| Configuration: ESM2-650M likelihood | Protocol: FLIP2 hydro low-to-high; held-out test set · hydro Dataset subset: hydro | 0.865 ndcg unitless · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceESM2-650M likelihood · FLIP2 hydro low-to-high; held-out test set · hydro FLIP2 hydro low-to-high; held-out test set Aggregation: reported point estimate FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A11; row ESM2-650M likelihood; column ndcg |
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| Configuration: ESMC-300M supervised | Protocol: FLIP2 hydro to-P0A9X9; held-out test set · hydro Dataset subset: hydro | 0.078 ± 0.133 spearman correlation · higher Uncertainty: printed spread: 0.133; type: unreported; value: 0.133 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceESMC-300M supervised · FLIP2 hydro to-P0A9X9; held-out test set · hydro FLIP2 hydro to-P0A9X9; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A13; row ESMC-300M supervised; column spearman |
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| Configuration: Ridge (one-hot) | Protocol: FLIP2 hydro to-P01053; held-out test set · hydro Dataset subset: hydro | 0.889 ndcg unitless · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceRidge (one-hot) · FLIP2 hydro to-P01053; held-out test set · hydro FLIP2 hydro to-P01053; held-out test set Aggregation: reported point estimate FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A14; row Ridge (one-hot); column ndcg |
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| Configuration: ESMC-300M naive supervised | Protocol: FLIP2 hydro to-P06241; held-out test set · hydro Dataset subset: hydro | 0.098 ± 0.024 spearman correlation · higher Uncertainty: printed spread: 0.024; type: unreported; value: 0.024 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceESMC-300M naive supervised · FLIP2 hydro to-P06241; held-out test set · hydro FLIP2 hydro to-P06241; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A12; row ESMC-300M naive supervised; column spearman |
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| Configuration: CARP-640M likelihood | Protocol: FLIP2 hydro low-to-high; held-out test set · hydro Dataset subset: hydro | 0.284 spearman correlation · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceCARP-640M likelihood · FLIP2 hydro low-to-high; held-out test set · hydro FLIP2 hydro low-to-high; held-out test set Aggregation: reported point estimate FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A11; row CARP-640M likelihood; column spearman |
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| Configuration: CARP-640M supervised | Protocol: FLIP2 hydro to-P0A9X9; held-out test set · hydro Dataset subset: hydro | 0.961 ± 0.004 ndcg unitless · higher Uncertainty: printed spread: 0.004; type: unreported; value: 0.004 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceCARP-640M supervised · FLIP2 hydro to-P0A9X9; held-out test set · hydro FLIP2 hydro to-P0A9X9; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A13; row CARP-640M supervised; column ndcg |
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| Configuration: Ridge (one-hot) | Protocol: FLIP2 hydro to-P06241; held-out test set · hydro Dataset subset: hydro | −0.138 spearman correlation · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceRidge (one-hot) · FLIP2 hydro to-P06241; held-out test set · hydro FLIP2 hydro to-P06241; held-out test set Aggregation: reported point estimate FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A12; row Ridge (one-hot); column spearman |
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| Configuration: ESM2-650M likelihood | Protocol: FLIP2 hydro to-P0A9X9; held-out test set · hydro Dataset subset: hydro | 0.049 spearman correlation · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceESM2-650M likelihood · FLIP2 hydro to-P0A9X9; held-out test set · hydro FLIP2 hydro to-P0A9X9; held-out test set Aggregation: reported point estimate FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A13; row ESM2-650M likelihood; column spearman |
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| Configuration: CARP-640M naive supervised | Protocol: FLIP2 hydro to-P06241; held-out test set · hydro Dataset subset: hydro | 0.927 ± 0.006 ndcg unitless · higher Uncertainty: printed spread: 0.006; type: unreported; value: 0.006 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceCARP-640M naive supervised · FLIP2 hydro to-P06241; held-out test set · hydro FLIP2 hydro to-P06241; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A12; row CARP-640M naive supervised; column ndcg |
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| Configuration: Ridge (one-hot) | Protocol: FLIP2 hydro three-to-many; held-out test set · hydro Dataset subset: hydro | 0.148 spearman correlation · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceRidge (one-hot) · FLIP2 hydro three-to-many; held-out test set · hydro FLIP2 hydro three-to-many; held-out test set Aggregation: reported point estimate FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A10; row Ridge (one-hot); column spearman |
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| Configuration: Ridge (one-hot) | Protocol: FLIP2 hydro to-P0A9X9; held-out test set · hydro Dataset subset: hydro | 0.957 ndcg unitless · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceRidge (one-hot) · FLIP2 hydro to-P0A9X9; held-out test set · hydro FLIP2 hydro to-P0A9X9; held-out test set Aggregation: reported point estimate FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A13; row Ridge (one-hot); column ndcg |
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| Configuration: ESM2-650M likelihood | Protocol: FLIP2 hydro three-to-many; held-out test set · hydro Dataset subset: hydro | −0.036 spearman correlation · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceESM2-650M likelihood · FLIP2 hydro three-to-many; held-out test set · hydro FLIP2 hydro three-to-many; held-out test set Aggregation: reported point estimate FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A10; row ESM2-650M likelihood; column spearman |
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| Configuration: CARP-640M supervised | Protocol: FLIP2 hydro three-to-many; held-out test set · hydro Dataset subset: hydro | 0.516 ± 0.035 spearman correlation · higher Uncertainty: printed spread: 0.035; type: unreported; value: 0.035 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceCARP-640M supervised · FLIP2 hydro three-to-many; held-out test set · hydro FLIP2 hydro three-to-many; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A10; row CARP-640M supervised; column spearman |
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| Configuration: CARP-640M likelihood | Protocol: FLIP2 hydro low-to-high; held-out test set · hydro Dataset subset: hydro | 0.921 ndcg unitless · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceCARP-640M likelihood · FLIP2 hydro low-to-high; held-out test set · hydro FLIP2 hydro low-to-high; held-out test set Aggregation: reported point estimate FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A11; row CARP-640M likelihood; column ndcg |
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| Configuration: ESMC-300M supervised | Protocol: FLIP2 hydro to-P01053; held-out test set · hydro Dataset subset: hydro | 0.949 ± 0.024 ndcg unitless · higher Uncertainty: printed spread: 0.024; type: unreported; value: 0.024 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceESMC-300M supervised · FLIP2 hydro to-P01053; held-out test set · hydro FLIP2 hydro to-P01053; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A14; row ESMC-300M supervised; column ndcg |
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| Configuration: CARP-640M naive supervised | Protocol: FLIP2 hydro to-P01053; held-out test set · hydro Dataset subset: hydro | 0.061 ± 0.094 spearman correlation · higher Uncertainty: printed spread: 0.094; type: unreported; value: 0.094 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceCARP-640M naive supervised · FLIP2 hydro to-P01053; held-out test set · hydro FLIP2 hydro to-P01053; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A14; row CARP-640M naive supervised; column spearman |
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| Configuration: CARP-640M likelihood | Protocol: FLIP2 hydro to-P06241; held-out test set · hydro Dataset subset: hydro | 0.957 ndcg unitless · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceCARP-640M likelihood · FLIP2 hydro to-P06241; held-out test set · hydro FLIP2 hydro to-P06241; held-out test set Aggregation: reported point estimate FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A12; row CARP-640M likelihood; column ndcg |
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| Configuration: ESMC-300M naive supervised | Protocol: FLIP2 hydro three-to-many; held-out test set · hydro Dataset subset: hydro | 0.367 ± 0.042 spearman correlation · higher Uncertainty: printed spread: 0.042; type: unreported; value: 0.042 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceESMC-300M naive supervised · FLIP2 hydro three-to-many; held-out test set · hydro FLIP2 hydro three-to-many; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A10; row ESMC-300M naive supervised; column spearman |
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| Configuration: CARP-640M supervised | Protocol: FLIP2 hydro to-P0A9X9; held-out test set · hydro Dataset subset: hydro | 0.004 ± 0.103 spearman correlation · higher Uncertainty: printed spread: 0.103; type: unreported; value: 0.103 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceCARP-640M supervised · FLIP2 hydro to-P0A9X9; held-out test set · hydro FLIP2 hydro to-P0A9X9; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A13; row CARP-640M supervised; column spearman |
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| Configuration: ESM2-650M likelihood | Protocol: FLIP2 hydro to-P01053; held-out test set · hydro Dataset subset: hydro | 0.053 spearman correlation · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceESM2-650M likelihood · FLIP2 hydro to-P01053; held-out test set · hydro FLIP2 hydro to-P01053; held-out test set Aggregation: reported point estimate FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A14; row ESM2-650M likelihood; column spearman |
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| Configuration: Ridge (one-hot) | Protocol: FLIP2 hydro three-to-many; held-out test set · hydro Dataset subset: hydro | 0.96 ndcg unitless · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceRidge (one-hot) · FLIP2 hydro three-to-many; held-out test set · hydro FLIP2 hydro three-to-many; held-out test set Aggregation: reported point estimate FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A10; row Ridge (one-hot); column ndcg |
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| Configuration: ESMC-300M supervised | Protocol: FLIP2 hydro to-P06241; held-out test set · hydro Dataset subset: hydro | 0.934 ± 0.011 ndcg unitless · higher Uncertainty: printed spread: 0.011; type: unreported; value: 0.011 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceESMC-300M supervised · FLIP2 hydro to-P06241; held-out test set · hydro FLIP2 hydro to-P06241; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A12; row ESMC-300M supervised; column ndcg |
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| Configuration: Ridge (one-hot + likelihoods) | Protocol: FLIP2 hydro to-P01053; held-out test set · hydro Dataset subset: hydro | 0.942 ndcg unitless · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceRidge (one-hot + likelihoods) · FLIP2 hydro to-P01053; held-out test set · hydro FLIP2 hydro to-P01053; held-out test set Aggregation: reported point estimate FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A14; row Ridge (one-hot + likelihoods); column ndcg |
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| Configuration: CARP-640M supervised | Protocol: FLIP2 hydro to-P01053; held-out test set · hydro Dataset subset: hydro | 0.909 ± 0.008 ndcg unitless · higher Uncertainty: printed spread: 0.008; type: unreported; value: 0.008 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceCARP-640M supervised · FLIP2 hydro to-P01053; held-out test set · hydro FLIP2 hydro to-P01053; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A14; row CARP-640M supervised; column ndcg |
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| Configuration: ESMC-300M naive supervised | Protocol: FLIP2 hydro to-P06241; held-out test set · hydro Dataset subset: hydro | 0.927 ± 0.001 ndcg unitless · higher Uncertainty: printed spread: 0.001; type: unreported; value: 0.001 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceESMC-300M naive supervised · FLIP2 hydro to-P06241; held-out test set · hydro FLIP2 hydro to-P06241; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A12; row ESMC-300M naive supervised; column ndcg |
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