| Configuration: ESMC-300M supervised | Protocol: FLIP2 TrpB by-position; held-out test set · TrpB Dataset subset: TrpB | 0.980 ± 0.007 NDCG (cutoff not stated) unitless · higher Uncertainty: ± 0.007 (type not stated) Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceESMC-300M supervised · FLIP2 TrpB by-position; held-out test set · TrpB FLIP2 TrpB by-position; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A9; row ESMC-300M supervised; column ndcg |
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| Configuration: CARP-640M naive supervised | Protocol: FLIP2 TrpB one-to-many; held-out test set · TrpB Dataset subset: TrpB | 0.298 ± 0.217 Spearman unitless · higher Uncertainty: ± 0.217 (type not stated) Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceCARP-640M naive supervised · FLIP2 TrpB one-to-many; held-out test set · TrpB FLIP2 TrpB one-to-many; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A7; row CARP-640M naive supervised; column spearman |
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| Configuration: Ridge (one-hot + likelihoods) | Protocol: FLIP2 TrpB one-to-many; held-out test set · TrpB Dataset subset: TrpB | 0.453 Spearman unitless · higher Uncertainty: Not yet extracted Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceRidge (one-hot + likelihoods) · FLIP2 TrpB one-to-many; held-out test set · TrpB FLIP2 TrpB one-to-many; held-out test set Aggregation: reported point estimate FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A7; row Ridge (one-hot + likelihoods); column spearman |
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| Configuration: CARP-640M naive supervised | Protocol: FLIP2 TrpB two-to-many; held-out test set · TrpB Dataset subset: TrpB | 0.985 ± 0.002 NDCG (cutoff not stated) unitless · higher Uncertainty: ± 0.002 (type not stated) Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceCARP-640M naive supervised · FLIP2 TrpB two-to-many; held-out test set · TrpB FLIP2 TrpB two-to-many; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A8; row CARP-640M naive supervised; column ndcg |
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| Configuration: Ridge (one-hot + likelihoods) | Protocol: FLIP2 TrpB two-to-many; held-out test set · TrpB Dataset subset: TrpB | 0.994 NDCG (cutoff not stated) unitless · higher Uncertainty: Not yet extracted Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceRidge (one-hot + likelihoods) · FLIP2 TrpB two-to-many; held-out test set · TrpB FLIP2 TrpB two-to-many; held-out test set Aggregation: reported point estimate FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A8; row Ridge (one-hot + likelihoods); column ndcg |
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| Configuration: Dayhoff likelihood | Protocol: FLIP2 TrpB by-position; held-out test set · TrpB Dataset subset: TrpB | 0.183 Spearman unitless · higher Uncertainty: Not yet extracted Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceDayhoff likelihood · FLIP2 TrpB by-position; held-out test set · TrpB FLIP2 TrpB by-position; held-out test set Aggregation: reported point estimate FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A9; row Dayhoff likelihood; column spearman |
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| Configuration: CARP-640M naive supervised | Protocol: FLIP2 TrpB one-to-many; held-out test set · TrpB Dataset subset: TrpB | 0.984 ± 0.002 NDCG (cutoff not stated) unitless · higher Uncertainty: ± 0.002 (type not stated) Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceCARP-640M naive supervised · FLIP2 TrpB one-to-many; held-out test set · TrpB FLIP2 TrpB one-to-many; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A7; row CARP-640M naive supervised; column ndcg |
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| Configuration: ESMC-300M naive supervised | Protocol: FLIP2 TrpB one-to-many; held-out test set · TrpB Dataset subset: TrpB | 0.986 ± 0.002 NDCG (cutoff not stated) unitless · higher Uncertainty: ± 0.002 (type not stated) Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceESMC-300M naive supervised · FLIP2 TrpB one-to-many; held-out test set · TrpB FLIP2 TrpB one-to-many; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A7; row ESMC-300M naive supervised; column ndcg |
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| Configuration: ESMC-300M naive supervised | Protocol: FLIP2 TrpB by-position; held-out test set · TrpB Dataset subset: TrpB | 0.154 ± 0.059 Spearman unitless · higher Uncertainty: ± 0.059 (type not stated) Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceESMC-300M naive supervised · FLIP2 TrpB by-position; held-out test set · TrpB FLIP2 TrpB by-position; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A9; row ESMC-300M naive supervised; column spearman |
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| Configuration: Dayhoff likelihood | Protocol: FLIP2 TrpB one-to-many; held-out test set · TrpB Dataset subset: TrpB | 0.991 NDCG (cutoff not stated) unitless · higher Uncertainty: Not yet extracted Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceDayhoff likelihood · FLIP2 TrpB one-to-many; held-out test set · TrpB FLIP2 TrpB one-to-many; held-out test set Aggregation: reported point estimate FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A7; row Dayhoff likelihood; column ndcg |
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| Configuration: CARP-640M supervised | Protocol: FLIP2 TrpB two-to-many; held-out test set · TrpB Dataset subset: TrpB | 0.996 ± 0.000 NDCG (cutoff not stated) unitless · higher Uncertainty: ± 0 (type not stated) Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceCARP-640M supervised · FLIP2 TrpB two-to-many; held-out test set · TrpB FLIP2 TrpB two-to-many; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A8; row CARP-640M supervised; column ndcg |
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| Configuration: CARP-640M supervised | Protocol: FLIP2 TrpB by-position; held-out test set · TrpB Dataset subset: TrpB | 0.983 ± 0.003 NDCG (cutoff not stated) unitless · higher Uncertainty: ± 0.003 (type not stated) Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceCARP-640M supervised · FLIP2 TrpB by-position; held-out test set · TrpB FLIP2 TrpB by-position; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A9; row CARP-640M supervised; column ndcg |
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| Configuration: Ridge (one-hot + likelihoods) | Protocol: FLIP2 TrpB by-position; held-out test set · TrpB Dataset subset: TrpB | 0.988 NDCG (cutoff not stated) unitless · higher Uncertainty: Not yet extracted Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceRidge (one-hot + likelihoods) · FLIP2 TrpB by-position; held-out test set · TrpB FLIP2 TrpB by-position; held-out test set Aggregation: reported point estimate FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A9; row Ridge (one-hot + likelihoods); column ndcg |
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| Configuration: CARP-640M likelihood | Protocol: FLIP2 TrpB one-to-many; held-out test set · TrpB Dataset subset: TrpB | 0.418 Spearman unitless · higher Uncertainty: Not yet extracted Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceCARP-640M likelihood · FLIP2 TrpB one-to-many; held-out test set · TrpB FLIP2 TrpB one-to-many; held-out test set Aggregation: reported point estimate FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A7; row CARP-640M likelihood; column spearman |
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| Configuration: ESMC-300M naive supervised | Protocol: FLIP2 TrpB two-to-many; held-out test set · TrpB Dataset subset: TrpB | 0.398 ± 0.020 Spearman unitless · higher Uncertainty: ± 0.02 (type not stated) Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceESMC-300M naive supervised · FLIP2 TrpB two-to-many; held-out test set · TrpB FLIP2 TrpB two-to-many; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A8; row ESMC-300M naive supervised; column spearman |
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| Configuration: CARP-640M likelihood | Protocol: FLIP2 TrpB two-to-many; held-out test set · TrpB Dataset subset: TrpB | 0.992 NDCG (cutoff not stated) unitless · higher Uncertainty: Not yet extracted Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceCARP-640M likelihood · FLIP2 TrpB two-to-many; held-out test set · TrpB FLIP2 TrpB two-to-many; held-out test set Aggregation: reported point estimate FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A8; row CARP-640M likelihood; column ndcg |
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| Configuration: ESM2-650M likelihood | Protocol: FLIP2 TrpB two-to-many; held-out test set · TrpB Dataset subset: TrpB | 0.992 NDCG (cutoff not stated) unitless · higher Uncertainty: Not yet extracted Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceESM2-650M likelihood · FLIP2 TrpB two-to-many; held-out test set · TrpB FLIP2 TrpB two-to-many; held-out test set Aggregation: reported point estimate FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A8; row ESM2-650M likelihood; column ndcg |
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| Configuration: CARP-640M naive supervised | Protocol: FLIP2 TrpB by-position; held-out test set · TrpB Dataset subset: TrpB | −0.009 ± nan Spearman unitless · higher Uncertainty: Not reported by the source: printed spread "nan" Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceCARP-640M naive supervised · FLIP2 TrpB by-position; held-out test set · TrpB FLIP2 TrpB by-position; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A9; row CARP-640M naive supervised; column spearman |
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| Configuration: ESMC-300M supervised | Protocol: FLIP2 TrpB two-to-many; held-out test set · TrpB Dataset subset: TrpB | 0.991 ± 0.003 NDCG (cutoff not stated) unitless · higher Uncertainty: ± 0.003 (type not stated) Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceESMC-300M supervised · FLIP2 TrpB two-to-many; held-out test set · TrpB FLIP2 TrpB two-to-many; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A8; row ESMC-300M supervised; column ndcg |
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| Configuration: ESMC-300M supervised | Protocol: FLIP2 TrpB one-to-many; held-out test set · TrpB Dataset subset: TrpB | 0.306 ± 0.063 Spearman unitless · higher Uncertainty: ± 0.063 (type not stated) Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceESMC-300M supervised · FLIP2 TrpB one-to-many; held-out test set · TrpB FLIP2 TrpB one-to-many; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A7; row ESMC-300M supervised; column spearman |
|---|
| Configuration: CARP-640M supervised | Protocol: FLIP2 TrpB two-to-many; held-out test set · TrpB Dataset subset: TrpB | 0.509 ± 0.010 Spearman unitless · higher Uncertainty: ± 0.01 (type not stated) Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceCARP-640M supervised · FLIP2 TrpB two-to-many; held-out test set · TrpB FLIP2 TrpB two-to-many; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A8; row CARP-640M supervised; column spearman |
|---|
| Configuration: ESMC-300M naive supervised | Protocol: FLIP2 TrpB by-position; held-out test set · TrpB Dataset subset: TrpB | 0.978 ± 0.004 NDCG (cutoff not stated) unitless · higher Uncertainty: ± 0.004 (type not stated) Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceESMC-300M naive supervised · FLIP2 TrpB by-position; held-out test set · TrpB FLIP2 TrpB by-position; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A9; row ESMC-300M naive supervised; column ndcg |
|---|
| Configuration: ESMC-300M naive supervised | Protocol: FLIP2 TrpB two-to-many; held-out test set · TrpB Dataset subset: TrpB | 0.986 ± 0.001 NDCG (cutoff not stated) unitless · higher Uncertainty: ± 0.001 (type not stated) Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceESMC-300M naive supervised · FLIP2 TrpB two-to-many; held-out test set · TrpB FLIP2 TrpB two-to-many; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A8; row ESMC-300M naive supervised; column ndcg |
|---|
| Configuration: Ridge (one-hot + likelihoods) | Protocol: FLIP2 TrpB by-position; held-out test set · TrpB Dataset subset: TrpB | 0.294 Spearman unitless · higher Uncertainty: Not yet extracted Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceRidge (one-hot + likelihoods) · FLIP2 TrpB by-position; held-out test set · TrpB FLIP2 TrpB by-position; held-out test set Aggregation: reported point estimate FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A9; row Ridge (one-hot + likelihoods); column spearman |
|---|
| Configuration: Dayhoff likelihood | Protocol: FLIP2 TrpB two-to-many; held-out test set · TrpB Dataset subset: TrpB | 0.991 NDCG (cutoff not stated) unitless · higher Uncertainty: Not yet extracted Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceDayhoff likelihood · FLIP2 TrpB two-to-many; held-out test set · TrpB FLIP2 TrpB two-to-many; held-out test set Aggregation: reported point estimate FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A8; row Dayhoff likelihood; column ndcg |
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