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Evo 1.5 (RNAGym fitness leaderboard v0.1.1)

Evo 1.5: Zero-shot.

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Evaluations and results

4 evaluations · 4 results. Different protocols are not a single leaderboard.

Sorted by Spearman (macro-mean over 3 ncRNA categories (equal category weights)) (higher is better). The best value in each column is highlighted. Decimals are rounded for display; each value links to the printed value and its source.

Tested configuration	Protocol and dataset	Spearman (macro-mean over 3 ncRNA categories (equal category weights))	Spearman (mean signed Spearman over the 2 Aptamer assays)	Spearman (mean signed Spearman over the 26 Ribozyme assays)	Spearman (mean signed Spearman over the 3 tRNA assays)
Evo 1.5 (RNAGym fitness leaderboard v0.1.1)Evaluation	RNAGym v0.1.1 fitness, signed Spearman, macro over 3 ncRNA categories, RNAGym ncRNA DMS assays (31)	0.138	Not reported	Not reported	Not reported
Evo 1.5 (RNAGym fitness leaderboard v0.1.1)Evaluation	RNAGym v0.1.1 fitness, signed Spearman, Aptamer, RNAGym Aptamer DMS assays (2)	Not reported	0.0007	Not reported	Not reported
Evo 1.5 (RNAGym fitness leaderboard v0.1.1)Evaluation	RNAGym v0.1.1 fitness, signed Spearman, Ribozyme, RNAGym Ribozyme DMS assays (26)	Not reported	Not reported	0.0278	Not reported
Evo 1.5 (RNAGym fitness leaderboard v0.1.1)Evaluation	RNAGym v0.1.1 fitness, signed Spearman, tRNA, RNAGym tRNA DMS assays (3)	Not reported	Not reported	Not reported	0.385

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Tested configuration	Protocol and dataset	Finding	Evidence and details
Configuration: Evo 1.5 (RNAGym fitness leaderboard v0.1.1)	Protocol: RNAGym v0.1.1 fitness, signed Spearman, Aptamer Dataset: RNAGym Aptamer DMS assays (2)	0.0007 Spearman (mean signed Spearman over the 2 Aptamer assays) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source Evo 1.5 on RNAGym v0.1.1 fitness (Aptamer) lit-rna-20261011-rnagym-protocol-signed-spearman-aptamer Aggregation: Not reported RNAGym fitness leaderboard (v0.1.1), leaderboard/fitness/README.md · leaderboard/fitness/README.md, main leaderboard table, row 'Evo 1.5', column 'Aptamer (n=2)'
Configuration: Evo 1.5 (RNAGym fitness leaderboard v0.1.1)	Protocol: RNAGym v0.1.1 fitness, signed Spearman, macro over 3 ncRNA categories Dataset: RNAGym ncRNA DMS assays (31)	0.138 Spearman (macro-mean over 3 ncRNA categories (equal category weights)) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source Evo 1.5 on RNAGym v0.1.1 fitness (Macro) lit-rna-20261011-rnagym-protocol-signed-spearman-macro Aggregation: Not reported RNAGym fitness leaderboard (v0.1.1), leaderboard/fitness/README.md · leaderboard/fitness/README.md, main leaderboard table, row 'Evo 1.5', column 'Macro (3 ncRNA)'
Configuration: Evo 1.5 (RNAGym fitness leaderboard v0.1.1)	Protocol: RNAGym v0.1.1 fitness, signed Spearman, Ribozyme Dataset: RNAGym Ribozyme DMS assays (26)	0.0278 Spearman (mean signed Spearman over the 26 Ribozyme assays) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source Evo 1.5 on RNAGym v0.1.1 fitness (Ribozyme) lit-rna-20261011-rnagym-protocol-signed-spearman-ribozyme Aggregation: Not reported RNAGym fitness leaderboard (v0.1.1), leaderboard/fitness/README.md · leaderboard/fitness/README.md, main leaderboard table, row 'Evo 1.5', column 'Ribozyme (n=26)'
Configuration: Evo 1.5 (RNAGym fitness leaderboard v0.1.1)	Protocol: RNAGym v0.1.1 fitness, signed Spearman, tRNA Dataset: RNAGym tRNA DMS assays (3)	0.385 Spearman (mean signed Spearman over the 3 tRNA assays) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source Evo 1.5 on RNAGym v0.1.1 fitness (tRNA) lit-rna-20261011-rnagym-protocol-signed-spearman-trna Aggregation: Not reported RNAGym fitness leaderboard (v0.1.1), leaderboard/fitness/README.md · leaderboard/fitness/README.md, main leaderboard table, row 'Evo 1.5', column 'tRNA (n=3)'

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Release 2026-10-22-1b7cf027e4f6 · Record review: source checked

1 source record and release history

RNAGym fitness leaderboard (v0.1.1), leaderboard/fitness/README.md · Original source · Commit 2828cf99316d75daaa8d832a2573cbb25bbd35fe (2026-08-14, 'Update fitness leaderboard v0.2 models'); leaderboard labelled v0.1.1

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Technical metadata and extraction receipts

Stable ID: lit-rna-20261011-rnagym-config-evo-1-5-rnagym-v0-1-1

areas: rna-transcriptomes
contexts: research
method types: foundation_model
reported name: Evo 1.5
foundation model eligible: true
parameters: Zero-shot. The leaderboard README states the scoring convention for masked language models only (masked-marginal log-likelihood ratio, 'Scoring convention'); the convention used for this model is not stated there.
access reuse: Scoring scripts on the RNAGym v0.2 branch (leaderboard README 'Scoring scripts')
source locator: Leaderboard README row 'Evo 1.5'
version: Evo 1.5
provenance note: Evo 1.5 as scored zero-shot on the RNAGym fitness leaderboard v0.1.1.

Related records

configuration of: Evo
system: Evo 1.5 on RNAGym v0.1.1 fitness (Aptamer)
system: Evo 1.5 on RNAGym v0.1.1 fitness (Macro)
system: Evo 1.5 on RNAGym v0.1.1 fitness (Ribozyme)
system: Evo 1.5 on RNAGym v0.1.1 fitness (tRNA)

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