rewirebio.iobenchmarks
Dataset subset

Amylase

Source-defined subset: Amylase. Exact membership and scoring coverage remain as reported in the cited artifact.

Evaluation results

36 evaluations · 71 results. Different protocols are not a single leaderboard.

Filter evaluations

Applied filters: All linked evaluations

Exact evaluated configurations and original reported results
Tested configurationProtocol and datasetFindingEvidence and details
Configuration: CARP-640M likelihoodProtocol: FLIP2 Amylase far-to-close; held-out test set · Amylase
Dataset subset: Amylase
0.919 NDCG (cutoff not stated)
unitless · higher

Uncertainty: Not yet extracted

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

CARP-640M likelihood · FLIP2 Amylase far-to-close; held-out test set · Amylase

FLIP2 Amylase far-to-close; held-out test set

Aggregation: reported point estimate

FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A3; row CARP-640M likelihood; column ndcg
Configuration: ESMC-300M naive supervisedProtocol: FLIP2 Amylase far-to-close; held-out test set · Amylase
Dataset subset: Amylase
0.818 ± 0.002 NDCG (cutoff not stated)
unitless · higher

Uncertainty: ± 0.002 (type not stated)

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

ESMC-300M naive supervised · FLIP2 Amylase far-to-close; held-out test set · Amylase

FLIP2 Amylase far-to-close; held-out test set

Aggregation: mean of five random-seed fits (Section 4.3)

FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A3; row ESMC-300M naive supervised; column ndcg
Configuration: CARP-640M naive supervisedProtocol: FLIP2 Amylase far-to-close; held-out test set · Amylase
Dataset subset: Amylase
0.825 ± 0.009 NDCG (cutoff not stated)
unitless · higher

Uncertainty: ± 0.009 (type not stated)

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

CARP-640M naive supervised · FLIP2 Amylase far-to-close; held-out test set · Amylase

FLIP2 Amylase far-to-close; held-out test set

Aggregation: mean of five random-seed fits (Section 4.3)

FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A3; row CARP-640M naive supervised; column ndcg
Configuration: Ridge (one-hot)Protocol: FLIP2 Amylase close-to-far; held-out test set · Amylase
Dataset subset: Amylase
0.865 NDCG (cutoff not stated)
unitless · higher

Uncertainty: Not yet extracted

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

Ridge (one-hot) · FLIP2 Amylase close-to-far; held-out test set · Amylase

FLIP2 Amylase close-to-far; held-out test set

Aggregation: reported point estimate

FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A2; row Ridge (one-hot); column ndcg
Configuration: CARP-640M supervisedProtocol: FLIP2 Amylase by-mutation; held-out test set · Amylase
Dataset subset: Amylase
0.926 ± 0.050 NDCG (cutoff not stated)
unitless · higher

Uncertainty: ± 0.05 (type not stated)

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

CARP-640M supervised · FLIP2 Amylase by-mutation; held-out test set · Amylase

FLIP2 Amylase by-mutation; held-out test set

Aggregation: mean of five random-seed fits (Section 4.3)

FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A4; row CARP-640M supervised; column ndcg
Configuration: Ridge (one-hot + likelihoods)Protocol: FLIP2 Amylase by-mutation; held-out test set · Amylase
Dataset subset: Amylase
0.94 NDCG (cutoff not stated)
unitless · higher

Uncertainty: Not yet extracted

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

Ridge (one-hot + likelihoods) · FLIP2 Amylase by-mutation; held-out test set · Amylase

FLIP2 Amylase by-mutation; held-out test set

Aggregation: reported point estimate

FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A4; row Ridge (one-hot + likelihoods); column ndcg
Configuration: ESMC-300M naive supervisedProtocol: FLIP2 Amylase one-to-many; held-out test set · Amylase
Dataset subset: Amylase
0.850 ± 0.007 NDCG (cutoff not stated)
unitless · higher

Uncertainty: ± 0.007 (type not stated)

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

ESMC-300M naive supervised · FLIP2 Amylase one-to-many; held-out test set · Amylase

FLIP2 Amylase one-to-many; held-out test set

Aggregation: mean of five random-seed fits (Section 4.3)

FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A1; row ESMC-300M naive supervised; column ndcg
Configuration: Dayhoff likelihoodProtocol: FLIP2 Amylase far-to-close; held-out test set · Amylase
Dataset subset: Amylase
0.58 Spearman
unitless · higher

Uncertainty: Not yet extracted

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

Dayhoff likelihood · FLIP2 Amylase far-to-close; held-out test set · Amylase

FLIP2 Amylase far-to-close; held-out test set

Aggregation: reported point estimate

FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A3; row Dayhoff likelihood; column spearman
Configuration: CARP-640M likelihoodProtocol: FLIP2 Amylase far-to-close; held-out test set · Amylase
Dataset subset: Amylase
0.566 Spearman
unitless · higher

Uncertainty: Not yet extracted

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

CARP-640M likelihood · FLIP2 Amylase far-to-close; held-out test set · Amylase

FLIP2 Amylase far-to-close; held-out test set

Aggregation: reported point estimate

FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A3; row CARP-640M likelihood; column spearman
Configuration: ESMC-300M naive supervisedProtocol: FLIP2 Amylase close-to-far; held-out test set · Amylase
Dataset subset: Amylase
0.864 ± 0.012 NDCG (cutoff not stated)
unitless · higher

Uncertainty: ± 0.012 (type not stated)

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

ESMC-300M naive supervised · FLIP2 Amylase close-to-far; held-out test set · Amylase

FLIP2 Amylase close-to-far; held-out test set

Aggregation: mean of five random-seed fits (Section 4.3)

FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A2; row ESMC-300M naive supervised; column ndcg
Configuration: Ridge (one-hot + likelihoods)Protocol: FLIP2 Amylase close-to-far; held-out test set · Amylase
Dataset subset: Amylase
0.955 NDCG (cutoff not stated)
unitless · higher

Uncertainty: Not yet extracted

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

Ridge (one-hot + likelihoods) · FLIP2 Amylase close-to-far; held-out test set · Amylase

FLIP2 Amylase close-to-far; held-out test set

Aggregation: reported point estimate

FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A2; row Ridge (one-hot + likelihoods); column ndcg
Configuration: ESMC-300M supervisedProtocol: FLIP2 Amylase by-mutation; held-out test set · Amylase
Dataset subset: Amylase
0.061 ± 0.130 Spearman
unitless · higher

Uncertainty: ± 0.13 (type not stated)

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

ESMC-300M supervised · FLIP2 Amylase by-mutation; held-out test set · Amylase

FLIP2 Amylase by-mutation; held-out test set

Aggregation: mean of five random-seed fits (Section 4.3)

FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A4; row ESMC-300M supervised; column spearman
Configuration: ESM2-650M likelihoodProtocol: FLIP2 Amylase close-to-far; held-out test set · Amylase
Dataset subset: Amylase
0.955 NDCG (cutoff not stated)
unitless · higher

Uncertainty: Not yet extracted

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

ESM2-650M likelihood · FLIP2 Amylase close-to-far; held-out test set · Amylase

FLIP2 Amylase close-to-far; held-out test set

Aggregation: reported point estimate

FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A2; row ESM2-650M likelihood; column ndcg
Configuration: CARP-640M likelihoodProtocol: FLIP2 Amylase by-mutation; held-out test set · Amylase
Dataset subset: Amylase
0.468 Spearman
unitless · higher

Uncertainty: Not yet extracted

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

CARP-640M likelihood · FLIP2 Amylase by-mutation; held-out test set · Amylase

FLIP2 Amylase by-mutation; held-out test set

Aggregation: reported point estimate

FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A4; row CARP-640M likelihood; column spearman
Configuration: ESMC-300M naive supervisedProtocol: FLIP2 Amylase close-to-far; held-out test set · Amylase
Dataset subset: Amylase
0.007 ± 0.032 Spearman
unitless · higher

Uncertainty: ± 0.032 (type not stated)

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

ESMC-300M naive supervised · FLIP2 Amylase close-to-far; held-out test set · Amylase

FLIP2 Amylase close-to-far; held-out test set

Aggregation: mean of five random-seed fits (Section 4.3)

FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A2; row ESMC-300M naive supervised; column spearman
Configuration: ESM2-650M likelihoodProtocol: FLIP2 Amylase one-to-many; held-out test set · Amylase
Dataset subset: Amylase
0.942 NDCG (cutoff not stated)
unitless · higher

Uncertainty: Not yet extracted

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

ESM2-650M likelihood · FLIP2 Amylase one-to-many; held-out test set · Amylase

FLIP2 Amylase one-to-many; held-out test set

Aggregation: reported point estimate

FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A1; row ESM2-650M likelihood; column ndcg
Configuration: CARP-640M supervisedProtocol: FLIP2 Amylase by-mutation; held-out test set · Amylase
Dataset subset: Amylase
0.551 ± 0.239 Spearman
unitless · higher

Uncertainty: ± 0.239 (type not stated)

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

CARP-640M supervised · FLIP2 Amylase by-mutation; held-out test set · Amylase

FLIP2 Amylase by-mutation; held-out test set

Aggregation: mean of five random-seed fits (Section 4.3)

FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A4; row CARP-640M supervised; column spearman
Configuration: Dayhoff likelihoodProtocol: FLIP2 Amylase by-mutation; held-out test set · Amylase
Dataset subset: Amylase
0.499 Spearman
unitless · higher

Uncertainty: Not yet extracted

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

Dayhoff likelihood · FLIP2 Amylase by-mutation; held-out test set · Amylase

FLIP2 Amylase by-mutation; held-out test set

Aggregation: reported point estimate

FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A4; row Dayhoff likelihood; column spearman
Configuration: ESMC-300M supervisedProtocol: FLIP2 Amylase one-to-many; held-out test set · Amylase
Dataset subset: Amylase
0.869 ± 0.028 NDCG (cutoff not stated)
unitless · higher

Uncertainty: ± 0.028 (type not stated)

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

ESMC-300M supervised · FLIP2 Amylase one-to-many; held-out test set · Amylase

FLIP2 Amylase one-to-many; held-out test set

Aggregation: mean of five random-seed fits (Section 4.3)

FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A1; row ESMC-300M supervised; column ndcg
Configuration: CARP-640M likelihoodProtocol: FLIP2 Amylase one-to-many; held-out test set · Amylase
Dataset subset: Amylase
0.931 NDCG (cutoff not stated)
unitless · higher

Uncertainty: Not yet extracted

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

CARP-640M likelihood · FLIP2 Amylase one-to-many; held-out test set · Amylase

FLIP2 Amylase one-to-many; held-out test set

Aggregation: reported point estimate

FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A1; row CARP-640M likelihood; column ndcg
Configuration: CARP-640M supervisedProtocol: FLIP2 Amylase one-to-many; held-out test set · Amylase
Dataset subset: Amylase
0.873 ± 0.029 NDCG (cutoff not stated)
unitless · higher

Uncertainty: ± 0.029 (type not stated)

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

CARP-640M supervised · FLIP2 Amylase one-to-many; held-out test set · Amylase

FLIP2 Amylase one-to-many; held-out test set

Aggregation: mean of five random-seed fits (Section 4.3)

FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A1; row CARP-640M supervised; column ndcg
Configuration: Dayhoff likelihoodProtocol: FLIP2 Amylase one-to-many; held-out test set · Amylase
Dataset subset: Amylase
0.522 Spearman
unitless · higher

Uncertainty: Not yet extracted

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

Dayhoff likelihood · FLIP2 Amylase one-to-many; held-out test set · Amylase

FLIP2 Amylase one-to-many; held-out test set

Aggregation: reported point estimate

FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A1; row Dayhoff likelihood; column spearman
Configuration: CARP-640M supervisedProtocol: FLIP2 Amylase far-to-close; held-out test set · Amylase
Dataset subset: Amylase
0.140 ± 0.102 Spearman
unitless · higher

Uncertainty: ± 0.102 (type not stated)

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

CARP-640M supervised · FLIP2 Amylase far-to-close; held-out test set · Amylase

FLIP2 Amylase far-to-close; held-out test set

Aggregation: mean of five random-seed fits (Section 4.3)

FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A3; row CARP-640M supervised; column spearman
Configuration: ESM2-650M likelihoodProtocol: FLIP2 Amylase one-to-many; held-out test set · Amylase
Dataset subset: Amylase
0.56 Spearman
unitless · higher

Uncertainty: Not yet extracted

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

ESM2-650M likelihood · FLIP2 Amylase one-to-many; held-out test set · Amylase

FLIP2 Amylase one-to-many; held-out test set

Aggregation: reported point estimate

FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A1; row ESM2-650M likelihood; column spearman
Configuration: CARP-640M supervisedProtocol: FLIP2 Amylase close-to-far; held-out test set · Amylase
Dataset subset: Amylase
0.081 ± 0.055 Spearman
unitless · higher

Uncertainty: ± 0.055 (type not stated)

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

CARP-640M supervised · FLIP2 Amylase close-to-far; held-out test set · Amylase

FLIP2 Amylase close-to-far; held-out test set

Aggregation: mean of five random-seed fits (Section 4.3)

FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A2; row CARP-640M supervised; column spearman

Source checking is not independent reproduction. Release 2026-11-02-a7f03c9e55a5.

Research readiness

0 of 4 readiness checks met. These checks assess whether the evidence supports a reproducible investigation; a source-checked score alone does not meet them.

Readiness checks, gaps and artifacts

Release 2026-11-02-a7f03c9e55a5 · Evidence verified: Not verified

Evidence incomplete

Replay metrics

Exact outcomes, predictions, identifiers and evaluator are connected.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • File checksums match the recorded files: not yet verified
  • Predictions are matched to the right samples: not yet verified
  • Score meaning and direction are confirmed: not yet verified
  • Metrics are recomputed from the saved predictions: not yet verified

Verified: Not verified

Evidence incomplete

Investigate discrepancies

Replay evidence includes annotations and an assessment of dependence. Unknown independence permits descriptive analysis only.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • File checksums match the recorded files: not yet verified
  • Predictions are matched to the right samples: not yet verified
  • Score meaning and direction are confirmed: not yet verified
  • Metrics are recomputed from the saved predictions: not yet verified
  • Sample annotations are recorded: not yet verified
  • Dependence between samples is assessed: not yet verified

Verified: Not verified

Evidence incomplete

Run locally

A pinned recipe describes the inputs, environment and resource requirements.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • File checksums match the recorded files: not yet verified
  • Predictions are matched to the right samples: not yet verified
  • Score meaning and direction are confirmed: not yet verified
  • A pinned run recipe exists: not yet verified
  • Compute requirements are estimated: not yet verified

Verified: Not verified

Evidence incomplete

Validate independently

Separate data and exposure records support an independent test.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • File checksums match the recorded files: not yet verified
  • Predictions are matched to the right samples: not yet verified
  • Score meaning and direction are confirmed: not yet verified
  • Independent validation data exist: not yet verified
  • Overlap with training data is checked: not yet verified

Verified: Not verified

Readiness describes the evidence in this release. Availability on your computer is checked separately when an investigation runs. Existing data exposure can prevent independent validation even when files are available.

Artifacts and reproduction

No verified artifact manifest is connected to this record yet. The gaps above identify what is needed before analysis can begin.

Subset and evaluation context

This record describes a particular subset or cohort used in an evaluation. Its results do not describe the full dataset.

Evidence

Source checking verifies the cited claim or transcription. It does not establish independent reproduction.

Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

3 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-11-02-a7f03c9e55a5
Property and statementOriginal source and locationReview and provenance
Source location
Table A1; row Ridge (one-hot); column spearman
Context-only references
FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications

Original source ↗

Table A1; row Ridge (one-hot); column spearman

Version: Primary full-text snapshot retrieved 2026-09-17; exact bytes pinned by SHA-256
Retrieved: 2026-09-17T08:06:28.183348+00:00

not individually reviewed

No individual claim review recorded

Audit details

Field: attributes.source_locator

Source artifact SHA-256: d0e61ca27863c023adddcc225a3e4af1718f2e3fdfe3642bef89c24c93621a17

Hash scope: Exact retrieved primary paper artifact bytes.

Inspected artifact

Description
Source-defined subset: Amylase. Exact membership and scoring coverage remain as reported in the cited artifact.
Context-only references
FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications

Original source ↗

Table A1; row Ridge (one-hot); column spearman

Version: Primary full-text snapshot retrieved 2026-09-17; exact bytes pinned by SHA-256
Retrieved: 2026-09-17T08:06:28.183348+00:00

not individually reviewed

No individual claim review recorded

Audit details

Field: description

Source artifact SHA-256: d0e61ca27863c023adddcc225a3e4af1718f2e3fdfe3642bef89c24c93621a17

Hash scope: Exact retrieved primary paper artifact bytes.

Inspected artifact

Name
Amylase
Context-only references
FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications

Original source ↗

Table A1; row Ridge (one-hot); column spearman

Version: Primary full-text snapshot retrieved 2026-09-17; exact bytes pinned by SHA-256
Retrieved: 2026-09-17T08:06:28.183348+00:00

not individually reviewed

No individual claim review recorded

Audit details

Field: name

Source artifact SHA-256: d0e61ca27863c023adddcc225a3e4af1718f2e3fdfe3642bef89c24c93621a17

Hash scope: Exact retrieved primary paper artifact bytes.

Inspected artifact

Sources and history

Release 2026-11-02-a7f03c9e55a5 · Record review: discovered

1 source record and release historyDownload this release (gzip)
Technical metadata and extraction receipts

Stable ID: acquired-dataset-b0b4eca267c04e159e7c

source locator
Table A1; row Ridge (one-hot); column spearman
missing metadata
split manifest: reason: unextracted
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