Method

Ridge

Ridge regression on one-hot encoded protein sequence, fitted with scikit-learn default parameters.

Overview

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Consult the linked sources for architecture or protocol details. Missing evidence is not evidence of a missing capability.

Evaluations and results

15 evaluations · 15 results. Different protocols are not a single leaderboard.

Sorted by Spearman (higher is better). The best value in each column is highlighted. Decimals are rounded for display; each value links to the printed value and its source.

Tested configuration	Protocol and dataset	Spearman
RidgeEvaluation	FLIP RANDOM-SAMPLED-SPLITS-AAV: Random sampled splits fitness prediction, AAV split, FLIP Random sampled splits, AAV split (FLIP split)	0.83 (best in column)
RidgeEvaluation	FLIP RANDOM-SAMPLED-SPLITS-GB1: Random sampled splits fitness prediction, GB1 split, FLIP Random sampled splits, GB1 split (FLIP split)	0.82
RidgeEvaluation	FLIP GB1-3-VS-REST: GB1 fitness prediction, 3-vs-rest split, FLIP GB1, 3-vs-rest split (FLIP split)	0.76
RidgeEvaluation	FLIP AAV-7-VS-REST: AAV fitness prediction, 7-vs-rest split, FLIP AAV, 7-vs-rest split (FLIP split)	0.65
RidgeEvaluation	FLIP AAV-MUT-DES: AAV fitness prediction, Mut-Des split, FLIP AAV, Mut-Des split (FLIP split)	0.64
RidgeEvaluation	FLIP GB1-2-VS-REST: GB1 fitness prediction, 2-vs-rest split, FLIP GB1, 2-vs-rest split (FLIP split)	0.59
RidgeEvaluation	FLIP AAV-DES-MUT: AAV fitness prediction, Des-Mut split, FLIP AAV, Des-Mut split (FLIP split)	0.53
RidgeEvaluation	FLIP GB1-LOW-VS-HIGH: GB1 fitness prediction, low-vs-high split, FLIP GB1, low-vs-high split (FLIP split)	0.34
RidgeEvaluation	FLIP GB1-1-VS-REST: GB1 fitness prediction, 1-vs-rest split, FLIP GB1, 1-vs-rest split (FLIP split)	0.28
RidgeEvaluation	FLIP THERMOSTABILITY-HUMAN-CELL: Thermostability fitness prediction, Human-Cell split, FLIP Thermostability, Human-Cell split (FLIP split)	0.24
RidgeEvaluation	FLIP AAV-1-VS-REST: AAV fitness prediction, 1-vs-rest split, FLIP AAV, 1-vs-rest split (FLIP split)	0.22
RidgeEvaluation	FLIP THERMOSTABILITY-MIXED: Thermostability fitness prediction, Mixed split, FLIP Thermostability, Mixed split (FLIP split)	0.17
RidgeEvaluation	FLIP THERMOSTABILITY-HUMAN: Thermostability fitness prediction, Human split, FLIP Thermostability, Human split (FLIP split)	0.15
RidgeEvaluation	FLIP AAV-LOW-VS-HIGH: AAV fitness prediction, low-vs-high split, FLIP AAV, low-vs-high split (FLIP split)	0.12
RidgeEvaluation	FLIP AAV-2-VS-REST: AAV fitness prediction, 2-vs-rest split, FLIP AAV, 2-vs-rest split (FLIP split)	0.03

All 15 result rows with coverage, uncertainty and sources

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Exact evaluated configurations and original reported results
Tested configuration	Protocol and dataset	Finding	Evidence and details
Method: Ridge	Task: FLIP AAV-1-VS-REST: AAV fitness prediction, 1-vs-rest split Dataset subset: FLIP AAV, 1-vs-rest split (FLIP split)	0.22 Spearman unitless · higher Uncertainty: Not yet extracted Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Ridge on FLIP AAV-1-VS-REST: AAV fitness prediction, 1-vs-rest split Trained on the split's training set with ten percent held out for validation, scored on its test set. Aggregation: Not reported flip primary benchmark evidence · Table 5, row(Ridge), column(1-vs-rest)
Method: Ridge	Task: FLIP AAV-2-VS-REST: AAV fitness prediction, 2-vs-rest split Dataset subset: FLIP AAV, 2-vs-rest split (FLIP split)	0.03 Spearman unitless · higher Uncertainty: Not yet extracted Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Ridge on FLIP AAV-2-VS-REST: AAV fitness prediction, 2-vs-rest split Trained on the split's training set with ten percent held out for validation, scored on its test set. Aggregation: Not reported flip primary benchmark evidence · Table 5, row(Ridge), column(2-vs-rest)
Method: Ridge	Task: FLIP AAV-7-VS-REST: AAV fitness prediction, 7-vs-rest split Dataset subset: FLIP AAV, 7-vs-rest split (FLIP split)	0.65 Spearman unitless · higher Uncertainty: Not yet extracted Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Ridge on FLIP AAV-7-VS-REST: AAV fitness prediction, 7-vs-rest split Trained on the split's training set with ten percent held out for validation, scored on its test set. Aggregation: Not reported flip primary benchmark evidence · Table 5, row(Ridge), column(7-vs-rest)
Method: Ridge	Task: FLIP AAV-DES-MUT: AAV fitness prediction, Des-Mut split Dataset subset: FLIP AAV, Des-Mut split (FLIP split)	0.53 Spearman unitless · higher Uncertainty: Not yet extracted Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Ridge on FLIP AAV-DES-MUT: AAV fitness prediction, Des-Mut split Trained on the split's training set with ten percent held out for validation, scored on its test set. Aggregation: Not reported flip primary benchmark evidence · Table 5, row(Ridge), column(Des-Mut)
Method: Ridge	Task: FLIP AAV-LOW-VS-HIGH: AAV fitness prediction, low-vs-high split Dataset subset: FLIP AAV, low-vs-high split (FLIP split)	0.12 Spearman unitless · higher Uncertainty: Not yet extracted Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Ridge on FLIP AAV-LOW-VS-HIGH: AAV fitness prediction, low-vs-high split Trained on the split's training set with ten percent held out for validation, scored on its test set. Aggregation: Not reported flip primary benchmark evidence · Table 5, row(Ridge), column(low-vs-high)
Method: Ridge	Task: FLIP AAV-MUT-DES: AAV fitness prediction, Mut-Des split Dataset subset: FLIP AAV, Mut-Des split (FLIP split)	0.64 Spearman unitless · higher Uncertainty: Not yet extracted Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Ridge on FLIP AAV-MUT-DES: AAV fitness prediction, Mut-Des split Trained on the split's training set with ten percent held out for validation, scored on its test set. Aggregation: Not reported flip primary benchmark evidence · Table 5, row(Ridge), column(Mut-Des)
Method: Ridge	Task: FLIP GB1-1-VS-REST: GB1 fitness prediction, 1-vs-rest split Dataset subset: FLIP GB1, 1-vs-rest split (FLIP split)	0.28 Spearman unitless · higher Uncertainty: Not yet extracted Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Ridge on FLIP GB1-1-VS-REST: GB1 fitness prediction, 1-vs-rest split Trained on the split's training set with ten percent held out for validation, scored on its test set. Aggregation: Not reported flip primary benchmark evidence · Table 4, row(Ridge), column(1-vs-rest)
Method: Ridge	Task: FLIP GB1-2-VS-REST: GB1 fitness prediction, 2-vs-rest split Dataset subset: FLIP GB1, 2-vs-rest split (FLIP split)	0.59 Spearman unitless · higher Uncertainty: Not yet extracted Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Ridge on FLIP GB1-2-VS-REST: GB1 fitness prediction, 2-vs-rest split Trained on the split's training set with ten percent held out for validation, scored on its test set. Aggregation: Not reported flip primary benchmark evidence · Table 4, row(Ridge), column(2-vs-rest)
Method: Ridge	Task: FLIP GB1-3-VS-REST: GB1 fitness prediction, 3-vs-rest split Dataset subset: FLIP GB1, 3-vs-rest split (FLIP split)	0.76 Spearman unitless · higher Uncertainty: Not yet extracted Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Ridge on FLIP GB1-3-VS-REST: GB1 fitness prediction, 3-vs-rest split Trained on the split's training set with ten percent held out for validation, scored on its test set. Aggregation: Not reported flip primary benchmark evidence · Table 4, row(Ridge), column(3-vs-rest)
Method: Ridge	Task: FLIP GB1-LOW-VS-HIGH: GB1 fitness prediction, low-vs-high split Dataset subset: FLIP GB1, low-vs-high split (FLIP split)	0.34 Spearman unitless · higher Uncertainty: Not yet extracted Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Ridge on FLIP GB1-LOW-VS-HIGH: GB1 fitness prediction, low-vs-high split Trained on the split's training set with ten percent held out for validation, scored on its test set. Aggregation: Not reported flip primary benchmark evidence · Table 4, row(Ridge), column(low-vs-high)
Method: Ridge	Task: FLIP RANDOM-SAMPLED-SPLITS-AAV: Random sampled splits fitness prediction, AAV split Dataset subset: FLIP Random sampled splits, AAV split (FLIP split)	0.83 Spearman unitless · higher Uncertainty: Not yet extracted Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Ridge on FLIP RANDOM-SAMPLED-SPLITS-AAV: Random sampled splits fitness prediction, AAV split Trained on the split's training set with ten percent held out for validation, scored on its test set. The authors report these separately and call them optimistic: a random split of a mutational landscape leaks close relatives between train and test. Aggregation: Not reported flip primary benchmark evidence · Table 7, row(Ridge), column(AAV)
Method: Ridge	Task: FLIP RANDOM-SAMPLED-SPLITS-GB1: Random sampled splits fitness prediction, GB1 split Dataset subset: FLIP Random sampled splits, GB1 split (FLIP split)	0.82 Spearman unitless · higher Uncertainty: Not yet extracted Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Ridge on FLIP RANDOM-SAMPLED-SPLITS-GB1: Random sampled splits fitness prediction, GB1 split Trained on the split's training set with ten percent held out for validation, scored on its test set. The authors report these separately and call them optimistic: a random split of a mutational landscape leaks close relatives between train and test. Aggregation: Not reported flip primary benchmark evidence · Table 7, row(Ridge), column(GB1)
Method: Ridge	Task: FLIP THERMOSTABILITY-HUMAN-CELL: Thermostability fitness prediction, Human-Cell split Dataset subset: FLIP Thermostability, Human-Cell split (FLIP split)	0.24 Spearman unitless · higher Uncertainty: Not yet extracted Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Ridge on FLIP THERMOSTABILITY-HUMAN-CELL: Thermostability fitness prediction, Human-Cell split Trained on the split's training set with ten percent held out for validation, scored on its test set. Aggregation: Not reported flip primary benchmark evidence · Table 6, row(Ridge), column(Human-Cell)
Method: Ridge	Task: FLIP THERMOSTABILITY-HUMAN: Thermostability fitness prediction, Human split Dataset subset: FLIP Thermostability, Human split (FLIP split)	0.15 Spearman unitless · higher Uncertainty: Not yet extracted Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Ridge on FLIP THERMOSTABILITY-HUMAN: Thermostability fitness prediction, Human split Trained on the split's training set with ten percent held out for validation, scored on its test set. Aggregation: Not reported flip primary benchmark evidence · Table 6, row(Ridge), column(Human)
Method: Ridge	Task: FLIP THERMOSTABILITY-MIXED: Thermostability fitness prediction, Mixed split Dataset subset: FLIP Thermostability, Mixed split (FLIP split)	0.17 Spearman unitless · higher Uncertainty: Not yet extracted Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Ridge on FLIP THERMOSTABILITY-MIXED: Thermostability fitness prediction, Mixed split Trained on the split's training set with ten percent held out for validation, scored on its test set. Aggregation: Not reported flip primary benchmark evidence · Table 6, row(Ridge), column(Mixed)

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Release 2026-11-02-a7f03c9e55a5 · Record review: source checked

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flip primary benchmark evidence · Original source · 2021 manuscript

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Technical metadata and extraction receipts

Stable ID: flip-method-ridge

areas: proteins-complexes
source locator: Table 4, row(Ridge)
missing metadata: checkpoint revision: reason: unreported; parameters: reason: unextracted
provenance note: Trained on each split by the FLIP authors.

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