Protocol

Mutated virus mock-community profiling against ground truth (Tisza et al. 2026 Table S9)

Mean F1, Bray-Curtis dissimilarity (reads per million) and Pearson correlation of each tool's profile against ground truth across six mock communities, by taxonomic rank under strict truth and under ANI-capped truth.

5 evaluations · 75 results

Overview

An explanatory profile has not yet been reviewed for this record.

Consult the linked sources for architecture or protocol details. Missing evidence is not evidence of a missing capability.

5 recorded evaluations, 75 metric rows. A comparison chart has not yet been validated for these results. The table retains the individual findings and their sources.

View coverage and remaining gaps across all benchmarks

Results

Results are available, but no reviewed comparison panel is linked in this release.

All evaluations

5 evaluations · 75 results. Different protocols are not a single leaderboard.

Protocol: Mutated virus mock-community profiling against ground truth (Tisza et al. 2026 Table S9) · Dataset: Six mutated virus mock communities with bacterial and human background (Tisza et al. 2026)

Sorted by Bray curtis dissimilarity (RPM-based abundance profile; mean over mock communities; ANI-capped truth) (lower is better). The best value in each column is highlighted. Decimals are rounded for display; each value links to the printed value and its source.

Tested configuration	Bray curtis dissimilarity (RPM-based abundance profile; mean over mock communities; ANI-capped truth)	Bray curtis dissimilarity (RPM-based abundance profile; mean over six mock communities; rank family, strict truth)	Bray curtis dissimilarity (RPM-based abundance profile; mean over six mock communities; rank genus, strict truth)	Bray curtis dissimilarity (RPM-based abundance profile; mean over six mock communities; rank species, strict truth)	Bray curtis dissimilarity (RPM-based abundance profile; mean over six mock communities; rank subspecies, strict truth)	F1 (taxon detection; mean over mock communities; ANI-capped truth)	F1 (taxon detection; mean over six mock communities; rank family, strict truth)	F1 (taxon detection; mean over six mock communities; rank genus, strict truth)	F1 (taxon detection; mean over six mock communities; rank species, strict truth)	F1 (taxon detection; mean over six mock communities; rank subspecies, strict truth)	Pearson (abundance profile against truth; mean over mock communities; ANI-capped truth)	Pearson (abundance profile against truth; mean over six mock communities; rank family, strict truth)	Pearson (abundance profile against truth; mean over six mock communities; rank genus, strict truth)	Pearson (abundance profile against truth; mean over six mock communities; rank species, strict truth)	Pearson (abundance profile against truth; mean over six mock communities; rank subspecies, strict truth)
EsViritu v1.3.1, headline setting (Tisza et al. 2026)Evaluation	0.241 (best in column)	0.267 (best in column)	0.27 (best in column)	0.275 (best in column)	0.382 (best in column)	0.922 (best in column)	0.948 (best in column)	0.929 (best in column)	0.845 (best in column)	0.671	0.825 (best in column)	0.831 (best in column)	0.817 (best in column)	0.776 (best in column)	0.564
Kraken2 v2.17.1, headline setting (Tisza et al. 2026)Evaluation	0.59	0.572	0.557	0.598	0.594	0.54	0.754	0.682	0.632	0.612	0.353	0.384	0.406	0.365	0.37
Metabuli v1.2.0, headline setting (Tisza et al. 2026)Evaluation	0.733	0.279	0.341	0.727	0.422	0.593	0.919	0.785	0.692	0.702 (best in column)	-0.026	0.698	0.545	-0.053	0.58 (best in column)
Centrifuger v1.1.1-r309, headline setting (Tisza et al. 2026)Evaluation	0.846	0.615	0.626	0.639	0.584	0.247	0.727	0.648	0.579	0.613	-0.105	0.321	0.321	0.304	0.335
Sylph v0.9.0, headline setting (Tisza et al. 2026)Evaluation	NA	NA	NA	NA	NA	0.477	0.601	0.569	0.499	0.537	NA	NA	NA	NA	NA

All 75 result rows with coverage, uncertainty and sources

Filter evaluations

Tested model or methodProtocolDatasetEvaluation setupMetricEvidence origin

Applied filters: All linked evaluations

Exact evaluated configurations and original reported results
Tested configuration	Protocol and dataset	Finding	Evidence and details
Configuration: Centrifuger v1.1.1-r309, headline setting (Tisza et al. 2026)	Protocol: Mutated virus mock-community profiling against ground truth (Tisza et al. 2026 Table S9) Dataset: Six mutated virus mock communities with bacterial and human background (Tisza et al. 2026)	0.846 Bray curtis dissimilarity (RPM-based abundance profile; mean over mock communities; ANI-capped truth) unitless · lower Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Centrifuger v1.1.1-r309 on Mutated virus mock-community profiling against ground truth (Tisza et al. 2026 Table S9) rna-pathogen-20261011-tisza2026-protocol-mock Aggregation: Not reported Tisza et al. 2026 Supplemental Tables S1-S25 (bioRxiv media-1.xlsx) · Supplemental Table S9, row 24 (base_tool 'Centrifuger', rank 'ani_capped', truth_mode 'capped'), column 'bray_curtis' (cell E24)
Configuration: Centrifuger v1.1.1-r309, headline setting (Tisza et al. 2026)	Protocol: Mutated virus mock-community profiling against ground truth (Tisza et al. 2026 Table S9) Dataset: Six mutated virus mock communities with bacterial and human background (Tisza et al. 2026)	0.247 F1 (taxon detection; mean over mock communities; ANI-capped truth) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Centrifuger v1.1.1-r309 on Mutated virus mock-community profiling against ground truth (Tisza et al. 2026 Table S9) rna-pathogen-20261011-tisza2026-protocol-mock Aggregation: Not reported Tisza et al. 2026 Supplemental Tables S1-S25 (bioRxiv media-1.xlsx) · Supplemental Table S9, row 24 (base_tool 'Centrifuger', rank 'ani_capped', truth_mode 'capped'), column 'F1' (cell D24)
Configuration: Centrifuger v1.1.1-r309, headline setting (Tisza et al. 2026)	Protocol: Mutated virus mock-community profiling against ground truth (Tisza et al. 2026 Table S9) Dataset: Six mutated virus mock communities with bacterial and human background (Tisza et al. 2026)	-0.105 Pearson (abundance profile against truth; mean over mock communities; ANI-capped truth) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Centrifuger v1.1.1-r309 on Mutated virus mock-community profiling against ground truth (Tisza et al. 2026 Table S9) rna-pathogen-20261011-tisza2026-protocol-mock Aggregation: Not reported Tisza et al. 2026 Supplemental Tables S1-S25 (bioRxiv media-1.xlsx) · Supplemental Table S9, row 24 (base_tool 'Centrifuger', rank 'ani_capped', truth_mode 'capped'), column 'pearson' (cell F24)
Configuration: Centrifuger v1.1.1-r309, headline setting (Tisza et al. 2026)	Protocol: Mutated virus mock-community profiling against ground truth (Tisza et al. 2026 Table S9) Dataset: Six mutated virus mock communities with bacterial and human background (Tisza et al. 2026)	0.615 Bray curtis dissimilarity (RPM-based abundance profile; mean over six mock communities; rank family, strict truth) unitless · lower Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Centrifuger v1.1.1-r309 on Mutated virus mock-community profiling against ground truth (Tisza et al. 2026 Table S9) rna-pathogen-20261011-tisza2026-protocol-mock Aggregation: Not reported Tisza et al. 2026 Supplemental Tables S1-S25 (bioRxiv media-1.xlsx) · Supplemental Table S9, row 4 (base_tool 'Centrifuger', rank 'family', truth_mode 'strict'), column 'bray_curtis' (cell E4)
Configuration: Centrifuger v1.1.1-r309, headline setting (Tisza et al. 2026)	Protocol: Mutated virus mock-community profiling against ground truth (Tisza et al. 2026 Table S9) Dataset: Six mutated virus mock communities with bacterial and human background (Tisza et al. 2026)	0.727 F1 (taxon detection; mean over six mock communities; rank family, strict truth) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Centrifuger v1.1.1-r309 on Mutated virus mock-community profiling against ground truth (Tisza et al. 2026 Table S9) rna-pathogen-20261011-tisza2026-protocol-mock Aggregation: Not reported Tisza et al. 2026 Supplemental Tables S1-S25 (bioRxiv media-1.xlsx) · Supplemental Table S9, row 4 (base_tool 'Centrifuger', rank 'family', truth_mode 'strict'), column 'F1' (cell D4)
Configuration: Centrifuger v1.1.1-r309, headline setting (Tisza et al. 2026)	Protocol: Mutated virus mock-community profiling against ground truth (Tisza et al. 2026 Table S9) Dataset: Six mutated virus mock communities with bacterial and human background (Tisza et al. 2026)	0.321 Pearson (abundance profile against truth; mean over six mock communities; rank family, strict truth) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Centrifuger v1.1.1-r309 on Mutated virus mock-community profiling against ground truth (Tisza et al. 2026 Table S9) rna-pathogen-20261011-tisza2026-protocol-mock Aggregation: Not reported Tisza et al. 2026 Supplemental Tables S1-S25 (bioRxiv media-1.xlsx) · Supplemental Table S9, row 4 (base_tool 'Centrifuger', rank 'family', truth_mode 'strict'), column 'pearson' (cell F4)
Configuration: Centrifuger v1.1.1-r309, headline setting (Tisza et al. 2026)	Protocol: Mutated virus mock-community profiling against ground truth (Tisza et al. 2026 Table S9) Dataset: Six mutated virus mock communities with bacterial and human background (Tisza et al. 2026)	0.626 Bray curtis dissimilarity (RPM-based abundance profile; mean over six mock communities; rank genus, strict truth) unitless · lower Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Centrifuger v1.1.1-r309 on Mutated virus mock-community profiling against ground truth (Tisza et al. 2026 Table S9) rna-pathogen-20261011-tisza2026-protocol-mock Aggregation: Not reported Tisza et al. 2026 Supplemental Tables S1-S25 (bioRxiv media-1.xlsx) · Supplemental Table S9, row 9 (base_tool 'Centrifuger', rank 'genus', truth_mode 'strict'), column 'bray_curtis' (cell E9)
Configuration: Centrifuger v1.1.1-r309, headline setting (Tisza et al. 2026)	Protocol: Mutated virus mock-community profiling against ground truth (Tisza et al. 2026 Table S9) Dataset: Six mutated virus mock communities with bacterial and human background (Tisza et al. 2026)	0.648 F1 (taxon detection; mean over six mock communities; rank genus, strict truth) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Centrifuger v1.1.1-r309 on Mutated virus mock-community profiling against ground truth (Tisza et al. 2026 Table S9) rna-pathogen-20261011-tisza2026-protocol-mock Aggregation: Not reported Tisza et al. 2026 Supplemental Tables S1-S25 (bioRxiv media-1.xlsx) · Supplemental Table S9, row 9 (base_tool 'Centrifuger', rank 'genus', truth_mode 'strict'), column 'F1' (cell D9)
Configuration: Centrifuger v1.1.1-r309, headline setting (Tisza et al. 2026)	Protocol: Mutated virus mock-community profiling against ground truth (Tisza et al. 2026 Table S9) Dataset: Six mutated virus mock communities with bacterial and human background (Tisza et al. 2026)	0.321 Pearson (abundance profile against truth; mean over six mock communities; rank genus, strict truth) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Centrifuger v1.1.1-r309 on Mutated virus mock-community profiling against ground truth (Tisza et al. 2026 Table S9) rna-pathogen-20261011-tisza2026-protocol-mock Aggregation: Not reported Tisza et al. 2026 Supplemental Tables S1-S25 (bioRxiv media-1.xlsx) · Supplemental Table S9, row 9 (base_tool 'Centrifuger', rank 'genus', truth_mode 'strict'), column 'pearson' (cell F9)
Configuration: Centrifuger v1.1.1-r309, headline setting (Tisza et al. 2026)	Protocol: Mutated virus mock-community profiling against ground truth (Tisza et al. 2026 Table S9) Dataset: Six mutated virus mock communities with bacterial and human background (Tisza et al. 2026)	0.639 Bray curtis dissimilarity (RPM-based abundance profile; mean over six mock communities; rank species, strict truth) unitless · lower Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Centrifuger v1.1.1-r309 on Mutated virus mock-community profiling against ground truth (Tisza et al. 2026 Table S9) rna-pathogen-20261011-tisza2026-protocol-mock Aggregation: Not reported Tisza et al. 2026 Supplemental Tables S1-S25 (bioRxiv media-1.xlsx) · Supplemental Table S9, row 14 (base_tool 'Centrifuger', rank 'species', truth_mode 'strict'), column 'bray_curtis' (cell E14)
Configuration: Centrifuger v1.1.1-r309, headline setting (Tisza et al. 2026)	Protocol: Mutated virus mock-community profiling against ground truth (Tisza et al. 2026 Table S9) Dataset: Six mutated virus mock communities with bacterial and human background (Tisza et al. 2026)	0.579 F1 (taxon detection; mean over six mock communities; rank species, strict truth) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Centrifuger v1.1.1-r309 on Mutated virus mock-community profiling against ground truth (Tisza et al. 2026 Table S9) rna-pathogen-20261011-tisza2026-protocol-mock Aggregation: Not reported Tisza et al. 2026 Supplemental Tables S1-S25 (bioRxiv media-1.xlsx) · Supplemental Table S9, row 14 (base_tool 'Centrifuger', rank 'species', truth_mode 'strict'), column 'F1' (cell D14)
Configuration: Centrifuger v1.1.1-r309, headline setting (Tisza et al. 2026)	Protocol: Mutated virus mock-community profiling against ground truth (Tisza et al. 2026 Table S9) Dataset: Six mutated virus mock communities with bacterial and human background (Tisza et al. 2026)	0.304 Pearson (abundance profile against truth; mean over six mock communities; rank species, strict truth) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Centrifuger v1.1.1-r309 on Mutated virus mock-community profiling against ground truth (Tisza et al. 2026 Table S9) rna-pathogen-20261011-tisza2026-protocol-mock Aggregation: Not reported Tisza et al. 2026 Supplemental Tables S1-S25 (bioRxiv media-1.xlsx) · Supplemental Table S9, row 14 (base_tool 'Centrifuger', rank 'species', truth_mode 'strict'), column 'pearson' (cell F14)
Configuration: Centrifuger v1.1.1-r309, headline setting (Tisza et al. 2026)	Protocol: Mutated virus mock-community profiling against ground truth (Tisza et al. 2026 Table S9) Dataset: Six mutated virus mock communities with bacterial and human background (Tisza et al. 2026)	0.584 Bray curtis dissimilarity (RPM-based abundance profile; mean over six mock communities; rank subspecies, strict truth) unitless · lower Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Centrifuger v1.1.1-r309 on Mutated virus mock-community profiling against ground truth (Tisza et al. 2026 Table S9) rna-pathogen-20261011-tisza2026-protocol-mock Aggregation: Not reported Tisza et al. 2026 Supplemental Tables S1-S25 (bioRxiv media-1.xlsx) · Supplemental Table S9, row 19 (base_tool 'Centrifuger', rank 'subspecies', truth_mode 'strict'), column 'bray_curtis' (cell E19)
Configuration: Centrifuger v1.1.1-r309, headline setting (Tisza et al. 2026)	Protocol: Mutated virus mock-community profiling against ground truth (Tisza et al. 2026 Table S9) Dataset: Six mutated virus mock communities with bacterial and human background (Tisza et al. 2026)	0.613 F1 (taxon detection; mean over six mock communities; rank subspecies, strict truth) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Centrifuger v1.1.1-r309 on Mutated virus mock-community profiling against ground truth (Tisza et al. 2026 Table S9) rna-pathogen-20261011-tisza2026-protocol-mock Aggregation: Not reported Tisza et al. 2026 Supplemental Tables S1-S25 (bioRxiv media-1.xlsx) · Supplemental Table S9, row 19 (base_tool 'Centrifuger', rank 'subspecies', truth_mode 'strict'), column 'F1' (cell D19)
Configuration: Centrifuger v1.1.1-r309, headline setting (Tisza et al. 2026)	Protocol: Mutated virus mock-community profiling against ground truth (Tisza et al. 2026 Table S9) Dataset: Six mutated virus mock communities with bacterial and human background (Tisza et al. 2026)	0.335 Pearson (abundance profile against truth; mean over six mock communities; rank subspecies, strict truth) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Centrifuger v1.1.1-r309 on Mutated virus mock-community profiling against ground truth (Tisza et al. 2026 Table S9) rna-pathogen-20261011-tisza2026-protocol-mock Aggregation: Not reported Tisza et al. 2026 Supplemental Tables S1-S25 (bioRxiv media-1.xlsx) · Supplemental Table S9, row 19 (base_tool 'Centrifuger', rank 'subspecies', truth_mode 'strict'), column 'pearson' (cell F19)
Configuration: EsViritu v1.3.1, headline setting (Tisza et al. 2026)	Protocol: Mutated virus mock-community profiling against ground truth (Tisza et al. 2026 Table S9) Dataset: Six mutated virus mock communities with bacterial and human background (Tisza et al. 2026)	0.241 Bray curtis dissimilarity (RPM-based abundance profile; mean over mock communities; ANI-capped truth) unitless · lower Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source EsViritu v1.3.1 on Mutated virus mock-community profiling against ground truth (Tisza et al. 2026 Table S9) rna-pathogen-20261011-tisza2026-protocol-mock Aggregation: Not reported Tisza et al. 2026 Supplemental Tables S1-S25 (bioRxiv media-1.xlsx) · Supplemental Table S9, row 25 (base_tool 'EsViritu', rank 'ani_capped', truth_mode 'capped'), column 'bray_curtis' (cell E25)
Configuration: EsViritu v1.3.1, headline setting (Tisza et al. 2026)	Protocol: Mutated virus mock-community profiling against ground truth (Tisza et al. 2026 Table S9) Dataset: Six mutated virus mock communities with bacterial and human background (Tisza et al. 2026)	0.922 F1 (taxon detection; mean over mock communities; ANI-capped truth) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source EsViritu v1.3.1 on Mutated virus mock-community profiling against ground truth (Tisza et al. 2026 Table S9) rna-pathogen-20261011-tisza2026-protocol-mock Aggregation: Not reported Tisza et al. 2026 Supplemental Tables S1-S25 (bioRxiv media-1.xlsx) · Supplemental Table S9, row 25 (base_tool 'EsViritu', rank 'ani_capped', truth_mode 'capped'), column 'F1' (cell D25)
Configuration: EsViritu v1.3.1, headline setting (Tisza et al. 2026)	Protocol: Mutated virus mock-community profiling against ground truth (Tisza et al. 2026 Table S9) Dataset: Six mutated virus mock communities with bacterial and human background (Tisza et al. 2026)	0.825 Pearson (abundance profile against truth; mean over mock communities; ANI-capped truth) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source EsViritu v1.3.1 on Mutated virus mock-community profiling against ground truth (Tisza et al. 2026 Table S9) rna-pathogen-20261011-tisza2026-protocol-mock Aggregation: Not reported Tisza et al. 2026 Supplemental Tables S1-S25 (bioRxiv media-1.xlsx) · Supplemental Table S9, row 25 (base_tool 'EsViritu', rank 'ani_capped', truth_mode 'capped'), column 'pearson' (cell F25)
Configuration: EsViritu v1.3.1, headline setting (Tisza et al. 2026)	Protocol: Mutated virus mock-community profiling against ground truth (Tisza et al. 2026 Table S9) Dataset: Six mutated virus mock communities with bacterial and human background (Tisza et al. 2026)	0.267 Bray curtis dissimilarity (RPM-based abundance profile; mean over six mock communities; rank family, strict truth) unitless · lower Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source EsViritu v1.3.1 on Mutated virus mock-community profiling against ground truth (Tisza et al. 2026 Table S9) rna-pathogen-20261011-tisza2026-protocol-mock Aggregation: Not reported Tisza et al. 2026 Supplemental Tables S1-S25 (bioRxiv media-1.xlsx) · Supplemental Table S9, row 5 (base_tool 'EsViritu', rank 'family', truth_mode 'strict'), column 'bray_curtis' (cell E5)
Configuration: EsViritu v1.3.1, headline setting (Tisza et al. 2026)	Protocol: Mutated virus mock-community profiling against ground truth (Tisza et al. 2026 Table S9) Dataset: Six mutated virus mock communities with bacterial and human background (Tisza et al. 2026)	0.948 F1 (taxon detection; mean over six mock communities; rank family, strict truth) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source EsViritu v1.3.1 on Mutated virus mock-community profiling against ground truth (Tisza et al. 2026 Table S9) rna-pathogen-20261011-tisza2026-protocol-mock Aggregation: Not reported Tisza et al. 2026 Supplemental Tables S1-S25 (bioRxiv media-1.xlsx) · Supplemental Table S9, row 5 (base_tool 'EsViritu', rank 'family', truth_mode 'strict'), column 'F1' (cell D5)
Configuration: EsViritu v1.3.1, headline setting (Tisza et al. 2026)	Protocol: Mutated virus mock-community profiling against ground truth (Tisza et al. 2026 Table S9) Dataset: Six mutated virus mock communities with bacterial and human background (Tisza et al. 2026)	0.831 Pearson (abundance profile against truth; mean over six mock communities; rank family, strict truth) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source EsViritu v1.3.1 on Mutated virus mock-community profiling against ground truth (Tisza et al. 2026 Table S9) rna-pathogen-20261011-tisza2026-protocol-mock Aggregation: Not reported Tisza et al. 2026 Supplemental Tables S1-S25 (bioRxiv media-1.xlsx) · Supplemental Table S9, row 5 (base_tool 'EsViritu', rank 'family', truth_mode 'strict'), column 'pearson' (cell F5)
Configuration: EsViritu v1.3.1, headline setting (Tisza et al. 2026)	Protocol: Mutated virus mock-community profiling against ground truth (Tisza et al. 2026 Table S9) Dataset: Six mutated virus mock communities with bacterial and human background (Tisza et al. 2026)	0.27 Bray curtis dissimilarity (RPM-based abundance profile; mean over six mock communities; rank genus, strict truth) unitless · lower Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source EsViritu v1.3.1 on Mutated virus mock-community profiling against ground truth (Tisza et al. 2026 Table S9) rna-pathogen-20261011-tisza2026-protocol-mock Aggregation: Not reported Tisza et al. 2026 Supplemental Tables S1-S25 (bioRxiv media-1.xlsx) · Supplemental Table S9, row 10 (base_tool 'EsViritu', rank 'genus', truth_mode 'strict'), column 'bray_curtis' (cell E10)
Configuration: EsViritu v1.3.1, headline setting (Tisza et al. 2026)	Protocol: Mutated virus mock-community profiling against ground truth (Tisza et al. 2026 Table S9) Dataset: Six mutated virus mock communities with bacterial and human background (Tisza et al. 2026)	0.929 F1 (taxon detection; mean over six mock communities; rank genus, strict truth) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source EsViritu v1.3.1 on Mutated virus mock-community profiling against ground truth (Tisza et al. 2026 Table S9) rna-pathogen-20261011-tisza2026-protocol-mock Aggregation: Not reported Tisza et al. 2026 Supplemental Tables S1-S25 (bioRxiv media-1.xlsx) · Supplemental Table S9, row 10 (base_tool 'EsViritu', rank 'genus', truth_mode 'strict'), column 'F1' (cell D10)
Configuration: EsViritu v1.3.1, headline setting (Tisza et al. 2026)	Protocol: Mutated virus mock-community profiling against ground truth (Tisza et al. 2026 Table S9) Dataset: Six mutated virus mock communities with bacterial and human background (Tisza et al. 2026)	0.817 Pearson (abundance profile against truth; mean over six mock communities; rank genus, strict truth) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source EsViritu v1.3.1 on Mutated virus mock-community profiling against ground truth (Tisza et al. 2026 Table S9) rna-pathogen-20261011-tisza2026-protocol-mock Aggregation: Not reported Tisza et al. 2026 Supplemental Tables S1-S25 (bioRxiv media-1.xlsx) · Supplemental Table S9, row 10 (base_tool 'EsViritu', rank 'genus', truth_mode 'strict'), column 'pearson' (cell F10)
Configuration: EsViritu v1.3.1, headline setting (Tisza et al. 2026)	Protocol: Mutated virus mock-community profiling against ground truth (Tisza et al. 2026 Table S9) Dataset: Six mutated virus mock communities with bacterial and human background (Tisza et al. 2026)	0.275 Bray curtis dissimilarity (RPM-based abundance profile; mean over six mock communities; rank species, strict truth) unitless · lower Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source EsViritu v1.3.1 on Mutated virus mock-community profiling against ground truth (Tisza et al. 2026 Table S9) rna-pathogen-20261011-tisza2026-protocol-mock Aggregation: Not reported Tisza et al. 2026 Supplemental Tables S1-S25 (bioRxiv media-1.xlsx) · Supplemental Table S9, row 15 (base_tool 'EsViritu', rank 'species', truth_mode 'strict'), column 'bray_curtis' (cell E15)

Source checking is not independent reproduction. Release 2026-10-22-1b7cf027e4f6.

Methods and evaluation design

Procedure, tasks and evaluated configurations

Recorded evaluations

Each evaluation records what was tested and under which conditions.

Baseline coverage

Reference methods help show what a model adds beyond simple controls. We track a null control and a conventional method for each protocol.

0 of 2 active baseline roles have published Rewire measurements in this release. Measurements on a selected protocol do not establish coverage of an entire suite.

No execution recipe linked to this protocol. Recipe availability does not establish a completed evaluation.

Author-reported evaluations: 5

Literature evidence is not a Rewire measurement. Executed but unpublished runs and private review status are not included.

Null control

Proposed control: requires review

Select a task-valid null control after reviewing inputs and metric

Protocol-specific applicability, permitted inputs, access, split, evaluator and execution requirements need review before implementation or execution.

This is a suggested selection rule, not a validated method or a measured score.

Conventional reference

Proposed control: requires review

Select an upstream conventional reference after reviewing the full protocol

Protocol-specific applicability, permitted inputs, access, split, evaluator and execution requirements need review before implementation or execution.

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Protocol coverage CSV (gzip) · Model evaluation matrix (gzip) · Source table (gzip) · Release and checksums (gzip)

Coverage is derived from release 2026-10-22-1b7cf027e4f6. Source citations describe the original records; they do not validate an unreviewed baseline proposal. No results have been generated by this audit.

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Evidence table

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Claims, original sources and review scope · Release 2026-10-22-1b7cf027e4f6
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Sources and history

Release 2026-10-22-1b7cf027e4f6 · Record review: source checked

2 source records and release history

EsViritu is a sensitive and specific profiler for viral pathogen detection and genome recovery in metagenomes · Original source · bioRxiv 10.64898/2026.09.29.755457 v1, posted 2026-09-30; JATS XML
Tisza et al. 2026 Supplemental Tables S1-S25 (bioRxiv media-1.xlsx) · Original source · bioRxiv 10.64898/2026.09.29.755457 v1 supplementary file DC1 (755457_file02.xlsx)

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Technical metadata and extraction receipts

Stable ID: rna-pathogen-20261011-tisza2026-protocol-mock

areas: microbes-communities
contexts: research
protocol: Strict truth uses the provenance lineage at each rank; capped truth caps the rank by ANI (98-100%: subspecies, 90-95%: species, 80-85%: genus). Profiles normalised to relative abundance per tool; means over the six communities.
version: bioRxiv v1
source locator: Methods 'Mock communities'; Supplemental Table S9 caption
limitations: The divergence cap is a heuristic, as the authors note (Discussion).; Sylph abundance metrics are not comparable and are printed NA.; Under divergence-capped truth the Results say only the three one-per-family communities were scored, while Methods say all six were analysed together; the capped means may cover three communities.

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