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CARP-640M supervised

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16 evaluations · 30 results. Different protocols are not a single leaderboard.

Sorted by NDCG (cutoff not stated) (higher is better). The best value in each column is highlighted. Decimals are rounded for display; each value links to the printed value and its source.

Tested configuration	Protocol and dataset	NDCG (cutoff not stated)	Spearman
CARP-640M supervisedEvaluation	FLIP2 TrpB two-to-many; held-out test set · TrpB, TrpB	0.996 ± 0.000 (best in column)	0.509 ± 0.010
CARP-640M supervisedEvaluation	FLIP2 TrpB one-to-many; held-out test set · TrpB, TrpB	0.992 ± 0.002	Not reported
CARP-640M supervisedEvaluation	FLIP2 TrpB by-position; held-out test set · TrpB, TrpB	0.983 ± 0.003	0.167 ± 0.018
CARP-640M supervisedEvaluation	FLIP2 hydro three-to-many; held-out test set · hydro, hydro	0.982 ± 0.002	0.516 ± 0.035
CARP-640M supervisedEvaluation	FLIP2 NucB two-to-many; held-out test set · NucB, NucB	0.970 ± 0.001	0.717 ± 0.012 (best in column)
CARP-640M supervisedEvaluation	FLIP2 hydro to-P0A9X9; held-out test set · hydro, hydro	0.961 ± 0.004	0.004 ± 0.103
CARP-640M supervisedEvaluation	FLIP2 IRED two-to-many; held-out test set · IRED, IRED	0.948 ± 0.004	0.072 ± 0.046
CARP-640M supervisedEvaluation	FLIP2 rhomax by-wild-type; held-out test set · rhomax, rhomax	0.934 ± 0.029	Not reported
CARP-640M supervisedEvaluation	FLIP2 hydro to-P06241; held-out test set · hydro, hydro	0.933 ± 0.008	0.150 ± 0.046
CARP-640M supervisedEvaluation	FLIP2 Amylase by-mutation; held-out test set · Amylase, Amylase	0.926 ± 0.050	0.551 ± 0.239
CARP-640M supervisedEvaluation	FLIP2 hydro to-P01053; held-out test set · hydro, hydro	0.909 ± 0.008	0.049 ± 0.088
CARP-640M supervisedEvaluation	FLIP2 hydro low-to-high; held-out test set · hydro, hydro	0.887 ± 0.007	0.188 ± 0.071
CARP-640M supervisedEvaluation	FLIP2 PDZ3 single-to-double; held-out test set · PDZ3, PDZ3	0.882 ± 0.015	0.512 ± 0.014
CARP-640M supervisedEvaluation	FLIP2 Amylase one-to-many; held-out test set · Amylase, Amylase	0.873 ± 0.029	0.242 ± 0.153
CARP-640M supervisedEvaluation	FLIP2 Amylase close-to-far; held-out test set · Amylase, Amylase	0.867 ± 0.015	0.081 ± 0.055
CARP-640M supervisedEvaluation	FLIP2 Amylase far-to-close; held-out test set · Amylase, Amylase	0.832 ± 0.019	0.140 ± 0.102

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FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Original source · Primary full-text snapshot retrieved 2026-09-17; exact bytes pinned by SHA-256

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Stable ID: acquired-configuration-511e75b9873e26bacc25

source locator: Table A1; row CARP-640M supervised; column spearman
reported configuration: CARP-640M supervised
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Tested configuration	Protocol and dataset	Finding	Evidence and details
Configuration: CARP-640M supervised	Protocol: FLIP2 hydro to-P0A9X9; held-out test set · hydro Dataset subset: hydro	0.961 ± 0.004 NDCG (cutoff not stated) unitless · higher Uncertainty: ± 0.004 (type not stated) Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source CARP-640M supervised · FLIP2 hydro to-P0A9X9; held-out test set · hydro FLIP2 hydro to-P0A9X9; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A13; row CARP-640M supervised; column ndcg
Configuration: CARP-640M supervised	Protocol: FLIP2 Amylase by-mutation; held-out test set · Amylase Dataset subset: Amylase	0.926 ± 0.050 NDCG (cutoff not stated) unitless · higher Uncertainty: ± 0.05 (type not stated) Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source CARP-640M supervised · FLIP2 Amylase by-mutation; held-out test set · Amylase FLIP2 Amylase by-mutation; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A4; row CARP-640M supervised; column ndcg
Configuration: CARP-640M supervised	Protocol: FLIP2 hydro three-to-many; held-out test set · hydro Dataset subset: hydro	0.516 ± 0.035 Spearman unitless · higher Uncertainty: ± 0.035 (type not stated) Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source CARP-640M supervised · FLIP2 hydro three-to-many; held-out test set · hydro FLIP2 hydro three-to-many; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A10; row CARP-640M supervised; column spearman
Configuration: CARP-640M supervised	Protocol: FLIP2 Amylase by-mutation; held-out test set · Amylase Dataset subset: Amylase	0.551 ± 0.239 Spearman unitless · higher Uncertainty: ± 0.239 (type not stated) Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source CARP-640M supervised · FLIP2 Amylase by-mutation; held-out test set · Amylase FLIP2 Amylase by-mutation; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A4; row CARP-640M supervised; column spearman
Configuration: CARP-640M supervised	Protocol: FLIP2 TrpB two-to-many; held-out test set · TrpB Dataset subset: TrpB	0.996 ± 0.000 NDCG (cutoff not stated) unitless · higher Uncertainty: ± 0 (type not stated) Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source CARP-640M supervised · FLIP2 TrpB two-to-many; held-out test set · TrpB FLIP2 TrpB two-to-many; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A8; row CARP-640M supervised; column ndcg
Configuration: CARP-640M supervised	Protocol: FLIP2 hydro to-P0A9X9; held-out test set · hydro Dataset subset: hydro	0.004 ± 0.103 Spearman unitless · higher Uncertainty: ± 0.103 (type not stated) Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source CARP-640M supervised · FLIP2 hydro to-P0A9X9; held-out test set · hydro FLIP2 hydro to-P0A9X9; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A13; row CARP-640M supervised; column spearman
Configuration: CARP-640M supervised	Protocol: FLIP2 Amylase one-to-many; held-out test set · Amylase Dataset subset: Amylase	0.873 ± 0.029 NDCG (cutoff not stated) unitless · higher Uncertainty: ± 0.029 (type not stated) Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source CARP-640M supervised · FLIP2 Amylase one-to-many; held-out test set · Amylase FLIP2 Amylase one-to-many; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A1; row CARP-640M supervised; column ndcg
Configuration: CARP-640M supervised	Protocol: FLIP2 Amylase far-to-close; held-out test set · Amylase Dataset subset: Amylase	0.140 ± 0.102 Spearman unitless · higher Uncertainty: ± 0.102 (type not stated) Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source CARP-640M supervised · FLIP2 Amylase far-to-close; held-out test set · Amylase FLIP2 Amylase far-to-close; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A3; row CARP-640M supervised; column spearman
Configuration: CARP-640M supervised	Protocol: FLIP2 hydro to-P01053; held-out test set · hydro Dataset subset: hydro	0.909 ± 0.008 NDCG (cutoff not stated) unitless · higher Uncertainty: ± 0.008 (type not stated) Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source CARP-640M supervised · FLIP2 hydro to-P01053; held-out test set · hydro FLIP2 hydro to-P01053; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A14; row CARP-640M supervised; column ndcg
Configuration: CARP-640M supervised	Protocol: FLIP2 TrpB by-position; held-out test set · TrpB Dataset subset: TrpB	0.983 ± 0.003 NDCG (cutoff not stated) unitless · higher Uncertainty: ± 0.003 (type not stated) Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source CARP-640M supervised · FLIP2 TrpB by-position; held-out test set · TrpB FLIP2 TrpB by-position; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A9; row CARP-640M supervised; column ndcg
Configuration: CARP-640M supervised	Protocol: FLIP2 hydro low-to-high; held-out test set · hydro Dataset subset: hydro	0.188 ± 0.071 Spearman unitless · higher Uncertainty: ± 0.071 (type not stated) Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source CARP-640M supervised · FLIP2 hydro low-to-high; held-out test set · hydro FLIP2 hydro low-to-high; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A11; row CARP-640M supervised; column spearman
Configuration: CARP-640M supervised	Protocol: FLIP2 Amylase close-to-far; held-out test set · Amylase Dataset subset: Amylase	0.081 ± 0.055 Spearman unitless · higher Uncertainty: ± 0.055 (type not stated) Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source CARP-640M supervised · FLIP2 Amylase close-to-far; held-out test set · Amylase FLIP2 Amylase close-to-far; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A2; row CARP-640M supervised; column spearman
Configuration: CARP-640M supervised	Protocol: FLIP2 hydro to-P06241; held-out test set · hydro Dataset subset: hydro	0.933 ± 0.008 NDCG (cutoff not stated) unitless · higher Uncertainty: ± 0.008 (type not stated) Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source CARP-640M supervised · FLIP2 hydro to-P06241; held-out test set · hydro FLIP2 hydro to-P06241; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A12; row CARP-640M supervised; column ndcg
Configuration: CARP-640M supervised	Protocol: FLIP2 IRED two-to-many; held-out test set · IRED Dataset subset: IRED	0.948 ± 0.004 NDCG (cutoff not stated) unitless · higher Uncertainty: ± 0.004 (type not stated) Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source CARP-640M supervised · FLIP2 IRED two-to-many; held-out test set · IRED FLIP2 IRED two-to-many; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A5; row CARP-640M supervised; column ndcg
Configuration: CARP-640M supervised	Protocol: FLIP2 Amylase far-to-close; held-out test set · Amylase Dataset subset: Amylase	0.832 ± 0.019 NDCG (cutoff not stated) unitless · higher Uncertainty: ± 0.019 (type not stated) Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source CARP-640M supervised · FLIP2 Amylase far-to-close; held-out test set · Amylase FLIP2 Amylase far-to-close; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A3; row CARP-640M supervised; column ndcg
Configuration: CARP-640M supervised	Protocol: FLIP2 TrpB two-to-many; held-out test set · TrpB Dataset subset: TrpB	0.509 ± 0.010 Spearman unitless · higher Uncertainty: ± 0.01 (type not stated) Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source CARP-640M supervised · FLIP2 TrpB two-to-many; held-out test set · TrpB FLIP2 TrpB two-to-many; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A8; row CARP-640M supervised; column spearman
Configuration: CARP-640M supervised	Protocol: FLIP2 hydro low-to-high; held-out test set · hydro Dataset subset: hydro	0.887 ± 0.007 NDCG (cutoff not stated) unitless · higher Uncertainty: ± 0.007 (type not stated) Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source CARP-640M supervised · FLIP2 hydro low-to-high; held-out test set · hydro FLIP2 hydro low-to-high; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A11; row CARP-640M supervised; column ndcg
Configuration: CARP-640M supervised	Protocol: FLIP2 PDZ3 single-to-double; held-out test set · PDZ3 Dataset subset: PDZ3	0.882 ± 0.015 NDCG (cutoff not stated) unitless · higher Uncertainty: ± 0.015 (type not stated) Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source CARP-640M supervised · FLIP2 PDZ3 single-to-double; held-out test set · PDZ3 FLIP2 PDZ3 single-to-double; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A16; row CARP-640M supervised; column ndcg
Configuration: CARP-640M supervised	Protocol: FLIP2 hydro to-P01053; held-out test set · hydro Dataset subset: hydro	0.049 ± 0.088 Spearman unitless · higher Uncertainty: ± 0.088 (type not stated) Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source CARP-640M supervised · FLIP2 hydro to-P01053; held-out test set · hydro FLIP2 hydro to-P01053; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A14; row CARP-640M supervised; column spearman
Configuration: CARP-640M supervised	Protocol: FLIP2 TrpB one-to-many; held-out test set · TrpB Dataset subset: TrpB	0.992 ± 0.002 NDCG (cutoff not stated) unitless · higher Uncertainty: ± 0.002 (type not stated) Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source CARP-640M supervised · FLIP2 TrpB one-to-many; held-out test set · TrpB FLIP2 TrpB one-to-many; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A7; row CARP-640M supervised; column ndcg
Configuration: CARP-640M supervised	Protocol: FLIP2 NucB two-to-many; held-out test set · NucB Dataset subset: NucB	0.970 ± 0.001 NDCG (cutoff not stated) unitless · higher Uncertainty: ± 0.001 (type not stated) Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source CARP-640M supervised · FLIP2 NucB two-to-many; held-out test set · NucB FLIP2 NucB two-to-many; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A6; row CARP-640M supervised; column ndcg
Configuration: CARP-640M supervised	Protocol: FLIP2 TrpB by-position; held-out test set · TrpB Dataset subset: TrpB	0.167 ± 0.018 Spearman unitless · higher Uncertainty: ± 0.018 (type not stated) Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source CARP-640M supervised · FLIP2 TrpB by-position; held-out test set · TrpB FLIP2 TrpB by-position; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A9; row CARP-640M supervised; column spearman
Configuration: CARP-640M supervised	Protocol: FLIP2 NucB two-to-many; held-out test set · NucB Dataset subset: NucB	0.717 ± 0.012 Spearman unitless · higher Uncertainty: ± 0.012 (type not stated) Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source CARP-640M supervised · FLIP2 NucB two-to-many; held-out test set · NucB FLIP2 NucB two-to-many; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A6; row CARP-640M supervised; column spearman
Configuration: CARP-640M supervised	Protocol: FLIP2 hydro to-P06241; held-out test set · hydro Dataset subset: hydro	0.150 ± 0.046 Spearman unitless · higher Uncertainty: ± 0.046 (type not stated) Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source CARP-640M supervised · FLIP2 hydro to-P06241; held-out test set · hydro FLIP2 hydro to-P06241; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A12; row CARP-640M supervised; column spearman
Configuration: CARP-640M supervised	Protocol: FLIP2 PDZ3 single-to-double; held-out test set · PDZ3 Dataset subset: PDZ3	0.512 ± 0.014 Spearman unitless · higher Uncertainty: ± 0.014 (type not stated) Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source CARP-640M supervised · FLIP2 PDZ3 single-to-double; held-out test set · PDZ3 FLIP2 PDZ3 single-to-double; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A16; row CARP-640M supervised; column spearman