RNAGym v0.1.1 fitness, signed Spearman, Ribozyme

Overview

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16 recorded evaluations, 16 metric rows. A comparison chart has not yet been validated for these results. The table retains the individual findings and their sources.

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Results

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All evaluations

16 evaluations · 16 results. Different protocols are not a single leaderboard.

Protocol: RNAGym v0.1.1 fitness, signed Spearman, Ribozyme · Dataset: RNAGym Ribozyme DMS assays (26)

Sorted by Spearman (mean signed Spearman over the 26 Ribozyme assays) (higher is better). The best value in each column is highlighted. Decimals are rounded for display; each value links to the printed value and its source.

Tested configuration	Spearman (mean signed Spearman over the 26 Ribozyme assays)
RNA-ERNIE (RNAGym fitness leaderboard v0.1.1)Evaluation	0.134 (best in column)
Nucleotide Transformer (RNAGym fitness leaderboard v0.1.1)Evaluation	0.133
Evo 2 (40B) (RNAGym fitness leaderboard v0.1.1)Evaluation	0.108
AIDO.RNA (1.6B) (RNAGym fitness leaderboard v0.1.1)Evaluation	0.074
Evo 2 (7B) (RNAGym fitness leaderboard v0.1.1)Evaluation	0.0651
RNAGenesis (RNAGym fitness leaderboard v0.1.1)Evaluation	0.0465
AIDO.RNA-650M (RNAGym fitness leaderboard v0.1.1)Evaluation	0.046
Evo 1.5 (RNAGym fitness leaderboard v0.1.1)Evaluation	0.0278
AIDO.RNA-300M-MARS (RNAGym fitness leaderboard v0.1.1)Evaluation	0.0058
AIDO.RNA-1M-MARS (RNAGym fitness leaderboard v0.1.1)Evaluation	0.0015
AIDO.RNA-25M-MARS (RNAGym fitness leaderboard v0.1.1)Evaluation	-0.0009
GenSLM (RNAGym fitness leaderboard v0.1.1)Evaluation	-0.0045
RiNALMo (RNAGym fitness leaderboard v0.1.1)Evaluation	-0.0092
Evo 1 (RNAGym fitness leaderboard v0.1.1)Evaluation	-0.0216
Orthrus (RNAGym fitness leaderboard v0.1.1)Evaluation	-0.0276
RNA-FM (RNAGym fitness leaderboard v0.1.1)Evaluation	-0.0303

All 16 result rows with coverage, uncertainty and sources

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Exact evaluated configurations and original reported results
Tested configuration	Protocol and dataset	Finding	Evidence and details
Configuration: AIDO.RNA (1.6B) (RNAGym fitness leaderboard v0.1.1)	Protocol: RNAGym v0.1.1 fitness, signed Spearman, Ribozyme Dataset: RNAGym Ribozyme DMS assays (26)	0.074 Spearman (mean signed Spearman over the 26 Ribozyme assays) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source AIDO.RNA (1.6B) on RNAGym v0.1.1 fitness (Ribozyme) lit-rna-20261011-rnagym-protocol-signed-spearman-ribozyme Aggregation: Not reported RNAGym fitness leaderboard (v0.1.1), leaderboard/fitness/README.md · leaderboard/fitness/README.md, main leaderboard table, row 'AIDO.RNA (1.6B)', column 'Ribozyme (n=26)'
Configuration: AIDO.RNA-1M-MARS (RNAGym fitness leaderboard v0.1.1)	Protocol: RNAGym v0.1.1 fitness, signed Spearman, Ribozyme Dataset: RNAGym Ribozyme DMS assays (26)	0.0015 Spearman (mean signed Spearman over the 26 Ribozyme assays) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source AIDO.RNA-1M-MARS on RNAGym v0.1.1 fitness (Ribozyme) lit-rna-20261011-rnagym-protocol-signed-spearman-ribozyme Aggregation: Not reported RNAGym fitness leaderboard (v0.1.1), leaderboard/fitness/README.md · leaderboard/fitness/README.md, 'AIDO.RNA across model sizes' table, row 'AIDO.RNA-1M-MARS', column 'Ribozyme'
Configuration: AIDO.RNA-25M-MARS (RNAGym fitness leaderboard v0.1.1)	Protocol: RNAGym v0.1.1 fitness, signed Spearman, Ribozyme Dataset: RNAGym Ribozyme DMS assays (26)	-0.0009 Spearman (mean signed Spearman over the 26 Ribozyme assays) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source AIDO.RNA-25M-MARS on RNAGym v0.1.1 fitness (Ribozyme) lit-rna-20261011-rnagym-protocol-signed-spearman-ribozyme Aggregation: Not reported RNAGym fitness leaderboard (v0.1.1), leaderboard/fitness/README.md · leaderboard/fitness/README.md, 'AIDO.RNA across model sizes' table, row 'AIDO.RNA-25M-MARS', column 'Ribozyme'
Configuration: AIDO.RNA-300M-MARS (RNAGym fitness leaderboard v0.1.1)	Protocol: RNAGym v0.1.1 fitness, signed Spearman, Ribozyme Dataset: RNAGym Ribozyme DMS assays (26)	0.0058 Spearman (mean signed Spearman over the 26 Ribozyme assays) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source AIDO.RNA-300M-MARS on RNAGym v0.1.1 fitness (Ribozyme) lit-rna-20261011-rnagym-protocol-signed-spearman-ribozyme Aggregation: Not reported RNAGym fitness leaderboard (v0.1.1), leaderboard/fitness/README.md · leaderboard/fitness/README.md, 'AIDO.RNA across model sizes' table, row 'AIDO.RNA-300M-MARS', column 'Ribozyme'
Configuration: AIDO.RNA-650M (RNAGym fitness leaderboard v0.1.1)	Protocol: RNAGym v0.1.1 fitness, signed Spearman, Ribozyme Dataset: RNAGym Ribozyme DMS assays (26)	0.046 Spearman (mean signed Spearman over the 26 Ribozyme assays) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source AIDO.RNA-650M on RNAGym v0.1.1 fitness (Ribozyme) lit-rna-20261011-rnagym-protocol-signed-spearman-ribozyme Aggregation: Not reported RNAGym fitness leaderboard (v0.1.1), leaderboard/fitness/README.md · leaderboard/fitness/README.md, 'AIDO.RNA across model sizes' table, row 'AIDO.RNA-650M', column 'Ribozyme'
Configuration: Evo 1.5 (RNAGym fitness leaderboard v0.1.1)	Protocol: RNAGym v0.1.1 fitness, signed Spearman, Ribozyme Dataset: RNAGym Ribozyme DMS assays (26)	0.0278 Spearman (mean signed Spearman over the 26 Ribozyme assays) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source Evo 1.5 on RNAGym v0.1.1 fitness (Ribozyme) lit-rna-20261011-rnagym-protocol-signed-spearman-ribozyme Aggregation: Not reported RNAGym fitness leaderboard (v0.1.1), leaderboard/fitness/README.md · leaderboard/fitness/README.md, main leaderboard table, row 'Evo 1.5', column 'Ribozyme (n=26)'
Configuration: Evo 1 (RNAGym fitness leaderboard v0.1.1)	Protocol: RNAGym v0.1.1 fitness, signed Spearman, Ribozyme Dataset: RNAGym Ribozyme DMS assays (26)	-0.0216 Spearman (mean signed Spearman over the 26 Ribozyme assays) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source Evo 1 on RNAGym v0.1.1 fitness (Ribozyme) lit-rna-20261011-rnagym-protocol-signed-spearman-ribozyme Aggregation: Not reported RNAGym fitness leaderboard (v0.1.1), leaderboard/fitness/README.md · leaderboard/fitness/README.md, main leaderboard table, row 'Evo 1', column 'Ribozyme (n=26)'
Configuration: Evo 2 (40B) (RNAGym fitness leaderboard v0.1.1)	Protocol: RNAGym v0.1.1 fitness, signed Spearman, Ribozyme Dataset: RNAGym Ribozyme DMS assays (26)	0.108 Spearman (mean signed Spearman over the 26 Ribozyme assays) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source Evo 2 (40B) on RNAGym v0.1.1 fitness (Ribozyme) lit-rna-20261011-rnagym-protocol-signed-spearman-ribozyme Aggregation: Not reported RNAGym fitness leaderboard (v0.1.1), leaderboard/fitness/README.md · leaderboard/fitness/README.md, main leaderboard table, row 'Evo 2 (40B)', column 'Ribozyme (n=26)'
Configuration: Evo 2 (7B) (RNAGym fitness leaderboard v0.1.1)	Protocol: RNAGym v0.1.1 fitness, signed Spearman, Ribozyme Dataset: RNAGym Ribozyme DMS assays (26)	0.0651 Spearman (mean signed Spearman over the 26 Ribozyme assays) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source Evo 2 (7B) on RNAGym v0.1.1 fitness (Ribozyme) lit-rna-20261011-rnagym-protocol-signed-spearman-ribozyme Aggregation: Not reported RNAGym fitness leaderboard (v0.1.1), leaderboard/fitness/README.md · leaderboard/fitness/README.md, main leaderboard table, row 'Evo 2 (7B)', column 'Ribozyme (n=26)'
Configuration: GenSLM (RNAGym fitness leaderboard v0.1.1)	Protocol: RNAGym v0.1.1 fitness, signed Spearman, Ribozyme Dataset: RNAGym Ribozyme DMS assays (26)	-0.0045 Spearman (mean signed Spearman over the 26 Ribozyme assays) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source GenSLM on RNAGym v0.1.1 fitness (Ribozyme) lit-rna-20261011-rnagym-protocol-signed-spearman-ribozyme Aggregation: Not reported RNAGym fitness leaderboard (v0.1.1), leaderboard/fitness/README.md · leaderboard/fitness/README.md, main leaderboard table, row 'GenSLM', column 'Ribozyme (n=26)'
Configuration: Nucleotide Transformer (RNAGym fitness leaderboard v0.1.1)	Protocol: RNAGym v0.1.1 fitness, signed Spearman, Ribozyme Dataset: RNAGym Ribozyme DMS assays (26)	0.133 Spearman (mean signed Spearman over the 26 Ribozyme assays) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source Nucleotide Transformer on RNAGym v0.1.1 fitness (Ribozyme) lit-rna-20261011-rnagym-protocol-signed-spearman-ribozyme Aggregation: Not reported RNAGym fitness leaderboard (v0.1.1), leaderboard/fitness/README.md · leaderboard/fitness/README.md, main leaderboard table, row 'Nucleotide Transformer', column 'Ribozyme (n=26)'
Configuration: Orthrus (RNAGym fitness leaderboard v0.1.1)	Protocol: RNAGym v0.1.1 fitness, signed Spearman, Ribozyme Dataset: RNAGym Ribozyme DMS assays (26)	-0.0276 Spearman (mean signed Spearman over the 26 Ribozyme assays) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source Orthrus on RNAGym v0.1.1 fitness (Ribozyme) lit-rna-20261011-rnagym-protocol-signed-spearman-ribozyme Aggregation: Not reported RNAGym fitness leaderboard (v0.1.1), leaderboard/fitness/README.md · leaderboard/fitness/README.md, main leaderboard table, row 'Orthrus', column 'Ribozyme (n=26)'
Configuration: RiNALMo (RNAGym fitness leaderboard v0.1.1)	Protocol: RNAGym v0.1.1 fitness, signed Spearman, Ribozyme Dataset: RNAGym Ribozyme DMS assays (26)	-0.0092 Spearman (mean signed Spearman over the 26 Ribozyme assays) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source RiNALMo on RNAGym v0.1.1 fitness (Ribozyme) lit-rna-20261011-rnagym-protocol-signed-spearman-ribozyme Aggregation: Not reported RNAGym fitness leaderboard (v0.1.1), leaderboard/fitness/README.md · leaderboard/fitness/README.md, main leaderboard table, row 'RiNALMo', column 'Ribozyme (n=26)'
Configuration: RNA-ERNIE (RNAGym fitness leaderboard v0.1.1)	Protocol: RNAGym v0.1.1 fitness, signed Spearman, Ribozyme Dataset: RNAGym Ribozyme DMS assays (26)	0.134 Spearman (mean signed Spearman over the 26 Ribozyme assays) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source RNA-ERNIE on RNAGym v0.1.1 fitness (Ribozyme) lit-rna-20261011-rnagym-protocol-signed-spearman-ribozyme Aggregation: Not reported RNAGym fitness leaderboard (v0.1.1), leaderboard/fitness/README.md · leaderboard/fitness/README.md, main leaderboard table, row 'RNA-ERNIE', column 'Ribozyme (n=26)'
Configuration: RNA-FM (RNAGym fitness leaderboard v0.1.1)	Protocol: RNAGym v0.1.1 fitness, signed Spearman, Ribozyme Dataset: RNAGym Ribozyme DMS assays (26)	-0.0303 Spearman (mean signed Spearman over the 26 Ribozyme assays) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source RNA-FM on RNAGym v0.1.1 fitness (Ribozyme) lit-rna-20261011-rnagym-protocol-signed-spearman-ribozyme Aggregation: Not reported RNAGym fitness leaderboard (v0.1.1), leaderboard/fitness/README.md · leaderboard/fitness/README.md, main leaderboard table, row 'RNA-FM', column 'Ribozyme (n=26)'
Configuration: RNAGenesis (RNAGym fitness leaderboard v0.1.1)	Protocol: RNAGym v0.1.1 fitness, signed Spearman, Ribozyme Dataset: RNAGym Ribozyme DMS assays (26)	0.0465 Spearman (mean signed Spearman over the 26 Ribozyme assays) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source RNAGenesis on RNAGym v0.1.1 fitness (Ribozyme) lit-rna-20261011-rnagym-protocol-signed-spearman-ribozyme Aggregation: Not reported RNAGym fitness leaderboard (v0.1.1), leaderboard/fitness/README.md · leaderboard/fitness/README.md, main leaderboard table, row 'RNAGenesis', column 'Ribozyme (n=26)'

Source checking is not independent reproduction. Release 2026-10-22-1b7cf027e4f6.

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External evaluations: 16

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Sources and history

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1 source record and release history

RNAGym fitness leaderboard (v0.1.1), leaderboard/fitness/README.md · Original source · Commit 2828cf99316d75daaa8d832a2573cbb25bbd35fe (2026-08-14, 'Update fitness leaderboard v0.2 models'); leaderboard labelled v0.1.1

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Technical metadata and extraction receipts

Stable ID: lit-rna-20261011-rnagym-protocol-signed-spearman-ribozyme

areas: rna-transcriptomes
contexts: research
protocol: Score every variant zero-shot, compute signed Spearman per assay, then mean signed Spearman over the 26 Ribozyme assays.
version: RNAGym v0.1.1
metric: spearman-correlation
metric direction: higher
unit: unitless
metric qualifier: mean signed Spearman over the 26 Ribozyme assays
source locator: Leaderboard README metric note and table column 'Ribozyme'
limitations: Signed Spearman; not comparable with absolute Spearman values reported elsewhere, including Wang et al. 2026 on 31 RNAGym ncRNA assays.

Related records

part of: RNAGym fitness leaderboard v0.1.1
uses data: RNAGym Ribozyme DMS assays (26)
assessment: AIDO.RNA (1.6B) on RNAGym v0.1.1 fitness (Ribozyme)
assessment: AIDO.RNA-1M-MARS on RNAGym v0.1.1 fitness (Ribozyme)
assessment: AIDO.RNA-25M-MARS on RNAGym v0.1.1 fitness (Ribozyme)
assessment: AIDO.RNA-300M-MARS on RNAGym v0.1.1 fitness (Ribozyme)
assessment: AIDO.RNA-650M on RNAGym v0.1.1 fitness (Ribozyme)
assessment: Evo 1.5 on RNAGym v0.1.1 fitness (Ribozyme)
assessment: Evo 1 on RNAGym v0.1.1 fitness (Ribozyme)
assessment: Evo 2 (40B) on RNAGym v0.1.1 fitness (Ribozyme)
assessment: Evo 2 (7B) on RNAGym v0.1.1 fitness (Ribozyme)
assessment: GenSLM on RNAGym v0.1.1 fitness (Ribozyme)
assessment: Nucleotide Transformer on RNAGym v0.1.1 fitness (Ribozyme)
assessment: Orthrus on RNAGym v0.1.1 fitness (Ribozyme)
assessment: RiNALMo on RNAGym v0.1.1 fitness (Ribozyme)
assessment: RNA-ERNIE on RNAGym v0.1.1 fitness (Ribozyme)
assessment: RNA-FM on RNAGym v0.1.1 fitness (Ribozyme)
assessment: RNAGenesis on RNAGym v0.1.1 fitness (Ribozyme)