FLIP RANDOM-SAMPLED-SPLITS-AAV: Random sampled splits fitness prediction, AAV split
Random sampled splits fitness prediction, AAV split. Scored with Spearman correlation on FLIP Random sampled splits, AAV split. Trained on the split's training set with ten percent held out for validation, scored on its test set. The authors report these separately and call them optimistic: a random split of a mutational landscape leaks close relatives between train and test.
Overview
Random sampled splits fitness prediction, AAV split. Scored with Spearman correlation on FLIP Random sampled splits, AAV split. Trained on the split's training set with ten percent held out for validation, scored on its test set. The authors report these separately and call them optimistic: a random split of a mutational landscape leaks close relatives between train and test.
Consult the linked sources for architecture or protocol details. Missing evidence is not evidence of a missing capability.
Results
Each comparison retains its reviewed evaluation scope, dataset and metric. Results are shown without a pooled ranking.
FLIP RANDOM-SAMPLED-SPLITS-AAV: Random sampled splits fitness prediction, AAV split
spearman (correlation) · Higher values are better.
FLIP RANDOM-SAMPLED-SPLITS-AAV: Random sampled splits fitness prediction, AAV split · FLIP Random sampled splits, AAV split (FLIP split)
Evidence origin: Author-reported evaluation.
flip primary benchmark evidence · Table 7, column(AAV)- The split is the task here. Figures from different splits of the same landscape are not comparable.
- The random sampled splits in Table 7 are the authors' own illustration of an optimistic evaluation, not a headline result.
- NA marks a baseline that cannot be applied to that landscape, and is recorded as no result rather than as a zero.
Comparison details and limitations
Every method FLIP reports on Random sampled splits fitness prediction, AAV split, scored with Spearman correlation on FLIP Random sampled splits, AAV split.
- Author-reported numbers, source checked but not independently reproduced.
Automated source review: 2026-09-18. Numerical source review does not establish independent reproduction.
Dots show point estimates. Whiskers show only explicitly defined uncertainty (standard deviation, standard error or a labelled interval); their definitions remain in Table. Unresolved uncertainty is not plotted. Differences do not establish statistical significance.
Showing 5 of 5 matching rows.
Methods and evaluation design
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Evaluation design
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Benchmarks
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Recorded evaluations
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- CNN on FLIP RANDOM-SAMPLED-SPLITS-AAV: Random sampled splits fitness prediction, AAV split
- ESM-1b (per AA) on FLIP RANDOM-SAMPLED-SPLITS-AAV: Random sampled splits fitness prediction, AAV split
- ESM-1v (per AA) on FLIP RANDOM-SAMPLED-SPLITS-AAV: Random sampled splits fitness prediction, AAV split
- ESM-untrained (per AA) on FLIP RANDOM-SAMPLED-SPLITS-AAV: Random sampled splits fitness prediction, AAV split
- Ridge on FLIP RANDOM-SAMPLED-SPLITS-AAV: Random sampled splits fitness prediction, AAV split
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Strengths, limitations and unresolved questions
Evidence
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Evidence table
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1 evidence row matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|---|---|
| Relationship: part of discovery-benchmark-flip Individual claims | flip primary benchmark evidence Table 7, column(AAV) Version: 2021 manuscript | source checked automated source review · 2026-09-18 Audit detailsPrimary-source transcription with no human sign-off and no independent reproduction. Field: Claim: flip-association-random-sampled-splits-aav Source artifact SHA-256: Hash scope: Exact retrieved primary paper artifact bytes. |
Sources and history
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Release 2026-09-29-06401fd5b220 · Record review: source checked
1 source records and release history
- flip primary benchmark evidence · Original source · 2021 manuscript
Technical metadata and extraction receipts
Stable ID: flip-task-random-sampled-splits-aav
- areas
- proteins-complexes
- tasks
- Random sampled splits fitness prediction, AAV split
- metric
- Spearman correlation
- metric direction
- higher
- dataset
- FLIP Random sampled splits, AAV split
- protocol
- Trained on the split's training set with ten percent held out for validation, scored on its test set. The authors report these separately and call them optimistic: a random split of a mutational landscape leaks close relatives between train and test.
- source locator
- Table 7, column(AAV)
- comparison panels
- id: flip-panel-random-sampled-splits-aav; title: FLIP RANDOM-SAMPLED-SPLITS-AAV: Random sampled splits fitness prediction, AAV split; protocol id: flip-task-random-sampled-splits-aav; dataset id: flip-dataset-flip-random-sampled-splits-aav-split; metric: spearman; unit: correlation; direction: higher; result ids: flip-result-esm-1b-per-aa-random-sampled-splits-aav-spearman; flip-result-esm-1v-per-aa-random-sampled-splits-aav-spearman; flip-result-esm-untrained-per-aa-random-sampled-splits-aav-spearman; flip-result-ridge-random-sampled-splits-aav-spearman; flip-result-cnn-random-sampled-splits-aav-spearman; source ids: expansion-p3-flip; source locator: Table 7, column(AAV); context: Every method FLIP reports on Random sampled splits fitness prediction, AAV split, scored with Spearman correlation on FLIP Random sampled splits, AAV split.; caveats: Author-reported numbers, source checked but not independently reproduced.; The split is the task here. Figures from different splits of the same landscape are not comparable.; The random sampled splits in Table 7 are the authors' own illustration of an optimistic evaluation, not a headline result.; NA marks a baseline that cannot be applied to that landscape, and is recorded as no result rather than as a zero.; review: method: automated_source_review; date: 2026-09-18
Related records
- part of: FLIP
- subject: FLIP RANDOM-SAMPLED-SPLITS-AAV: part of discovery-benchmark-flip
- benchmark: CNN on FLIP RANDOM-SAMPLED-SPLITS-AAV: Random sampled splits fitness prediction, AAV split
- benchmark: ESM-1b (per AA) on FLIP RANDOM-SAMPLED-SPLITS-AAV: Random sampled splits fitness prediction, AAV split
- benchmark: ESM-1v (per AA) on FLIP RANDOM-SAMPLED-SPLITS-AAV: Random sampled splits fitness prediction, AAV split
- benchmark: ESM-untrained (per AA) on FLIP RANDOM-SAMPLED-SPLITS-AAV: Random sampled splits fitness prediction, AAV split
- benchmark: Ridge on FLIP RANDOM-SAMPLED-SPLITS-AAV: Random sampled splits fitness prediction, AAV split