature 'Both', Variant_Type 'SNV', Sub_category '', column 'AUROC'
Configuration: Evo 2 7B base (Evo 2 paper variant effect evaluations)	Protocol: Zero-shot SpliceVarDB exonic SNVs classification (Evo 2 paper, Supplementary Data 1) Dataset: SpliceVarDB experimentally validated splice variants (Brixi et al. 2026)	0.54 AUPRC (zero-shot; SpliceVarDB exonic SNVs) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Evo 2 7B base on SpliceVarDB exonic SNVs (Evo 2 paper) gfm-guides-20261014-evo2-brixi2026-protocol-splicevardb-exonic-snv Aggregation: Not reported Genome modelling and design across all domains of life with Evo 2: Supplementary Data 1, human variant effect prediction results (Nature 2026); Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) · Supplementary Data 1 (sheet 'Sheet1') cell J489, row 489: Model 'Evo 2 7B base', Data 'SpliceVarDB', Genomic_Feature 'Exonic', Variant_Type 'SNV', Sub_category '', column 'AUPRC'
Configuration: Evo 2 7B base (Evo 2 paper variant effect evaluations)	Protocol: Zero-shot SpliceVarDB exonic SNVs classification (Evo 2 paper, Supplementary Data 1) Dataset: SpliceVarDB experimentally validated splice variants (Brixi et al. 2026)	0.687 AUROC (zero-shot; SpliceVarDB exonic SNVs) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Evo 2 7B base on SpliceVarDB exonic SNVs (Evo 2 paper) gfm-guides-20261014-evo2-brixi2026-protocol-splicevardb-exonic-snv Aggregation: Not reported Genome modelling and design across all domains of life with Evo 2: Supplementary Data 1, human variant effect prediction results (Nature 2026); Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) · Supplementary Data 1 (sheet 'Sheet1') cell I489, row 489: Model 'Evo 2 7B base', Data 'SpliceVarDB', Genomic_Feature 'Exonic', Variant_Type 'SNV', Sub_category '', column 'AUROC'
Configuration: Evo 2 7B (Evo 2 paper variant effect evaluations)	Protocol: Zero-shot SpliceVarDB 'Both' (coding and noncoding) SNVs classification (Evo 2 paper, Supplementary Data 1) Dataset: SpliceVarDB experimentally validated splice variants (Brixi et al. 2026)	0.871 AUPRC (zero-shot; SpliceVarDB 'Both' (coding and noncoding) SNVs) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Evo 2 7B on SpliceVarDB 'Both' (coding and noncoding) SNVs (Evo 2 paper) gfm-guides-20261014-evo2-brixi2026-protocol-splicevardb-both-snv Aggregation: Not reported Genome modelling and design across all domains of life with Evo 2: Supplementary Data 1, human variant effect prediction results (Nature 2026); Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) · Supplementary Data 1 (sheet 'Sheet1') cell J520, row 520: Model 'Evo 2 7B', Data 'SpliceVarDB', Genomic_Feature 'Both', Variant_Type 'SNV', Sub_category '', column 'AUPRC'
Configuration: Evo 2 7B (Evo 2 paper variant effect evaluations)	Protocol: Zero-shot SpliceVarDB 'Both' (coding and noncoding) SNVs classification (Evo 2 paper, Supplementary Data 1) Dataset: SpliceVarDB experimentally validated splice variants (Brixi et al. 2026)	0.827 AUROC (zero-shot; SpliceVarDB 'Both' (coding and noncoding) SNVs) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Evo 2 7B on SpliceVarDB 'Both' (coding and noncoding) SNVs (Evo 2 paper) gfm-guides-20261014-evo2-brixi2026-protocol-splicevardb-both-snv Aggregation: Not reported Genome modelling and design across all domains of life with Evo 2: Supplementary Data 1, human variant effect prediction results (Nature 2026); Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) · Supplementary Data 1 (sheet 'Sheet1') cell I520, row 520: Model 'Evo 2 7B', Data 'SpliceVarDB', Genomic_Feature 'Both', Variant_Type 'SNV', Sub_category '', column 'AUROC'
Configuration: Evo 2 7B (Evo 2 paper variant effect evaluations)	Protocol: Zero-shot SpliceVarDB exonic SNVs classification (Evo 2 paper, Supplementary Data 1) Dataset: SpliceVarDB experimentally validated splice variants (Brixi et al. 2026)	0.534 AUPRC (zero-shot; SpliceVarDB exonic SNVs) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Evo 2 7B on SpliceVarDB exonic SNVs (Evo 2 paper) gfm-guides-20261014-evo2-brixi2026-protocol-splicevardb-exonic-snv Aggregation: Not reported Genome modelling and design across all domains of life with Evo 2: Supplementary Data 1, human variant effect prediction results (Nature 2026); Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) · Supplementary Data 1 (sheet 'Sheet1') cell J491, row 491: Model 'Evo 2 7B', Data 'SpliceVarDB', Genomic_Feature 'Exonic', Variant_Type 'SNV', Sub_category '', column 'AUPRC'

Source checking is not independent reproduction. Release 2026-10-22-1b7cf027e4f6.

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Release 2026-10-22-1b7cf027e4f6 · Evidence verified: Not verified

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Verified: Not verified

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Verified: Not verified

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Verified: Not verified

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One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

15 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-10-22-1b7cf027e4f6
Property and statement	Original source and location	Review and provenance
Label semantics Variants that cause aberrant splicing versus other variants (SpliceVarDB classification; class names not printed) Context-only references	evo2: Journal full-text XML Original source ↗ Supplementary Information A.3.14 (page 14); Fig. 3d legend Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Retrieved page snapshot; no immutable publisher revision supplied Retrieved: 2026-09-16T20:16:14.422554+00:00	not individually reviewed No individual claim review recorded Audit details Field: `attributes.label_semantics` Source artifact SHA-256: `d043dbda49e023ef6b70e36e7ca7832bda6b7af6c5934368e8778a7f23cda8bd` Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact Inspected artifact
Label semantics Variants that cause aberrant splicing versus other variants (SpliceVarDB classification; class names not printed) Context-only references	Genome modelling and design across all domains of life with Evo 2: Supplementary Data 1, human variant effect prediction results (Nature 2026) Original source ↗ Supplementary Information A.3.14 (page 14); Fig. 3d legend Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Nature 652 (2026), published 2026-03-04; Supplementary Data 1 file 41586_2026_10176_MOESM3_ESM.xlsx Retrieved: 2026-10-14T12:01:04Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.label_semantics` Source artifact SHA-256: `159f321775d634d9ed53b7a81c5cc1b5ef3d407880997e0f8c69bb8315a20a51` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Label semantics Variants that cause aberrant splicing versus other variants (SpliceVarDB classification; class names not printed) Context-only references	Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) Original source ↗ Supplementary Information A.3.14 (page 14); Fig. 3d legend Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Nature 652 (2026), published 2026-03-04; Supplementary Information file 41586_2026_10176_MOESM1_ESM.pdf (73 pages) Retrieved: 2026-10-14T12:01:04Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.label_semantics` Source artifact SHA-256: `fe2a99108a4ce5c0f4ef1595605eaec709fa86204410d5b66c1384327eb7b925` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Source location Supplementary Information A.3.14 (page 14); Fig. 3d legend Context-only references	evo2: Journal full-text XML Original source ↗ Supplementary Information A.3.14 (page 14); Fig. 3d legend Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Retrieved page snapshot; no immutable publisher revision supplied Retrieved: 2026-09-16T20:16:14.422554+00:00	not individually reviewed No individual claim review recorded Audit details Field: `attributes.source_locator` Source artifact SHA-256: `d043dbda49e023ef6b70e36e7ca7832bda6b7af6c5934368e8778a7f23cda8bd` Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact Inspected artifact
Source location Supplementary Information A.3.14 (page 14); Fig. 3d legend Context-only references	Genome modelling and design across all domains of life with Evo 2: Supplementary Data 1, human variant effect prediction results (Nature 2026) Original source ↗ Supplementary Information A.3.14 (page 14); Fig. 3d legend Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Nature 652 (2026), published 2026-03-04; Supplementary Data 1 file 41586_2026_10176_MOESM3_ESM.xlsx Retrieved: 2026-10-14T12:01:04Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.source_locator` Source artifact SHA-256: `159f321775d634d9ed53b7a81c5cc1b5ef3d407880997e0f8c69bb8315a20a51` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Source location Supplementary Information A.3.14 (page 14); Fig. 3d legend Context-only references	Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) Original source ↗ Supplementary Information A.3.14 (page 14); Fig. 3d legend Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Nature 652 (2026), published 2026-03-04; Supplementary Information file 41586_2026_10176_MOESM1_ESM.pdf (73 pages) Retrieved: 2026-10-14T12:01:04Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.source_locator` Source artifact SHA-256: `fe2a99108a4ce5c0f4ef1595605eaec709fa86204410d5b66c1384327eb7b925` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Split No split; all retained variants scored zero-shot Context-only references	evo2: Journal full-text XML Original source ↗ Supplementary Information A.3.14 (page 14); Fig. 3d legend Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Retrieved page snapshot; no immutable publisher revision supplied Retrieved: 2026-09-16T20:16:14.422554+00:00	not individually reviewed No individual claim review recorded Audit details Field: `attributes.split` Source artifact SHA-256: `d043dbda49e023ef6b70e36e7ca7832bda6b7af6c5934368e8778a7f23cda8bd` Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact Inspected artifact
Split No split; all retained variants scored zero-shot Context-only references	Genome modelling and design across all domains of life with Evo 2: Supplementary Data 1, human variant effect prediction results (Nature 2026) Original source ↗ Supplementary Information A.3.14 (page 14); Fig. 3d legend Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Nature 652 (2026), published 2026-03-04; Supplementary Data 1 file 41586_2026_10176_MOESM3_ESM.xlsx Retrieved: 2026-10-14T12:01:04Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.split` Source artifact SHA-256: `159f321775d634d9ed53b7a81c5cc1b5ef3d407880997e0f8c69bb8315a20a51` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Split No split; all retained variants scored zero-shot Context-only references	Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) Original source ↗ Supplementary Information A.3.14 (page 14); Fig. 3d legend Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Nature 652 (2026), published 2026-03-04; Supplementary Information file 41586_2026_10176_MOESM1_ESM.pdf (73 pages) Retrieved: 2026-10-14T12:01:04Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.split` Source artifact SHA-256: `fe2a99108a4ce5c0f4ef1595605eaec709fa86204410d5b66c1384327eb7b925` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Description SpliceVarDB variants with experimentally validated splicing effects, excluding variants labelled 'low frequency'. Context-only references	evo2: Journal full-text XML Original source ↗ Supplementary Information A.3.14 (page 14); Fig. 3d legend Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Retrieved page snapshot; no immutable publisher revision supplied Retrieved: 2026-09-16T20:16:14.422554+00:00	not individually reviewed No individual claim review recorded Audit details Field: `description` Source artifact SHA-256: `d043dbda49e023ef6b70e36e7ca7832bda6b7af6c5934368e8778a7f23cda8bd` Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact Inspected artifact

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Sources and history

Release 2026-10-22-1b7cf027e4f6 · Record review: source checked

3 source records and release history

evo2: Journal full-text XML · Original source · Retrieved page snapshot; no immutable publisher revision supplied
Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) · Original source · Nature 652 (2026), published 2026-03-04; Supplementary Information file 41586_2026_10176_MOESM1_ESM.pdf (73 pages)
Genome modelling and design across all domains of life with Evo 2: Supplementary Data 1, human variant effect prediction results (Nature 2026) · Original source · Nature 652 (2026), published 2026-03-04; Supplementary Data 1 file 41586_2026_10176_MOESM3_ESM.xlsx

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Technical metadata and extraction receipts

Stable ID: gfm-guides-20261014-evo2-brixi2026-data-splicevardb

areas: dna-genomes
contexts: research
split: No split; all retained variants scored zero-shot
label semantics: Variants that cause aberrant splicing versus other variants (SpliceVarDB classification; class names not printed)
source locator: Supplementary Information A.3.14 (page 14); Fig. 3d legend
missing metadata: version: reason: unreported; note: SpliceVarDB release or download date not stated

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