| Configuration: CARP-640M likelihood | Protocol: FLIP2 NucB two-to-many; held-out test set · NucB Dataset subset: NucB | 0.188 spearman correlation · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceCARP-640M likelihood · FLIP2 NucB two-to-many; held-out test set · NucB FLIP2 NucB two-to-many; held-out test set Aggregation: reported point estimate FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A6; row CARP-640M likelihood; column spearman |
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| Configuration: ESMC-300M naive supervised | Protocol: FLIP2 NucB two-to-many; held-out test set · NucB Dataset subset: NucB | 0.956 ± 0.003 ndcg unitless · higher Uncertainty: printed spread: 0.003; type: unreported; value: 0.003 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceESMC-300M naive supervised · FLIP2 NucB two-to-many; held-out test set · NucB FLIP2 NucB two-to-many; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A6; row ESMC-300M naive supervised; column ndcg |
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| Configuration: Ridge (one-hot) | Protocol: FLIP2 NucB two-to-many; held-out test set · NucB Dataset subset: NucB | 0.606 spearman correlation · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceRidge (one-hot) · FLIP2 NucB two-to-many; held-out test set · NucB FLIP2 NucB two-to-many; held-out test set Aggregation: reported point estimate FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A6; row Ridge (one-hot); column spearman |
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| Configuration: ESM2-650M likelihood | Protocol: FLIP2 NucB two-to-many; held-out test set · NucB Dataset subset: NucB | 0.906 ndcg unitless · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceESM2-650M likelihood · FLIP2 NucB two-to-many; held-out test set · NucB FLIP2 NucB two-to-many; held-out test set Aggregation: reported point estimate FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A6; row ESM2-650M likelihood; column ndcg |
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| Configuration: Ridge (one-hot + likelihoods) | Protocol: FLIP2 NucB two-to-many; held-out test set · NucB Dataset subset: NucB | 0.623 spearman correlation · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceRidge (one-hot + likelihoods) · FLIP2 NucB two-to-many; held-out test set · NucB FLIP2 NucB two-to-many; held-out test set Aggregation: reported point estimate FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A6; row Ridge (one-hot + likelihoods); column spearman |
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| Configuration: CARP-640M supervised | Protocol: FLIP2 NucB two-to-many; held-out test set · NucB Dataset subset: NucB | 0.970 ± 0.001 ndcg unitless · higher Uncertainty: printed spread: 0.001; type: unreported; value: 0.001 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceCARP-640M supervised · FLIP2 NucB two-to-many; held-out test set · NucB FLIP2 NucB two-to-many; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A6; row CARP-640M supervised; column ndcg |
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| Configuration: ESMC-300M supervised | Protocol: FLIP2 NucB two-to-many; held-out test set · NucB Dataset subset: NucB | 0.723 ± 0.002 spearman correlation · higher Uncertainty: printed spread: 0.002; type: unreported; value: 0.002 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceESMC-300M supervised · FLIP2 NucB two-to-many; held-out test set · NucB FLIP2 NucB two-to-many; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A6; row ESMC-300M supervised; column spearman |
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| Configuration: CARP-640M naive supervised | Protocol: FLIP2 NucB two-to-many; held-out test set · NucB Dataset subset: NucB | 0.704 ± 0.007 spearman correlation · higher Uncertainty: printed spread: 0.007; type: unreported; value: 0.007 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceCARP-640M naive supervised · FLIP2 NucB two-to-many; held-out test set · NucB FLIP2 NucB two-to-many; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A6; row CARP-640M naive supervised; column spearman |
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| Configuration: ESMC-300M supervised | Protocol: FLIP2 NucB two-to-many; held-out test set · NucB Dataset subset: NucB | 0.966 ± 0.000 ndcg unitless · higher Uncertainty: printed spread: 0.000; type: unreported; value: 0 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceESMC-300M supervised · FLIP2 NucB two-to-many; held-out test set · NucB FLIP2 NucB two-to-many; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A6; row ESMC-300M supervised; column ndcg |
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| Configuration: Ridge (one-hot + likelihoods) | Protocol: FLIP2 NucB two-to-many; held-out test set · NucB Dataset subset: NucB | 0.946 ndcg unitless · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceRidge (one-hot + likelihoods) · FLIP2 NucB two-to-many; held-out test set · NucB FLIP2 NucB two-to-many; held-out test set Aggregation: reported point estimate FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A6; row Ridge (one-hot + likelihoods); column ndcg |
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| Configuration: CARP-640M supervised | Protocol: FLIP2 NucB two-to-many; held-out test set · NucB Dataset subset: NucB | 0.717 ± 0.012 spearman correlation · higher Uncertainty: printed spread: 0.012; type: unreported; value: 0.012 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceCARP-640M supervised · FLIP2 NucB two-to-many; held-out test set · NucB FLIP2 NucB two-to-many; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A6; row CARP-640M supervised; column spearman |
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| Configuration: CARP-640M likelihood | Protocol: FLIP2 NucB two-to-many; held-out test set · NucB Dataset subset: NucB | 0.889 ndcg unitless · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceCARP-640M likelihood · FLIP2 NucB two-to-many; held-out test set · NucB FLIP2 NucB two-to-many; held-out test set Aggregation: reported point estimate FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A6; row CARP-640M likelihood; column ndcg |
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| Configuration: Ridge (one-hot) | Protocol: FLIP2 NucB two-to-many; held-out test set · NucB Dataset subset: NucB | 0.943 ndcg unitless · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceRidge (one-hot) · FLIP2 NucB two-to-many; held-out test set · NucB FLIP2 NucB two-to-many; held-out test set Aggregation: reported point estimate FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A6; row Ridge (one-hot); column ndcg |
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| Configuration: Dayhoff likelihood | Protocol: FLIP2 NucB two-to-many; held-out test set · NucB Dataset subset: NucB | 0.919 ndcg unitless · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceDayhoff likelihood · FLIP2 NucB two-to-many; held-out test set · NucB FLIP2 NucB two-to-many; held-out test set Aggregation: reported point estimate FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A6; row Dayhoff likelihood; column ndcg |
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| Configuration: CARP-640M naive supervised | Protocol: FLIP2 NucB two-to-many; held-out test set · NucB Dataset subset: NucB | 0.967 ± 0.001 ndcg unitless · higher Uncertainty: printed spread: 0.001; type: unreported; value: 0.001 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceCARP-640M naive supervised · FLIP2 NucB two-to-many; held-out test set · NucB FLIP2 NucB two-to-many; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A6; row CARP-640M naive supervised; column ndcg |
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| Configuration: ESM2-650M likelihood | Protocol: FLIP2 NucB two-to-many; held-out test set · NucB Dataset subset: NucB | 0.397 spearman correlation · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceESM2-650M likelihood · FLIP2 NucB two-to-many; held-out test set · NucB FLIP2 NucB two-to-many; held-out test set Aggregation: reported point estimate FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A6; row ESM2-650M likelihood; column spearman |
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| Configuration: ESMC-300M naive supervised | Protocol: FLIP2 NucB two-to-many; held-out test set · NucB Dataset subset: NucB | 0.635 ± 0.011 spearman correlation · higher Uncertainty: printed spread: 0.011; type: unreported; value: 0.011 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceESMC-300M naive supervised · FLIP2 NucB two-to-many; held-out test set · NucB FLIP2 NucB two-to-many; held-out test set Aggregation: mean of five random-seed fits (Section 4.3) FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A6; row ESMC-300M naive supervised; column spearman |
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| Configuration: Dayhoff likelihood | Protocol: FLIP2 NucB two-to-many; held-out test set · NucB Dataset subset: NucB | 0.478 spearman correlation · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceDayhoff likelihood · FLIP2 NucB two-to-many; held-out test set · NucB FLIP2 NucB two-to-many; held-out test set Aggregation: reported point estimate FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A6; row Dayhoff likelihood; column spearman |
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