| Configuration: CARP-640M likelihood | Protocol: FLIP2 Amylase far-to-close; held-out test set · Amylase Dataset subset: Amylase | 0.919 ndcg unitless · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceCARP-640M likelihood · FLIP2 Amylase far-to-close; held-out test set · Amylase FLIP2 Amylase far-to-close; held-out test set Aggregation: reported point estimate FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A3; row CARP-640M likelihood; column ndcg |
|---|
| Configuration: ESMC-300M naive supervised | Protocol: FLIP2 Amylase far-to-close; held-out test set · Amylase Dataset subset: Amylase | 0.818 ± 0.002 ndcg unitless · higher Uncertainty: printed spread: 0.002; type: unreported; value: 0.002 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceESMC-300M naive supervised · FLIP2 Amylase far-to-close; held-out test set · Amylase FLIP2 Amylase far-to-close; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A3; row ESMC-300M naive supervised; column ndcg |
|---|
| Configuration: CARP-640M naive supervised | Protocol: FLIP2 Amylase far-to-close; held-out test set · Amylase Dataset subset: Amylase | 0.825 ± 0.009 ndcg unitless · higher Uncertainty: printed spread: 0.009; type: unreported; value: 0.009 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceCARP-640M naive supervised · FLIP2 Amylase far-to-close; held-out test set · Amylase FLIP2 Amylase far-to-close; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A3; row CARP-640M naive supervised; column ndcg |
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| Configuration: Ridge (one-hot) | Protocol: FLIP2 Amylase close-to-far; held-out test set · Amylase Dataset subset: Amylase | 0.865 ndcg unitless · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceRidge (one-hot) · FLIP2 Amylase close-to-far; held-out test set · Amylase FLIP2 Amylase close-to-far; held-out test set Aggregation: reported point estimate FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A2; row Ridge (one-hot); column ndcg |
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| Configuration: CARP-640M supervised | Protocol: FLIP2 Amylase by-mutation; held-out test set · Amylase Dataset subset: Amylase | 0.926 ± 0.050 ndcg unitless · higher Uncertainty: printed spread: 0.050; type: unreported; value: 0.05 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceCARP-640M supervised · FLIP2 Amylase by-mutation; held-out test set · Amylase FLIP2 Amylase by-mutation; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A4; row CARP-640M supervised; column ndcg |
|---|
| Configuration: Ridge (one-hot + likelihoods) | Protocol: FLIP2 Amylase by-mutation; held-out test set · Amylase Dataset subset: Amylase | 0.94 ndcg unitless · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceRidge (one-hot + likelihoods) · FLIP2 Amylase by-mutation; held-out test set · Amylase FLIP2 Amylase by-mutation; held-out test set Aggregation: reported point estimate FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A4; row Ridge (one-hot + likelihoods); column ndcg |
|---|
| Configuration: ESMC-300M naive supervised | Protocol: FLIP2 Amylase one-to-many; held-out test set · Amylase Dataset subset: Amylase | 0.850 ± 0.007 ndcg unitless · higher Uncertainty: printed spread: 0.007; type: unreported; value: 0.007 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceESMC-300M naive supervised · FLIP2 Amylase one-to-many; held-out test set · Amylase FLIP2 Amylase one-to-many; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A1; row ESMC-300M naive supervised; column ndcg |
|---|
| Configuration: Dayhoff likelihood | Protocol: FLIP2 Amylase far-to-close; held-out test set · Amylase Dataset subset: Amylase | 0.58 spearman correlation · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceDayhoff likelihood · FLIP2 Amylase far-to-close; held-out test set · Amylase FLIP2 Amylase far-to-close; held-out test set Aggregation: reported point estimate FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A3; row Dayhoff likelihood; column spearman |
|---|
| Configuration: CARP-640M likelihood | Protocol: FLIP2 Amylase far-to-close; held-out test set · Amylase Dataset subset: Amylase | 0.566 spearman correlation · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceCARP-640M likelihood · FLIP2 Amylase far-to-close; held-out test set · Amylase FLIP2 Amylase far-to-close; held-out test set Aggregation: reported point estimate FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A3; row CARP-640M likelihood; column spearman |
|---|
| Configuration: ESMC-300M naive supervised | Protocol: FLIP2 Amylase close-to-far; held-out test set · Amylase Dataset subset: Amylase | 0.864 ± 0.012 ndcg unitless · higher Uncertainty: printed spread: 0.012; type: unreported; value: 0.012 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceESMC-300M naive supervised · FLIP2 Amylase close-to-far; held-out test set · Amylase FLIP2 Amylase close-to-far; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A2; row ESMC-300M naive supervised; column ndcg |
|---|
| Configuration: Ridge (one-hot + likelihoods) | Protocol: FLIP2 Amylase close-to-far; held-out test set · Amylase Dataset subset: Amylase | 0.955 ndcg unitless · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceRidge (one-hot + likelihoods) · FLIP2 Amylase close-to-far; held-out test set · Amylase FLIP2 Amylase close-to-far; held-out test set Aggregation: reported point estimate FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A2; row Ridge (one-hot + likelihoods); column ndcg |
|---|
| Configuration: ESMC-300M supervised | Protocol: FLIP2 Amylase by-mutation; held-out test set · Amylase Dataset subset: Amylase | 0.061 ± 0.130 spearman correlation · higher Uncertainty: printed spread: 0.130; type: unreported; value: 0.13 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceESMC-300M supervised · FLIP2 Amylase by-mutation; held-out test set · Amylase FLIP2 Amylase by-mutation; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A4; row ESMC-300M supervised; column spearman |
|---|
| Configuration: ESM2-650M likelihood | Protocol: FLIP2 Amylase close-to-far; held-out test set · Amylase Dataset subset: Amylase | 0.955 ndcg unitless · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceESM2-650M likelihood · FLIP2 Amylase close-to-far; held-out test set · Amylase FLIP2 Amylase close-to-far; held-out test set Aggregation: reported point estimate FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A2; row ESM2-650M likelihood; column ndcg |
|---|
| Configuration: CARP-640M likelihood | Protocol: FLIP2 Amylase by-mutation; held-out test set · Amylase Dataset subset: Amylase | 0.468 spearman correlation · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceCARP-640M likelihood · FLIP2 Amylase by-mutation; held-out test set · Amylase FLIP2 Amylase by-mutation; held-out test set Aggregation: reported point estimate FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A4; row CARP-640M likelihood; column spearman |
|---|
| Configuration: ESMC-300M naive supervised | Protocol: FLIP2 Amylase close-to-far; held-out test set · Amylase Dataset subset: Amylase | 0.007 ± 0.032 spearman correlation · higher Uncertainty: printed spread: 0.032; type: unreported; value: 0.032 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceESMC-300M naive supervised · FLIP2 Amylase close-to-far; held-out test set · Amylase FLIP2 Amylase close-to-far; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A2; row ESMC-300M naive supervised; column spearman |
|---|
| Configuration: ESM2-650M likelihood | Protocol: FLIP2 Amylase one-to-many; held-out test set · Amylase Dataset subset: Amylase | 0.942 ndcg unitless · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceESM2-650M likelihood · FLIP2 Amylase one-to-many; held-out test set · Amylase FLIP2 Amylase one-to-many; held-out test set Aggregation: reported point estimate FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A1; row ESM2-650M likelihood; column ndcg |
|---|
| Configuration: CARP-640M supervised | Protocol: FLIP2 Amylase by-mutation; held-out test set · Amylase Dataset subset: Amylase | 0.551 ± 0.239 spearman correlation · higher Uncertainty: printed spread: 0.239; type: unreported; value: 0.239 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceCARP-640M supervised · FLIP2 Amylase by-mutation; held-out test set · Amylase FLIP2 Amylase by-mutation; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A4; row CARP-640M supervised; column spearman |
|---|
| Configuration: Dayhoff likelihood | Protocol: FLIP2 Amylase by-mutation; held-out test set · Amylase Dataset subset: Amylase | 0.499 spearman correlation · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceDayhoff likelihood · FLIP2 Amylase by-mutation; held-out test set · Amylase FLIP2 Amylase by-mutation; held-out test set Aggregation: reported point estimate FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A4; row Dayhoff likelihood; column spearman |
|---|
| Configuration: ESMC-300M supervised | Protocol: FLIP2 Amylase one-to-many; held-out test set · Amylase Dataset subset: Amylase | 0.869 ± 0.028 ndcg unitless · higher Uncertainty: printed spread: 0.028; type: unreported; value: 0.028 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceESMC-300M supervised · FLIP2 Amylase one-to-many; held-out test set · Amylase FLIP2 Amylase one-to-many; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A1; row ESMC-300M supervised; column ndcg |
|---|
| Configuration: CARP-640M likelihood | Protocol: FLIP2 Amylase one-to-many; held-out test set · Amylase Dataset subset: Amylase | 0.931 ndcg unitless · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceCARP-640M likelihood · FLIP2 Amylase one-to-many; held-out test set · Amylase FLIP2 Amylase one-to-many; held-out test set Aggregation: reported point estimate FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A1; row CARP-640M likelihood; column ndcg |
|---|
| Configuration: CARP-640M supervised | Protocol: FLIP2 Amylase one-to-many; held-out test set · Amylase Dataset subset: Amylase | 0.873 ± 0.029 ndcg unitless · higher Uncertainty: printed spread: 0.029; type: unreported; value: 0.029 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceCARP-640M supervised · FLIP2 Amylase one-to-many; held-out test set · Amylase FLIP2 Amylase one-to-many; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A1; row CARP-640M supervised; column ndcg |
|---|
| Configuration: Dayhoff likelihood | Protocol: FLIP2 Amylase one-to-many; held-out test set · Amylase Dataset subset: Amylase | 0.522 spearman correlation · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceDayhoff likelihood · FLIP2 Amylase one-to-many; held-out test set · Amylase FLIP2 Amylase one-to-many; held-out test set Aggregation: reported point estimate FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A1; row Dayhoff likelihood; column spearman |
|---|
| Configuration: CARP-640M supervised | Protocol: FLIP2 Amylase far-to-close; held-out test set · Amylase Dataset subset: Amylase | 0.140 ± 0.102 spearman correlation · higher Uncertainty: printed spread: 0.102; type: unreported; value: 0.102 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceCARP-640M supervised · FLIP2 Amylase far-to-close; held-out test set · Amylase FLIP2 Amylase far-to-close; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A3; row CARP-640M supervised; column spearman |
|---|
| Configuration: ESM2-650M likelihood | Protocol: FLIP2 Amylase one-to-many; held-out test set · Amylase Dataset subset: Amylase | 0.56 spearman correlation · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceESM2-650M likelihood · FLIP2 Amylase one-to-many; held-out test set · Amylase FLIP2 Amylase one-to-many; held-out test set Aggregation: reported point estimate FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A1; row ESM2-650M likelihood; column spearman |
|---|
| Configuration: CARP-640M supervised | Protocol: FLIP2 Amylase close-to-far; held-out test set · Amylase Dataset subset: Amylase | 0.081 ± 0.055 spearman correlation · higher Uncertainty: printed spread: 0.055; type: unreported; value: 0.055 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceCARP-640M supervised · FLIP2 Amylase close-to-far; held-out test set · Amylase FLIP2 Amylase close-to-far; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A2; row CARP-640M supervised; column spearman |
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