| Configuration: CARP-640M likelihood | Protocol: FLIP2 IRED two-to-many; held-out test set · IRED Dataset subset: IRED | 0.144 spearman correlation · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceCARP-640M likelihood · FLIP2 IRED two-to-many; held-out test set · IRED FLIP2 IRED two-to-many; held-out test set Aggregation: reported point estimate FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A5; row CARP-640M likelihood; column spearman |
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| Configuration: ESMC-300M naive supervised | Protocol: FLIP2 IRED two-to-many; held-out test set · IRED Dataset subset: IRED | 0.106 ± 0.005 spearman correlation · higher Uncertainty: printed spread: 0.005; type: unreported; value: 0.005 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceESMC-300M naive supervised · FLIP2 IRED two-to-many; held-out test set · IRED FLIP2 IRED two-to-many; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A5; row ESMC-300M naive supervised; column spearman |
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| Configuration: Dayhoff likelihood | Protocol: FLIP2 IRED two-to-many; held-out test set · IRED Dataset subset: IRED | 0.955 ndcg unitless · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceDayhoff likelihood · FLIP2 IRED two-to-many; held-out test set · IRED FLIP2 IRED two-to-many; held-out test set Aggregation: reported point estimate FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A5; row Dayhoff likelihood; column ndcg |
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| Configuration: Ridge (one-hot + likelihoods) | Protocol: FLIP2 IRED two-to-many; held-out test set · IRED Dataset subset: IRED | 0.211 spearman correlation · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceRidge (one-hot + likelihoods) · FLIP2 IRED two-to-many; held-out test set · IRED FLIP2 IRED two-to-many; held-out test set Aggregation: reported point estimate FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A5; row Ridge (one-hot + likelihoods); column spearman |
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| Configuration: ESM2-650M likelihood | Protocol: FLIP2 IRED two-to-many; held-out test set · IRED Dataset subset: IRED | 0.141 spearman correlation · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceESM2-650M likelihood · FLIP2 IRED two-to-many; held-out test set · IRED FLIP2 IRED two-to-many; held-out test set Aggregation: reported point estimate FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A5; row ESM2-650M likelihood; column spearman |
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| Configuration: CARP-640M naive supervised | Protocol: FLIP2 IRED two-to-many; held-out test set · IRED Dataset subset: IRED | 0.012 ± 0.017 spearman correlation · higher Uncertainty: printed spread: 0.017; type: unreported; value: 0.017 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceCARP-640M naive supervised · FLIP2 IRED two-to-many; held-out test set · IRED FLIP2 IRED two-to-many; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A5; row CARP-640M naive supervised; column spearman |
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| Configuration: CARP-640M supervised | Protocol: FLIP2 IRED two-to-many; held-out test set · IRED Dataset subset: IRED | 0.948 ± 0.004 ndcg unitless · higher Uncertainty: printed spread: 0.004; type: unreported; value: 0.004 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceCARP-640M supervised · FLIP2 IRED two-to-many; held-out test set · IRED FLIP2 IRED two-to-many; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A5; row CARP-640M supervised; column ndcg |
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| Configuration: Ridge (one-hot + likelihoods) | Protocol: FLIP2 IRED two-to-many; held-out test set · IRED Dataset subset: IRED | 0.964 ndcg unitless · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceRidge (one-hot + likelihoods) · FLIP2 IRED two-to-many; held-out test set · IRED FLIP2 IRED two-to-many; held-out test set Aggregation: reported point estimate FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A5; row Ridge (one-hot + likelihoods); column ndcg |
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| Configuration: Ridge (one-hot) | Protocol: FLIP2 IRED two-to-many; held-out test set · IRED Dataset subset: IRED | 0.193 spearman correlation · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceRidge (one-hot) · FLIP2 IRED two-to-many; held-out test set · IRED FLIP2 IRED two-to-many; held-out test set Aggregation: reported point estimate FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A5; row Ridge (one-hot); column spearman |
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| Configuration: Ridge (one-hot) | Protocol: FLIP2 IRED two-to-many; held-out test set · IRED Dataset subset: IRED | 0.96 ndcg unitless · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceRidge (one-hot) · FLIP2 IRED two-to-many; held-out test set · IRED FLIP2 IRED two-to-many; held-out test set Aggregation: reported point estimate FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A5; row Ridge (one-hot); column ndcg |
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| Configuration: ESMC-300M naive supervised | Protocol: FLIP2 IRED two-to-many; held-out test set · IRED Dataset subset: IRED | 0.949 ± 0.001 ndcg unitless · higher Uncertainty: printed spread: 0.001; type: unreported; value: 0.001 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceESMC-300M naive supervised · FLIP2 IRED two-to-many; held-out test set · IRED FLIP2 IRED two-to-many; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A5; row ESMC-300M naive supervised; column ndcg |
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| Configuration: ESMC-300M supervised | Protocol: FLIP2 IRED two-to-many; held-out test set · IRED Dataset subset: IRED | 0.954 ± 0.002 ndcg unitless · higher Uncertainty: printed spread: 0.002; type: unreported; value: 0.002 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceESMC-300M supervised · FLIP2 IRED two-to-many; held-out test set · IRED FLIP2 IRED two-to-many; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A5; row ESMC-300M supervised; column ndcg |
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| Configuration: Dayhoff likelihood | Protocol: FLIP2 IRED two-to-many; held-out test set · IRED Dataset subset: IRED | 0.142 spearman correlation · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceDayhoff likelihood · FLIP2 IRED two-to-many; held-out test set · IRED FLIP2 IRED two-to-many; held-out test set Aggregation: reported point estimate FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A5; row Dayhoff likelihood; column spearman |
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| Configuration: ESM2-650M likelihood | Protocol: FLIP2 IRED two-to-many; held-out test set · IRED Dataset subset: IRED | 0.953 ndcg unitless · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceESM2-650M likelihood · FLIP2 IRED two-to-many; held-out test set · IRED FLIP2 IRED two-to-many; held-out test set Aggregation: reported point estimate FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A5; row ESM2-650M likelihood; column ndcg |
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| Configuration: CARP-640M naive supervised | Protocol: FLIP2 IRED two-to-many; held-out test set · IRED Dataset subset: IRED | 0.944 ± 0.001 ndcg unitless · higher Uncertainty: printed spread: 0.001; type: unreported; value: 0.001 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceCARP-640M naive supervised · FLIP2 IRED two-to-many; held-out test set · IRED FLIP2 IRED two-to-many; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A5; row CARP-640M naive supervised; column ndcg |
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| Configuration: CARP-640M likelihood | Protocol: FLIP2 IRED two-to-many; held-out test set · IRED Dataset subset: IRED | 0.956 ndcg unitless · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceCARP-640M likelihood · FLIP2 IRED two-to-many; held-out test set · IRED FLIP2 IRED two-to-many; held-out test set Aggregation: reported point estimate FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A5; row CARP-640M likelihood; column ndcg |
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| Configuration: ESMC-300M supervised | Protocol: FLIP2 IRED two-to-many; held-out test set · IRED Dataset subset: IRED | 0.160 ± 0.022 spearman correlation · higher Uncertainty: printed spread: 0.022; type: unreported; value: 0.022 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceESMC-300M supervised · FLIP2 IRED two-to-many; held-out test set · IRED FLIP2 IRED two-to-many; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A5; row ESMC-300M supervised; column spearman |
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| Configuration: CARP-640M supervised | Protocol: FLIP2 IRED two-to-many; held-out test set · IRED Dataset subset: IRED | 0.072 ± 0.046 spearman correlation · higher Uncertainty: printed spread: 0.046; type: unreported; value: 0.046 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceCARP-640M supervised · FLIP2 IRED two-to-many; held-out test set · IRED FLIP2 IRED two-to-many; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A5; row CARP-640M supervised; column spearman |
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