Configuration

ESM-untrained (per AA)

Protein language model embedding with the stated pooling, fed to a supervised head by the FLIP authors.

Overview

Protein language model embedding with the stated pooling, fed to a supervised head by the FLIP authors.

Consult the linked sources for architecture or protocol details. Missing evidence is not evidence of a missing capability.

Evaluations and results

14 evaluations · 14 results. Different protocols are not a single leaderboard.

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Tested model or methodProtocolDatasetEvaluation setupMetricEvidence origin

Applied filters: All linked evaluations

Exact evaluated configurations and original reported results
Tested configuration	Protocol and dataset	Finding	Evidence and details
Configuration: ESM-untrained (per AA)	Task: FLIP AAV-1-VS-REST: AAV fitness prediction, 1-vs-rest split Dataset subset: FLIP AAV, 1-vs-rest split (FLIP split)	0.18 spearman correlation · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESM-untrained (per AA) on FLIP AAV-1-VS-REST: AAV fitness prediction, 1-vs-rest split Trained on the split's training set with ten percent held out for validation, scored on its test set. Aggregation: Not reported flip primary benchmark evidence · Table 5, row(ESM-untrained (per AA)), column(1-vs-rest)
Configuration: ESM-untrained (per AA)	Task: FLIP AAV-2-VS-REST: AAV fitness prediction, 2-vs-rest split Dataset subset: FLIP AAV, 2-vs-rest split (FLIP split)	0.22 spearman correlation · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESM-untrained (per AA) on FLIP AAV-2-VS-REST: AAV fitness prediction, 2-vs-rest split Trained on the split's training set with ten percent held out for validation, scored on its test set. Aggregation: Not reported flip primary benchmark evidence · Table 5, row(ESM-untrained (per AA)), column(2-vs-rest)
Configuration: ESM-untrained (per AA)	Task: FLIP AAV-7-VS-REST: AAV fitness prediction, 7-vs-rest split Dataset subset: FLIP AAV, 7-vs-rest split (FLIP split)	0.42 spearman correlation · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESM-untrained (per AA) on FLIP AAV-7-VS-REST: AAV fitness prediction, 7-vs-rest split Trained on the split's training set with ten percent held out for validation, scored on its test set. Aggregation: Not reported flip primary benchmark evidence · Table 5, row(ESM-untrained (per AA)), column(7-vs-rest)
Configuration: ESM-untrained (per AA)	Task: FLIP AAV-LOW-VS-HIGH: AAV fitness prediction, low-vs-high split Dataset subset: FLIP AAV, low-vs-high split (FLIP split)	0.08 spearman correlation · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESM-untrained (per AA) on FLIP AAV-LOW-VS-HIGH: AAV fitness prediction, low-vs-high split Trained on the split's training set with ten percent held out for validation, scored on its test set. Aggregation: Not reported flip primary benchmark evidence · Table 5, row(ESM-untrained (per AA)), column(low-vs-high)
Configuration: ESM-untrained (per AA)	Task: FLIP AAV-MUT-DES: AAV fitness prediction, Mut-Des split Dataset subset: FLIP AAV, Mut-Des split (FLIP split)	0.56 spearman correlation · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESM-untrained (per AA) on FLIP AAV-MUT-DES: AAV fitness prediction, Mut-Des split Trained on the split's training set with ten percent held out for validation, scored on its test set. Aggregation: Not reported flip primary benchmark evidence · Table 5, row(ESM-untrained (per AA)), column(Mut-Des)
Configuration: ESM-untrained (per AA)	Task: FLIP GB1-1-VS-REST: GB1 fitness prediction, 1-vs-rest split Dataset subset: FLIP GB1, 1-vs-rest split (FLIP split)	0.06 spearman correlation · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESM-untrained (per AA) on FLIP GB1-1-VS-REST: GB1 fitness prediction, 1-vs-rest split Trained on the split's training set with ten percent held out for validation, scored on its test set. Aggregation: Not reported flip primary benchmark evidence · Table 4, row(ESM-untrained (per AA)), column(1-vs-rest)
Configuration: ESM-untrained (per AA)	Task: FLIP GB1-2-VS-REST: GB1 fitness prediction, 2-vs-rest split Dataset subset: FLIP GB1, 2-vs-rest split (FLIP split)	0.06 spearman correlation · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESM-untrained (per AA) on FLIP GB1-2-VS-REST: GB1 fitness prediction, 2-vs-rest split Trained on the split's training set with ten percent held out for validation, scored on its test set. Aggregation: Not reported flip primary benchmark evidence · Table 4, row(ESM-untrained (per AA)), column(2-vs-rest)
Configuration: ESM-untrained (per AA)	Task: FLIP GB1-3-VS-REST: GB1 fitness prediction, 3-vs-rest split Dataset subset: FLIP GB1, 3-vs-rest split (FLIP split)	0.48 spearman correlation · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESM-untrained (per AA) on FLIP GB1-3-VS-REST: GB1 fitness prediction, 3-vs-rest split Trained on the split's training set with ten percent held out for validation, scored on its test set. Aggregation: Not reported flip primary benchmark evidence · Table 4, row(ESM-untrained (per AA)), column(3-vs-rest)
Configuration: ESM-untrained (per AA)	Task: FLIP GB1-LOW-VS-HIGH: GB1 fitness prediction, low-vs-high split Dataset subset: FLIP GB1, low-vs-high split (FLIP split)	0.23 spearman correlation · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESM-untrained (per AA) on FLIP GB1-LOW-VS-HIGH: GB1 fitness prediction, low-vs-high split Trained on the split's training set with ten percent held out for validation, scored on its test set. Aggregation: Not reported flip primary benchmark evidence · Table 4, row(ESM-untrained (per AA)), column(low-vs-high)
Configuration: ESM-untrained (per AA)	Task: FLIP RANDOM-SAMPLED-SPLITS-AAV: Random sampled splits fitness prediction, AAV split Dataset subset: FLIP Random sampled splits, AAV split (FLIP split)	0.78 spearman correlation · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESM-untrained (per AA) on FLIP RANDOM-SAMPLED-SPLITS-AAV: Random sampled splits fitness prediction, AAV split Trained on the split's training set with ten percent held out for validation, scored on its test set. The authors report these separately and call them optimistic: a random split of a mutational landscape leaks close relatives between train and test. Aggregation: Not reported flip primary benchmark evidence · Table 7, row(ESM-untrained (per AA)), column(AAV)
Configuration: ESM-untrained (per AA)	Task: FLIP RANDOM-SAMPLED-SPLITS-GB1: Random sampled splits fitness prediction, GB1 split Dataset subset: FLIP Random sampled splits, GB1 split (FLIP split)	0.79 spearman correlation · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESM-untrained (per AA) on FLIP RANDOM-SAMPLED-SPLITS-GB1: Random sampled splits fitness prediction, GB1 split Trained on the split's training set with ten percent held out for validation, scored on its test set. The authors report these separately and call them optimistic: a random split of a mutational landscape leaks close relatives between train and test. Aggregation: Not reported flip primary benchmark evidence · Table 7, row(ESM-untrained (per AA)), column(GB1)
Configuration: ESM-untrained (per AA)	Task: FLIP THERMOSTABILITY-HUMAN-CELL: Thermostability fitness prediction, Human-Cell split Dataset subset: FLIP Thermostability, Human-Cell split (FLIP split)	0.46 spearman correlation · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESM-untrained (per AA) on FLIP THERMOSTABILITY-HUMAN-CELL: Thermostability fitness prediction, Human-Cell split Trained on the split's training set with ten percent held out for validation, scored on its test set. Aggregation: Not reported flip primary benchmark evidence · Table 6, row(ESM-untrained (per AA)), column(Human-Cell)
Configuration: ESM-untrained (per AA)	Task: FLIP THERMOSTABILITY-HUMAN: Thermostability fitness prediction, Human split Dataset subset: FLIP Thermostability, Human split (FLIP split)	0.44 spearman correlation · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESM-untrained (per AA) on FLIP THERMOSTABILITY-HUMAN: Thermostability fitness prediction, Human split Trained on the split's training set with ten percent held out for validation, scored on its test set. Aggregation: Not reported flip primary benchmark evidence · Table 6, row(ESM-untrained (per AA)), column(Human)
Configuration: ESM-untrained (per AA)	Task: FLIP THERMOSTABILITY-MIXED: Thermostability fitness prediction, Mixed split Dataset subset: FLIP Thermostability, Mixed split (FLIP split)	0.44 spearman correlation · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESM-untrained (per AA) on FLIP THERMOSTABILITY-MIXED: Thermostability fitness prediction, Mixed split Trained on the split's training set with ten percent held out for validation, scored on its test set. Aggregation: Not reported flip primary benchmark evidence · Table 6, row(ESM-untrained (per AA)), column(Mixed)

Source checking is not independent reproduction. Release 2026-09-29-06401fd5b220.

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Evidence

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Evidence table

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One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

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