AIDO.RNA-25M-MARS (RNAGym fitness leaderboard v0.1.1)
AIDO.RNA-25M-MARS: Zero-shot.
Overview
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Consult the linked sources for architecture or protocol details. Missing evidence is not evidence of a missing capability.
Evaluations and results
4 evaluations · 4 results. Different protocols are not a single leaderboard.
Sorted by Spearman (macro-mean over 3 ncRNA categories (equal category weights)) (higher is better). The best value in each column is highlighted. Decimals are rounded for display; each value links to the printed value and its source.
All 4 result rows with coverage, uncertainty and sources
Filter evaluations
Applied filters: All linked evaluations
| Tested configuration | Protocol and dataset | Finding | Evidence and details |
|---|---|---|---|
| Configuration: AIDO.RNA-25M-MARS (RNAGym fitness leaderboard v0.1.1) | Protocol: RNAGym v0.1.1 fitness, signed Spearman, Aptamer Dataset: RNAGym Aptamer DMS assays (2) | 0.0367 Spearman (mean signed Spearman over the 2 Aptamer assays) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceAIDO.RNA-25M-MARS on RNAGym v0.1.1 fitness (Aptamer) lit-rna-20261011-rnagym-protocol-signed-spearman-aptamer Aggregation: Not reported RNAGym fitness leaderboard (v0.1.1), leaderboard/fitness/README.md · leaderboard/fitness/README.md, 'AIDO.RNA across model sizes' table, row 'AIDO.RNA-25M-MARS', column 'Aptamer' |
| Configuration: AIDO.RNA-25M-MARS (RNAGym fitness leaderboard v0.1.1) | Protocol: RNAGym v0.1.1 fitness, signed Spearman, macro over 3 ncRNA categories Dataset: RNAGym ncRNA DMS assays (31) | 0.102 Spearman (macro-mean over 3 ncRNA categories (equal category weights)) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceAIDO.RNA-25M-MARS on RNAGym v0.1.1 fitness (Macro) lit-rna-20261011-rnagym-protocol-signed-spearman-macro Aggregation: Not reported RNAGym fitness leaderboard (v0.1.1), leaderboard/fitness/README.md · leaderboard/fitness/README.md, 'AIDO.RNA across model sizes' table, row 'AIDO.RNA-25M-MARS', column 'Macro' |
| Configuration: AIDO.RNA-25M-MARS (RNAGym fitness leaderboard v0.1.1) | Protocol: RNAGym v0.1.1 fitness, signed Spearman, Ribozyme Dataset: RNAGym Ribozyme DMS assays (26) | -0.0009 Spearman (mean signed Spearman over the 26 Ribozyme assays) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceAIDO.RNA-25M-MARS on RNAGym v0.1.1 fitness (Ribozyme) lit-rna-20261011-rnagym-protocol-signed-spearman-ribozyme Aggregation: Not reported RNAGym fitness leaderboard (v0.1.1), leaderboard/fitness/README.md · leaderboard/fitness/README.md, 'AIDO.RNA across model sizes' table, row 'AIDO.RNA-25M-MARS', column 'Ribozyme' |
| Configuration: AIDO.RNA-25M-MARS (RNAGym fitness leaderboard v0.1.1) | Protocol: RNAGym v0.1.1 fitness, signed Spearman, tRNA Dataset: RNAGym tRNA DMS assays (3) | 0.272 Spearman (mean signed Spearman over the 3 tRNA assays) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceAIDO.RNA-25M-MARS on RNAGym v0.1.1 fitness (tRNA) lit-rna-20261011-rnagym-protocol-signed-spearman-trna Aggregation: Not reported RNAGym fitness leaderboard (v0.1.1), leaderboard/fitness/README.md · leaderboard/fitness/README.md, 'AIDO.RNA across model sizes' table, row 'AIDO.RNA-25M-MARS', column 'tRNA' |
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Evidence
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Evidence table
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Sources and history
Release 2026-10-22-1b7cf027e4f6 · Record review: source checked
1 source record and release history
- RNAGym fitness leaderboard (v0.1.1), leaderboard/fitness/README.md · Original source · Commit 2828cf99316d75daaa8d832a2573cbb25bbd35fe (2026-08-14, 'Update fitness leaderboard v0.2 models'); leaderboard labelled v0.1.1
Technical metadata and extraction receipts
Stable ID: lit-rna-20261011-rnagym-config-aido-rna-25m-mars-rnagym-v0-1-1
- areas
- rna-transcriptomes
- contexts
- research
- method types
- foundation_model
- reported name
- AIDO.RNA-25M-MARS
- foundation model eligible
- true
- parameters
- Zero-shot. Masked language models scored by the masked-marginal log-likelihood ratio, each mutated position masked one at a time in the variant sequence and summed over mutated positions (leaderboard 'Scoring convention')
- access reuse
- Scoring scripts on the RNAGym v0.2 branch (leaderboard README 'Scoring scripts')
- source locator
- Leaderboard README row 'AIDO.RNA-25M-MARS'; AIDO.RNA scaling table
- version
- AIDO.RNA-25M-MARS
- model identity note
- Params column: 25MM
- provenance note
- AIDO.RNA-25M-MARS as scored zero-shot on the RNAGym fitness leaderboard v0.1.1.