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ESMC-300M naive supervised

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16 evaluations · 31 results

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16 evaluations · 31 results. Different protocols are not a single leaderboard.

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source locator: Table A1; row ESMC-300M naive supervised; column spearman
reported configuration: ESMC-300M naive supervised
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Tested configuration	Protocol and dataset	Finding	Evidence and details
Configuration: ESMC-300M naive supervised	Protocol: FLIP2 Amylase far-to-close; held-out test set · Amylase Dataset subset: Amylase	0.818 ± 0.002 ndcg unitless · higher Uncertainty: printed spread: 0.002; type: unreported; value: 0.002 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESMC-300M naive supervised · FLIP2 Amylase far-to-close; held-out test set · Amylase FLIP2 Amylase far-to-close; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A3; row ESMC-300M naive supervised; column ndcg
Configuration: ESMC-300M naive supervised	Protocol: FLIP2 hydro to-P06241; held-out test set · hydro Dataset subset: hydro	0.098 ± 0.024 spearman correlation · higher Uncertainty: printed spread: 0.024; type: unreported; value: 0.024 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESMC-300M naive supervised · FLIP2 hydro to-P06241; held-out test set · hydro FLIP2 hydro to-P06241; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A12; row ESMC-300M naive supervised; column spearman
Configuration: ESMC-300M naive supervised	Protocol: FLIP2 IRED two-to-many; held-out test set · IRED Dataset subset: IRED	0.106 ± 0.005 spearman correlation · higher Uncertainty: printed spread: 0.005; type: unreported; value: 0.005 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESMC-300M naive supervised · FLIP2 IRED two-to-many; held-out test set · IRED FLIP2 IRED two-to-many; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A5; row ESMC-300M naive supervised; column spearman
Configuration: ESMC-300M naive supervised	Protocol: FLIP2 PDZ3 single-to-double; held-out test set · PDZ3 Dataset subset: PDZ3	0.880 ± 0.006 ndcg unitless · higher Uncertainty: printed spread: 0.006; type: unreported; value: 0.006 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESMC-300M naive supervised · FLIP2 PDZ3 single-to-double; held-out test set · PDZ3 FLIP2 PDZ3 single-to-double; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A16; row ESMC-300M naive supervised; column ndcg
Configuration: ESMC-300M naive supervised	Protocol: FLIP2 Amylase one-to-many; held-out test set · Amylase Dataset subset: Amylase	0.850 ± 0.007 ndcg unitless · higher Uncertainty: printed spread: 0.007; type: unreported; value: 0.007 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESMC-300M naive supervised · FLIP2 Amylase one-to-many; held-out test set · Amylase FLIP2 Amylase one-to-many; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A1; row ESMC-300M naive supervised; column ndcg
Configuration: ESMC-300M naive supervised	Protocol: FLIP2 Amylase close-to-far; held-out test set · Amylase Dataset subset: Amylase	0.864 ± 0.012 ndcg unitless · higher Uncertainty: printed spread: 0.012; type: unreported; value: 0.012 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESMC-300M naive supervised · FLIP2 Amylase close-to-far; held-out test set · Amylase FLIP2 Amylase close-to-far; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A2; row ESMC-300M naive supervised; column ndcg
Configuration: ESMC-300M naive supervised	Protocol: FLIP2 rhomax by-wild-type; held-out test set · rhomax Dataset subset: rhomax	0.936 ± 0.022 ndcg unitless · higher Uncertainty: printed spread: 0.022; type: unreported; value: 0.022 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESMC-300M naive supervised · FLIP2 rhomax by-wild-type; held-out test set · rhomax FLIP2 rhomax by-wild-type; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A15; row ESMC-300M naive supervised; column ndcg
Configuration: ESMC-300M naive supervised	Protocol: FLIP2 TrpB one-to-many; held-out test set · TrpB Dataset subset: TrpB	0.986 ± 0.002 ndcg unitless · higher Uncertainty: printed spread: 0.002; type: unreported; value: 0.002 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESMC-300M naive supervised · FLIP2 TrpB one-to-many; held-out test set · TrpB FLIP2 TrpB one-to-many; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A7; row ESMC-300M naive supervised; column ndcg
Configuration: ESMC-300M naive supervised	Protocol: FLIP2 TrpB by-position; held-out test set · TrpB Dataset subset: TrpB	0.154 ± 0.059 spearman correlation · higher Uncertainty: printed spread: 0.059; type: unreported; value: 0.059 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESMC-300M naive supervised · FLIP2 TrpB by-position; held-out test set · TrpB FLIP2 TrpB by-position; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A9; row ESMC-300M naive supervised; column spearman
Configuration: ESMC-300M naive supervised	Protocol: FLIP2 Amylase close-to-far; held-out test set · Amylase Dataset subset: Amylase	0.007 ± 0.032 spearman correlation · higher Uncertainty: printed spread: 0.032; type: unreported; value: 0.032 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESMC-300M naive supervised · FLIP2 Amylase close-to-far; held-out test set · Amylase FLIP2 Amylase close-to-far; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A2; row ESMC-300M naive supervised; column spearman
Configuration: ESMC-300M naive supervised	Protocol: FLIP2 hydro three-to-many; held-out test set · hydro Dataset subset: hydro	0.367 ± 0.042 spearman correlation · higher Uncertainty: printed spread: 0.042; type: unreported; value: 0.042 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESMC-300M naive supervised · FLIP2 hydro three-to-many; held-out test set · hydro FLIP2 hydro three-to-many; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A10; row ESMC-300M naive supervised; column spearman
Configuration: ESMC-300M naive supervised	Protocol: FLIP2 rhomax by-wild-type; held-out test set · rhomax Dataset subset: rhomax	0.036 ± 0.218 spearman correlation · higher Uncertainty: printed spread: 0.218; type: unreported; value: 0.218 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESMC-300M naive supervised · FLIP2 rhomax by-wild-type; held-out test set · rhomax FLIP2 rhomax by-wild-type; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A15; row ESMC-300M naive supervised; column spearman
Configuration: ESMC-300M naive supervised	Protocol: FLIP2 hydro to-P06241; held-out test set · hydro Dataset subset: hydro	0.927 ± 0.001 ndcg unitless · higher Uncertainty: printed spread: 0.001; type: unreported; value: 0.001 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESMC-300M naive supervised · FLIP2 hydro to-P06241; held-out test set · hydro FLIP2 hydro to-P06241; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A12; row ESMC-300M naive supervised; column ndcg
Configuration: ESMC-300M naive supervised	Protocol: FLIP2 NucB two-to-many; held-out test set · NucB Dataset subset: NucB	0.956 ± 0.003 ndcg unitless · higher Uncertainty: printed spread: 0.003; type: unreported; value: 0.003 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESMC-300M naive supervised · FLIP2 NucB two-to-many; held-out test set · NucB FLIP2 NucB two-to-many; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A6; row ESMC-300M naive supervised; column ndcg
Configuration: ESMC-300M naive supervised	Protocol: FLIP2 TrpB two-to-many; held-out test set · TrpB Dataset subset: TrpB	0.398 ± 0.020 spearman correlation · higher Uncertainty: printed spread: 0.020; type: unreported; value: 0.02 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESMC-300M naive supervised · FLIP2 TrpB two-to-many; held-out test set · TrpB FLIP2 TrpB two-to-many; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A8; row ESMC-300M naive supervised; column spearman
Configuration: ESMC-300M naive supervised	Protocol: FLIP2 hydro to-P01053; held-out test set · hydro Dataset subset: hydro	−0.086 ± 0.135 spearman correlation · higher Uncertainty: printed spread: 0.135; type: unreported; value: 0.135 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESMC-300M naive supervised · FLIP2 hydro to-P01053; held-out test set · hydro FLIP2 hydro to-P01053; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A14; row ESMC-300M naive supervised; column spearman
Configuration: ESMC-300M naive supervised	Protocol: FLIP2 hydro low-to-high; held-out test set · hydro Dataset subset: hydro	0.905 ± 0.008 ndcg unitless · higher Uncertainty: printed spread: 0.008; type: unreported; value: 0.008 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESMC-300M naive supervised · FLIP2 hydro low-to-high; held-out test set · hydro FLIP2 hydro low-to-high; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A11; row ESMC-300M naive supervised; column ndcg
Configuration: ESMC-300M naive supervised	Protocol: FLIP2 IRED two-to-many; held-out test set · IRED Dataset subset: IRED	0.949 ± 0.001 ndcg unitless · higher Uncertainty: printed spread: 0.001; type: unreported; value: 0.001 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESMC-300M naive supervised · FLIP2 IRED two-to-many; held-out test set · IRED FLIP2 IRED two-to-many; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A5; row ESMC-300M naive supervised; column ndcg
Configuration: ESMC-300M naive supervised	Protocol: FLIP2 hydro to-P0A9X9; held-out test set · hydro Dataset subset: hydro	−0.050 ± 0.193 spearman correlation · higher Uncertainty: printed spread: 0.193; type: unreported; value: 0.193 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESMC-300M naive supervised · FLIP2 hydro to-P0A9X9; held-out test set · hydro FLIP2 hydro to-P0A9X9; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A13; row ESMC-300M naive supervised; column spearman
Configuration: ESMC-300M naive supervised	Protocol: FLIP2 Amylase by-mutation; held-out test set · Amylase Dataset subset: Amylase	0.819 ± 0.048 ndcg unitless · higher Uncertainty: printed spread: 0.048; type: unreported; value: 0.048 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESMC-300M naive supervised · FLIP2 Amylase by-mutation; held-out test set · Amylase FLIP2 Amylase by-mutation; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A4; row ESMC-300M naive supervised; column ndcg
Configuration: ESMC-300M naive supervised	Protocol: FLIP2 TrpB by-position; held-out test set · TrpB Dataset subset: TrpB	0.978 ± 0.004 ndcg unitless · higher Uncertainty: printed spread: 0.004; type: unreported; value: 0.004 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESMC-300M naive supervised · FLIP2 TrpB by-position; held-out test set · TrpB FLIP2 TrpB by-position; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A9; row ESMC-300M naive supervised; column ndcg
Configuration: ESMC-300M naive supervised	Protocol: FLIP2 TrpB two-to-many; held-out test set · TrpB Dataset subset: TrpB	0.986 ± 0.001 ndcg unitless · higher Uncertainty: printed spread: 0.001; type: unreported; value: 0.001 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESMC-300M naive supervised · FLIP2 TrpB two-to-many; held-out test set · TrpB FLIP2 TrpB two-to-many; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A8; row ESMC-300M naive supervised; column ndcg
Configuration: ESMC-300M naive supervised	Protocol: FLIP2 hydro to-P01053; held-out test set · hydro Dataset subset: hydro	0.895 ± 0.006 ndcg unitless · higher Uncertainty: printed spread: 0.006; type: unreported; value: 0.006 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESMC-300M naive supervised · FLIP2 hydro to-P01053; held-out test set · hydro FLIP2 hydro to-P01053; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A14; row ESMC-300M naive supervised; column ndcg
Configuration: ESMC-300M naive supervised	Protocol: FLIP2 hydro low-to-high; held-out test set · hydro Dataset subset: hydro	0.270 ± 0.048 spearman correlation · higher Uncertainty: printed spread: 0.048; type: unreported; value: 0.048 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESMC-300M naive supervised · FLIP2 hydro low-to-high; held-out test set · hydro FLIP2 hydro low-to-high; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A11; row ESMC-300M naive supervised; column spearman
Configuration: ESMC-300M naive supervised	Protocol: FLIP2 hydro three-to-many; held-out test set · hydro Dataset subset: hydro	0.973 ± 0.002 ndcg unitless · higher Uncertainty: printed spread: 0.002; type: unreported; value: 0.002 Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ESMC-300M naive supervised · FLIP2 hydro three-to-many; held-out test set · hydro FLIP2 hydro three-to-many; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A10; row ESMC-300M naive supervised; column ndcg