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RNAGym fitness leaderboard v0.1.1

Official RNAGym zero-shot fitness leaderboard: signed Spearman correlation between model scores and DMS fitness on 31 ncRNA assays (26 ribozyme, 3 tRNA, 2 aptamer), macro-averaged over the three categories.

Results are recorded on the linked protocols, tasks or configurations listed below. Their settings and evaluations are kept separate.

4 protocols with results

Overview

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Consult the linked sources for architecture or protocol details. Missing evidence is not evidence of a missing capability.

Results on linked records

This benchmark has no results of its own in this release. 4 linked records have results. They are not assigned to the underlying benchmark: each record keeps its own settings and evaluations, and its scores are on its own page.

Methods and evaluation design

Procedure, tasks and evaluated configurations

Baseline coverage

Reference methods help show what a model adds beyond simple controls. We track a null control and a conventional method for each protocol.

0 of 8 active baseline roles have published Rewire measurements in this release. Measurements on a selected protocol do not establish coverage of an entire suite.

Baseline status by linked protocol

Protocol coverage CSV (gzip) · Model evaluation matrix (gzip) · Source table (gzip) · Release and checksums (gzip)

Coverage is derived from release 2026-10-22-1b7cf027e4f6. Source citations describe the original records; they do not validate an unreviewed baseline proposal. No results have been generated by this audit.

Run instructions

No runnable recipe has been reviewed for this benchmark. Dataset access, model requirements, licences and compute requirements must be checked against its sources before execution.

Strengths, limitations and unresolved questions

Evidence

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Evidence table

Inspect claims, sources and review details

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Claims, original sources and review scope · Release 2026-10-22-1b7cf027e4f6
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How to read the evidence

Sources and history

Release 2026-10-22-1b7cf027e4f6 · Record review: source checked

1 source record and release historyDownload this release (gzip)
Technical metadata and extraction receipts

Stable ID: lit-rna-20261011-rnagym-benchmark-rnagym-fitness-leaderboard-v0-1-1

areas
rna-transcriptomes
contexts
research
entity level
suite
version
v0.1.1 at commit 2828cf99316d75daaa8d832a2573cbb25bbd35fe
task
Zero-shot ncRNA mutational fitness prediction
scope note
mRNA coding (37) and splicing (2) assays are excluded from v0.1.1. Signed, not absolute, Spearman.
source locator
leaderboard/fitness/README.md, metric note and 'Why we now exclude the mRNA assays'
limitations
The leaderboard notes that ranks differing by less than about 0.01 should not be read as meaningful separations.; 99.4% of ncRNA variants are multi-mutants; scores depend on the scoring convention.
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