Protocol

RNAGym v0.1.1 fitness, signed Spearman, tRNA

Zero-shot signed Spearman correlation between model score and measured DMS fitness; mean signed Spearman over the 3 tRNA assays.

16 evaluations · 16 results

Overview

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16 recorded evaluations, 16 metric rows. A comparison chart has not yet been validated for these results. The table retains the individual findings and their sources.

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Results

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All evaluations

16 evaluations · 16 results. Different protocols are not a single leaderboard.

Protocol: RNAGym v0.1.1 fitness, signed Spearman, tRNA · Dataset: RNAGym tRNA DMS assays (3)

Sorted by Spearman (mean signed Spearman over the 3 tRNA assays) (higher is better). The best value in each column is highlighted. Decimals are rounded for display; each value links to the printed value and its source.

Tested configuration	Spearman (mean signed Spearman over the 3 tRNA assays)
Evo 2 (40B) (RNAGym fitness leaderboard v0.1.1)Evaluation	0.431 (best in column)
RNA-ERNIE (RNAGym fitness leaderboard v0.1.1)Evaluation	0.416
AIDO.RNA-650M (RNAGym fitness leaderboard v0.1.1)Evaluation	0.393
RiNALMo (RNAGym fitness leaderboard v0.1.1)Evaluation	0.391
AIDO.RNA (1.6B) (RNAGym fitness leaderboard v0.1.1)Evaluation	0.389
Evo 2 (7B) (RNAGym fitness leaderboard v0.1.1)Evaluation	0.387
Evo 1.5 (RNAGym fitness leaderboard v0.1.1)Evaluation	0.385
RNAGenesis (RNAGym fitness leaderboard v0.1.1)Evaluation	0.373
AIDO.RNA-300M-MARS (RNAGym fitness leaderboard v0.1.1)Evaluation	0.368
RNA-FM (RNAGym fitness leaderboard v0.1.1)Evaluation	0.334
Nucleotide Transformer (RNAGym fitness leaderboard v0.1.1)Evaluation	0.317
AIDO.RNA-25M-MARS (RNAGym fitness leaderboard v0.1.1)Evaluation	0.272
AIDO.RNA-1M-MARS (RNAGym fitness leaderboard v0.1.1)Evaluation	0.176
Evo 1 (RNAGym fitness leaderboard v0.1.1)Evaluation	0.0948
Orthrus (RNAGym fitness leaderboard v0.1.1)Evaluation	-0.0068
GenSLM (RNAGym fitness leaderboard v0.1.1)Evaluation	-0.0934

All 16 result rows with coverage, uncertainty and sources

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Tested model or methodProtocolDatasetEvaluation setupMetricEvidence origin

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Exact evaluated configurations and original reported results
Tested configuration	Protocol and dataset	Finding	Evidence and details
Configuration: AIDO.RNA (1.6B) (RNAGym fitness leaderboard v0.1.1)	Protocol: RNAGym v0.1.1 fitness, signed Spearman, tRNA Dataset: RNAGym tRNA DMS assays (3)	0.389 Spearman (mean signed Spearman over the 3 tRNA assays) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source AIDO.RNA (1.6B) on RNAGym v0.1.1 fitness (tRNA) lit-rna-20261011-rnagym-protocol-signed-spearman-trna Aggregation: Not reported RNAGym fitness leaderboard (v0.1.1), leaderboard/fitness/README.md · leaderboard/fitness/README.md, main leaderboard table, row 'AIDO.RNA (1.6B)', column 'tRNA (n=3)'
Configuration: AIDO.RNA-1M-MARS (RNAGym fitness leaderboard v0.1.1)	Protocol: RNAGym v0.1.1 fitness, signed Spearman, tRNA Dataset: RNAGym tRNA DMS assays (3)	0.176 Spearman (mean signed Spearman over the 3 tRNA assays) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source AIDO.RNA-1M-MARS on RNAGym v0.1.1 fitness (tRNA) lit-rna-20261011-rnagym-protocol-signed-spearman-trna Aggregation: Not reported RNAGym fitness leaderboard (v0.1.1), leaderboard/fitness/README.md · leaderboard/fitness/README.md, 'AIDO.RNA across model sizes' table, row 'AIDO.RNA-1M-MARS', column 'tRNA'
Configuration: AIDO.RNA-25M-MARS (RNAGym fitness leaderboard v0.1.1)	Protocol: RNAGym v0.1.1 fitness, signed Spearman, tRNA Dataset: RNAGym tRNA DMS assays (3)	0.272 Spearman (mean signed Spearman over the 3 tRNA assays) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source AIDO.RNA-25M-MARS on RNAGym v0.1.1 fitness (tRNA) lit-rna-20261011-rnagym-protocol-signed-spearman-trna Aggregation: Not reported RNAGym fitness leaderboard (v0.1.1), leaderboard/fitness/README.md · leaderboard/fitness/README.md, 'AIDO.RNA across model sizes' table, row 'AIDO.RNA-25M-MARS', column 'tRNA'
Configuration: AIDO.RNA-300M-MARS (RNAGym fitness leaderboard v0.1.1)	Protocol: RNAGym v0.1.1 fitness, signed Spearman, tRNA Dataset: RNAGym tRNA DMS assays (3)	0.368 Spearman (mean signed Spearman over the 3 tRNA assays) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source AIDO.RNA-300M-MARS on RNAGym v0.1.1 fitness (tRNA) lit-rna-20261011-rnagym-protocol-signed-spearman-trna Aggregation: Not reported RNAGym fitness leaderboard (v0.1.1), leaderboard/fitness/README.md · leaderboard/fitness/README.md, 'AIDO.RNA across model sizes' table, row 'AIDO.RNA-300M-MARS', column 'tRNA'
Configuration: AIDO.RNA-650M (RNAGym fitness leaderboard v0.1.1)	Protocol: RNAGym v0.1.1 fitness, signed Spearman, tRNA Dataset: RNAGym tRNA DMS assays (3)	0.393 Spearman (mean signed Spearman over the 3 tRNA assays) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source AIDO.RNA-650M on RNAGym v0.1.1 fitness (tRNA) lit-rna-20261011-rnagym-protocol-signed-spearman-trna Aggregation: Not reported RNAGym fitness leaderboard (v0.1.1), leaderboard/fitness/README.md · leaderboard/fitness/README.md, 'AIDO.RNA across model sizes' table, row 'AIDO.RNA-650M', column 'tRNA'
Configuration: Evo 1.5 (RNAGym fitness leaderboard v0.1.1)	Protocol: RNAGym v0.1.1 fitness, signed Spearman, tRNA Dataset: RNAGym tRNA DMS assays (3)	0.385 Spearman (mean signed Spearman over the 3 tRNA assays) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source Evo 1.5 on RNAGym v0.1.1 fitness (tRNA) lit-rna-20261011-rnagym-protocol-signed-spearman-trna Aggregation: Not reported RNAGym fitness leaderboard (v0.1.1), leaderboard/fitness/README.md · leaderboard/fitness/README.md, main leaderboard table, row 'Evo 1.5', column 'tRNA (n=3)'
Configuration: Evo 1 (RNAGym fitness leaderboard v0.1.1)	Protocol: RNAGym v0.1.1 fitness, signed Spearman, tRNA Dataset: RNAGym tRNA DMS assays (3)	0.0948 Spearman (mean signed Spearman over the 3 tRNA assays) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source Evo 1 on RNAGym v0.1.1 fitness (tRNA) lit-rna-20261011-rnagym-protocol-signed-spearman-trna Aggregation: Not reported RNAGym fitness leaderboard (v0.1.1), leaderboard/fitness/README.md · leaderboard/fitness/README.md, main leaderboard table, row 'Evo 1', column 'tRNA (n=3)'
Configuration: Evo 2 (40B) (RNAGym fitness leaderboard v0.1.1)	Protocol: RNAGym v0.1.1 fitness, signed Spearman, tRNA Dataset: RNAGym tRNA DMS assays (3)	0.431 Spearman (mean signed Spearman over the 3 tRNA assays) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source Evo 2 (40B) on RNAGym v0.1.1 fitness (tRNA) lit-rna-20261011-rnagym-protocol-signed-spearman-trna Aggregation: Not reported RNAGym fitness leaderboard (v0.1.1), leaderboard/fitness/README.md · leaderboard/fitness/README.md, main leaderboard table, row 'Evo 2 (40B)', column 'tRNA (n=3)'
Configuration: Evo 2 (7B) (RNAGym fitness leaderboard v0.1.1)	Protocol: RNAGym v0.1.1 fitness, signed Spearman, tRNA Dataset: RNAGym tRNA DMS assays (3)	0.387 Spearman (mean signed Spearman over the 3 tRNA assays) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source Evo 2 (7B) on RNAGym v0.1.1 fitness (tRNA) lit-rna-20261011-rnagym-protocol-signed-spearman-trna Aggregation: Not reported RNAGym fitness leaderboard (v0.1.1), leaderboard/fitness/README.md · leaderboard/fitness/README.md, main leaderboard table, row 'Evo 2 (7B)', column 'tRNA (n=3)'
Configuration: GenSLM (RNAGym fitness leaderboard v0.1.1)	Protocol: RNAGym v0.1.1 fitness, signed Spearman, tRNA Dataset: RNAGym tRNA DMS assays (3)	-0.0934 Spearman (mean signed Spearman over the 3 tRNA assays) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source GenSLM on RNAGym v0.1.1 fitness (tRNA) lit-rna-20261011-rnagym-protocol-signed-spearman-trna Aggregation: Not reported RNAGym fitness leaderboard (v0.1.1), leaderboard/fitness/README.md · leaderboard/fitness/README.md, main leaderboard table, row 'GenSLM', column 'tRNA (n=3)'
Configuration: Nucleotide Transformer (RNAGym fitness leaderboard v0.1.1)	Protocol: RNAGym v0.1.1 fitness, signed Spearman, tRNA Dataset: RNAGym tRNA DMS assays (3)	0.317 Spearman (mean signed Spearman over the 3 tRNA assays) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source Nucleotide Transformer on RNAGym v0.1.1 fitness (tRNA) lit-rna-20261011-rnagym-protocol-signed-spearman-trna Aggregation: Not reported RNAGym fitness leaderboard (v0.1.1), leaderboard/fitness/README.md · leaderboard/fitness/README.md, main leaderboard table, row 'Nucleotide Transformer', column 'tRNA (n=3)'
Configuration: Orthrus (RNAGym fitness leaderboard v0.1.1)	Protocol: RNAGym v0.1.1 fitness, signed Spearman, tRNA Dataset: RNAGym tRNA DMS assays (3)	-0.0068 Spearman (mean signed Spearman over the 3 tRNA assays) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source Orthrus on RNAGym v0.1.1 fitness (tRNA) lit-rna-20261011-rnagym-protocol-signed-spearman-trna Aggregation: Not reported RNAGym fitness leaderboard (v0.1.1), leaderboard/fitness/README.md · leaderboard/fitness/README.md, main leaderboard table, row 'Orthrus', column 'tRNA (n=3)'
Configuration: RiNALMo (RNAGym fitness leaderboard v0.1.1)	Protocol: RNAGym v0.1.1 fitness, signed Spearman, tRNA Dataset: RNAGym tRNA DMS assays (3)	0.391 Spearman (mean signed Spearman over the 3 tRNA assays) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source RiNALMo on RNAGym v0.1.1 fitness (tRNA) lit-rna-20261011-rnagym-protocol-signed-spearman-trna Aggregation: Not reported RNAGym fitness leaderboard (v0.1.1), leaderboard/fitness/README.md · leaderboard/fitness/README.md, main leaderboard table, row 'RiNALMo', column 'tRNA (n=3)'
Configuration: RNA-ERNIE (RNAGym fitness leaderboard v0.1.1)	Protocol: RNAGym v0.1.1 fitness, signed Spearman, tRNA Dataset: RNAGym tRNA DMS assays (3)	0.416 Spearman (mean signed Spearman over the 3 tRNA assays) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source RNA-ERNIE on RNAGym v0.1.1 fitness (tRNA) lit-rna-20261011-rnagym-protocol-signed-spearman-trna Aggregation: Not reported RNAGym fitness leaderboard (v0.1.1), leaderboard/fitness/README.md · leaderboard/fitness/README.md, main leaderboard table, row 'RNA-ERNIE', column 'tRNA (n=3)'
Configuration: RNA-FM (RNAGym fitness leaderboard v0.1.1)	Protocol: RNAGym v0.1.1 fitness, signed Spearman, tRNA Dataset: RNAGym tRNA DMS assays (3)	0.334 Spearman (mean signed Spearman over the 3 tRNA assays) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source RNA-FM on RNAGym v0.1.1 fitness (tRNA) lit-rna-20261011-rnagym-protocol-signed-spearman-trna Aggregation: Not reported RNAGym fitness leaderboard (v0.1.1), leaderboard/fitness/README.md · leaderboard/fitness/README.md, main leaderboard table, row 'RNA-FM', column 'tRNA (n=3)'
Configuration: RNAGenesis (RNAGym fitness leaderboard v0.1.1)	Protocol: RNAGym v0.1.1 fitness, signed Spearman, tRNA Dataset: RNAGym tRNA DMS assays (3)	0.373 Spearman (mean signed Spearman over the 3 tRNA assays) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source RNAGenesis on RNAGym v0.1.1 fitness (tRNA) lit-rna-20261011-rnagym-protocol-signed-spearman-trna Aggregation: Not reported RNAGym fitness leaderboard (v0.1.1), leaderboard/fitness/README.md · leaderboard/fitness/README.md, main leaderboard table, row 'RNAGenesis', column 'tRNA (n=3)'

Source checking is not independent reproduction. Release 2026-10-22-1b7cf027e4f6.

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External evaluations: 16

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Release 2026-10-22-1b7cf027e4f6 · Record review: source checked

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RNAGym fitness leaderboard (v0.1.1), leaderboard/fitness/README.md · Original source · Commit 2828cf99316d75daaa8d832a2573cbb25bbd35fe (2026-08-14, 'Update fitness leaderboard v0.2 models'); leaderboard labelled v0.1.1

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Technical metadata and extraction receipts

Stable ID: lit-rna-20261011-rnagym-protocol-signed-spearman-trna

areas: rna-transcriptomes
contexts: research
protocol: Score every variant zero-shot, compute signed Spearman per assay, then mean signed Spearman over the 3 tRNA assays.
version: RNAGym v0.1.1
metric: spearman-correlation
metric direction: higher
unit: unitless
metric qualifier: mean signed Spearman over the 3 tRNA assays
source locator: Leaderboard README metric note and table column 'tRNA'
limitations: Signed Spearman; not comparable with absolute Spearman values reported elsewhere, including Wang et al. 2026 on 31 RNAGym ncRNA assays.

Related records

part of: RNAGym fitness leaderboard v0.1.1
uses data: RNAGym tRNA DMS assays (3)
assessment: AIDO.RNA (1.6B) on RNAGym v0.1.1 fitness (tRNA)
assessment: AIDO.RNA-1M-MARS on RNAGym v0.1.1 fitness (tRNA)
assessment: AIDO.RNA-25M-MARS on RNAGym v0.1.1 fitness (tRNA)
assessment: AIDO.RNA-300M-MARS on RNAGym v0.1.1 fitness (tRNA)
assessment: AIDO.RNA-650M on RNAGym v0.1.1 fitness (tRNA)
assessment: Evo 1.5 on RNAGym v0.1.1 fitness (tRNA)
assessment: Evo 1 on RNAGym v0.1.1 fitness (tRNA)
assessment: Evo 2 (40B) on RNAGym v0.1.1 fitness (tRNA)
assessment: Evo 2 (7B) on RNAGym v0.1.1 fitness (tRNA)
assessment: GenSLM on RNAGym v0.1.1 fitness (tRNA)
assessment: Nucleotide Transformer on RNAGym v0.1.1 fitness (tRNA)
assessment: Orthrus on RNAGym v0.1.1 fitness (tRNA)
assessment: RiNALMo on RNAGym v0.1.1 fitness (tRNA)
assessment: RNA-ERNIE on RNAGym v0.1.1 fitness (tRNA)
assessment: RNA-FM on RNAGym v0.1.1 fitness (tRNA)
assessment: RNAGenesis on RNAGym v0.1.1 fitness (tRNA)

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