Dataset

122 ICU patients with severe pneumonia-associated sepsis and paired blood and BALF (Huang et al. 2026)

Retrospective cohort from the First Affiliated Hospital, Sun Yat-sen University, February 2022 to February 2024.

Evaluation results

4 evaluations · 80 results. Different protocols are not a single leaderboard.

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Exact evaluated configurations and original reported results
Tested configuration	Protocol and dataset	Finding	Evidence and details
Configuration: Geneplus broad-spectrum targeted NGS of microbial cell-free DNA (bstNGS), as run in Huang et al. 2026	Protocol: Patient-level detection of causative pathogens in blood against the final clinical diagnosis (Huang et al. 2026 Table 2) Dataset: 122 ICU patients with severe pneumonia-associated sepsis and paired blood and BALF (Huang et al. 2026)	60.7% Accuracy (patient level; all pneumonia; reference: final clinical diagnosis) percent · higher Uncertainty: 95% CI 51.79 to 68.87 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Blood-bstNGS against the final clinical diagnosis (Huang et al. 2026) dna-pathogen-20261011-huang2026-protocol-clinical-diagnosis Aggregation: Not reported Blood-based targeted sequencing of microbial cell-free DNA in severe pneumonia-associated sepsis · Table 2, stratum 'All pneumonia', row 'Blood-bstNGS', column 'Accuracy (95%CI)'
Configuration: Geneplus broad-spectrum targeted NGS of microbial cell-free DNA (bstNGS), as run in Huang et al. 2026	Protocol: Patient-level detection of causative pathogens in blood against the final clinical diagnosis (Huang et al. 2026 Table 2) Dataset: 122 ICU patients with severe pneumonia-associated sepsis and paired blood and BALF (Huang et al. 2026)	17.4% Negative predictive value (patient level; all pneumonia; reference: final clinical diagnosis) percent · higher Uncertainty: 95% CI 9.09 to 30.72 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Blood-bstNGS against the final clinical diagnosis (Huang et al. 2026) dna-pathogen-20261011-huang2026-protocol-clinical-diagnosis Aggregation: Not reported Blood-based targeted sequencing of microbial cell-free DNA in severe pneumonia-associated sepsis · Table 2, stratum 'All pneumonia', row 'Blood-bstNGS', column 'NPV (95%CI)'
Configuration: Geneplus broad-spectrum targeted NGS of microbial cell-free DNA (bstNGS), as run in Huang et al. 2026	Protocol: Patient-level detection of causative pathogens in blood against the final clinical diagnosis (Huang et al. 2026 Table 2) Dataset: 122 ICU patients with severe pneumonia-associated sepsis and paired blood and BALF (Huang et al. 2026)	86.8% Precision (patient level; all pneumonia; reference: final clinical diagnosis) percent · higher Uncertainty: 95% CI 77.45 to 92.69 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Blood-bstNGS against the final clinical diagnosis (Huang et al. 2026) dna-pathogen-20261011-huang2026-protocol-clinical-diagnosis Aggregation: Not reported Blood-based targeted sequencing of microbial cell-free DNA in severe pneumonia-associated sepsis · Table 2, stratum 'All pneumonia', row 'Blood-bstNGS', column 'PPV (95%CI)'
Configuration: Geneplus broad-spectrum targeted NGS of microbial cell-free DNA (bstNGS), as run in Huang et al. 2026	Protocol: Patient-level detection of causative pathogens in blood against the final clinical diagnosis (Huang et al. 2026 Table 2) Dataset: 122 ICU patients with severe pneumonia-associated sepsis and paired blood and BALF (Huang et al. 2026)	63.5% Recall (patient level; all pneumonia; reference: final clinical diagnosis) percent · higher Uncertainty: 95% CI 53.88 to 72.08 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Blood-bstNGS against the final clinical diagnosis (Huang et al. 2026) dna-pathogen-20261011-huang2026-protocol-clinical-diagnosis Aggregation: Not reported Blood-based targeted sequencing of microbial cell-free DNA in severe pneumonia-associated sepsis · Table 2, stratum 'All pneumonia', row 'Blood-bstNGS', column 'Sensitivity (95%CI)'
Configuration: Geneplus broad-spectrum targeted NGS of microbial cell-free DNA (bstNGS), as run in Huang et al. 2026	Protocol: Patient-level detection of causative pathogens in blood against the final clinical diagnosis (Huang et al. 2026 Table 2) Dataset: 122 ICU patients with severe pneumonia-associated sepsis and paired blood and BALF (Huang et al. 2026)	44.4% Specificity (patient level; all pneumonia; reference: final clinical diagnosis) percent · higher Uncertainty: 95% CI 24.56 to 66.28 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Blood-bstNGS against the final clinical diagnosis (Huang et al. 2026) dna-pathogen-20261011-huang2026-protocol-clinical-diagnosis Aggregation: Not reported Blood-based targeted sequencing of microbial cell-free DNA in severe pneumonia-associated sepsis · Table 2, stratum 'All pneumonia', row 'Blood-bstNGS', column 'Specificity (95%CI)'
Configuration: Conventional microbiological tests (Huang et al. 2026), as run in Huang et al. 2026	Protocol: Patient-level detection of causative pathogens in blood against the final clinical diagnosis (Huang et al. 2026 Table 2) Dataset: 122 ICU patients with severe pneumonia-associated sepsis and paired blood and BALF (Huang et al. 2026)	54.9% Accuracy (patient level; all pneumonia; reference: final clinical diagnosis) percent · higher Uncertainty: 95% CI 46.07 to 63.46 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source CMTs against the final clinical diagnosis (Huang et al. 2026) dna-pathogen-20261011-huang2026-protocol-clinical-diagnosis Aggregation: Not reported Blood-based targeted sequencing of microbial cell-free DNA in severe pneumonia-associated sepsis · Table 2, stratum 'All pneumonia', row 'CMTs', column 'Accuracy (95%CI)'
Configuration: Conventional microbiological tests (Huang et al. 2026), as run in Huang et al. 2026	Protocol: Patient-level detection of causative pathogens in blood against the final clinical diagnosis (Huang et al. 2026 Table 2) Dataset: 122 ICU patients with severe pneumonia-associated sepsis and paired blood and BALF (Huang et al. 2026)	23.2% Negative predictive value (patient level; all pneumonia; reference: final clinical diagnosis) percent · higher Uncertainty: 95% CI 14.81 to 34.40 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source CMTs against the final clinical diagnosis (Huang et al. 2026) dna-pathogen-20261011-huang2026-protocol-clinical-diagnosis Aggregation: Not reported Blood-based targeted sequencing of microbial cell-free DNA in severe pneumonia-associated sepsis · Table 2, stratum 'All pneumonia', row 'CMTs', column 'NPV (95%CI)'
Configuration: Conventional microbiological tests (Huang et al. 2026), as run in Huang et al. 2026	Protocol: Patient-level detection of causative pathogens in blood against the final clinical diagnosis (Huang et al. 2026 Table 2) Dataset: 122 ICU patients with severe pneumonia-associated sepsis and paired blood and BALF (Huang et al. 2026)	96.2% Precision (patient level; all pneumonia; reference: final clinical diagnosis) percent · higher Uncertainty: 95% CI 87.25 to 98.96 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source CMTs against the final clinical diagnosis (Huang et al. 2026) dna-pathogen-20261011-huang2026-protocol-clinical-diagnosis Aggregation: Not reported Blood-based targeted sequencing of microbial cell-free DNA in severe pneumonia-associated sepsis · Table 2, stratum 'All pneumonia', row 'CMTs', column 'PPV (95%CI)'
Configuration: Conventional microbiological tests (Huang et al. 2026), as run in Huang et al. 2026	Protocol: Patient-level detection of causative pathogens in blood against the final clinical diagnosis (Huang et al. 2026 Table 2) Dataset: 122 ICU patients with severe pneumonia-associated sepsis and paired blood and BALF (Huang et al. 2026)	49% Recall (patient level; all pneumonia; reference: final clinical diagnosis) percent · higher Uncertainty: 95% CI 39.64 to 58.51 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source CMTs against the final clinical diagnosis (Huang et al. 2026) dna-pathogen-20261011-huang2026-protocol-clinical-diagnosis Aggregation: Not reported Blood-based targeted sequencing of microbial cell-free DNA in severe pneumonia-associated sepsis · Table 2, stratum 'All pneumonia', row 'CMTs', column 'Sensitivity (95%CI)'
Configuration: Conventional microbiological tests (Huang et al. 2026), as run in Huang et al. 2026	Protocol: Patient-level detection of causative pathogens in blood against the final clinical diagnosis (Huang et al. 2026 Table 2) Dataset: 122 ICU patients with severe pneumonia-associated sepsis and paired blood and BALF (Huang et al. 2026)	88.9% Specificity (patient level; all pneumonia; reference: final clinical diagnosis) percent · higher Uncertainty: 95% CI 67.20 to 96.90 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source CMTs against the final clinical diagnosis (Huang et al. 2026) dna-pathogen-20261011-huang2026-protocol-clinical-diagnosis Aggregation: Not reported Blood-based targeted sequencing of microbial cell-free DNA in severe pneumonia-associated sepsis · Table 2, stratum 'All pneumonia', row 'CMTs', column 'Specificity (95%CI)'
Configuration: Blood culture (Huang et al. 2026), as run in Huang et al. 2026	Protocol: Patient-level detection of causative pathogens in blood against the final clinical diagnosis (Huang et al. 2026 Table 2) Dataset: 122 ICU patients with severe pneumonia-associated sepsis and paired blood and BALF (Huang et al. 2026)	22.9% Accuracy (patient level; all pneumonia; reference: final clinical diagnosis) percent · higher Uncertainty: 95% CI 16.38 to 31.17 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Blood-culture only against the final clinical diagnosis (Huang et al. 2026) dna-pathogen-20261011-huang2026-protocol-clinical-diagnosis Aggregation: Not reported Blood-based targeted sequencing of microbial cell-free DNA in severe pneumonia-associated sepsis · Table 2, stratum 'All pneumonia', row 'Blood-culture only', column 'Accuracy (95%CI)'
Configuration: Blood culture (Huang et al. 2026), as run in Huang et al. 2026	Protocol: Patient-level detection of causative pathogens in blood against the final clinical diagnosis (Huang et al. 2026 Table 2) Dataset: 122 ICU patients with severe pneumonia-associated sepsis and paired blood and BALF (Huang et al. 2026)	16.1% Negative predictive value (patient level; all pneumonia; reference: final clinical diagnosis) percent · higher Uncertainty: 95% CI 10.41 to 23.98 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Blood-culture only against the final clinical diagnosis (Huang et al. 2026) dna-pathogen-20261011-huang2026-protocol-clinical-diagnosis Aggregation: Not reported Blood-based targeted sequencing of microbial cell-free DNA in severe pneumonia-associated sepsis · Table 2, stratum 'All pneumonia', row 'Blood-culture only', column 'NPV (95%CI)'
Configuration: Blood culture (Huang et al. 2026), as run in Huang et al. 2026	Protocol: Patient-level detection of causative pathogens in blood against the final clinical diagnosis (Huang et al. 2026 Table 2) Dataset: 122 ICU patients with severe pneumonia-associated sepsis and paired blood and BALF (Huang et al. 2026)	100% Precision (patient level; all pneumonia; reference: final clinical diagnosis) percent · higher Uncertainty: 95% CI 72.25 to 100.00 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Blood-culture only against the final clinical diagnosis (Huang et al. 2026) dna-pathogen-20261011-huang2026-protocol-clinical-diagnosis Aggregation: Not reported Blood-based targeted sequencing of microbial cell-free DNA in severe pneumonia-associated sepsis · Table 2, stratum 'All pneumonia', row 'Blood-culture only', column 'PPV (95%CI)'
Configuration: Blood culture (Huang et al. 2026), as run in Huang et al. 2026	Protocol: Patient-level detection of causative pathogens in blood against the final clinical diagnosis (Huang et al. 2026 Table 2) Dataset: 122 ICU patients with severe pneumonia-associated sepsis and paired blood and BALF (Huang et al. 2026)	9.62% Recall (patient level; all pneumonia; reference: final clinical diagnosis) percent · higher Uncertainty: 95% CI 5.31 to 16.80 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Blood-culture only against the final clinical diagnosis (Huang et al. 2026) dna-pathogen-20261011-huang2026-protocol-clinical-diagnosis Aggregation: Not reported Blood-based targeted sequencing of microbial cell-free DNA in severe pneumonia-associated sepsis · Table 2, stratum 'All pneumonia', row 'Blood-culture only', column 'Sensitivity (95%CI)'
Configuration: Blood culture (Huang et al. 2026), as run in Huang et al. 2026	Protocol: Patient-level detection of causative pathogens in blood against the final clinical diagnosis (Huang et al. 2026 Table 2) Dataset: 122 ICU patients with severe pneumonia-associated sepsis and paired blood and BALF (Huang et al. 2026)	100% Specificity (patient level; all pneumonia; reference: final clinical diagnosis) percent · higher Uncertainty: 95% CI 82.41 to 100.00 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Blood-culture only against the final clinical diagnosis (Huang et al. 2026) dna-pathogen-20261011-huang2026-protocol-clinical-diagnosis Aggregation: Not reported Blood-based targeted sequencing of microbial cell-free DNA in severe pneumonia-associated sepsis · Table 2, stratum 'All pneumonia', row 'Blood-culture only', column 'Specificity (95%CI)'
Configuration: Blood metagenomic NGS (Illumina NextSeq 550; Huang et al. 2026), as run in Huang et al. 2026	Protocol: Patient-level detection of causative pathogens in blood against the final clinical diagnosis (Huang et al. 2026 Table 2) Dataset: 122 ICU patients with severe pneumonia-associated sepsis and paired blood and BALF (Huang et al. 2026)	39.3% Accuracy (patient level; all pneumonia; reference: final clinical diagnosis) percent · higher Uncertainty: 95% CI 31.13 to 48.21 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Blood-mNGS against the final clinical diagnosis (Huang et al. 2026) dna-pathogen-20261011-huang2026-protocol-clinical-diagnosis Aggregation: Not reported Blood-based targeted sequencing of microbial cell-free DNA in severe pneumonia-associated sepsis · Table 2, stratum 'All pneumonia', row 'Blood-mNGS', column 'Accuracy (95%CI)'
Configuration: Blood metagenomic NGS (Illumina NextSeq 550; Huang et al. 2026), as run in Huang et al. 2026	Protocol: Patient-level detection of causative pathogens in blood against the final clinical diagnosis (Huang et al. 2026 Table 2) Dataset: 122 ICU patients with severe pneumonia-associated sepsis and paired blood and BALF (Huang et al. 2026)	14.1% Negative predictive value (patient level; all pneumonia; reference: final clinical diagnosis) percent · higher Uncertainty: 95% CI 8.06 to 23.51 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Blood-mNGS against the final clinical diagnosis (Huang et al. 2026) dna-pathogen-20261011-huang2026-protocol-clinical-diagnosis Aggregation: Not reported Blood-based targeted sequencing of microbial cell-free DNA in severe pneumonia-associated sepsis · Table 2, stratum 'All pneumonia', row 'Blood-mNGS', column 'NPV (95%CI)'
Configuration: Blood metagenomic NGS (Illumina NextSeq 550; Huang et al. 2026), as run in Huang et al. 2026	Protocol: Patient-level detection of causative pathogens in blood against the final clinical diagnosis (Huang et al. 2026 Table 2) Dataset: 122 ICU patients with severe pneumonia-associated sepsis and paired blood and BALF (Huang et al. 2026)	84.1% Precision (patient level; all pneumonia; reference: final clinical diagnosis) percent · higher Uncertainty: 95% CI 70.63 to 92.07 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Blood-mNGS against the final clinical diagnosis (Huang et al. 2026) dna-pathogen-20261011-huang2026-protocol-clinical-diagnosis Aggregation: Not reported Blood-based targeted sequencing of microbial cell-free DNA in severe pneumonia-associated sepsis · Table 2, stratum 'All pneumonia', row 'Blood-mNGS', column 'PPV (95%CI)'
Configuration: Blood metagenomic NGS (Illumina NextSeq 550; Huang et al. 2026), as run in Huang et al. 2026	Protocol: Patient-level detection of causative pathogens in blood against the final clinical diagnosis (Huang et al. 2026 Table 2) Dataset: 122 ICU patients with severe pneumonia-associated sepsis and paired blood and BALF (Huang et al. 2026)	35.6% Recall (patient level; all pneumonia; reference: final clinical diagnosis) percent · higher Uncertainty: 95% CI 27.04 to 45.14 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Blood-mNGS against the final clinical diagnosis (Huang et al. 2026) dna-pathogen-20261011-huang2026-protocol-clinical-diagnosis Aggregation: Not reported Blood-based targeted sequencing of microbial cell-free DNA in severe pneumonia-associated sepsis · Table 2, stratum 'All pneumonia', row 'Blood-mNGS', column 'Sensitivity (95%CI)'
Configuration: Blood metagenomic NGS (Illumina NextSeq 550; Huang et al. 2026), as run in Huang et al. 2026	Protocol: Patient-level detection of causative pathogens in blood against the final clinical diagnosis (Huang et al. 2026 Table 2) Dataset: 122 ICU patients with severe pneumonia-associated sepsis and paired blood and BALF (Huang et al. 2026)	61.1% Specificity (patient level; all pneumonia; reference: final clinical diagnosis) percent · higher Uncertainty: 95% CI 38.62 to 79.70 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Blood-mNGS against the final clinical diagnosis (Huang et al. 2026) dna-pathogen-20261011-huang2026-protocol-clinical-diagnosis Aggregation: Not reported Blood-based targeted sequencing of microbial cell-free DNA in severe pneumonia-associated sepsis · Table 2, stratum 'All pneumonia', row 'Blood-mNGS', column 'Specificity (95%CI)'
Configuration: Geneplus broad-spectrum targeted NGS of microbial cell-free DNA (bstNGS), as run in Huang et al. 2026	Protocol: Patient-level detection of causative pathogens in blood against the final clinical diagnosis (Huang et al. 2026 Table 2) Dataset: 122 ICU patients with severe pneumonia-associated sepsis and paired blood and BALF (Huang et al. 2026)	73% Accuracy (patient level; fungal pneumonia; reference: final clinical diagnosis) percent · higher Uncertainty: 95% CI 64.46 to 80.04 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Blood-bstNGS against the final clinical diagnosis (Huang et al. 2026) dna-pathogen-20261011-huang2026-protocol-clinical-diagnosis Aggregation: Not reported Blood-based targeted sequencing of microbial cell-free DNA in severe pneumonia-associated sepsis · Table 2, stratum 'Fungal pneumonia', row 'Blood-bstNGS', column 'Accuracy (95%CI)'
Configuration: Geneplus broad-spectrum targeted NGS of microbial cell-free DNA (bstNGS), as run in Huang et al. 2026	Protocol: Patient-level detection of causative pathogens in blood against the final clinical diagnosis (Huang et al. 2026 Table 2) Dataset: 122 ICU patients with severe pneumonia-associated sepsis and paired blood and BALF (Huang et al. 2026)	71.4% Negative predictive value (patient level; fungal pneumonia; reference: final clinical diagnosis) percent · higher Uncertainty: 95% CI 62.46 to 78.98 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Blood-bstNGS against the final clinical diagnosis (Huang et al. 2026) dna-pathogen-20261011-huang2026-protocol-clinical-diagnosis Aggregation: Not reported Blood-based targeted sequencing of microbial cell-free DNA in severe pneumonia-associated sepsis · Table 2, stratum 'Fungal pneumonia', row 'Blood-bstNGS', column 'NPV (95%CI)'
Configuration: Geneplus broad-spectrum targeted NGS of microbial cell-free DNA (bstNGS), as run in Huang et al. 2026	Protocol: Patient-level detection of causative pathogens in blood against the final clinical diagnosis (Huang et al. 2026 Table 2) Dataset: 122 ICU patients with severe pneumonia-associated sepsis and paired blood and BALF (Huang et al. 2026)	90% Precision (patient level; fungal pneumonia; reference: final clinical diagnosis) percent · higher Uncertainty: 95% CI 59.58 to 98.21 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Blood-bstNGS against the final clinical diagnosis (Huang et al. 2026) dna-pathogen-20261011-huang2026-protocol-clinical-diagnosis Aggregation: Not reported Blood-based targeted sequencing of microbial cell-free DNA in severe pneumonia-associated sepsis · Table 2, stratum 'Fungal pneumonia', row 'Blood-bstNGS', column 'PPV (95%CI)'
Configuration: Geneplus broad-spectrum targeted NGS of microbial cell-free DNA (bstNGS), as run in Huang et al. 2026	Protocol: Patient-level detection of causative pathogens in blood against the final clinical diagnosis (Huang et al. 2026 Table 2) Dataset: 122 ICU patients with severe pneumonia-associated sepsis and paired blood and BALF (Huang et al. 2026)	21.9% Recall (patient level; fungal pneumonia; reference: final clinical diagnosis) percent · higher Uncertainty: 95% CI 12.00 to 36.71 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Blood-bstNGS against the final clinical diagnosis (Huang et al. 2026) dna-pathogen-20261011-huang2026-protocol-clinical-diagnosis Aggregation: Not reported Blood-based targeted sequencing of microbial cell-free DNA in severe pneumonia-associated sepsis · Table 2, stratum 'Fungal pneumonia', row 'Blood-bstNGS', column 'Sensitivity (95%CI)'
Configuration: Geneplus broad-spectrum targeted NGS of microbial cell-free DNA (bstNGS), as run in Huang et al. 2026	Protocol: Patient-level detection of causative pathogens in blood against the final clinical diagnosis (Huang et al. 2026 Table 2) Dataset: 122 ICU patients with severe pneumonia-associated sepsis and paired blood and BALF (Huang et al. 2026)	98.8% Specificity (patient level; fungal pneumonia; reference: final clinical diagnosis) percent · higher Uncertainty: 95% CI 93.33 to 99.78 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Blood-bstNGS against the final clinical diagnosis (Huang et al. 2026) dna-pathogen-20261011-huang2026-protocol-clinical-diagnosis Aggregation: Not reported Blood-based targeted sequencing of microbial cell-free DNA in severe pneumonia-associated sepsis · Table 2, stratum 'Fungal pneumonia', row 'Blood-bstNGS', column 'Specificity (95%CI)'

Source checking is not independent reproduction. Release 2026-10-22-1b7cf027e4f6.

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Release 2026-10-22-1b7cf027e4f6 · Evidence verified: Not verified

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Evidence table

Inspect claims, sources and review details

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8 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-10-22-1b7cf027e4f6
Property and statement	Original source and location	Review and provenance
Access Not stated in the inspected text Context-only references	Blood-based targeted sequencing of microbial cell-free DNA in severe pneumonia-associated sepsis Original source ↗ Methods 'Sample enrollment and standard-of-care microbiology testing'; Results paragraph 1; Table 1 Version: Respiratory Research 27:357, published 2026-06-24; PMC13584460 full-text XML Retrieved: 2026-10-11T22:07:38Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.access` Source artifact SHA-256: `79b237d733d9ad3af33722c30013afb0539adf03098ca1e1c2f18344bcc4a67d` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Denominator 122 Context-only references	Blood-based targeted sequencing of microbial cell-free DNA in severe pneumonia-associated sepsis Original source ↗ Methods 'Sample enrollment and standard-of-care microbiology testing'; Results paragraph 1; Table 1 Version: Respiratory Research 27:357, published 2026-06-24; PMC13584460 full-text XML Retrieved: 2026-10-11T22:07:38Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.denominator` Source artifact SHA-256: `79b237d733d9ad3af33722c30013afb0539adf03098ca1e1c2f18344bcc4a67d` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Population 122 of 183 screened adults (61 excluded for missing paired samples or clinical information); 73.0% immunocompromised; blood tested by bstNGS, mNGS and culture from the same batch, BALF by mNGS Context-only references	Blood-based targeted sequencing of microbial cell-free DNA in severe pneumonia-associated sepsis Original source ↗ Methods 'Sample enrollment and standard-of-care microbiology testing'; Results paragraph 1; Table 1 Version: Respiratory Research 27:357, published 2026-06-24; PMC13584460 full-text XML Retrieved: 2026-10-11T22:07:38Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.population` Source artifact SHA-256: `79b237d733d9ad3af33722c30013afb0539adf03098ca1e1c2f18344bcc4a67d` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Source location Methods 'Sample enrollment and standard-of-care microbiology testing'; Results paragraph 1; Table 1 Context-only references	Blood-based targeted sequencing of microbial cell-free DNA in severe pneumonia-associated sepsis Original source ↗ Methods 'Sample enrollment and standard-of-care microbiology testing'; Results paragraph 1; Table 1 Version: Respiratory Research 27:357, published 2026-06-24; PMC13584460 full-text XML Retrieved: 2026-10-11T22:07:38Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.source_locator` Source artifact SHA-256: `79b237d733d9ad3af33722c30013afb0539adf03098ca1e1c2f18344bcc4a67d` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Split Single retrospective cohort; no split Context-only references	Blood-based targeted sequencing of microbial cell-free DNA in severe pneumonia-associated sepsis Original source ↗ Methods 'Sample enrollment and standard-of-care microbiology testing'; Results paragraph 1; Table 1 Version: Respiratory Research 27:357, published 2026-06-24; PMC13584460 full-text XML Retrieved: 2026-10-11T22:07:38Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.split` Source artifact SHA-256: `79b237d733d9ad3af33722c30013afb0539adf03098ca1e1c2f18344bcc4a67d` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Version As described in Huang et al. 2026 Context-only references	Blood-based targeted sequencing of microbial cell-free DNA in severe pneumonia-associated sepsis Original source ↗ Methods 'Sample enrollment and standard-of-care microbiology testing'; Results paragraph 1; Table 1 Version: Respiratory Research 27:357, published 2026-06-24; PMC13584460 full-text XML Retrieved: 2026-10-11T22:07:38Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.version` Source artifact SHA-256: `79b237d733d9ad3af33722c30013afb0539adf03098ca1e1c2f18344bcc4a67d` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Description Retrospective cohort from the First Affiliated Hospital, Sun Yat-sen University, February 2022 to February 2024. Context-only references	Blood-based targeted sequencing of microbial cell-free DNA in severe pneumonia-associated sepsis Original source ↗ Methods 'Sample enrollment and standard-of-care microbiology testing'; Results paragraph 1; Table 1 Version: Respiratory Research 27:357, published 2026-06-24; PMC13584460 full-text XML Retrieved: 2026-10-11T22:07:38Z	not individually reviewed No individual claim review recorded Audit details Field: `description` Source artifact SHA-256: `79b237d733d9ad3af33722c30013afb0539adf03098ca1e1c2f18344bcc4a67d` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Name 122 ICU patients with severe pneumonia-associated sepsis and paired blood and BALF (Huang et al. 2026) Context-only references	Blood-based targeted sequencing of microbial cell-free DNA in severe pneumonia-associated sepsis Original source ↗ Methods 'Sample enrollment and standard-of-care microbiology testing'; Results paragraph 1; Table 1 Version: Respiratory Research 27:357, published 2026-06-24; PMC13584460 full-text XML Retrieved: 2026-10-11T22:07:38Z	not individually reviewed No individual claim review recorded Audit details Field: `name` Source artifact SHA-256: `79b237d733d9ad3af33722c30013afb0539adf03098ca1e1c2f18344bcc4a67d` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact

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Release 2026-10-22-1b7cf027e4f6 · Record review: source checked

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Blood-based targeted sequencing of microbial cell-free DNA in severe pneumonia-associated sepsis · Original source · Respiratory Research 27:357, published 2026-06-24; PMC13584460 full-text XML

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Technical metadata and extraction receipts

Stable ID: dna-pathogen-20261011-huang2026-data-sepsis122

areas: microbes-communities
contexts: clinical_research
version: As described in Huang et al. 2026
population: 122 of 183 screened adults (61 excluded for missing paired samples or clinical information); 73.0% immunocompromised; blood tested by bstNGS, mNGS and culture from the same batch, BALF by mNGS
split: Single retrospective cohort; no split
denominator: 122
access: Not stated in the inspected text
source locator: Methods 'Sample enrollment and standard-of-care microbiology testing'; Results paragraph 1; Table 1

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