| Configuration: ESMC-300M supervised | Protocol: FLIP2 TrpB by-position; held-out test set · TrpB Dataset subset: TrpB | 0.980 ± 0.007 ndcg unitless · higher Uncertainty: printed spread: 0.007; type: unreported; value: 0.007 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceESMC-300M supervised · FLIP2 TrpB by-position; held-out test set · TrpB FLIP2 TrpB by-position; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A9; row ESMC-300M supervised; column ndcg |
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| Configuration: CARP-640M naive supervised | Protocol: FLIP2 TrpB one-to-many; held-out test set · TrpB Dataset subset: TrpB | 0.298 ± 0.217 spearman correlation · higher Uncertainty: printed spread: 0.217; type: unreported; value: 0.217 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceCARP-640M naive supervised · FLIP2 TrpB one-to-many; held-out test set · TrpB FLIP2 TrpB one-to-many; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A7; row CARP-640M naive supervised; column spearman |
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| Configuration: Ridge (one-hot + likelihoods) | Protocol: FLIP2 TrpB one-to-many; held-out test set · TrpB Dataset subset: TrpB | 0.453 spearman correlation · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceRidge (one-hot + likelihoods) · FLIP2 TrpB one-to-many; held-out test set · TrpB FLIP2 TrpB one-to-many; held-out test set Aggregation: reported point estimate FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A7; row Ridge (one-hot + likelihoods); column spearman |
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| Configuration: CARP-640M naive supervised | Protocol: FLIP2 TrpB two-to-many; held-out test set · TrpB Dataset subset: TrpB | 0.985 ± 0.002 ndcg unitless · higher Uncertainty: printed spread: 0.002; type: unreported; value: 0.002 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceCARP-640M naive supervised · FLIP2 TrpB two-to-many; held-out test set · TrpB FLIP2 TrpB two-to-many; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A8; row CARP-640M naive supervised; column ndcg |
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| Configuration: Ridge (one-hot + likelihoods) | Protocol: FLIP2 TrpB two-to-many; held-out test set · TrpB Dataset subset: TrpB | 0.994 ndcg unitless · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceRidge (one-hot + likelihoods) · FLIP2 TrpB two-to-many; held-out test set · TrpB FLIP2 TrpB two-to-many; held-out test set Aggregation: reported point estimate FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A8; row Ridge (one-hot + likelihoods); column ndcg |
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| Configuration: Dayhoff likelihood | Protocol: FLIP2 TrpB by-position; held-out test set · TrpB Dataset subset: TrpB | 0.183 spearman correlation · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceDayhoff likelihood · FLIP2 TrpB by-position; held-out test set · TrpB FLIP2 TrpB by-position; held-out test set Aggregation: reported point estimate FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A9; row Dayhoff likelihood; column spearman |
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| Configuration: CARP-640M naive supervised | Protocol: FLIP2 TrpB one-to-many; held-out test set · TrpB Dataset subset: TrpB | 0.984 ± 0.002 ndcg unitless · higher Uncertainty: printed spread: 0.002; type: unreported; value: 0.002 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceCARP-640M naive supervised · FLIP2 TrpB one-to-many; held-out test set · TrpB FLIP2 TrpB one-to-many; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A7; row CARP-640M naive supervised; column ndcg |
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| Configuration: ESMC-300M naive supervised | Protocol: FLIP2 TrpB one-to-many; held-out test set · TrpB Dataset subset: TrpB | 0.986 ± 0.002 ndcg unitless · higher Uncertainty: printed spread: 0.002; type: unreported; value: 0.002 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceESMC-300M naive supervised · FLIP2 TrpB one-to-many; held-out test set · TrpB FLIP2 TrpB one-to-many; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A7; row ESMC-300M naive supervised; column ndcg |
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| Configuration: ESMC-300M naive supervised | Protocol: FLIP2 TrpB by-position; held-out test set · TrpB Dataset subset: TrpB | 0.154 ± 0.059 spearman correlation · higher Uncertainty: printed spread: 0.059; type: unreported; value: 0.059 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceESMC-300M naive supervised · FLIP2 TrpB by-position; held-out test set · TrpB FLIP2 TrpB by-position; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A9; row ESMC-300M naive supervised; column spearman |
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| Configuration: Dayhoff likelihood | Protocol: FLIP2 TrpB one-to-many; held-out test set · TrpB Dataset subset: TrpB | 0.991 ndcg unitless · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceDayhoff likelihood · FLIP2 TrpB one-to-many; held-out test set · TrpB FLIP2 TrpB one-to-many; held-out test set Aggregation: reported point estimate FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A7; row Dayhoff likelihood; column ndcg |
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| Configuration: CARP-640M supervised | Protocol: FLIP2 TrpB two-to-many; held-out test set · TrpB Dataset subset: TrpB | 0.996 ± 0.000 ndcg unitless · higher Uncertainty: printed spread: 0.000; type: unreported; value: 0 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceCARP-640M supervised · FLIP2 TrpB two-to-many; held-out test set · TrpB FLIP2 TrpB two-to-many; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A8; row CARP-640M supervised; column ndcg |
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| Configuration: CARP-640M supervised | Protocol: FLIP2 TrpB by-position; held-out test set · TrpB Dataset subset: TrpB | 0.983 ± 0.003 ndcg unitless · higher Uncertainty: printed spread: 0.003; type: unreported; value: 0.003 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceCARP-640M supervised · FLIP2 TrpB by-position; held-out test set · TrpB FLIP2 TrpB by-position; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A9; row CARP-640M supervised; column ndcg |
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| Configuration: Ridge (one-hot + likelihoods) | Protocol: FLIP2 TrpB by-position; held-out test set · TrpB Dataset subset: TrpB | 0.988 ndcg unitless · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceRidge (one-hot + likelihoods) · FLIP2 TrpB by-position; held-out test set · TrpB FLIP2 TrpB by-position; held-out test set Aggregation: reported point estimate FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A9; row Ridge (one-hot + likelihoods); column ndcg |
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| Configuration: CARP-640M likelihood | Protocol: FLIP2 TrpB one-to-many; held-out test set · TrpB Dataset subset: TrpB | 0.418 spearman correlation · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceCARP-640M likelihood · FLIP2 TrpB one-to-many; held-out test set · TrpB FLIP2 TrpB one-to-many; held-out test set Aggregation: reported point estimate FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A7; row CARP-640M likelihood; column spearman |
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| Configuration: ESMC-300M naive supervised | Protocol: FLIP2 TrpB two-to-many; held-out test set · TrpB Dataset subset: TrpB | 0.398 ± 0.020 spearman correlation · higher Uncertainty: printed spread: 0.020; type: unreported; value: 0.02 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceESMC-300M naive supervised · FLIP2 TrpB two-to-many; held-out test set · TrpB FLIP2 TrpB two-to-many; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A8; row ESMC-300M naive supervised; column spearman |
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| Configuration: CARP-640M likelihood | Protocol: FLIP2 TrpB two-to-many; held-out test set · TrpB Dataset subset: TrpB | 0.992 ndcg unitless · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceCARP-640M likelihood · FLIP2 TrpB two-to-many; held-out test set · TrpB FLIP2 TrpB two-to-many; held-out test set Aggregation: reported point estimate FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A8; row CARP-640M likelihood; column ndcg |
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| Configuration: ESM2-650M likelihood | Protocol: FLIP2 TrpB two-to-many; held-out test set · TrpB Dataset subset: TrpB | 0.992 ndcg unitless · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceESM2-650M likelihood · FLIP2 TrpB two-to-many; held-out test set · TrpB FLIP2 TrpB two-to-many; held-out test set Aggregation: reported point estimate FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A8; row ESM2-650M likelihood; column ndcg |
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| Configuration: CARP-640M naive supervised | Protocol: FLIP2 TrpB by-position; held-out test set · TrpB Dataset subset: TrpB | −0.009 ± nan spearman correlation · higher Uncertainty: printed spread: nan; type: unreported; value: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceCARP-640M naive supervised · FLIP2 TrpB by-position; held-out test set · TrpB FLIP2 TrpB by-position; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A9; row CARP-640M naive supervised; column spearman |
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| Configuration: ESMC-300M supervised | Protocol: FLIP2 TrpB two-to-many; held-out test set · TrpB Dataset subset: TrpB | 0.991 ± 0.003 ndcg unitless · higher Uncertainty: printed spread: 0.003; type: unreported; value: 0.003 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceESMC-300M supervised · FLIP2 TrpB two-to-many; held-out test set · TrpB FLIP2 TrpB two-to-many; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A8; row ESMC-300M supervised; column ndcg |
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| Configuration: ESMC-300M supervised | Protocol: FLIP2 TrpB one-to-many; held-out test set · TrpB Dataset subset: TrpB | 0.306 ± 0.063 spearman correlation · higher Uncertainty: printed spread: 0.063; type: unreported; value: 0.063 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceESMC-300M supervised · FLIP2 TrpB one-to-many; held-out test set · TrpB FLIP2 TrpB one-to-many; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A7; row ESMC-300M supervised; column spearman |
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| Configuration: CARP-640M supervised | Protocol: FLIP2 TrpB two-to-many; held-out test set · TrpB Dataset subset: TrpB | 0.509 ± 0.010 spearman correlation · higher Uncertainty: printed spread: 0.010; type: unreported; value: 0.01 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceCARP-640M supervised · FLIP2 TrpB two-to-many; held-out test set · TrpB FLIP2 TrpB two-to-many; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A8; row CARP-640M supervised; column spearman |
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| Configuration: ESMC-300M naive supervised | Protocol: FLIP2 TrpB by-position; held-out test set · TrpB Dataset subset: TrpB | 0.978 ± 0.004 ndcg unitless · higher Uncertainty: printed spread: 0.004; type: unreported; value: 0.004 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceESMC-300M naive supervised · FLIP2 TrpB by-position; held-out test set · TrpB FLIP2 TrpB by-position; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A9; row ESMC-300M naive supervised; column ndcg |
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| Configuration: ESMC-300M naive supervised | Protocol: FLIP2 TrpB two-to-many; held-out test set · TrpB Dataset subset: TrpB | 0.986 ± 0.001 ndcg unitless · higher Uncertainty: printed spread: 0.001; type: unreported; value: 0.001 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceESMC-300M naive supervised · FLIP2 TrpB two-to-many; held-out test set · TrpB FLIP2 TrpB two-to-many; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A8; row ESMC-300M naive supervised; column ndcg |
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| Configuration: Ridge (one-hot + likelihoods) | Protocol: FLIP2 TrpB by-position; held-out test set · TrpB Dataset subset: TrpB | 0.294 spearman correlation · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceRidge (one-hot + likelihoods) · FLIP2 TrpB by-position; held-out test set · TrpB FLIP2 TrpB by-position; held-out test set Aggregation: reported point estimate FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A9; row Ridge (one-hot + likelihoods); column spearman |
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| Configuration: Dayhoff likelihood | Protocol: FLIP2 TrpB two-to-many; held-out test set · TrpB Dataset subset: TrpB | 0.991 ndcg unitless · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceDayhoff likelihood · FLIP2 TrpB two-to-many; held-out test set · TrpB FLIP2 TrpB two-to-many; held-out test set Aggregation: reported point estimate FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A8; row Dayhoff likelihood; column ndcg |
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