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Evo 1 (RNAGym fitness leaderboard v0.1.1)

Evo 1: Zero-shot.

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Evaluations and results

4 evaluations · 4 results. Different protocols are not a single leaderboard.

Sorted by Spearman (macro-mean over 3 ncRNA categories (equal category weights)) (higher is better). The best value in each column is highlighted. Decimals are rounded for display; each value links to the printed value and its source.

Tested configuration	Protocol and dataset	Spearman (macro-mean over 3 ncRNA categories (equal category weights))	Spearman (mean signed Spearman over the 2 Aptamer assays)	Spearman (mean signed Spearman over the 26 Ribozyme assays)	Spearman (mean signed Spearman over the 3 tRNA assays)
Evo 1 (RNAGym fitness leaderboard v0.1.1)Evaluation	RNAGym v0.1.1 fitness, signed Spearman, macro over 3 ncRNA categories, RNAGym ncRNA DMS assays (31)	0.0263	Not reported	Not reported	Not reported
Evo 1 (RNAGym fitness leaderboard v0.1.1)Evaluation	RNAGym v0.1.1 fitness, signed Spearman, Aptamer, RNAGym Aptamer DMS assays (2)	Not reported	0.0058	Not reported	Not reported
Evo 1 (RNAGym fitness leaderboard v0.1.1)Evaluation	RNAGym v0.1.1 fitness, signed Spearman, Ribozyme, RNAGym Ribozyme DMS assays (26)	Not reported	Not reported	-0.0216	Not reported
Evo 1 (RNAGym fitness leaderboard v0.1.1)Evaluation	RNAGym v0.1.1 fitness, signed Spearman, tRNA, RNAGym tRNA DMS assays (3)	Not reported	Not reported	Not reported	0.0948

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Tested configuration	Protocol and dataset	Finding	Evidence and details
Configuration: Evo 1 (RNAGym fitness leaderboard v0.1.1)	Protocol: RNAGym v0.1.1 fitness, signed Spearman, Aptamer Dataset: RNAGym Aptamer DMS assays (2)	0.0058 Spearman (mean signed Spearman over the 2 Aptamer assays) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source Evo 1 on RNAGym v0.1.1 fitness (Aptamer) lit-rna-20261011-rnagym-protocol-signed-spearman-aptamer Aggregation: Not reported RNAGym fitness leaderboard (v0.1.1), leaderboard/fitness/README.md · leaderboard/fitness/README.md, main leaderboard table, row 'Evo 1', column 'Aptamer (n=2)'
Configuration: Evo 1 (RNAGym fitness leaderboard v0.1.1)	Protocol: RNAGym v0.1.1 fitness, signed Spearman, macro over 3 ncRNA categories Dataset: RNAGym ncRNA DMS assays (31)	0.0263 Spearman (macro-mean over 3 ncRNA categories (equal category weights)) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source Evo 1 on RNAGym v0.1.1 fitness (Macro) lit-rna-20261011-rnagym-protocol-signed-spearman-macro Aggregation: Not reported RNAGym fitness leaderboard (v0.1.1), leaderboard/fitness/README.md · leaderboard/fitness/README.md, main leaderboard table, row 'Evo 1', column 'Macro (3 ncRNA)'
Configuration: Evo 1 (RNAGym fitness leaderboard v0.1.1)	Protocol: RNAGym v0.1.1 fitness, signed Spearman, Ribozyme Dataset: RNAGym Ribozyme DMS assays (26)	-0.0216 Spearman (mean signed Spearman over the 26 Ribozyme assays) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source Evo 1 on RNAGym v0.1.1 fitness (Ribozyme) lit-rna-20261011-rnagym-protocol-signed-spearman-ribozyme Aggregation: Not reported RNAGym fitness leaderboard (v0.1.1), leaderboard/fitness/README.md · leaderboard/fitness/README.md, main leaderboard table, row 'Evo 1', column 'Ribozyme (n=26)'
Configuration: Evo 1 (RNAGym fitness leaderboard v0.1.1)	Protocol: RNAGym v0.1.1 fitness, signed Spearman, tRNA Dataset: RNAGym tRNA DMS assays (3)	0.0948 Spearman (mean signed Spearman over the 3 tRNA assays) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source Evo 1 on RNAGym v0.1.1 fitness (tRNA) lit-rna-20261011-rnagym-protocol-signed-spearman-trna Aggregation: Not reported RNAGym fitness leaderboard (v0.1.1), leaderboard/fitness/README.md · leaderboard/fitness/README.md, main leaderboard table, row 'Evo 1', column 'tRNA (n=3)'

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Release 2026-10-22-1b7cf027e4f6 · Record review: source checked

1 source record and release history

RNAGym fitness leaderboard (v0.1.1), leaderboard/fitness/README.md · Original source · Commit 2828cf99316d75daaa8d832a2573cbb25bbd35fe (2026-08-14, 'Update fitness leaderboard v0.2 models'); leaderboard labelled v0.1.1

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Technical metadata and extraction receipts

Stable ID: lit-rna-20261011-rnagym-config-evo-1-rnagym-v0-1-1

areas: rna-transcriptomes
contexts: research
method types: foundation_model
reported name: Evo 1
foundation model eligible: true
parameters: Zero-shot. The leaderboard README states the scoring convention for masked language models only (masked-marginal log-likelihood ratio, 'Scoring convention'); the convention used for this model is not stated there.
access reuse: Scoring scripts on the RNAGym v0.2 branch (leaderboard README 'Scoring scripts')
source locator: Leaderboard README row 'Evo 1'
version: Evo 1
provenance note: Evo 1 as scored zero-shot on the RNAGym fitness leaderboard v0.1.1.

Related records

configuration of: Evo
system: Evo 1 on RNAGym v0.1.1 fitness (Aptamer)
system: Evo 1 on RNAGym v0.1.1 fitness (Macro)
system: Evo 1 on RNAGym v0.1.1 fitness (Ribozyme)
system: Evo 1 on RNAGym v0.1.1 fitness (tRNA)

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